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Q95MP7

- FRIH_CANFA

UniProt

Q95MP7 - FRIH_CANFA

Protein

Ferritin heavy chain

Gene

FTH1

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney By similarity.By similarity

    Catalytic activityi

    4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi28 – 281Iron 1PROSITE-ProRule annotation
    Metal bindingi63 – 631Iron 1PROSITE-ProRule annotation
    Metal bindingi63 – 631Iron 2PROSITE-ProRule annotation
    Metal bindingi66 – 661Iron 1PROSITE-ProRule annotation
    Metal bindingi108 – 1081Iron 2PROSITE-ProRule annotation
    Metal bindingi142 – 1421Iron 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ferric iron binding Source: InterPro
    2. ferroxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular iron ion homeostasis Source: UniProtKB-KW
    2. immune response Source: UniProtKB
    3. iron ion transport Source: InterPro
    4. negative regulation of cell proliferation Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Iron storage

    Keywords - Ligandi

    Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ferritin heavy chain (EC:1.16.3.1)
    Short name:
    Ferritin H subunit
    Cleaved into the following chain:
    Gene namesi
    Name:FTH1
    Synonyms:FTH
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Chromosome 11, UP000002254: Chromosome 18

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 183183Ferritin heavy chainPRO_0000201046Add
    BLAST
    Initiator methioninei1 – 11Removed; alternateBy similarity
    Chaini2 – 183182Ferritin heavy chain, N-terminally processedPRO_0000424469Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei2 – 21N-acetylthreonine; in Ferritin heavy chain, N-terminally processedBy similarity
    Modified residuei179 – 1791PhosphoserineBy similarity
    Modified residuei183 – 1831PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ95MP7.

    Interactioni

    Subunit structurei

    Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.

    Structurei

    3D structure databases

    ProteinModelPortaliQ95MP7.
    SMRiQ95MP7. Positions 7-177.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini11 – 160150Ferritin-like diironPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ferritin family.Curated
    Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1528.
    GeneTreeiENSGT00700000104283.
    HOGENOMiHOG000223383.
    HOVERGENiHBG000410.
    InParanoidiQ95MP7.
    KOiK00522.
    OMAiESAHEER.
    OrthoDBiEOG7DRJ49.
    TreeFamiTF313885.

    Family and domain databases

    Gene3Di1.20.1260.10. 1 hit.
    InterProiIPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR014034. Ferritin_CS.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view]
    PANTHERiPTHR11431. PTHR11431. 1 hit.
    PfamiPF00210. Ferritin. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS00540. FERRITIN_1. 1 hit.
    PS00204. FERRITIN_2. 1 hit.
    PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q95MP7-1 [UniParc]FASTAAdd to Basket

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    MTTASPSQVR QNYHQDSEAA INRQINLELY ASYVYLSMSY YFDRDDVALK    50
    NFAKYFLHQS HEEREHAEKL MKLQNQRGGR IFLQDIKKPD RDDWENGLNA 100
    MECALHLEKS VNQSLLELHK LATDKNDPHL CDFIETHYLN EQVKSIKELG 150
    DHVTNLRKMG APESGMAEYL FDKHTLGNSD NES 183
    Length:183
    Mass (Da):21,308
    Last modified:January 23, 2007 - v3
    Checksum:i9D22750A1AC4BE72
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF285177 mRNA. Translation: AAK82992.1.
    AB175610 mRNA. Translation: BAD96175.1.
    AB175611 mRNA. Translation: BAD96176.1.
    RefSeqiNP_001003080.1. NM_001003080.1.
    NP_001180585.1. NM_001193656.1.
    UniGeneiCfa.38608.
    Cfa.47833.

    Genome annotation databases

    EnsembliENSCAFT00000025200; ENSCAFP00000023396; ENSCAFG00000015901.
    ENSCAFT00000038151; ENSCAFP00000033829; ENSCAFG00000030465.
    GeneIDi100499480.
    403631.
    KEGGicfa:100499480.
    cfa:403631.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF285177 mRNA. Translation: AAK82992.1 .
    AB175610 mRNA. Translation: BAD96175.1 .
    AB175611 mRNA. Translation: BAD96176.1 .
    RefSeqi NP_001003080.1. NM_001003080.1.
    NP_001180585.1. NM_001193656.1.
    UniGenei Cfa.38608.
    Cfa.47833.

    3D structure databases

    ProteinModelPortali Q95MP7.
    SMRi Q95MP7. Positions 7-177.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q95MP7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCAFT00000025200 ; ENSCAFP00000023396 ; ENSCAFG00000015901 .
    ENSCAFT00000038151 ; ENSCAFP00000033829 ; ENSCAFG00000030465 .
    GeneIDi 100499480.
    403631.
    KEGGi cfa:100499480.
    cfa:403631.

    Organism-specific databases

    CTDi 2495.

    Phylogenomic databases

    eggNOGi COG1528.
    GeneTreei ENSGT00700000104283.
    HOGENOMi HOG000223383.
    HOVERGENi HBG000410.
    InParanoidi Q95MP7.
    KOi K00522.
    OMAi ESAHEER.
    OrthoDBi EOG7DRJ49.
    TreeFami TF313885.

    Miscellaneous databases

    NextBioi 20817136.

    Family and domain databases

    Gene3Di 1.20.1260.10. 1 hit.
    InterProi IPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR014034. Ferritin_CS.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view ]
    PANTHERi PTHR11431. PTHR11431. 1 hit.
    Pfami PF00210. Ferritin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS00540. FERRITIN_1. 1 hit.
    PS00204. FERRITIN_2. 1 hit.
    PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Jeoung D., Jung D., Kim H.
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Sequence analysis of canine and equine ferritin H and L subunit cDNAs."
      Orino K., Miura T., Muto S., Watanabe K.
      DNA Seq. 16:58-64(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver and Spleen.

    Entry informationi

    Entry nameiFRIH_CANFA
    AccessioniPrimary (citable) accession number: Q95MP7
    Secondary accession number(s): Q53VC0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 81 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3