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Q95N03 (CLTR2_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cysteinyl leukotriene receptor 2

Short name=CysLTR2
Gene names
Name:CYSLTR2
Synonyms:CYSLT2
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length345 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 345345Cysteinyl leukotriene receptor 2
PRO_0000069305

Regions

Topological domain1 – 4343Extracellular Potential
Transmembrane44 – 6421Helical; Name=1; Potential
Topological domain65 – 739Cytoplasmic Potential
Transmembrane74 – 9421Helical; Name=2; Potential
Topological domain95 – 12430Extracellular Potential
Transmembrane125 – 14521Helical; Name=3; Potential
Topological domain146 – 1549Cytoplasmic Potential
Transmembrane155 – 17521Helical; Name=4; Potential
Topological domain176 – 20530Extracellular Potential
Transmembrane206 – 22621Helical; Name=5; Potential
Topological domain227 – 24620Cytoplasmic Potential
Transmembrane247 – 26721Helical; Name=6; Potential
Topological domain268 – 28720Extracellular Potential
Transmembrane288 – 30821Helical; Name=7; Potential
Topological domain309 – 34537Cytoplasmic Potential

Amino acid modifications

Glycosylation201N-linked (GlcNAc...) Potential
Glycosylation291N-linked (GlcNAc...) Potential
Glycosylation1771N-linked (GlcNAc...) Potential
Glycosylation1841N-linked (GlcNAc...) Potential
Disulfide bond112 ↔ 188 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q95N03 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 5D1B1FB89BB95905

FASTA34539,411
        10         20         30         40         50         60 
MERKLMSLLP SISLSEMEPN STLGNHNSNR SCTTENFKRE FYPIVYLVIF IWGALGNGFS 

        70         80         90        100        110        120 
IYVFLKPYKK STSVNVFMLN LAISDLLFTI TLPFRVDYYL RGSNXIFGDT PCRIMSYSMY 

       130        140        150        160        170        180 
VNMYSSIYFL TVLSVVRFLA TVHPFRLLHT TSIKNAWILC GVIWIFIMAS STVLLKNGSE 

       190        200        210        220        230        240 
QKDNVTLCLE LNSNKVTKLK TMNYVALVVG FVLPFGTLSI CYLLIIRALL KVEVPESGLR 

       250        260        270        280        290        300 
LSHRKALITV IIALIIFLLC FLPYHVLRTL HLLEWKADKC KDRLHKAVAV TLALAAANSC 

       310        320        330        340 
FNPFLYYFAG ENFKDRLKSA LRKGRPQKTR CGFSVCVWLK KETRV 

« Hide

References

[1]"Characterization of the cloned rat and porcine cysteinyl leukotriene receptors."
Kamohara M., Takasaki J., Matsumoto M., Matsumoto S., Saito T., Ohishi T., Soga T., Matsushime H., Furuichi K.
Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB052662 mRNA. Translation: BAB60817.1.
UniGeneSsc.15880.

3D structure databases

ProteinModelPortalQ95N03.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9823.ENSSSCP00000010030.

Protein family/group databases

GPCRDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG119185.
HOGENOMHOG000236328.
HOVERGENHBG099611.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR013311. CLT2_recept.
IPR004071. Cyst_leuk_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01903. CYSLT2RECPTR.
PR01533. CYSLTRECPTR.
PR00237. GPCRRHODOPSN.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCLTR2_PIG
AccessionPrimary (citable) accession number: Q95N03
Entry history
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries