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Q95PM9

- KARG_PLOIN

UniProt

Q95PM9 - KARG_PLOIN

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Protein

Arginine kinase

Gene

ARGK

Organism
Plodia interpunctella (Indianmeal moth)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-arginine = ADP + N(omega)-phospho-L-arginine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei184 – 1841ATPPROSITE-ProRule annotation
Binding sitei224 – 2241SubstrateBy similarity
Binding sitei228 – 2281ATPPROSITE-ProRule annotation
Binding sitei270 – 2701SubstrateBy similarity
Binding sitei313 – 3131SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi121 – 1255ATPPROSITE-ProRule annotation
Nucleotide bindingi279 – 2835ATPPROSITE-ProRule annotation
Nucleotide bindingi308 – 3136ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. arginine kinase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine kinase (EC:2.7.3.3)
Short name:
AK
Alternative name(s):
Allergen: Plo i 1
Gene namesi
Name:ARGK
OrganismiPlodia interpunctella (Indianmeal moth)
Taxonomic identifieri58824 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaPyraloideaPyralidaePhycitinaePlodia

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei575. Plo i 1.
8301. Plo i 1.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 355355Arginine kinasePRO_0000211993Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ95PM9.
SMRiQ95PM9. Positions 2-354.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 9085Phosphagen kinase N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini118 – 355238Phosphagen kinase C-terminalPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni63 – 675Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the ATP:guanido phosphotransferase family.PROSITE-ProRule annotation
Contains 1 phosphagen kinase C-terminal domain.PROSITE-ProRule annotation
Contains 1 phosphagen kinase N-terminal domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di1.10.135.10. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR022415. ATP-guanido_PTrfase_AS.
IPR022414. ATP-guanido_PTrfase_cat.
IPR022413. ATP-guanido_PTrfase_N.
IPR014746. Gln_synth/guanido_kin_cat_dom.
[Graphical view]
PfamiPF00217. ATP-gua_Ptrans. 1 hit.
PF02807. ATP-gua_PtransN. 1 hit.
[Graphical view]
SUPFAMiSSF48034. SSF48034. 1 hit.
PROSITEiPS00112. PHOSPHAGEN_KINASE. 1 hit.
PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
PS51509. PHOSPHAGEN_KINASE_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q95PM9 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVDAATLEKL EAGFSKLAAS DSKSLLKKYL TREVFDALKN KKTSFGSTLL
60 70 80 90 100
DSIQSGVENL HSGVGIYAPD AEAYVVFADL FDPIIEDYHN GFKKTDKHPP
110 120 130 140 150
KNWGDVETLG NLDPAGEFVV STRVRCGRSM EGYPFNPCLT EAQYKEMEEK
160 170 180 190 200
VSSTLSGLEG ELKGTFFPLT GMSKETQQQL IDDHFLFKEG DRFLQAANAC
210 220 230 240 250
RFWPSGRGIY HNENKTFLVW CNEEDHLRLI SMQMGGDLKQ VYKRLVRGVN
260 270 280 290 300
DIAKRIPFSH NERLGFLTFC PTNLGTTVRA SVHIKLPKLA ADKAKLEEVA
310 320 330 340 350
SKYHLQVRGT RGEHTEAEGG VYDISNKRRM GLTEYEAVKE MYDGIAELIK

IEKSL
Length:355
Mass (Da):39,879
Last modified:December 1, 2001 - v1
Checksum:i6C497931E9A854F7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ315030 mRNA. Translation: CAC85911.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ315030 mRNA. Translation: CAC85911.1 .

3D structure databases

ProteinModelPortali Q95PM9.
SMRi Q95PM9. Positions 2-354.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 575. Plo i 1.
8301. Plo i 1.0101.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.135.10. 1 hit.
3.30.590.10. 1 hit.
InterProi IPR022415. ATP-guanido_PTrfase_AS.
IPR022414. ATP-guanido_PTrfase_cat.
IPR022413. ATP-guanido_PTrfase_N.
IPR014746. Gln_synth/guanido_kin_cat_dom.
[Graphical view ]
Pfami PF00217. ATP-gua_Ptrans. 1 hit.
PF02807. ATP-gua_PtransN. 1 hit.
[Graphical view ]
SUPFAMi SSF48034. SSF48034. 1 hit.
PROSITEi PS00112. PHOSPHAGEN_KINASE. 1 hit.
PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
PS51509. PHOSPHAGEN_KINASE_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular and immunological characterization of arginine kinase from the Indianmeal moth, Plodia interpunctella, a novel cross-reactive invertebrate pan-allergen."
    Binder M., Mahler V., Hayek B., Sperr W.R., Scholler M., Prozell S., Wiedermann G., Valent P., Valenta R., Duchene M.
    J. Immunol. 167:5470-5477(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiKARG_PLOIN
AccessioniPrimary (citable) accession number: Q95PM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: December 1, 2001
Last modified: October 1, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3