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Protein

Ferritin heavy chain

Gene

FTH1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).By similarity

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi28Iron 1PROSITE-ProRule annotation1
Metal bindingi63Iron 1PROSITE-ProRule annotation1
Metal bindingi63Iron 2PROSITE-ProRule annotation1
Metal bindingi66Iron 1PROSITE-ProRule annotation1
Metal bindingi108Iron 2PROSITE-ProRule annotation1
Metal bindingi142Iron 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processIron storage
LigandIron, Metal-binding

Enzyme and pathway databases

ReactomeiR-CFA-6798695. Neutrophil degranulation.
R-CFA-917937. Iron uptake and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin heavy chain (EC:1.16.3.1)
Short name:
Ferritin H subunit
Cleaved into the following chain:
Gene namesi
Name:FTH1
Synonyms:FTH
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componentsi: Chromosome 11, Chromosome 18

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004244691 – 183Ferritin heavy chainAdd BLAST183
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00002010462 – 183Ferritin heavy chain, N-terminally processedAdd BLAST182

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei2N-acetylthreonine; in Ferritin heavy chain, N-terminally processedBy similarity1
Modified residuei179PhosphoserineBy similarity1
Modified residuei183PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ95MP7.
PRIDEiQ95MP7.

Expressioni

Gene expression databases

BgeeiENSCAFG00000015901.

Interactioni

Subunit structurei

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000033829.

Structurei

3D structure databases

ProteinModelPortaliQ95MP7.
SMRiQ95MP7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 160Ferritin-like diironPROSITE-ProRule annotationAdd BLAST150

Sequence similaritiesi

Belongs to the ferritin family.Curated

Phylogenomic databases

eggNOGiKOG2332. Eukaryota.
COG1528. LUCA.
GeneTreeiENSGT00760000119129.
HOGENOMiHOG000223383.
HOVERGENiHBG000410.
InParanoidiQ95MP7.
KOiK00522.
OMAiQALHNFA.
OrthoDBiEOG091G0J20.
TreeFamiTF313885.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiView protein in InterPro
IPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiView protein in Pfam
PF00210. Ferritin. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiView protein in PROSITE
PS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q95MP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTASPSQVR QNYHQDSEAA INRQINLELY ASYVYLSMSY YFDRDDVALK
60 70 80 90 100
NFAKYFLHQS HEEREHAEKL MKLQNQRGGR IFLQDIKKPD RDDWENGLNA
110 120 130 140 150
MECALHLEKS VNQSLLELHK LATDKNDPHL CDFIETHYLN EQVKSIKELG
160 170 180
DHVTNLRKMG APESGMAEYL FDKHTLGNSD NES
Length:183
Mass (Da):21,308
Last modified:January 23, 2007 - v3
Checksum:i9D22750A1AC4BE72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285177 mRNA. Translation: AAK82992.1.
AB175610 mRNA. Translation: BAD96175.1.
AB175611 mRNA. Translation: BAD96176.1.
RefSeqiNP_001003080.1. NM_001003080.1.
NP_001180585.1. NM_001193656.1.
UniGeneiCfa.38608.
Cfa.47833.

Genome annotation databases

EnsembliENSCAFT00000025200; ENSCAFP00000023396; ENSCAFG00000015901.
ENSCAFT00000038151; ENSCAFP00000033829; ENSCAFG00000030465.
GeneIDi100499480.
403631.
KEGGicfa:100499480.
cfa:403631.

Similar proteinsi

Entry informationi

Entry nameiFRIH_CANLF
AccessioniPrimary (citable) accession number: Q95MP7
Secondary accession number(s): Q53VC0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 100 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families