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Protein

Peroxisome proliferator-activated receptor alpha

Gene

PPARA

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2 (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei433Essential for heterodimerization with RXRABy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi99 – 173Nuclear receptorPROSITE-ProRule annotationAdd BLAST75
Zinc fingeri102 – 122NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri139 – 161NR C4-typePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Receptor

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Lipid-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-CFA-383280. Nuclear Receptor transcription pathway.
R-CFA-400206. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome proliferator-activated receptor alpha
Short name:
PPAR-alpha
Alternative name(s):
Nuclear receptor subfamily 1 group C member 1
Gene namesi
Name:PPARA
Synonyms:NR1C1
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 10

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2847.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000534791 – 468Peroxisome proliferator-activated receptor alphaAdd BLAST468

Proteomic databases

PaxDbiQ95N78.

Interactioni

Subunit structurei

Heterodimer; with RXRA. This heterodimerization is required for DNA binding and transactivation activity. Interacts with NCOA3 coactivator. Interacts with CITED2; the interaction stimulates its transcriptional activity. Also interacts with PPARBP in vitro. Interacts with AKAP13, LPIN1, PRDM16 and coactivator NCOA6. Interacts with ASXL1 and ASXL2. Interacts with PER2. Interacts with SIRT1; the interaction seems to be modulated by NAD+ levels (By similarity).By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000001118.

Chemistry databases

BindingDBiQ95N78.

Structurei

3D structure databases

ProteinModelPortaliQ95N78.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni280 – 468Ligand-bindingBy similarityAdd BLAST189
Regioni304 – 433Required for heterodimerization with RXRABy similarityAdd BLAST130

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri102 – 122NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri139 – 161NR C4-typePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00850000132242.
HOGENOMiHOG000261626.
HOVERGENiHBG106004.
InParanoidiQ95N78.
KOiK07294.
OMAiYGSGFIT.
OrthoDBiEOG091G05U8.
TreeFamiTF316304.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR003074. 1Cnucl_rcpt.
IPR003076. 1Cnucl_rcpt_A.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01288. PROXISOMEPAR.
PR01289. PROXISOMPAAR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q95N78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDTESPICP LSPLEADDLE SPLSEEFLQE MGNIQEISQS IGEDSSGSFS
60 70 80 90 100
FTEYQYLGSG PGSDGSVITD TLSPAPSPSS VTHPAAPGGA EEPSSVALNI
110 120 130 140 150
ECRICGDRAS GYHYGVHACE GCKGFFRRTI RLKLAYDKCD RSCKIQKKNR
160 170 180 190 200
NKCQYCRFHK CLSVGMSHNA IRFGRMPRSE KAKLKAEILT CEQDPEDAET
210 220 230 240 250
ADLKSLAKRI YEAYLKNFNM NKVKARVILA GKASNNPPFV IHDMETLCMA
260 270 280 290 300
EKTLVAKLVA NGIQNKEAEV RIFHCCQCTS VETVTELTEF AKSIPGFANL
310 320 330 340 350
DLNDQVTLLK YGVYEAIFAM LSSVMNKDGM LVAYGNGFIT REFLKSLRKP
360 370 380 390 400
FCDIMEPKFD FAMKFNALEL DDSDISLFVA AIICCGDRPG LLNVGHIEKM
410 420 430 440 450
QEGIVHVLKL HLQTNHPDNI FLFPKLLQKM ADLRQLVTEH AQLVQVIKKT
460
ESDAALHPLL QEIYRDMY
Length:468
Mass (Da):52,123
Last modified:December 1, 2001 - v1
Checksum:i11F2C2F9AAB176D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF350327 mRNA. Translation: AAK38655.1.
RefSeqiNP_001003093.1. NM_001003093.1.
XP_005625734.1. XM_005625677.1.
XP_013972720.1. XM_014117245.1.
UniGeneiCfa.3519.

Genome annotation databases

EnsembliENSCAFT00000001222; ENSCAFP00000001118; ENSCAFG00000000788.
GeneIDi403654.
KEGGicfa:403654.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF350327 mRNA. Translation: AAK38655.1.
RefSeqiNP_001003093.1. NM_001003093.1.
XP_005625734.1. XM_005625677.1.
XP_013972720.1. XM_014117245.1.
UniGeneiCfa.3519.

3D structure databases

ProteinModelPortaliQ95N78.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000001118.

Chemistry databases

BindingDBiQ95N78.
ChEMBLiCHEMBL2847.

Proteomic databases

PaxDbiQ95N78.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000001222; ENSCAFP00000001118; ENSCAFG00000000788.
GeneIDi403654.
KEGGicfa:403654.

Organism-specific databases

CTDi5465.

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00850000132242.
HOGENOMiHOG000261626.
HOVERGENiHBG106004.
InParanoidiQ95N78.
KOiK07294.
OMAiYGSGFIT.
OrthoDBiEOG091G05U8.
TreeFamiTF316304.

Enzyme and pathway databases

ReactomeiR-CFA-383280. Nuclear Receptor transcription pathway.
R-CFA-400206. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).

Miscellaneous databases

PROiQ95N78.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR003074. 1Cnucl_rcpt.
IPR003076. 1Cnucl_rcpt_A.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01288. PROXISOMEPAR.
PR01289. PROXISOMPAAR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPARA_CANLF
AccessioniPrimary (citable) accession number: Q95N78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: December 1, 2001
Last modified: October 5, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.