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Q95N01

- CCL17_CANFA

UniProt

Q95N01 - CCL17_CANFA

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Protein

C-C motif chemokine 17

Gene
CCL17, TARC
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Chemotactic factor for t lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 and CCR8 By similarity.

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. immune response Source: InterPro
  3. inflammatory response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 17
Alternative name(s):
CC chemokine TARC
Small-inducible cytokine A17
Thymus and activation-regulated chemokine
Gene namesi
Name:CCL17
Synonyms:TARC
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Chromosome 2

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 By similarityAdd
BLAST
Chaini24 – 9976C-C motif chemokine 17PRO_0000005210Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 57 By similarity
Disulfide bondi34 ↔ 73 By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed in thymus, spleen, lymph node, lung and heart.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000012872.

Structurei

3D structure databases

ProteinModelPortaliQ95N01.
SMRiQ95N01. Positions 25-89.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45053.
GeneTreeiENSGT00530000064258.
HOVERGENiHBG098492.
InParanoidiQ95N01.
KOiK05514.
OMAiCSDPKDT.
OrthoDBiEOG7K0ZFZ.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q95N01-1 [UniParc]FASTAAdd to Basket

« Hide

MIPLKMLLLV TLLLGASLQV THAARGTNVG RECCLEYFKG AIPISRLTRW   50
YKTSGECPKD AIVFVTVQGK SICSDPKDKR VKKAVRYLQR TWKGGPQES 99
Length:99
Mass (Da):11,052
Last modified:December 1, 2001 - v1
Checksum:i6BA28EDDF857BE81
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB054642 mRNA. Translation: BAB62131.1.
RefSeqiNP_001003051.1. NM_001003051.1.
XP_005617272.1. XM_005617215.1.
UniGeneiCfa.3450.

Genome annotation databases

EnsembliENSCAFT00000013912; ENSCAFP00000012872; ENSCAFG00000008754.
GeneIDi403586.
KEGGicfa:403586.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB054642 mRNA. Translation: BAB62131.1 .
RefSeqi NP_001003051.1. NM_001003051.1.
XP_005617272.1. XM_005617215.1.
UniGenei Cfa.3450.

3D structure databases

ProteinModelPortali Q95N01.
SMRi Q95N01. Positions 25-89.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000012872.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCAFT00000013912 ; ENSCAFP00000012872 ; ENSCAFG00000008754 .
GeneIDi 403586.
KEGGi cfa:403586.

Organism-specific databases

CTDi 6361.

Phylogenomic databases

eggNOGi NOG45053.
GeneTreei ENSGT00530000064258.
HOVERGENi HBG098492.
InParanoidi Q95N01.
KOi K05514.
OMAi CSDPKDT.
OrthoDBi EOG7K0ZFZ.
TreeFami TF334888.

Miscellaneous databases

NextBioi 20817092.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of canine thymus and activation-regulated chemokine (TARC) gene and its expression in various tissues."
    Maeda S., Mizuno T., Yamashita K., Kurata K., Masuda K., Ohno K., Tsujimoto H.
    J. Vet. Med. Sci. 63:1035-1038(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Thymus.

Entry informationi

Entry nameiCCL17_CANFA
AccessioniPrimary (citable) accession number: Q95N01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: December 1, 2001
Last modified: March 19, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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