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Protein

Agouti-signaling protein

Gene

ASIP

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Agouti-signaling protein
Short name:
ASP
Alternative name(s):
Agouti switch protein
Gene namesi
Name:ASIP
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Chromosome 22

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 133111Agouti-signaling proteinPRO_0000001027Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi38 – 381N-linked (GlcNAc...)Sequence analysis
Glycosylationi39 – 391N-linked (GlcNAc...)Sequence analysis
Disulfide bondi94 ↔ 109PROSITE-ProRule annotation
Disulfide bondi101 ↔ 115PROSITE-ProRule annotation
Disulfide bondi108 ↔ 126PROSITE-ProRule annotation
Disulfide bondi112 ↔ 133PROSITE-ProRule annotation
Disulfide bondi117 ↔ 124PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ95MP2.

Interactioni

Protein-protein interaction databases

STRINGi9796.ENSECAP00000003317.

Structurei

3D structure databases

ProteinModelPortaliQ95MP2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini94 – 13340AgoutiPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi57 – 8630Arg/Lys-rich (basic)Add
BLAST

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity

Sequence similaritiesi

Contains 1 agouti domain.PROSITE-ProRule annotation

Keywords - Domaini

Knottin, Signal

Phylogenomic databases

eggNOGiENOG410J1GH. Eukaryota.
ENOG410ZCK9. LUCA.
GeneTreeiENSGT00510000048661.
HOGENOMiHOG000111779.
HOVERGENiHBG050593.
InParanoidiQ95MP2.
KOiK08725.
OMAiCSCRVLN.
OrthoDBiEOG79PJRV.
TreeFamiTF330729.

Family and domain databases

Gene3Di4.10.760.10. 1 hit.
InterProiIPR007733. Agouti.
IPR027300. Agouti_dom.
[Graphical view]
PANTHERiPTHR16551. PTHR16551. 1 hit.
PfamiPF05039. Agouti. 1 hit.
[Graphical view]
SMARTiSM00792. Agouti. 1 hit.
[Graphical view]
SUPFAMiSSF57055. SSF57055. 1 hit.
PROSITEiPS60024. AGOUTI_1. 1 hit.
PS51150. AGOUTI_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q95MP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVIHLFLAT LLVSLCFLTA YSHLSPEEKP KDDRSLRNNS SMNLLDSPSV
60 70 80 90 100
SIMALNKKSK KISRKEAEKK KRSSKKKASM TKVARPRLLQ PAPCVATRDS
110 120 130
CKPPAPACCD PCASCQCRFF RSACSCRVLT RTC
Length:133
Mass (Da):14,780
Last modified:December 1, 2001 - v1
Checksum:i332CE78470392507
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288358 Genomic DNA. Translation: AAK70925.1.
RefSeqiNP_001157489.1. NM_001164017.1.
UniGeneiEca.16921.

Genome annotation databases

EnsembliENSECAT00000004772; ENSECAP00000003317; ENSECAG00000004241.
GeneIDi100054335.
KEGGiecb:100054335.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288358 Genomic DNA. Translation: AAK70925.1.
RefSeqiNP_001157489.1. NM_001164017.1.
UniGeneiEca.16921.

3D structure databases

ProteinModelPortaliQ95MP2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9796.ENSECAP00000003317.

Proteomic databases

PaxDbiQ95MP2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSECAT00000004772; ENSECAP00000003317; ENSECAG00000004241.
GeneIDi100054335.
KEGGiecb:100054335.

Organism-specific databases

CTDi434.

Phylogenomic databases

eggNOGiENOG410J1GH. Eukaryota.
ENOG410ZCK9. LUCA.
GeneTreeiENSGT00510000048661.
HOGENOMiHOG000111779.
HOVERGENiHBG050593.
InParanoidiQ95MP2.
KOiK08725.
OMAiCSCRVLN.
OrthoDBiEOG79PJRV.
TreeFamiTF330729.

Family and domain databases

Gene3Di4.10.760.10. 1 hit.
InterProiIPR007733. Agouti.
IPR027300. Agouti_dom.
[Graphical view]
PANTHERiPTHR16551. PTHR16551. 1 hit.
PfamiPF05039. Agouti. 1 hit.
[Graphical view]
SMARTiSM00792. Agouti. 1 hit.
[Graphical view]
SUPFAMiSSF57055. SSF57055. 1 hit.
PROSITEiPS60024. AGOUTI_1. 1 hit.
PS51150. AGOUTI_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Mutations in the agouti (ASIP), the extension (MC1R), and the brown (TYRP1) loci and their association to coat color phenotypes in horses (Equus caballus)."
    Rieder S., Taourit S., Mariat D., Langlois B., Guerin G.
    Mamm. Genome 12:450-455(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiASIP_HORSE
AccessioniPrimary (citable) accession number: Q95MP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: December 1, 2001
Last modified: May 11, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.