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Q95N02

- CLTR1_PIG

UniProt

Q95N02 - CLTR1_PIG

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Protein
Cysteinyl leukotriene receptor 1
Gene
CYSLTR1, CYSLT1
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for cysteinyl leukotrienes mediating constriction of the microvascular smooth muscle during an inflammatory response. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system By similarity.

GO - Molecular functioni

  1. leukotriene receptor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cysteinyl leukotriene receptor 1
    Short name:
    CysLTR1
    Gene namesi
    Name:CYSLTR1
    Synonyms:CYSLT1
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Unplaced

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3131Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei32 – 5221Helical; Name=1; Reviewed prediction
    Add
    BLAST
    Topological domaini53 – 608Cytoplasmic Reviewed prediction
    Transmembranei61 – 8121Helical; Name=2; Reviewed prediction
    Add
    BLAST
    Topological domaini82 – 10928Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei110 – 13021Helical; Name=3; Reviewed prediction
    Add
    BLAST
    Topological domaini131 – 14414Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei145 – 16521Helical; Name=4; Reviewed prediction
    Add
    BLAST
    Topological domaini166 – 19631Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei197 – 21721Helical; Name=5; Reviewed prediction
    Add
    BLAST
    Topological domaini218 – 23316Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei234 – 25421Helical; Name=6; Reviewed prediction
    Add
    BLAST
    Topological domaini255 – 27925Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei280 – 30021Helical; Name=7; Reviewed prediction
    Add
    BLAST
    Topological domaini301 – 34040Cytoplasmic Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 340340Cysteinyl leukotriene receptor 1
    PRO_0000069301Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi6 – 61N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi18 – 181N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi99 ↔ 176 By similarity
    Glycosylationi172 – 1721N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi265 – 2651N-linked (GlcNAc...) Reviewed prediction

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi9823.ENSSSCP00000013241.

    Structurei

    3D structure databases

    ProteinModelPortaliQ95N02.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG119185.
    HOGENOMiHOG000236328.
    HOVERGENiHBG099611.
    KOiK04322.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR013310. CLT1_recept.
    IPR004071. Cyst_leuk_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01902. CYSLT1RECPTR.
    PR01533. CYSLTRECPTR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q95N02-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDGVRNLTVS CASSNTCNDT IDDFRNQVYS TLYSMITVVG FFGNGFVLYV    50
    LIKTYHEKSA YQVYMINLAV ADLLCVCTLP LRVVYYVHKG IWLFGDFLCR 100
    LSTYALYVNL YCSIFFMTAM SFFRCIAIVF PVQNINLITH KKAKIVCIAI 150
    WIFVILTSSP FLMSTSYKDE KNNTKCFEPP QXNQAKYHVL VLHYVSLFVG 200
    FIIPFVIIIV CYTMIILTLL KNSMKKNISS RKKAIGMIIV VTAAFLISFM 250
    PYHIQRTIHL HFLHNDTKHC DSVLRMQKSV XITLSLAASN CCFDPLLYFF 300
    SGGNFREGLS TFRKHSLSTM TYVPKKKTSL PEKAQEIYKE 340
    Length:340
    Mass (Da):38,989
    Last modified:December 1, 2001 - v1
    Checksum:i54F9372A121CE413
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB052686 mRNA. Translation: BAB60826.1.
    RefSeqiNP_999294.1. NM_214129.1.
    UniGeneiSsc.15879.

    Genome annotation databases

    GeneIDi397242.
    KEGGissc:397242.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB052686 mRNA. Translation: BAB60826.1 .
    RefSeqi NP_999294.1. NM_214129.1.
    UniGenei Ssc.15879.

    3D structure databases

    ProteinModelPortali Q95N02.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 9823.ENSSSCP00000013241.

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 397242.
    KEGGi ssc:397242.

    Organism-specific databases

    CTDi 397242.

    Phylogenomic databases

    eggNOGi NOG119185.
    HOGENOMi HOG000236328.
    HOVERGENi HBG099611.
    KOi K04322.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR013310. CLT1_recept.
    IPR004071. Cyst_leuk_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01902. CYSLT1RECPTR.
    PR01533. CYSLTRECPTR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of cloned rat and porcine cysteinyl leukotriene receptors."
      Takasaki J., Kamohara M., Saito T., Matsumoto M., Matsumoto S., Ohishi T., Soga T., Matsushime H., Furuichi K.
      Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCLTR1_PIG
    AccessioniPrimary (citable) accession number: Q95N02
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 11, 2002
    Last sequence update: December 1, 2001
    Last modified: April 16, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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