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Protein

Agouti-signaling protein

Gene

ASIP

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Agouti-signaling protein
Short name:
ASP
Alternative name(s):
Agouti switch protein
Gene namesi
Name:ASIP
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Chromosome 22

Organism-specific databases

VGNCiVGNC:15585 ASIP

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000102723 – 133Agouti-signaling proteinAdd BLAST111

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi94 ↔ 109PROSITE-ProRule annotation
Disulfide bondi101 ↔ 115PROSITE-ProRule annotation
Disulfide bondi108 ↔ 126PROSITE-ProRule annotation
Disulfide bondi112 ↔ 133PROSITE-ProRule annotation
Disulfide bondi117 ↔ 124PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ95MP2

Expressioni

Gene expression databases

BgeeiENSECAG00000004241

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9796.ENSECAP00000003317

Structurei

3D structure databases

ProteinModelPortaliQ95MP2
SMRiQ95MP2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 133AgoutiPROSITE-ProRule annotationAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi57 – 86Arg/Lys-rich (basic)Add BLAST30

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity

Keywords - Domaini

Knottin, Signal

Phylogenomic databases

eggNOGiENOG410J1GH Eukaryota
ENOG410ZCK9 LUCA
GeneTreeiENSGT00510000048661
HOGENOMiHOG000111779
HOVERGENiHBG050593
InParanoidiQ95MP2
KOiK08725
OMAiCSCRVLN
OrthoDBiEOG091G0ZG5
TreeFamiTF330729

Family and domain databases

Gene3Di4.10.760.10, 1 hit
InterProiView protein in InterPro
IPR007733 Agouti
IPR027300 Agouti_dom
IPR036836 Agouti_dom_sf
PANTHERiPTHR16551 PTHR16551, 1 hit
PfamiView protein in Pfam
PF05039 Agouti, 1 hit
SMARTiView protein in SMART
SM00792 Agouti, 1 hit
SUPFAMiSSF57055 SSF57055, 1 hit
PROSITEiView protein in PROSITE
PS60024 AGOUTI_1, 1 hit
PS51150 AGOUTI_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q95MP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVIHLFLAT LLVSLCFLTA YSHLSPEEKP KDDRSLRNNS SMNLLDSPSV
60 70 80 90 100
SIMALNKKSK KISRKEAEKK KRSSKKKASM TKVARPRLLQ PAPCVATRDS
110 120 130
CKPPAPACCD PCASCQCRFF RSACSCRVLT RTC
Length:133
Mass (Da):14,780
Last modified:December 1, 2001 - v1
Checksum:i332CE78470392507
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288358 Genomic DNA Translation: AAK70925.1
RefSeqiNP_001157489.1, NM_001164017.1
UniGeneiEca.16921

Genome annotation databases

EnsembliENSECAT00000004772; ENSECAP00000003317; ENSECAG00000004241
GeneIDi100054335
KEGGiecb:100054335

Similar proteinsi

Entry informationi

Entry nameiASIP_HORSE
AccessioniPrimary (citable) accession number: Q95MP2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health