Q95N02 (CLTR1_PIG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cysteinyl leukotriene receptor 1
Short name=CysLTR1

Gene names

Name:	CYSLTR1
Synonyms:	CYSLT1

Organism

Sus scrofa (Pig) [Reference proteome]

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	340 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for cysteinyl leukotrienes mediating constriction of the microvascular smooth muscle during an inflammatory response. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	leukotriene receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 340	340	Cysteinyl leukotriene receptor 1		PRO_0000069301
Regions
	Topological domain	1 – 31	31	Extracellular Potential
	Transmembrane	32 – 52	21	Helical; Name=1; Potential
	Topological domain	53 – 60	8	Cytoplasmic Potential
	Transmembrane	61 – 81	21	Helical; Name=2; Potential
	Topological domain	82 – 109	28	Extracellular Potential
	Transmembrane	110 – 130	21	Helical; Name=3; Potential
	Topological domain	131 – 144	14	Cytoplasmic Potential
	Transmembrane	145 – 165	21	Helical; Name=4; Potential
	Topological domain	166 – 196	31	Extracellular Potential
	Transmembrane	197 – 217	21	Helical; Name=5; Potential
	Topological domain	218 – 233	16	Cytoplasmic Potential
	Transmembrane	234 – 254	21	Helical; Name=6; Potential
	Topological domain	255 – 279	25	Extracellular Potential
	Transmembrane	280 – 300	21	Helical; Name=7; Potential
	Topological domain	301 – 340	40	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	6	1	N-linked (GlcNAc...) Potential
	Glycosylation	18	1	N-linked (GlcNAc...) Potential
	Glycosylation	172	1	N-linked (GlcNAc...) Potential
	Glycosylation	265	1	N-linked (GlcNAc...) Potential
	Disulfide bond	99 ↔ 176		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q95N02 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 54F9372A121CE413	FASTA	340	38,989
	10 20 30 40 50 60 MDGVRNLTVS CASSNTCNDT IDDFRNQVYS TLYSMITVVG FFGNGFVLYV LIKTYHEKSA 70 80 90 100 110 120 YQVYMINLAV ADLLCVCTLP LRVVYYVHKG IWLFGDFLCR LSTYALYVNL YCSIFFMTAM 130 140 150 160 170 180 SFFRCIAIVF PVQNINLITH KKAKIVCIAI WIFVILTSSP FLMSTSYKDE KNNTKCFEPP 190 200 210 220 230 240 QXNQAKYHVL VLHYVSLFVG FIIPFVIIIV CYTMIILTLL KNSMKKNISS RKKAIGMIIV 250 260 270 280 290 300 VTAAFLISFM PYHIQRTIHL HFLHNDTKHC DSVLRMQKSV XITLSLAASN CCFDPLLYFF 310 320 330 340 SGGNFREGLS TFRKHSLSTM TYVPKKKTSL PEKAQEIYKE

References

[1]	"Characterization of cloned rat and porcine cysteinyl leukotriene receptors." Takasaki J., Kamohara M., Saito T., Matsumoto M., Matsumoto S., Ohishi T., Soga T., Matsushime H., Furuichi K. Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB052686 mRNA. Translation: BAB60826.1.
RefSeq	NP_999294.1. NM_214129.1.
UniGene	Ssc.15879.
3D structure databases
ProteinModelPortal	Q95N02.
ModBase	Search...
Protein-protein interaction databases
STRING	9823.ENSSSCP00000013241.
Protein family/group databases
GPCRDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	397242.
KEGG	ssc:397242.
Organism-specific databases
CTD	397242.
Phylogenomic databases
eggNOG	NOG119185.
HOGENOM	HOG000236328.
HOVERGEN	HBG099611.
KO	K04322.
OrthoDB	EOG46T31Z.
Family and domain databases
InterPro	IPR013310. CLT1_recept. IPR004071. Cyst_leuk_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR01902. CYSLT1RECPTR. PR01533. CYSLTRECPTR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CLTR1_PIG

Accession

Primary (citable) accession number: Q95N02

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 11, 2002
Last sequence update:	December 1, 2001
Last modified:	April 3, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program