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Q95N03

- CLTR2_PIG

UniProt

Q95N03 - CLTR2_PIG

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Protein

Cysteinyl leukotriene receptor 2

Gene
CYSLTR2, CYSLT2
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system By similarity.

GO - Molecular functioni

  1. leukotriene receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteinyl leukotriene receptor 2
Short name:
CysLTR2
Gene namesi
Name:CYSLTR2
Synonyms:CYSLT2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343Extracellular Reviewed predictionAdd
BLAST
Transmembranei44 – 6421Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini65 – 739Cytoplasmic Reviewed prediction
Transmembranei74 – 9421Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini95 – 12430Extracellular Reviewed predictionAdd
BLAST
Transmembranei125 – 14521Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini146 – 1549Cytoplasmic Reviewed prediction
Transmembranei155 – 17521Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini176 – 20530Extracellular Reviewed predictionAdd
BLAST
Transmembranei206 – 22621Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini227 – 24620Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei247 – 26721Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini268 – 28720Extracellular Reviewed predictionAdd
BLAST
Transmembranei288 – 30821Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini309 – 34537Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 345345Cysteinyl leukotriene receptor 2PRO_0000069305Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi20 – 201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi29 – 291N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi112 ↔ 188 By similarity
Glycosylationi177 – 1771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi184 – 1841N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000010030.

Structurei

3D structure databases

ProteinModelPortaliQ95N03.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG119185.
HOGENOMiHOG000236328.
HOVERGENiHBG099611.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR013311. CLT2_recept.
IPR004071. Cyst_leuk_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01903. CYSLT2RECPTR.
PR01533. CYSLTRECPTR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q95N03-1 [UniParc]FASTAAdd to Basket

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MERKLMSLLP SISLSEMEPN STLGNHNSNR SCTTENFKRE FYPIVYLVIF    50
IWGALGNGFS IYVFLKPYKK STSVNVFMLN LAISDLLFTI TLPFRVDYYL 100
RGSNXIFGDT PCRIMSYSMY VNMYSSIYFL TVLSVVRFLA TVHPFRLLHT 150
TSIKNAWILC GVIWIFIMAS STVLLKNGSE QKDNVTLCLE LNSNKVTKLK 200
TMNYVALVVG FVLPFGTLSI CYLLIIRALL KVEVPESGLR LSHRKALITV 250
IIALIIFLLC FLPYHVLRTL HLLEWKADKC KDRLHKAVAV TLALAAANSC 300
FNPFLYYFAG ENFKDRLKSA LRKGRPQKTR CGFSVCVWLK KETRV 345
Length:345
Mass (Da):39,411
Last modified:December 1, 2001 - v1
Checksum:i5D1B1FB89BB95905
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB052662 mRNA. Translation: BAB60817.1.
UniGeneiSsc.15880.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB052662 mRNA. Translation: BAB60817.1 .
UniGenei Ssc.15880.

3D structure databases

ProteinModelPortali Q95N03.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9823.ENSSSCP00000010030.

Protein family/group databases

GPCRDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG119185.
HOGENOMi HOG000236328.
HOVERGENi HBG099611.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR013311. CLT2_recept.
IPR004071. Cyst_leuk_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01903. CYSLT2RECPTR.
PR01533. CYSLTRECPTR.
PR00237. GPCRRHODOPSN.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of the cloned rat and porcine cysteinyl leukotriene receptors."
    Kamohara M., Takasaki J., Matsumoto M., Matsumoto S., Saito T., Ohishi T., Soga T., Matsushime H., Furuichi K.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCLTR2_PIG
AccessioniPrimary (citable) accession number: Q95N03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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