Q95N00 (IOD1_SUNMU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Type I iodothyronine deiodinase
EC=1.97.1.10

Alternative name(s):
5DI
DIOI
Type 1 DI
Type-I 5'-deiodinase

Gene names

Name:	DIO1
Synonyms:	TXDI1

Organism

Suncus murinus (Asian house shrew) (Musk shrew)

Taxonomic identifier

9378 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Insectivora › Soricidae › Crocidurinae › Suncus

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Ref.1
Catalytic activity	3,5,3'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.
Subcellular location	Endoplasmic reticulum membrane; Single-pass membrane protein By similarity.
Tissue specificity	Liver specific. Ref.1
Sequence similarities	Belongs to the iodothyronine deiodinase family.

Ontologies

Keywords
Biological process	Thyroid hormones biosynthesis
Cellular component	Endoplasmic reticulum Membrane
Coding sequence diversity	Selenocysteine
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	hormone biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	thyroxine 5'-deiodinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 257	257	Type I iodothyronine deiodinase		PRO_0000154314
Regions
	Transmembrane	13 – 33	21	Helical; Potential
Sites
	Active site	126	1
Amino acid modifications
	Non-standard residue	126	1	Selenocysteine

Sequences

	Sequence		Length	Mass (Da)
	Q95N00 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: 74F0965683F8F384	FASTA	257	29,454
	10 20 30 40 50 60 MGLPGLGLLL KRFGVLVRVA LKVAVGKVLL TLWPSAIRPH LLAMSEKTGM AKNPRFTYED 70 80 90 100 110 120 WAPTFFSTQY FWFVLKVNWQ QLEDRTKQGD IAPDSPVVHL SGQRARLWDF MQGNRPLVLN 130 140 150 160 170 180 FGSCSUPSFL FKFDQFKRLV EDFSSVADFL TVYIEEAHAS DGWAFKNNVD IRRHRDLQER 190 200 210 220 230 240 LQAARLLLDR NPGCPVVVDT MENRSSQLYA ALPERLYVLQ EGRILYKGGP GPWNYHPEEV 250 HAVLEQLCRS SAQSPRL

References

[1]

"Type 1 iodothyronine deiodinase in the house musk shrew (Suncus murinus, Insectivora: Soricidae): cloning and characterization of complementary DNA, unique tissue distribution and regulation by T3." Rogatcheva M., Hayashi Y., Oda S., Seo H., Cua K., Refetoff S., Murakami M., Mori M., Murata Y. Gen. Comp. Endocrinol. 127:48-58(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB055517 mRNA. Translation: BAB62750.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG000099.
Family and domain databases
Gene3D	3.40.30.10. 1 hit.
InterPro	IPR000643. Iodothyronine_deiodinase. IPR008261. Iodothyronine_deiodinase_AS. IPR027252. Iodothyronine_deiodinase_I/III. IPR012336. Thioredoxin-like_fold. [Graphical view]
PANTHER	PTHR11781. PTHR11781. 1 hit.
Pfam	PF00837. T4_deiodinase. 1 hit. [Graphical view]
PIRSF	PIRSF001330. IOD. 1 hit. PIRSF500144. IODI_III. 1 hit.
PROSITE	PS01205. T4_DEIODINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOD1_SUNMU

Accession

Primary (citable) accession number: Q95N00

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	February 26, 2008
Last modified:	March 6, 2013
This is version 61 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program