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Protein

Cysteinyl leukotriene receptor 1

Gene

CYSLTR1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for cysteinyl leukotrienes mediating constriction of the microvascular smooth muscle during an inflammatory response. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity).By similarity

GO - Molecular functioni

  1. leukotriene receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteinyl leukotriene receptor 1
Short name:
CysLTR1
Gene namesi
Name:CYSLTR1
Synonyms:CYSLT1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3131ExtracellularSequence AnalysisAdd
BLAST
Transmembranei32 – 5221Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini53 – 608CytoplasmicSequence Analysis
Transmembranei61 – 8121Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini82 – 10928ExtracellularSequence AnalysisAdd
BLAST
Transmembranei110 – 13021Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini131 – 14414CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei145 – 16521Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini166 – 19631ExtracellularSequence AnalysisAdd
BLAST
Transmembranei197 – 21721Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini218 – 23316CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei234 – 25421Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini255 – 27925ExtracellularSequence AnalysisAdd
BLAST
Transmembranei280 – 30021Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini301 – 34040CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340Cysteinyl leukotriene receptor 1PRO_0000069301Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
Glycosylationi18 – 181N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi99 ↔ 176PROSITE-ProRule annotation
Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000013241.

Structurei

3D structure databases

ProteinModelPortaliQ95N02.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG119185.
HOGENOMiHOG000236328.
HOVERGENiHBG099611.
InParanoidiQ95N02.
KOiK04322.

Family and domain databases

InterProiIPR013310. CLT1_recept.
IPR004071. Cyst_leuk_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01902. CYSLT1RECPTR.
PR01533. CYSLTRECPTR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q95N02-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGVRNLTVS CASSNTCNDT IDDFRNQVYS TLYSMITVVG FFGNGFVLYV
60 70 80 90 100
LIKTYHEKSA YQVYMINLAV ADLLCVCTLP LRVVYYVHKG IWLFGDFLCR
110 120 130 140 150
LSTYALYVNL YCSIFFMTAM SFFRCIAIVF PVQNINLITH KKAKIVCIAI
160 170 180 190 200
WIFVILTSSP FLMSTSYKDE KNNTKCFEPP QXNQAKYHVL VLHYVSLFVG
210 220 230 240 250
FIIPFVIIIV CYTMIILTLL KNSMKKNISS RKKAIGMIIV VTAAFLISFM
260 270 280 290 300
PYHIQRTIHL HFLHNDTKHC DSVLRMQKSV XITLSLAASN CCFDPLLYFF
310 320 330 340
SGGNFREGLS TFRKHSLSTM TYVPKKKTSL PEKAQEIYKE
Length:340
Mass (Da):38,989
Last modified:November 30, 2001 - v1
Checksum:i54F9372A121CE413
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052686 mRNA. Translation: BAB60826.1.
RefSeqiNP_999294.1. NM_214129.1.
UniGeneiSsc.15879.

Genome annotation databases

GeneIDi397242.
KEGGissc:397242.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052686 mRNA. Translation: BAB60826.1.
RefSeqiNP_999294.1. NM_214129.1.
UniGeneiSsc.15879.

3D structure databases

ProteinModelPortaliQ95N02.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000013241.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397242.
KEGGissc:397242.

Organism-specific databases

CTDi397242.

Phylogenomic databases

eggNOGiNOG119185.
HOGENOMiHOG000236328.
HOVERGENiHBG099611.
InParanoidiQ95N02.
KOiK04322.

Family and domain databases

InterProiIPR013310. CLT1_recept.
IPR004071. Cyst_leuk_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01902. CYSLT1RECPTR.
PR01533. CYSLTRECPTR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of cloned rat and porcine cysteinyl leukotriene receptors."
    Takasaki J., Kamohara M., Saito T., Matsumoto M., Matsumoto S., Ohishi T., Soga T., Matsushime H., Furuichi K.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCLTR1_PIG
AccessioniPrimary (citable) accession number: Q95N02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2002
Last sequence update: November 30, 2001
Last modified: January 6, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.