Reviewed, UniProtKB/Swiss-Prot Q95NE0 (NAR4_PANTR)

Names and origin

Protein names

Recommended name:
    Ecto-ADP-ribosyltransferase 4
    EC=2.4.2.31
Alternative name(s):
    NAD(P)(+)--arginine ADP-ribosyltransferase 4
    Mono(ADP-ribosyl)transferase 4
    Dombrock molecule 1
    CD_antigen=CD297

Gene names

Name:	ART4
Synonyms:	DO

Organism

Pan troglodytes (Chimpanzee)

Taxonomic identifier

9598 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan

Protein attributes

Sequence length	314 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	NAD+ + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine. NADP+ + protein-L-arginine = nicotinamide + N(omega)-((2'-phospho-ADP)-D-ribosyl)-protein-L-arginine.
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor By similarity.
Sequence similarities	Belongs to the Arg-specific ADP-ribosyltransferase family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Signal
Ligand	NAD NADP
Molecular function	Glycosyltransferase Transferase
PTM	Disulfide bond GPI-anchor Glycoprotein Lipoprotein
Gene Ontology (GO)
Biological process	protein amino acid ADP-ribosylation Inferred from electronic annotation. Source: InterPro
Cellular component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD(P)+-protein-arginine ADP-ribosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 46	46	Potential
	Chain	47 – 285	239	Ecto-ADP-ribosyltransferase 4		PRO_0000019331
	Propeptide	286 – 314	29	Removed in mature form Potential		PRO_0000019332
Sites
	Active site	251	1	By similarity
	Binding site	126	1	NAD By similarity
	Binding site	206	1	NAD By similarity
	Binding site	240	1	NAD By similarity
Amino acid modifications
	Lipidation	285	1	GPI-anchor amidated alanine Potential
	Glycosylation	114	1	N-linked (GlcNAc...) Potential
	Glycosylation	178	1	N-linked (GlcNAc...) Potential
	Glycosylation	222	1	N-linked (GlcNAc...) Potential
	Glycosylation	257	1	N-linked (GlcNAc...) Potential
	Glycosylation	274	1	N-linked (GlcNAc...) Potential
	Disulfide bond	69 ↔ 280		By similarity
	Disulfide bond	182 ↔ 231		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q95NE0-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 1CD76A650B87A423	FASTA	314	35,862
	10 20 30 40 50 60 MGPLINRCKK ILLPTTVPPA TMRIWLLGGP LPFLLLLSGL QRPTEGSEVA IKIDFDFAPG 70 80 90 100 110 120 SFDDQYQGCS KQVMEKLTQG DYFTKDIEAQ KNYFRMWQKA HLAWLNQGKV LPQNMTTTHA 130 140 150 160 170 180 VAILFYTLNS NVHSDFTRAM ASVARTPQQY ERSFHFKYLH YYLTSAIQLL RKDSIMENGT 190 200 210 220 230 240 LCYEVHYRTK DVHFNAYTGA TIRFGQFLST SLLKEEAQEF GNQTLFTIFT CLGAPVQYFS 250 260 270 280 290 300 LKKEVLIPPY ELFKVINMSY HPRGNWLQLR STGNLSTYNC QLLKASSKKC IPDPIAIASL 310 SFLTSVIIFS KSRV

References

[1]	"Pan troglodytes Dombrock glycoprotein (DO) gene exon 3." Rios M., Reid M. Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF373017, AF373016, AF374727 Genomic DNA. Translation: AAK53821.1.
RefSeq	NP_001009134.1.
3D structure databases
SMR	Q95NE0. Positions 54-281.
ModBase	Search...
Genome annotation databases
Ensembl	ENSPTRT00000008731; ENSPTRP00000008068; ENSPTRG00000004726; Pan troglodytes. [Genome view]
GeneID	473376.
KEGG	ptr:473376.
Organism-specific databases
CTD	473376.
Phylogenomic databases
eggNOG	prNOG15608.
HOVERGEN	Q95NE0.
InParanoid	Q95NE0.
Enzyme and pathway databases
BRENDA	2.4.2.31. 264977.
Family and domain databases
InterPro	IPR000768. ART. [Graphical view]
PANTHER	PTHR10339. ART. 1 hit.
Pfam	PF01129. ART. 1 hit. [Graphical view]
PRINTS	PR00970. RIBTRNSFRASE.
PROSITE	PS01291. ART. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NAR4_PANTR

Accession

Primary (citable) accession number: Q95NE0

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 13, 2002
Last sequence update:	December 1, 2001
Last modified:	January 19, 2010
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)