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Q95N01 (CCL17_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 17
Alternative name(s):
CC chemokine TARC
Small-inducible cytokine A17
Thymus and activation-regulated chemokine
Gene names
Name:CCL17
Synonyms:TARC
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length99 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Chemotactic factor for t lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 and CCR8 By similarity.

Subcellular location

Secreted.

Tissue specificity

Expressed in thymus, spleen, lymph node, lung and heart. Ref.1

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
   Biological processChemotaxis
Inflammatory response
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell chemotaxis

Inferred from electronic annotation. Source: GOC

immune response

Inferred from electronic annotation. Source: InterPro

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 By similarity
Chain24 – 9976C-C motif chemokine 17
PRO_0000005210

Amino acid modifications

Disulfide bond33 ↔ 57 By similarity
Disulfide bond34 ↔ 73 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q95N01 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 6BA28EDDF857BE81

FASTA9911,052
        10         20         30         40         50         60 
MIPLKMLLLV TLLLGASLQV THAARGTNVG RECCLEYFKG AIPISRLTRW YKTSGECPKD 

        70         80         90 
AIVFVTVQGK SICSDPKDKR VKKAVRYLQR TWKGGPQES 

« Hide

References

[1]"Molecular cloning of canine thymus and activation-regulated chemokine (TARC) gene and its expression in various tissues."
Maeda S., Mizuno T., Yamashita K., Kurata K., Masuda K., Ohno K., Tsujimoto H.
J. Vet. Med. Sci. 63:1035-1038(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Thymus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB054642 mRNA. Translation: BAB62131.1.
RefSeqNP_001003051.1. NM_001003051.1.
XP_005617272.1. XM_005617215.1.
UniGeneCfa.3450.

3D structure databases

ProteinModelPortalQ95N01.
SMRQ95N01. Positions 25-89.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9615.ENSCAFP00000012872.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSCAFT00000013912; ENSCAFP00000012872; ENSCAFG00000008754.
GeneID403586.
KEGGcfa:403586.

Organism-specific databases

CTD6361.

Phylogenomic databases

eggNOGNOG45053.
GeneTreeENSGT00530000064258.
HOVERGENHBG098492.
InParanoidQ95N01.
KOK05514.
OMACSDPKDT.
OrthoDBEOG7K0ZFZ.
TreeFamTF334888.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20817092.

Entry information

Entry nameCCL17_CANFA
AccessionPrimary (citable) accession number: Q95N01
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: December 1, 2001
Last modified: March 19, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families