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Q95N00 (IOD1_SUNMU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Type I iodothyronine deiodinase

EC=1.97.1.10
Alternative name(s):
5DI
DIOI
Type 1 DI
Type-I 5'-deiodinase
Gene names
Name:DIO1
Synonyms:TXDI1
OrganismSuncus murinus (Asian house shrew) (Musk shrew)
Taxonomic identifier9378 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaInsectivoraSoricidaeCrocidurinaeSuncus

Protein attributes

Sequence length257 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Ref.1

Catalytic activity

3,5,3'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.

Subcellular location

Endoplasmic reticulum membrane; Single-pass membrane protein By similarity.

Tissue specificity

Liver specific. Ref.1

Sequence similarities

Belongs to the iodothyronine deiodinase family.

Ontologies

Keywords
   Biological processThyroid hormones biosynthesis
   Cellular componentEndoplasmic reticulum
Membrane
   Coding sequence diversitySelenocysteine
   DomainTransmembrane
Transmembrane helix
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processhormone biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionthyroxine 5'-deiodinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 257257Type I iodothyronine deiodinase
PRO_0000154314

Regions

Transmembrane13 – 3321Helical; Potential

Sites

Active site1261

Amino acid modifications

Non-standard residue1261Selenocysteine

Sequences

Sequence LengthMass (Da)Tools
Q95N00 [UniParc].

Last modified February 26, 2008. Version 2.
Checksum: 74F0965683F8F384

FASTA25729,454
        10         20         30         40         50         60 
MGLPGLGLLL KRFGVLVRVA LKVAVGKVLL TLWPSAIRPH LLAMSEKTGM AKNPRFTYED 

        70         80         90        100        110        120 
WAPTFFSTQY FWFVLKVNWQ QLEDRTKQGD IAPDSPVVHL SGQRARLWDF MQGNRPLVLN 

       130        140        150        160        170        180 
FGSCSUPSFL FKFDQFKRLV EDFSSVADFL TVYIEEAHAS DGWAFKNNVD IRRHRDLQER 

       190        200        210        220        230        240 
LQAARLLLDR NPGCPVVVDT MENRSSQLYA ALPERLYVLQ EGRILYKGGP GPWNYHPEEV 

       250 
HAVLEQLCRS SAQSPRL 

« Hide

References

[1]"Type 1 iodothyronine deiodinase in the house musk shrew (Suncus murinus, Insectivora: Soricidae): cloning and characterization of complementary DNA, unique tissue distribution and regulation by T3."
Rogatcheva M., Hayashi Y., Oda S., Seo H., Cua K., Refetoff S., Murakami M., Mori M., Murata Y.
Gen. Comp. Endocrinol. 127:48-58(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB055517 mRNA. Translation: BAB62750.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG000099.

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR000643. Iodothyronine_deiodinase.
IPR008261. Iodothyronine_deiodinase_AS.
IPR027252. Iodothyronine_deiodinase_I/III.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERPTHR11781. PTHR11781. 1 hit.
PfamPF00837. T4_deiodinase. 1 hit.
[Graphical view]
PIRSFPIRSF001330. IOD. 1 hit.
PIRSF500144. IODI_III. 1 hit.
SUPFAMSSF52833. SSF52833. 1 hit.
PROSITEPS01205. T4_DEIODINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIOD1_SUNMU
AccessionPrimary (citable) accession number: Q95N00
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: February 26, 2008
Last modified: February 19, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families