Q95N03 (CLTR2_PIG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cysteinyl leukotriene receptor 2
Short name=CysLTR2

Gene names

Name:	CYSLTR2
Synonyms:	CYSLT2

Organism

Sus scrofa (Pig) [Reference proteome]

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	345 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	leukotriene receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 345	345	Cysteinyl leukotriene receptor 2		PRO_0000069305
Regions
	Topological domain	1 – 43	43	Extracellular Potential
	Transmembrane	44 – 64	21	Helical; Name=1; Potential
	Topological domain	65 – 73	9	Cytoplasmic Potential
	Transmembrane	74 – 94	21	Helical; Name=2; Potential
	Topological domain	95 – 124	30	Extracellular Potential
	Transmembrane	125 – 145	21	Helical; Name=3; Potential
	Topological domain	146 – 154	9	Cytoplasmic Potential
	Transmembrane	155 – 175	21	Helical; Name=4; Potential
	Topological domain	176 – 205	30	Extracellular Potential
	Transmembrane	206 – 226	21	Helical; Name=5; Potential
	Topological domain	227 – 246	20	Cytoplasmic Potential
	Transmembrane	247 – 267	21	Helical; Name=6; Potential
	Topological domain	268 – 287	20	Extracellular Potential
	Transmembrane	288 – 308	21	Helical; Name=7; Potential
	Topological domain	309 – 345	37	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	20	1	N-linked (GlcNAc...) Potential
	Glycosylation	29	1	N-linked (GlcNAc...) Potential
	Glycosylation	177	1	N-linked (GlcNAc...) Potential
	Glycosylation	184	1	N-linked (GlcNAc...) Potential
	Disulfide bond	112 ↔ 188		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q95N03 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 5D1B1FB89BB95905	FASTA	345	39,411
	10 20 30 40 50 60 MERKLMSLLP SISLSEMEPN STLGNHNSNR SCTTENFKRE FYPIVYLVIF IWGALGNGFS 70 80 90 100 110 120 IYVFLKPYKK STSVNVFMLN LAISDLLFTI TLPFRVDYYL RGSNXIFGDT PCRIMSYSMY 130 140 150 160 170 180 VNMYSSIYFL TVLSVVRFLA TVHPFRLLHT TSIKNAWILC GVIWIFIMAS STVLLKNGSE 190 200 210 220 230 240 QKDNVTLCLE LNSNKVTKLK TMNYVALVVG FVLPFGTLSI CYLLIIRALL KVEVPESGLR 250 260 270 280 290 300 LSHRKALITV IIALIIFLLC FLPYHVLRTL HLLEWKADKC KDRLHKAVAV TLALAAANSC 310 320 330 340 FNPFLYYFAG ENFKDRLKSA LRKGRPQKTR CGFSVCVWLK KETRV

References

[1]	"Characterization of the cloned rat and porcine cysteinyl leukotriene receptors." Kamohara M., Takasaki J., Matsumoto M., Matsumoto S., Saito T., Ohishi T., Soga T., Matsushime H., Furuichi K. Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB052662 mRNA. Translation: BAB60817.1.
UniGene	Ssc.15880.
3D structure databases
ProteinModelPortal	Q95N03.
ModBase	Search...
Protein-protein interaction databases
STRING	9823.ENSSSCP00000010030.
Protein family/group databases
GPCRDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	NOG119185.
HOGENOM	HOG000236328.
HOVERGEN	HBG099611.
OrthoDB	EOG4PNXH8.
Family and domain databases
InterPro	IPR013311. CLT2_recept. IPR004071. Cyst_leuk_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR01903. CYSLT2RECPTR. PR01533. CYSLTRECPTR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CLTR2_PIG

Accession

Primary (citable) accession number: Q95N03

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 11, 2002
Last sequence update:	December 1, 2001
Last modified:	April 3, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program