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Q95PM9

- KARG_PLOIN

UniProt

Q95PM9 - KARG_PLOIN

Protein

Arginine kinase

Gene

ARGK

Organism
Plodia interpunctella (Indianmeal moth)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-arginine = ADP + N(omega)-phospho-L-arginine.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei184 – 1841ATPPROSITE-ProRule annotation
    Binding sitei224 – 2241SubstrateBy similarity
    Binding sitei228 – 2281ATPPROSITE-ProRule annotation
    Binding sitei270 – 2701SubstrateBy similarity
    Binding sitei313 – 3131SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi121 – 1255ATPPROSITE-ProRule annotation
    Nucleotide bindingi279 – 2835ATPPROSITE-ProRule annotation
    Nucleotide bindingi308 – 3136ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. arginine kinase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arginine kinase (EC:2.7.3.3)
    Short name:
    AK
    Alternative name(s):
    Allergen: Plo i 1
    Gene namesi
    Name:ARGK
    OrganismiPlodia interpunctella (Indianmeal moth)
    Taxonomic identifieri58824 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaPyraloideaPyralidaePhycitinaePlodia

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human.

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei575. Plo i 1.
    8301. Plo i 1.0101.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 355355Arginine kinasePRO_0000211993Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ95PM9.
    SMRiQ95PM9. Positions 2-354.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 9085Phosphagen kinase N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini118 – 355238Phosphagen kinase C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni63 – 675Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the ATP:guanido phosphotransferase family.PROSITE-ProRule annotation
    Contains 1 phosphagen kinase C-terminal domain.PROSITE-ProRule annotation
    Contains 1 phosphagen kinase N-terminal domain.PROSITE-ProRule annotation

    Family and domain databases

    Gene3Di1.10.135.10. 1 hit.
    3.30.590.10. 1 hit.
    InterProiIPR022415. ATP-guanido_PTrfase_AS.
    IPR022414. ATP-guanido_PTrfase_cat.
    IPR022413. ATP-guanido_PTrfase_N.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    [Graphical view]
    PfamiPF00217. ATP-gua_Ptrans. 1 hit.
    PF02807. ATP-gua_PtransN. 1 hit.
    [Graphical view]
    SUPFAMiSSF48034. SSF48034. 1 hit.
    PROSITEiPS00112. PHOSPHAGEN_KINASE. 1 hit.
    PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
    PS51509. PHOSPHAGEN_KINASE_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q95PM9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVDAATLEKL EAGFSKLAAS DSKSLLKKYL TREVFDALKN KKTSFGSTLL    50
    DSIQSGVENL HSGVGIYAPD AEAYVVFADL FDPIIEDYHN GFKKTDKHPP 100
    KNWGDVETLG NLDPAGEFVV STRVRCGRSM EGYPFNPCLT EAQYKEMEEK 150
    VSSTLSGLEG ELKGTFFPLT GMSKETQQQL IDDHFLFKEG DRFLQAANAC 200
    RFWPSGRGIY HNENKTFLVW CNEEDHLRLI SMQMGGDLKQ VYKRLVRGVN 250
    DIAKRIPFSH NERLGFLTFC PTNLGTTVRA SVHIKLPKLA ADKAKLEEVA 300
    SKYHLQVRGT RGEHTEAEGG VYDISNKRRM GLTEYEAVKE MYDGIAELIK 350
    IEKSL 355
    Length:355
    Mass (Da):39,879
    Last modified:December 1, 2001 - v1
    Checksum:i6C497931E9A854F7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ315030 mRNA. Translation: CAC85911.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ315030 mRNA. Translation: CAC85911.1 .

    3D structure databases

    ProteinModelPortali Q95PM9.
    SMRi Q95PM9. Positions 2-354.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 575. Plo i 1.
    8301. Plo i 1.0101.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.135.10. 1 hit.
    3.30.590.10. 1 hit.
    InterProi IPR022415. ATP-guanido_PTrfase_AS.
    IPR022414. ATP-guanido_PTrfase_cat.
    IPR022413. ATP-guanido_PTrfase_N.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    [Graphical view ]
    Pfami PF00217. ATP-gua_Ptrans. 1 hit.
    PF02807. ATP-gua_PtransN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48034. SSF48034. 1 hit.
    PROSITEi PS00112. PHOSPHAGEN_KINASE. 1 hit.
    PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
    PS51509. PHOSPHAGEN_KINASE_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular and immunological characterization of arginine kinase from the Indianmeal moth, Plodia interpunctella, a novel cross-reactive invertebrate pan-allergen."
      Binder M., Mahler V., Hayek B., Sperr W.R., Scholler M., Prozell S., Wiedermann G., Valent P., Valenta R., Duchene M.
      J. Immunol. 167:5470-5477(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiKARG_PLOIN
    AccessioniPrimary (citable) accession number: Q95PM9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 25, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3