Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q95N02

- CLTR1_PIG

UniProt

Q95N02 - CLTR1_PIG

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cysteinyl leukotriene receptor 1

Gene

CYSLTR1

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for cysteinyl leukotrienes mediating constriction of the microvascular smooth muscle during an inflammatory response. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system By similarity.By similarity

GO - Molecular functioni

  1. leukotriene receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteinyl leukotriene receptor 1
Short name:
CysLTR1
Gene namesi
Name:CYSLTR1
Synonyms:CYSLT1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340Cysteinyl leukotriene receptor 1PRO_0000069301Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
Glycosylationi18 – 181N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi99 ↔ 176PROSITE-ProRule annotation
Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000013241.

Structurei

3D structure databases

ProteinModelPortaliQ95N02.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3131ExtracellularSequence AnalysisAdd
BLAST
Topological domaini53 – 608CytoplasmicSequence Analysis
Topological domaini82 – 10928ExtracellularSequence AnalysisAdd
BLAST
Topological domaini131 – 14414CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini166 – 19631ExtracellularSequence AnalysisAdd
BLAST
Topological domaini218 – 23316CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini255 – 27925ExtracellularSequence AnalysisAdd
BLAST
Topological domaini301 – 34040CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei32 – 5221Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei61 – 8121Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei110 – 13021Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei145 – 16521Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei197 – 21721Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei234 – 25421Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei280 – 30021Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG119185.
HOGENOMiHOG000236328.
HOVERGENiHBG099611.
InParanoidiQ95N02.
KOiK04322.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR013310. CLT1_recept.
IPR004071. Cyst_leuk_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01902. CYSLT1RECPTR.
PR01533. CYSLTRECPTR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q95N02-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDGVRNLTVS CASSNTCNDT IDDFRNQVYS TLYSMITVVG FFGNGFVLYV
60 70 80 90 100
LIKTYHEKSA YQVYMINLAV ADLLCVCTLP LRVVYYVHKG IWLFGDFLCR
110 120 130 140 150
LSTYALYVNL YCSIFFMTAM SFFRCIAIVF PVQNINLITH KKAKIVCIAI
160 170 180 190 200
WIFVILTSSP FLMSTSYKDE KNNTKCFEPP QXNQAKYHVL VLHYVSLFVG
210 220 230 240 250
FIIPFVIIIV CYTMIILTLL KNSMKKNISS RKKAIGMIIV VTAAFLISFM
260 270 280 290 300
PYHIQRTIHL HFLHNDTKHC DSVLRMQKSV XITLSLAASN CCFDPLLYFF
310 320 330 340
SGGNFREGLS TFRKHSLSTM TYVPKKKTSL PEKAQEIYKE
Length:340
Mass (Da):38,989
Last modified:December 1, 2001 - v1
Checksum:i54F9372A121CE413
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB052686 mRNA. Translation: BAB60826.1.
RefSeqiNP_999294.1. NM_214129.1.
UniGeneiSsc.15879.

Genome annotation databases

GeneIDi397242.
KEGGissc:397242.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB052686 mRNA. Translation: BAB60826.1 .
RefSeqi NP_999294.1. NM_214129.1.
UniGenei Ssc.15879.

3D structure databases

ProteinModelPortali Q95N02.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9823.ENSSSCP00000013241.

Protein family/group databases

GPCRDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 397242.
KEGGi ssc:397242.

Organism-specific databases

CTDi 397242.

Phylogenomic databases

eggNOGi NOG119185.
HOGENOMi HOG000236328.
HOVERGENi HBG099611.
InParanoidi Q95N02.
KOi K04322.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR013310. CLT1_recept.
IPR004071. Cyst_leuk_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01902. CYSLT1RECPTR.
PR01533. CYSLTRECPTR.
PR00237. GPCRRHODOPSN.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of cloned rat and porcine cysteinyl leukotriene receptors."
    Takasaki J., Kamohara M., Saito T., Matsumoto M., Matsumoto S., Ohishi T., Soga T., Matsushime H., Furuichi K.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCLTR1_PIG
AccessioniPrimary (citable) accession number: Q95N02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3