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Protein

Agouti-signaling protein

Gene

ASIP

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Agouti-signaling protein
Short name:
ASP
Alternative name(s):
Agouti switch protein
Gene namesi
Name:ASIP
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Chromosome 22

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000102723 – 133Agouti-signaling proteinAdd BLAST111

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...)Sequence analysis1
Glycosylationi39N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi94 ↔ 109PROSITE-ProRule annotation
Disulfide bondi101 ↔ 115PROSITE-ProRule annotation
Disulfide bondi108 ↔ 126PROSITE-ProRule annotation
Disulfide bondi112 ↔ 133PROSITE-ProRule annotation
Disulfide bondi117 ↔ 124PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ95MP2.

Interactioni

Protein-protein interaction databases

STRINGi9796.ENSECAP00000003317.

Structurei

3D structure databases

ProteinModelPortaliQ95MP2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 133AgoutiPROSITE-ProRule annotationAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi57 – 86Arg/Lys-rich (basic)Add BLAST30

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity

Sequence similaritiesi

Contains 1 agouti domain.PROSITE-ProRule annotation

Keywords - Domaini

Knottin, Signal

Phylogenomic databases

eggNOGiENOG410J1GH. Eukaryota.
ENOG410ZCK9. LUCA.
GeneTreeiENSGT00510000048661.
HOGENOMiHOG000111779.
HOVERGENiHBG050593.
InParanoidiQ95MP2.
KOiK08725.
OMAiCSCRVLN.
OrthoDBiEOG091G0ZG5.
TreeFamiTF330729.

Family and domain databases

Gene3Di4.10.760.10. 1 hit.
InterProiIPR007733. Agouti.
IPR027300. Agouti_dom.
[Graphical view]
PANTHERiPTHR16551. PTHR16551. 1 hit.
PfamiPF05039. Agouti. 1 hit.
[Graphical view]
SMARTiSM00792. Agouti. 1 hit.
[Graphical view]
SUPFAMiSSF57055. SSF57055. 1 hit.
PROSITEiPS60024. AGOUTI_1. 1 hit.
PS51150. AGOUTI_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q95MP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVIHLFLAT LLVSLCFLTA YSHLSPEEKP KDDRSLRNNS SMNLLDSPSV
60 70 80 90 100
SIMALNKKSK KISRKEAEKK KRSSKKKASM TKVARPRLLQ PAPCVATRDS
110 120 130
CKPPAPACCD PCASCQCRFF RSACSCRVLT RTC
Length:133
Mass (Da):14,780
Last modified:December 1, 2001 - v1
Checksum:i332CE78470392507
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288358 Genomic DNA. Translation: AAK70925.1.
RefSeqiNP_001157489.1. NM_001164017.1.
UniGeneiEca.16921.

Genome annotation databases

EnsembliENSECAT00000004772; ENSECAP00000003317; ENSECAG00000004241.
GeneIDi100054335.
KEGGiecb:100054335.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288358 Genomic DNA. Translation: AAK70925.1.
RefSeqiNP_001157489.1. NM_001164017.1.
UniGeneiEca.16921.

3D structure databases

ProteinModelPortaliQ95MP2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9796.ENSECAP00000003317.

Proteomic databases

PaxDbiQ95MP2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSECAT00000004772; ENSECAP00000003317; ENSECAG00000004241.
GeneIDi100054335.
KEGGiecb:100054335.

Organism-specific databases

CTDi434.

Phylogenomic databases

eggNOGiENOG410J1GH. Eukaryota.
ENOG410ZCK9. LUCA.
GeneTreeiENSGT00510000048661.
HOGENOMiHOG000111779.
HOVERGENiHBG050593.
InParanoidiQ95MP2.
KOiK08725.
OMAiCSCRVLN.
OrthoDBiEOG091G0ZG5.
TreeFamiTF330729.

Family and domain databases

Gene3Di4.10.760.10. 1 hit.
InterProiIPR007733. Agouti.
IPR027300. Agouti_dom.
[Graphical view]
PANTHERiPTHR16551. PTHR16551. 1 hit.
PfamiPF05039. Agouti. 1 hit.
[Graphical view]
SMARTiSM00792. Agouti. 1 hit.
[Graphical view]
SUPFAMiSSF57055. SSF57055. 1 hit.
PROSITEiPS60024. AGOUTI_1. 1 hit.
PS51150. AGOUTI_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiASIP_HORSE
AccessioniPrimary (citable) accession number: Q95MP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.