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Reviewed, UniProtKB/Swiss-Prot Q95NE0 (NAR4_PANTR)

Last modified October 13, 2009. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Ecto-ADP-ribosyltransferase 4
    EC=2.4.2.31
Alternative name(s):
    NAD(P)(+)--arginine ADP-ribosyltransferase 4
    Mono(ADP-ribosyl)transferase 4
    Dombrock molecule 1
    CD_antigen=CD297
Gene names
Name: ART4
Synonyms: DO
OrganismPan troglodytes (Chimpanzee)
Taxonomic identifier9598 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan

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Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

NAD+ + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine.

NADP+ + protein-L-arginine = nicotinamide + N(omega)-((2'-phospho-ADP)-D-ribosyl)-protein-L-arginine.

Subcellular location

Cell membrane; Lipid-anchor › GPI-anchor By similarity.

Sequence similarities

Belongs to the Arg-specific ADP-ribosyltransferase family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4646 Potential
Chain47 – 285239Ecto-ADP-ribosyltransferase 4
PRO_0000019331
Propeptide286 – 31429Removed in mature form Potential
PRO_0000019332

Sites

Active site2511 By similarity
Binding site1261NAD By similarity
Binding site2061NAD By similarity
Binding site2401NAD By similarity

Amino acid modifications

Lipidation2851GPI-anchor amidated alanine Potential
Glycosylation1141N-linked (GlcNAc...) Potential
Glycosylation1781N-linked (GlcNAc...) Potential
Glycosylation2221N-linked (GlcNAc...) Potential
Glycosylation2571N-linked (GlcNAc...) Potential
Glycosylation2741N-linked (GlcNAc...) Potential
Disulfide bond69 ↔ 280 By similarity
Disulfide bond182 ↔ 231 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q95NE0-1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 1CD76A650B87A423

FASTA31435,862
        10         20         30         40         50         60 
MGPLINRCKK ILLPTTVPPA TMRIWLLGGP LPFLLLLSGL QRPTEGSEVA IKIDFDFAPG 

        70         80         90        100        110        120 
SFDDQYQGCS KQVMEKLTQG DYFTKDIEAQ KNYFRMWQKA HLAWLNQGKV LPQNMTTTHA 

       130        140        150        160        170        180 
VAILFYTLNS NVHSDFTRAM ASVARTPQQY ERSFHFKYLH YYLTSAIQLL RKDSIMENGT 

       190        200        210        220        230        240 
LCYEVHYRTK DVHFNAYTGA TIRFGQFLST SLLKEEAQEF GNQTLFTIFT CLGAPVQYFS 

       250        260        270        280        290        300 
LKKEVLIPPY ELFKVINMSY HPRGNWLQLR STGNLSTYNC QLLKASSKKC IPDPIAIASL 

       310 
SFLTSVIIFS KSRV

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References

[1]"Pan troglodytes Dombrock glycoprotein (DO) gene exon 3."
Rios M., Reid M.
Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

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Cross-references

Sequence databases

AF373017, AF373016, AF374727 Genomic DNA. Translation: AAK53821.1.
RefSeqNP_001009134.1.

3D structure databases

HSSPHSSP built from PDB template 1GXY based on UniProtKB P20974.
ModBaseSearch...

Genome annotation databases

EnsemblENSPTRT00000008731; ENSPTRP00000008068; ENSPTRG00000004726; Pan troglodytes. [Genome view]
GeneID473376.
KEGGptr:473376.

Organism-specific databases

CTD473376.

Phylogenomic databases

HOVERGENQ95NE0.

Enzyme and pathway databases

BRENDA2.4.2.31. 264977.

Family and domain databases

InterProIPR000768. ART.
[Graphical view]
PANTHERPTHR10339. ART. 1 hit.
PfamPF01129. ART. 1 hit.
[Graphical view]
PRINTSPR00970. RIBTRNSFRASE.
PROSITEPS01291. ART. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameNAR4_PANTR
AccessionPrimary (citable) accession number: Q95NE0
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: December 1, 2001
Last modified: October 13, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents