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Q95N01

- CCL17_CANFA

UniProt

Q95N01 - CCL17_CANFA

Protein

C-C motif chemokine 17

Gene

CCL17

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Chemotactic factor for t lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 and CCR8 By similarity.By similarity

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. immune response Source: InterPro
    3. inflammatory response Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 17
    Alternative name(s):
    CC chemokine TARC
    Small-inducible cytokine A17
    Thymus and activation-regulated chemokine
    Gene namesi
    Name:CCL17
    Synonyms:TARC
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Chromosome 2

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Chaini24 – 9976C-C motif chemokine 17PRO_0000005210Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 57By similarity
    Disulfide bondi34 ↔ 73By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed in thymus, spleen, lymph node, lung and heart.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi9615.ENSCAFP00000012872.

    Structurei

    3D structure databases

    ProteinModelPortaliQ95N01.
    SMRiQ95N01. Positions 25-89.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG45053.
    GeneTreeiENSGT00530000064258.
    HOVERGENiHBG098492.
    InParanoidiQ95N01.
    KOiK05514.
    OMAiCSDPKDT.
    OrthoDBiEOG7K0ZFZ.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q95N01-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIPLKMLLLV TLLLGASLQV THAARGTNVG RECCLEYFKG AIPISRLTRW   50
    YKTSGECPKD AIVFVTVQGK SICSDPKDKR VKKAVRYLQR TWKGGPQES 99
    Length:99
    Mass (Da):11,052
    Last modified:December 1, 2001 - v1
    Checksum:i6BA28EDDF857BE81
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB054642 mRNA. Translation: BAB62131.1.
    RefSeqiNP_001003051.1. NM_001003051.1.
    XP_005617272.1. XM_005617215.1.
    UniGeneiCfa.3450.

    Genome annotation databases

    EnsembliENSCAFT00000013912; ENSCAFP00000012872; ENSCAFG00000008754.
    GeneIDi403586.
    KEGGicfa:403586.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB054642 mRNA. Translation: BAB62131.1 .
    RefSeqi NP_001003051.1. NM_001003051.1.
    XP_005617272.1. XM_005617215.1.
    UniGenei Cfa.3450.

    3D structure databases

    ProteinModelPortali Q95N01.
    SMRi Q95N01. Positions 25-89.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9615.ENSCAFP00000012872.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCAFT00000013912 ; ENSCAFP00000012872 ; ENSCAFG00000008754 .
    GeneIDi 403586.
    KEGGi cfa:403586.

    Organism-specific databases

    CTDi 6361.

    Phylogenomic databases

    eggNOGi NOG45053.
    GeneTreei ENSGT00530000064258.
    HOVERGENi HBG098492.
    InParanoidi Q95N01.
    KOi K05514.
    OMAi CSDPKDT.
    OrthoDBi EOG7K0ZFZ.
    TreeFami TF334888.

    Miscellaneous databases

    NextBioi 20817092.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of canine thymus and activation-regulated chemokine (TARC) gene and its expression in various tissues."
      Maeda S., Mizuno T., Yamashita K., Kurata K., Masuda K., Ohno K., Tsujimoto H.
      J. Vet. Med. Sci. 63:1035-1038(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Thymus.

    Entry informationi

    Entry nameiCCL17_CANFA
    AccessioniPrimary (citable) accession number: Q95N01
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3