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Q95N02 (CLTR1_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cysteinyl leukotriene receptor 1

Short name=CysLTR1
Gene names
Name:CYSLTR1
Synonyms:CYSLT1
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length340 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for cysteinyl leukotrienes mediating constriction of the microvascular smooth muscle during an inflammatory response. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 340340Cysteinyl leukotriene receptor 1
PRO_0000069301

Regions

Topological domain1 – 3131Extracellular Potential
Transmembrane32 – 5221Helical; Name=1; Potential
Topological domain53 – 608Cytoplasmic Potential
Transmembrane61 – 8121Helical; Name=2; Potential
Topological domain82 – 10928Extracellular Potential
Transmembrane110 – 13021Helical; Name=3; Potential
Topological domain131 – 14414Cytoplasmic Potential
Transmembrane145 – 16521Helical; Name=4; Potential
Topological domain166 – 19631Extracellular Potential
Transmembrane197 – 21721Helical; Name=5; Potential
Topological domain218 – 23316Cytoplasmic Potential
Transmembrane234 – 25421Helical; Name=6; Potential
Topological domain255 – 27925Extracellular Potential
Transmembrane280 – 30021Helical; Name=7; Potential
Topological domain301 – 34040Cytoplasmic Potential

Amino acid modifications

Glycosylation61N-linked (GlcNAc...) Potential
Glycosylation181N-linked (GlcNAc...) Potential
Glycosylation1721N-linked (GlcNAc...) Potential
Glycosylation2651N-linked (GlcNAc...) Potential
Disulfide bond99 ↔ 176 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q95N02 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 54F9372A121CE413

FASTA34038,989
        10         20         30         40         50         60 
MDGVRNLTVS CASSNTCNDT IDDFRNQVYS TLYSMITVVG FFGNGFVLYV LIKTYHEKSA 

        70         80         90        100        110        120 
YQVYMINLAV ADLLCVCTLP LRVVYYVHKG IWLFGDFLCR LSTYALYVNL YCSIFFMTAM 

       130        140        150        160        170        180 
SFFRCIAIVF PVQNINLITH KKAKIVCIAI WIFVILTSSP FLMSTSYKDE KNNTKCFEPP 

       190        200        210        220        230        240 
QXNQAKYHVL VLHYVSLFVG FIIPFVIIIV CYTMIILTLL KNSMKKNISS RKKAIGMIIV 

       250        260        270        280        290        300 
VTAAFLISFM PYHIQRTIHL HFLHNDTKHC DSVLRMQKSV XITLSLAASN CCFDPLLYFF 

       310        320        330        340 
SGGNFREGLS TFRKHSLSTM TYVPKKKTSL PEKAQEIYKE 

« Hide

References

[1]"Characterization of cloned rat and porcine cysteinyl leukotriene receptors."
Takasaki J., Kamohara M., Saito T., Matsumoto M., Matsumoto S., Ohishi T., Soga T., Matsushime H., Furuichi K.
Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB052686 mRNA. Translation: BAB60826.1.
RefSeqNP_999294.1. NM_214129.1.
UniGeneSsc.15879.

3D structure databases

ProteinModelPortalQ95N02.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9823.ENSSSCP00000013241.

Protein family/group databases

GPCRDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID397242.
KEGGssc:397242.

Organism-specific databases

CTD397242.

Phylogenomic databases

eggNOGNOG119185.
HOGENOMHOG000236328.
HOVERGENHBG099611.
KOK04322.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR013310. CLT1_recept.
IPR004071. Cyst_leuk_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01902. CYSLT1RECPTR.
PR01533. CYSLTRECPTR.
PR00237. GPCRRHODOPSN.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCLTR1_PIG
AccessionPrimary (citable) accession number: Q95N02
Entry history
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries