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Q95N03

- CLTR2_PIG

UniProt

Q95N03 - CLTR2_PIG

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Protein
Cysteinyl leukotriene receptor 2
Gene
CYSLTR2, CYSLT2
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system By similarity.

GO - Molecular functioni

  1. leukotriene receptor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cysteinyl leukotriene receptor 2
    Short name:
    CysLTR2
    Gene namesi
    Name:CYSLTR2
    Synonyms:CYSLT2
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Unplaced

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4343Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei44 – 6421Helical; Name=1; Reviewed prediction
    Add
    BLAST
    Topological domaini65 – 739Cytoplasmic Reviewed prediction
    Transmembranei74 – 9421Helical; Name=2; Reviewed prediction
    Add
    BLAST
    Topological domaini95 – 12430Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei125 – 14521Helical; Name=3; Reviewed prediction
    Add
    BLAST
    Topological domaini146 – 1549Cytoplasmic Reviewed prediction
    Transmembranei155 – 17521Helical; Name=4; Reviewed prediction
    Add
    BLAST
    Topological domaini176 – 20530Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei206 – 22621Helical; Name=5; Reviewed prediction
    Add
    BLAST
    Topological domaini227 – 24620Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei247 – 26721Helical; Name=6; Reviewed prediction
    Add
    BLAST
    Topological domaini268 – 28720Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei288 – 30821Helical; Name=7; Reviewed prediction
    Add
    BLAST
    Topological domaini309 – 34537Cytoplasmic Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 345345Cysteinyl leukotriene receptor 2
    PRO_0000069305Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi20 – 201N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi29 – 291N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi112 ↔ 188 By similarity
    Glycosylationi177 – 1771N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi184 – 1841N-linked (GlcNAc...) Reviewed prediction

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi9823.ENSSSCP00000010030.

    Structurei

    3D structure databases

    ProteinModelPortaliQ95N03.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG119185.
    HOGENOMiHOG000236328.
    HOVERGENiHBG099611.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR013311. CLT2_recept.
    IPR004071. Cyst_leuk_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01903. CYSLT2RECPTR.
    PR01533. CYSLTRECPTR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q95N03-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERKLMSLLP SISLSEMEPN STLGNHNSNR SCTTENFKRE FYPIVYLVIF    50
    IWGALGNGFS IYVFLKPYKK STSVNVFMLN LAISDLLFTI TLPFRVDYYL 100
    RGSNXIFGDT PCRIMSYSMY VNMYSSIYFL TVLSVVRFLA TVHPFRLLHT 150
    TSIKNAWILC GVIWIFIMAS STVLLKNGSE QKDNVTLCLE LNSNKVTKLK 200
    TMNYVALVVG FVLPFGTLSI CYLLIIRALL KVEVPESGLR LSHRKALITV 250
    IIALIIFLLC FLPYHVLRTL HLLEWKADKC KDRLHKAVAV TLALAAANSC 300
    FNPFLYYFAG ENFKDRLKSA LRKGRPQKTR CGFSVCVWLK KETRV 345
    Length:345
    Mass (Da):39,411
    Last modified:December 1, 2001 - v1
    Checksum:i5D1B1FB89BB95905
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB052662 mRNA. Translation: BAB60817.1.
    UniGeneiSsc.15880.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB052662 mRNA. Translation: BAB60817.1 .
    UniGenei Ssc.15880.

    3D structure databases

    ProteinModelPortali Q95N03.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 9823.ENSSSCP00000010030.

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG119185.
    HOGENOMi HOG000236328.
    HOVERGENi HBG099611.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR013311. CLT2_recept.
    IPR004071. Cyst_leuk_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01903. CYSLT2RECPTR.
    PR01533. CYSLTRECPTR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the cloned rat and porcine cysteinyl leukotriene receptors."
      Kamohara M., Takasaki J., Matsumoto M., Matsumoto S., Saito T., Ohishi T., Soga T., Matsushime H., Furuichi K.
      Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCLTR2_PIG
    AccessioniPrimary (citable) accession number: Q95N03
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 11, 2002
    Last sequence update: December 1, 2001
    Last modified: April 16, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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