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Reviewed, UniProtKB/Swiss-Prot Q95M61 (CP19A_CALJA)

Last modified June 16, 2009. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Cytochrome P450 19A1
    EC=1.14.14.1
Alternative name(s):
    CYPXIX
    Aromatase
    Estrogen synthetase
    P-450AROM
Gene names
Name: CYP19A1
Synonyms: CYP19
OrganismCallithrix jacchus (Common marmoset)
Taxonomic identifier9483 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Platyrrhini › Cebidae › Callitrichinae › Callithrix

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Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Catalyzes the formation of aromatic C18 estrogens from C19 androgens By similarity.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Membrane; Peripheral membrane protein.

Sequence similarities

Belongs to the cytochrome P450 family.

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Ontologies

Keywords
   Cellular componentMembrane
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
   PTMPhosphoprotein
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentmembrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionaromatase activity

Inferred from electronic annotation. Source: EC

electron carrier activity

Inferred from electronic annotation. Source: InterPro

heme binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 503503Cytochrome P450 19A1
PRO_0000051951

Sites

Metal binding4371Iron (heme axial ligand) By similarity

Amino acid modifications

Modified residue1621Phosphothreonine By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q95M61-1 [UniParc].

Last modified October 1, 2002. Version 2.
Checksum: 775E8F1734412099

FASTA50357,794
        10         20         30         40         50         60 
MVLEMLNPMH YNITSMVPEA MPAATMPILL LTGLFLLVWN YEGTSSIPGP GYCMGIGPLI 

        70         80         90        100        110        120 
SHGRFLWMGI GNACNYYNRM YGEFMRVWIS GEETLIISKS SSMFHVMKHN HYSSRFGSKL 

       130        140        150        160        170        180 
GLQCIGMHEK GIIFNNNPDL WKTTRPLFMK ALSGPGLVRM VTVCAESLNT HLDRLEEVTN 

       190        200        210        220        230        240 
ESGFIDVLTL LRCVMLDTSN TLFLRIPLDE NAIVFKIQGY FDAWQALLIK PDIFFKISWL 

       250        260        270        280        290        300 
YKKYEKSVKD LKDAIEVLMA EKRRRISAEE KLEEHIDFAT ELILAEKRGD LTRENVNQCM 

       310        320        330        340        350        360 
LEMLIAAPDT MSVSLFFMLF LIAKHPNVEE AIMKEIQTVV GERDVKIDDI QKLKVVENFI 

       370        380        390        400        410        420 
YESMRYQPVV DLVMRKALED DVIDGYPVKK GTNIILNIGR MHRLEFFPKP NEFTLENFAK 

       430        440        450        460        470        480 
NVPYRYFQPF GFGPRSCAGK YIAMVMMKSI LVTLLRRFHV KTLGGECVES LQKTNDLALH 

       490        500 
PDHTKSMLEM IFTPRNSGWC LEH

« Hide

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References

[1]"Regulation of 17-beta-hydroxysteroid dehydrogenases type 1 and type 7 during pregnancy in the marmoset monkey."
Husen B., Einspanier A.
Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

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Cross-references

Sequence databases

AY034779 mRNA. Translation: AAK58465.2.

3D structure databases

ModBaseSearch...

Phylogenomic databases

HOVERGENQ95M61.

Enzyme and pathway databases

BRENDA1.14.14.1. 265156.

Family and domain databases

InterProIPR001128. Cyt_P450.
IPR017973. Cyt_P450_C.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
Gene3DG3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHERPTHR19383. Cyt_P450. 1 hit.
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameCP19A_CALJA
AccessionPrimary (citable) accession number: Q95M61
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2002
Last modified: June 16, 2009
This is version 42 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents