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Protein

Arginine kinase

Gene

ARGK

Organism
Plodia interpunctella (Indianmeal moth)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-arginine = ADP + N(omega)-phospho-L-arginine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei184ATPPROSITE-ProRule annotation1
Binding sitei224SubstrateBy similarity1
Binding sitei228ATPPROSITE-ProRule annotation1
Binding sitei270SubstrateBy similarity1
Binding sitei313SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi121 – 125ATPPROSITE-ProRule annotation5
Nucleotide bindingi279 – 283ATPPROSITE-ProRule annotation5
Nucleotide bindingi308 – 313ATPPROSITE-ProRule annotation6

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine kinase (EC:2.7.3.3)
Short name:
AK
Alternative name(s):
Allergen: Plo i 1
Gene namesi
Name:ARGK
OrganismiPlodia interpunctella (Indianmeal moth)
Taxonomic identifieri58824 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaPyraloideaPyralidaePhycitinaePlodia

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei575. Plo i 1.
8301. Plo i 1.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002119931 – 355Arginine kinaseAdd BLAST355

Proteomic databases

PRIDEiQ95PM9.

Structurei

3D structure databases

ProteinModelPortaliQ95PM9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 90Phosphagen kinase N-terminalPROSITE-ProRule annotationAdd BLAST85
Domaini118 – 355Phosphagen kinase C-terminalPROSITE-ProRule annotationAdd BLAST238

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni63 – 67Substrate bindingBy similarity5

Sequence similaritiesi

Belongs to the ATP:guanido phosphotransferase family.PROSITE-ProRule annotation
Contains 1 phosphagen kinase C-terminal domain.PROSITE-ProRule annotation
Contains 1 phosphagen kinase N-terminal domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di1.10.135.10. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR000749. ATP-guanido_PTrfase.
IPR022415. ATP-guanido_PTrfase_AS.
IPR022414. ATP-guanido_PTrfase_cat.
IPR022413. ATP-guanido_PTrfase_N.
IPR014746. Gln_synth/guanido_kin_cat_dom.
[Graphical view]
PANTHERiPTHR11547. PTHR11547. 1 hit.
PfamiPF00217. ATP-gua_Ptrans. 1 hit.
PF02807. ATP-gua_PtransN. 1 hit.
[Graphical view]
SUPFAMiSSF48034. SSF48034. 1 hit.
PROSITEiPS00112. PHOSPHAGEN_KINASE. 1 hit.
PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
PS51509. PHOSPHAGEN_KINASE_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q95PM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDAATLEKL EAGFSKLAAS DSKSLLKKYL TREVFDALKN KKTSFGSTLL
60 70 80 90 100
DSIQSGVENL HSGVGIYAPD AEAYVVFADL FDPIIEDYHN GFKKTDKHPP
110 120 130 140 150
KNWGDVETLG NLDPAGEFVV STRVRCGRSM EGYPFNPCLT EAQYKEMEEK
160 170 180 190 200
VSSTLSGLEG ELKGTFFPLT GMSKETQQQL IDDHFLFKEG DRFLQAANAC
210 220 230 240 250
RFWPSGRGIY HNENKTFLVW CNEEDHLRLI SMQMGGDLKQ VYKRLVRGVN
260 270 280 290 300
DIAKRIPFSH NERLGFLTFC PTNLGTTVRA SVHIKLPKLA ADKAKLEEVA
310 320 330 340 350
SKYHLQVRGT RGEHTEAEGG VYDISNKRRM GLTEYEAVKE MYDGIAELIK

IEKSL
Length:355
Mass (Da):39,879
Last modified:December 1, 2001 - v1
Checksum:i6C497931E9A854F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ315030 mRNA. Translation: CAC85911.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ315030 mRNA. Translation: CAC85911.1.

3D structure databases

ProteinModelPortaliQ95PM9.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei575. Plo i 1.
8301. Plo i 1.0101.

Proteomic databases

PRIDEiQ95PM9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.135.10. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR000749. ATP-guanido_PTrfase.
IPR022415. ATP-guanido_PTrfase_AS.
IPR022414. ATP-guanido_PTrfase_cat.
IPR022413. ATP-guanido_PTrfase_N.
IPR014746. Gln_synth/guanido_kin_cat_dom.
[Graphical view]
PANTHERiPTHR11547. PTHR11547. 1 hit.
PfamiPF00217. ATP-gua_Ptrans. 1 hit.
PF02807. ATP-gua_PtransN. 1 hit.
[Graphical view]
SUPFAMiSSF48034. SSF48034. 1 hit.
PROSITEiPS00112. PHOSPHAGEN_KINASE. 1 hit.
PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
PS51509. PHOSPHAGEN_KINASE_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKARG_PLOIN
AccessioniPrimary (citable) accession number: Q95PM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: December 1, 2001
Last modified: October 5, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.