Q95MI7SCD_CAPHIStearoyl-CoA desaturase1.14.19.1Acyl-CoA desaturaseDelta(9)-desaturaseDelta-9 desaturaseFatty acid desaturaseSCDCapra hircusGoatEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeCaprinaeCapraPartial nucleotide sequence of the goat stearoyl coenzyme A desaturase cDNA and gene structure.NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (By similarity). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity).2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2OFe(2+)Expected to bind 2 Fe(2+) ions per subunit.Endoplasmic reticulum membraneMulti-pass membrane proteinThe histidine box domains are involved in binding the catalytic metal ions.Belongs to the fatty acid desaturase type 1 family.Endoplasmic reticulumFatty acid biosynthesisFatty acid metabolismIronLipid biosynthesisLipid metabolismMembraneMetal-bindingOxidoreductasePhosphoproteinReference proteomeTransmembraneTransmembrane helixsubstrateFe cationFe cationsubstratesubstratesubstrateFe cationFe cationFe cationsubstratesubstratesubstrateFe cationFe cationFe cationFe cationMPAHLLQEEISSSYTTTTTITAPPSKVLQNGGGKLEKTPLYLEEDIRPEMRDDIYDPTYQDKEGPKPKLEYVWRNIILMGLLHLGALYGITLIPTCKIYTFLWVLFYYMMSALGITAGVHRLWSHRTYKARLPLRVFLIIANTMAFQNDVFEWSRDHRAHHKFSETDADPHNSRRGFFFSHVGWLLVRKHPAVREKGATLDLSDLRAEKLVMFQRRYYKPGVLLLCFILPTLVPWYLWGETFQNSLFFATLLRYAVVLNATWLVNSAAHMYGYRPYDKTINPRENILVSLGAVGEGFHNYHHTFPYDYSASEYRWHINFTTFFIDCMAAIGLAYDRKKVSKAAALARMKRTGEESCKSG
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