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Protein

C-C motif chemokine 17

Gene

CCL17

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Chemotactic factor for t lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 and CCR8 (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_299681. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 17
Alternative name(s):
CC chemokine TARC
Small-inducible cytokine A17
Thymus and activation-regulated chemokine
Gene namesi
Name:CCL17
Synonyms:TARC
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 9976C-C motif chemokine 17PRO_0000005210Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 57By similarity
Disulfide bondi34 ↔ 73By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed in thymus, spleen, lymph node, lung and heart.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000012872.

Structurei

3D structure databases

ProteinModelPortaliQ95N01.
SMRiQ95N01. Positions 25-89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45053.
GeneTreeiENSGT00530000064258.
HOVERGENiHBG098492.
InParanoidiQ95N01.
KOiK05514.
OMAiCSDPKDT.
OrthoDBiEOG7K0ZFZ.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q95N01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPLKMLLLV TLLLGASLQV THAARGTNVG RECCLEYFKG AIPISRLTRW
60 70 80 90
YKTSGECPKD AIVFVTVQGK SICSDPKDKR VKKAVRYLQR TWKGGPQES
Length:99
Mass (Da):11,052
Last modified:December 1, 2001 - v1
Checksum:i6BA28EDDF857BE81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB054642 mRNA. Translation: BAB62131.1.
RefSeqiNP_001003051.1. NM_001003051.1.
XP_005617272.1. XM_005617215.1.
UniGeneiCfa.3450.

Genome annotation databases

EnsembliENSCAFT00000013912; ENSCAFP00000012872; ENSCAFG00000008754.
GeneIDi403586.
KEGGicfa:403586.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB054642 mRNA. Translation: BAB62131.1.
RefSeqiNP_001003051.1. NM_001003051.1.
XP_005617272.1. XM_005617215.1.
UniGeneiCfa.3450.

3D structure databases

ProteinModelPortaliQ95N01.
SMRiQ95N01. Positions 25-89.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000012872.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000013912; ENSCAFP00000012872; ENSCAFG00000008754.
GeneIDi403586.
KEGGicfa:403586.

Organism-specific databases

CTDi6361.

Phylogenomic databases

eggNOGiNOG45053.
GeneTreeiENSGT00530000064258.
HOVERGENiHBG098492.
InParanoidiQ95N01.
KOiK05514.
OMAiCSDPKDT.
OrthoDBiEOG7K0ZFZ.
TreeFamiTF334888.

Enzyme and pathway databases

ReactomeiREACT_299681. Chemokine receptors bind chemokines.

Miscellaneous databases

NextBioi20817092.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of canine thymus and activation-regulated chemokine (TARC) gene and its expression in various tissues."
    Maeda S., Mizuno T., Yamashita K., Kurata K., Masuda K., Ohno K., Tsujimoto H.
    J. Vet. Med. Sci. 63:1035-1038(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Thymus.

Entry informationi

Entry nameiCCL17_CANFA
AccessioniPrimary (citable) accession number: Q95N01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: December 1, 2001
Last modified: April 1, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.