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Protein
Submitted name:

Uncharacterized protein

Gene

rad-51

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • ATPase activity Source: WormBase
  • ATP binding Source: UniProtKB-KW
  • DEAD/H-box RNA helicase binding Source: WormBase
  • DNA-dependent ATPase activity Source: WormBase
  • double-stranded DNA binding Source: WormBase
  • four-way junction DNA binding Source: GO_Central
  • identical protein binding Source: IntAct
  • recombinase activity Source: WormBase
  • single-stranded DNA binding Source: GO_Central

GO - Biological processi

  • cellular response to DNA damage stimulus Source: WormBase
  • DNA recombinase assembly Source: GO_Central
  • embryo development ending in birth or egg hatching Source: WormBase
  • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: WormBase
  • meiotic chromosome condensation Source: WormBase
  • mitotic recombination Source: GO_Central
  • mitotic recombination-dependent replication fork processing Source: InterPro
  • negative regulation of apoptotic process Source: WormBase
  • reciprocal meiotic recombination Source: GO_Central
  • response to ionizing radiation Source: GO_Central
  • strand invasion Source: GO_Central

Keywordsi

LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:rad-51Imported
ORF Names:CELE_Y43C5A.6Imported, Y43C5A.6Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiY43C5A.6a; CE29064; WBGene00004297; rad-51.

Subcellular locationi

GO - Cellular componenti

  • condensed nuclear chromosome Source: WormBase
  • germ cell nucleus Source: WormBase
  • nucleoplasm Source: GO_Central
  • nucleus Source: WormBase
  • site of double-strand break Source: WormBase

PTM / Processingi

Proteomic databases

PaxDbiQ95Q25.

Expressioni

Gene expression databases

BgeeiWBGene00004297.
ExpressionAtlasiQ95Q25. baseline.

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • DEAD/H-box RNA helicase binding Source: WormBase
  • identical protein binding Source: IntAct

Protein-protein interaction databases

DIPiDIP-25225N.
IntActiQ95Q25. 9 interactors.
MINTiMINT-226974.
STRINGi6239.Y43C5A.6a.

Structurei

3D structure databases

ProteinModelPortaliQ95Q25.
SMRiQ95Q25.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini152 – 323RECA_2InterPro annotationAdd BLAST172
Domaini331 – 394RECA_3InterPro annotationAdd BLAST64

Sequence similaritiesi

Belongs to the RecA family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1433. Eukaryota.
COG0468. LUCA.
GeneTreeiENSGT00860000133731.
HOGENOMiHOG000227426.
InParanoidiQ95Q25.
KOiK04482.
OMAiFRPQRLI.
OrthoDBiEOG091G09QY.
PhylomeDBiQ95Q25.

Family and domain databases

CDDicd01123. Rad51_DMC1_radA. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011941. DNA_recomb/repair_Rad51.
IPR013632. DNA_recomb/repair_Rad51_C.
IPR016467. DNA_recomb/repair_RecA-like.
IPR010995. DNA_repair_Rad51/TF_NusA_a-hlx.
IPR027417. P-loop_NTPase.
IPR033925. Rad51_DMC1_RadA.
IPR020588. RecA_ATP-bd.
IPR020587. RecA_monomer-monomer_interface.
PfamiView protein in Pfam
PF08423. Rad51. 1 hit.
PIRSFiPIRSF005856. Rad51. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF47794. SSF47794. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02239. recomb_RAD51. 1 hit.
PROSITEiView protein in PROSITE
PS50162. RECA_2. 1 hit.
PS50163. RECA_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q95Q25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQSWGYEGI AKRSLCTHKW LYNLNLHSIN LFLPIESKMS AQASRQKKSD
60 70 80 90 100
QEQRAADQAL LNAAIEDNAM EQDENFTVID KLESSGISSG DISKLKEAGY
110 120 130 140 150
YTYESLAFTT RRELRNVKGI SDQKAEKIMK EAMKFVQMGF TTGAEVHVKR
160 170 180 190 200
SQLVQIRTGS ASLDRLLGGG IETGSITEVY GEYRTGKTQL CHSLAVLCQL
210 220 230 240 250
PIDMGGGEGK CMYIDTNATF RPERIIAIAQ RYNMDSAHVL ENIAVARAYN
260 270 280 290 300
SEHLMALIIR AGAMMSESRY AVVIVDCATA HFRNEYTGRG DLAERQMKLS
310 320 330 340 350
AFLKCLAKLA DEYGVAVIIT NQVVAQVDGG ASMFQADAKK PIGGHIIAHM
360 370 380 390
STTRLYLRKG KGENRVAKMV QSPNLPEAEA TYSITNHGIE DARED
Length:395
Mass (Da):43,625
Last modified:December 1, 2001 - v1
Checksum:iE844516B0C1A6AF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CAB61038.2.
RefSeqiNP_001023465.1. NM_001028294.2.
UniGeneiCel.19596.

Genome annotation databases

EnsemblMetazoaiY43C5A.6a; Y43C5A.6a; WBGene00004297.
GeneIDi177914.
KEGGicel:CELE_Y43C5A.6.
UCSCiY43C5A.6b. c. elegans.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ95Q25_CAEEL
AccessioniPrimary (citable) accession number: Q95Q25
Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: June 7, 2017
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported