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Q95PM9 (KARG_PLOIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine kinase

Short name=AK
EC=2.7.3.3
Alternative name(s):
Allergen=Plo i 1
Gene names
Name:ARGK
OrganismPlodia interpunctella (Indianmeal moth)
Taxonomic identifier58824 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaPyraloideaPyralidaePhycitinaePlodia

Protein attributes

Sequence length355 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + L-arginine = ADP + N(omega)-phospho-L-arginine.

Allergenic properties

Causes an allergic reaction in human.

Sequence similarities

Belongs to the ATP:guanido phosphotransferase family.

Contains 1 phosphagen kinase C-terminal domain.

Contains 1 phosphagen kinase N-terminal domain.

Ontologies

Keywords
   DiseaseAllergen
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

arginine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 355355Arginine kinase
PRO_0000211993

Regions

Domain6 – 9085Phosphagen kinase N-terminal
Domain118 – 355238Phosphagen kinase C-terminal
Nucleotide binding121 – 1255ATP By similarity
Nucleotide binding279 – 2835ATP By similarity
Nucleotide binding308 – 3136ATP By similarity
Region63 – 675Substrate binding By similarity

Sites

Binding site1841ATP By similarity
Binding site2241Substrate By similarity
Binding site2281ATP By similarity
Binding site2701Substrate By similarity
Binding site3131Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q95PM9 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 6C497931E9A854F7

FASTA35539,879
        10         20         30         40         50         60 
MVDAATLEKL EAGFSKLAAS DSKSLLKKYL TREVFDALKN KKTSFGSTLL DSIQSGVENL 

        70         80         90        100        110        120 
HSGVGIYAPD AEAYVVFADL FDPIIEDYHN GFKKTDKHPP KNWGDVETLG NLDPAGEFVV 

       130        140        150        160        170        180 
STRVRCGRSM EGYPFNPCLT EAQYKEMEEK VSSTLSGLEG ELKGTFFPLT GMSKETQQQL 

       190        200        210        220        230        240 
IDDHFLFKEG DRFLQAANAC RFWPSGRGIY HNENKTFLVW CNEEDHLRLI SMQMGGDLKQ 

       250        260        270        280        290        300 
VYKRLVRGVN DIAKRIPFSH NERLGFLTFC PTNLGTTVRA SVHIKLPKLA ADKAKLEEVA 

       310        320        330        340        350 
SKYHLQVRGT RGEHTEAEGG VYDISNKRRM GLTEYEAVKE MYDGIAELIK IEKSL 

« Hide

References

[1]"Molecular and immunological characterization of arginine kinase from the Indianmeal moth, Plodia interpunctella, a novel cross-reactive invertebrate pan-allergen."
Binder M., Mahler V., Hayek B., Sperr W.R., Scholler M., Prozell S., Wiedermann G., Valent P., Valenta R., Duchene M.
J. Immunol. 167:5470-5477(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ315030 mRNA. Translation: CAC85911.1.

3D structure databases

ProteinModelPortalQ95PM9.
SMRQ95PM9. Positions 2-354.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome575. Plo i 1.
8301. Plo i 1.0101.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.135.10. 1 hit.
3.30.590.10. 1 hit.
InterProIPR022415. ATP-guanido_PTrfase_AS.
IPR022414. ATP-guanido_PTrfase_cat.
IPR022413. ATP-guanido_PTrfase_N.
IPR014746. Gln_synth/guanido_kin_cat_dom.
[Graphical view]
PfamPF00217. ATP-gua_Ptrans. 1 hit.
PF02807. ATP-gua_PtransN. 1 hit.
[Graphical view]
SUPFAMSSF48034. SSF48034. 1 hit.
PROSITEPS00112. PHOSPHAGEN_KINASE. 1 hit.
PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
PS51509. PHOSPHAGEN_KINASE_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKARG_PLOIN
AccessionPrimary (citable) accession number: Q95PM9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Allergens

Nomenclature of allergens and list of entries