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Q95N00

- IOD1_SUNMU

UniProt

Q95N00 - IOD1_SUNMU

Protein

Type I iodothyronine deiodinase

Gene

DIO1

Organism
Suncus murinus (Asian house shrew) (Musk shrew)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 2 (26 Feb 2008)
      Previous versions | rss
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    • Comment

    Functioni

    Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).1 Publication

    Catalytic activityi

    3,5,3'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei126 – 1261

    GO - Molecular functioni

    1. thyroxine 5'-deiodinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. hormone biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Thyroid hormones biosynthesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Type I iodothyronine deiodinase (EC:1.97.1.10)
    Alternative name(s):
    5DI
    DIOI
    Type 1 DI
    Type-I 5'-deiodinase
    Gene namesi
    Name:DIO1
    Synonyms:TXDI1
    OrganismiSuncus murinus (Asian house shrew) (Musk shrew)
    Taxonomic identifieri9378 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaInsectivoraSoricidaeCrocidurinaeSuncus

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 257257Type I iodothyronine deiodinasePRO_0000154314Add
    BLAST

    Expressioni

    Tissue specificityi

    Liver specific.1 Publication

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 3321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the iodothyronine deiodinase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG000099.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR000643. Iodothyronine_deiodinase.
    IPR008261. Iodothyronine_deiodinase_AS.
    IPR027252. Iodothyronine_deiodinase_I/III.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PANTHERiPTHR11781. PTHR11781. 1 hit.
    PfamiPF00837. T4_deiodinase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001330. IOD. 1 hit.
    PIRSF500144. IODI_III. 1 hit.
    SUPFAMiSSF52833. SSF52833. 1 hit.
    PROSITEiPS01205. T4_DEIODINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q95N00-1 [UniParc]FASTAAdd to Basket

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    MGLPGLGLLL KRFGVLVRVA LKVAVGKVLL TLWPSAIRPH LLAMSEKTGM    50
    AKNPRFTYED WAPTFFSTQY FWFVLKVNWQ QLEDRTKQGD IAPDSPVVHL 100
    SGQRARLWDF MQGNRPLVLN FGSCSUPSFL FKFDQFKRLV EDFSSVADFL 150
    TVYIEEAHAS DGWAFKNNVD IRRHRDLQER LQAARLLLDR NPGCPVVVDT 200
    MENRSSQLYA ALPERLYVLQ EGRILYKGGP GPWNYHPEEV HAVLEQLCRS 250
    SAQSPRL 257
    Length:257
    Mass (Da):29,454
    Last modified:February 26, 2008 - v2
    Checksum:i74F0965683F8F384
    GO

    Non-standard residue

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-standard residuei126 – 1261Selenocysteine

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB055517 mRNA. Translation: BAB62750.1.

    Keywords - Coding sequence diversityi

    Selenocysteine

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB055517 mRNA. Translation: BAB62750.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG000099.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR000643. Iodothyronine_deiodinase.
    IPR008261. Iodothyronine_deiodinase_AS.
    IPR027252. Iodothyronine_deiodinase_I/III.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    PANTHERi PTHR11781. PTHR11781. 1 hit.
    Pfami PF00837. T4_deiodinase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001330. IOD. 1 hit.
    PIRSF500144. IODI_III. 1 hit.
    SUPFAMi SSF52833. SSF52833. 1 hit.
    PROSITEi PS01205. T4_DEIODINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Type 1 iodothyronine deiodinase in the house musk shrew (Suncus murinus, Insectivora: Soricidae): cloning and characterization of complementary DNA, unique tissue distribution and regulation by T3."
      Rogatcheva M., Hayashi Y., Oda S., Seo H., Cua K., Refetoff S., Murakami M., Mori M., Murata Y.
      Gen. Comp. Endocrinol. 127:48-58(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiIOD1_SUNMU
    AccessioniPrimary (citable) accession number: Q95N00
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 64 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3