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Protein
Submitted name:

Protein RAD-51, isoform a

Gene

rad-51

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ATPase activity Source: WormBase
  2. ATP binding Source: UniProtKB-KW
  3. damaged DNA binding Source: InterPro
  4. DEAD/H-box RNA helicase binding Source: WormBase
  5. DNA-dependent ATPase activity Source: WormBase
  6. double-stranded DNA binding Source: WormBase
  7. identical protein binding Source: IntAct
  8. recombinase activity Source: WormBase

GO - Biological processi

  1. ATP catabolic process Source: WormBase
  2. cellular response to DNA damage stimulus Source: WormBase
  3. DNA recombination Source: GOC
  4. DNA repair Source: InterPro
  5. embryo development ending in birth or egg hatching Source: WormBase
  6. intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: WormBase
  7. meiotic chromosome condensation Source: WormBase
  8. negative regulation of apoptotic process Source: WormBase
Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_234359. Assembly of the RAD51-ssDNA nucleoprotein complex.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein RAD-51, isoform aImported
Gene namesi
Name:rad-51Imported
ORF Names:CELE_Y43C5A.6Imported, Y43C5A.6Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome IV

Organism-specific databases

WormBaseiY43C5A.6a; CE29064; WBGene00004297; rad-51.

Subcellular locationi

GO - Cellular componenti

  1. condensed nuclear chromosome Source: WormBase
  2. germ cell nucleus Source: WormBase
  3. nucleus Source: WormBase
  4. site of double-strand break Source: WormBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ95Q25.

Expressioni

Gene expression databases

ExpressionAtlasiQ95Q25. baseline.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself6EBI-321895,EBI-321895
rfs-1P343483EBI-321895,EBI-330791
ubc-9Q950174EBI-321895,EBI-328938

Protein-protein interaction databases

DIPiDIP-25225N.
IntActiQ95Q25. 10 interactions.
MINTiMINT-226974.
STRINGi6239.Y43C5A.6a.

Structurei

3D structure databases

ProteinModelPortaliQ95Q25.
SMRiQ95Q25. Positions 79-394.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RecA family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00770000120539.
HOGENOMiHOG000227426.
InParanoidiQ95Q25.
KOiK04482.
OMAiCQLPIDQ.
OrthoDBiEOG715Q4H.
PhylomeDBiQ95Q25.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011941. DNA_recomb/repair_Rad51.
IPR013632. DNA_recomb/repair_Rad51_C.
IPR016467. DNA_recomb/repair_RecA-like.
IPR010995. DNA_repair_Rad51/TF_NusA_a-hlx.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR027417. P-loop_NTPase.
IPR020588. RecA_ATP-bd.
IPR020587. RecA_monomer-monomer_interface.
[Graphical view]
PfamiPF08423. Rad51. 1 hit.
[Graphical view]
PIRSFiPIRSF005856. Rad51. 1 hit.
SMARTiSM00382. AAA. 1 hit.
SM00278. HhH1. 1 hit.
[Graphical view]
SUPFAMiSSF47794. SSF47794. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02239. recomb_RAD51. 1 hit.
PROSITEiPS50162. RECA_2. 1 hit.
PS50163. RECA_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q95Q25-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGQSWGYEGI AKRSLCTHKW LYNLNLHSIN LFLPIESKMS AQASRQKKSD
60 70 80 90 100
QEQRAADQAL LNAAIEDNAM EQDENFTVID KLESSGISSG DISKLKEAGY
110 120 130 140 150
YTYESLAFTT RRELRNVKGI SDQKAEKIMK EAMKFVQMGF TTGAEVHVKR
160 170 180 190 200
SQLVQIRTGS ASLDRLLGGG IETGSITEVY GEYRTGKTQL CHSLAVLCQL
210 220 230 240 250
PIDMGGGEGK CMYIDTNATF RPERIIAIAQ RYNMDSAHVL ENIAVARAYN
260 270 280 290 300
SEHLMALIIR AGAMMSESRY AVVIVDCATA HFRNEYTGRG DLAERQMKLS
310 320 330 340 350
AFLKCLAKLA DEYGVAVIIT NQVVAQVDGG ASMFQADAKK PIGGHIIAHM
360 370 380 390
STTRLYLRKG KGENRVAKMV QSPNLPEAEA TYSITNHGIE DARED
Length:395
Mass (Da):43,625
Last modified:December 1, 2001 - v1
Checksum:iE844516B0C1A6AF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL023838 Genomic DNA. Translation: CAB61038.2.
RefSeqiNP_001023465.1. NM_001028294.2.
UniGeneiCel.19596.

Genome annotation databases

EnsemblMetazoaiY43C5A.6a; Y43C5A.6a; WBGene00004297.
GeneIDi177914.
KEGGicel:CELE_Y43C5A.6.
UCSCiY43C5A.6b. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL023838 Genomic DNA. Translation: CAB61038.2.
RefSeqiNP_001023465.1. NM_001028294.2.
UniGeneiCel.19596.

3D structure databases

ProteinModelPortaliQ95Q25.
SMRiQ95Q25. Positions 79-394.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-25225N.
IntActiQ95Q25. 10 interactions.
MINTiMINT-226974.
STRINGi6239.Y43C5A.6a.

Proteomic databases

PRIDEiQ95Q25.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY43C5A.6a; Y43C5A.6a; WBGene00004297.
GeneIDi177914.
KEGGicel:CELE_Y43C5A.6.
UCSCiY43C5A.6b. c. elegans.

Organism-specific databases

CTDi177914.
WormBaseiY43C5A.6a; CE29064; WBGene00004297; rad-51.

Phylogenomic databases

GeneTreeiENSGT00770000120539.
HOGENOMiHOG000227426.
InParanoidiQ95Q25.
KOiK04482.
OMAiCQLPIDQ.
OrthoDBiEOG715Q4H.
PhylomeDBiQ95Q25.

Enzyme and pathway databases

ReactomeiREACT_234359. Assembly of the RAD51-ssDNA nucleoprotein complex.

Miscellaneous databases

NextBioi898916.
PROiQ95Q25.

Gene expression databases

ExpressionAtlasiQ95Q25. baseline.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011941. DNA_recomb/repair_Rad51.
IPR013632. DNA_recomb/repair_Rad51_C.
IPR016467. DNA_recomb/repair_RecA-like.
IPR010995. DNA_repair_Rad51/TF_NusA_a-hlx.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR027417. P-loop_NTPase.
IPR020588. RecA_ATP-bd.
IPR020587. RecA_monomer-monomer_interface.
[Graphical view]
PfamiPF08423. Rad51. 1 hit.
[Graphical view]
PIRSFiPIRSF005856. Rad51. 1 hit.
SMARTiSM00382. AAA. 1 hit.
SM00278. HhH1. 1 hit.
[Graphical view]
SUPFAMiSSF47794. SSF47794. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02239. recomb_RAD51. 1 hit.
PROSITEiPS50162. RECA_2. 1 hit.
PS50163. RECA_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ95Q25_CAEEL
AccessioniPrimary (citable) accession number: Q95Q25
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: January 7, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.