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Q95M61 (CP19A_CALJA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aromatase

EC=1.14.14.14
Alternative name(s):
CYPXIX
Cytochrome P-450AROM
Cytochrome P450 19A1
Estrogen synthase
Gene names
Name:CYP19A1
Synonyms:CYP19
OrganismCallithrix jacchus (White-tufted-ear marmoset) [Reference proteome]
Taxonomic identifier9483 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrix

Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the formation of aromatic C18 estrogens from C19 androgens By similarity.

Catalytic activity

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.

Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactor

Heme group By similarity.

Subcellular location

Membrane; Peripheral membrane protein.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Keywords
   Cellular componentMembrane
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentmembrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaromatase activity

Inferred from sequence or structural similarity. Source: UniProtKB

heme binding

Inferred from sequence or structural similarity. Source: UniProtKB

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 503503Aromatase
PRO_0000051951

Sites

Metal binding4371Iron (heme axial ligand) By similarity
Binding site3091Substrate By similarity
Binding site3741Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q95M61 [UniParc].

Last modified October 1, 2002. Version 2.
Checksum: 775E8F1734412099

FASTA50357,794
        10         20         30         40         50         60 
MVLEMLNPMH YNITSMVPEA MPAATMPILL LTGLFLLVWN YEGTSSIPGP GYCMGIGPLI 

        70         80         90        100        110        120 
SHGRFLWMGI GNACNYYNRM YGEFMRVWIS GEETLIISKS SSMFHVMKHN HYSSRFGSKL 

       130        140        150        160        170        180 
GLQCIGMHEK GIIFNNNPDL WKTTRPLFMK ALSGPGLVRM VTVCAESLNT HLDRLEEVTN 

       190        200        210        220        230        240 
ESGFIDVLTL LRCVMLDTSN TLFLRIPLDE NAIVFKIQGY FDAWQALLIK PDIFFKISWL 

       250        260        270        280        290        300 
YKKYEKSVKD LKDAIEVLMA EKRRRISAEE KLEEHIDFAT ELILAEKRGD LTRENVNQCM 

       310        320        330        340        350        360 
LEMLIAAPDT MSVSLFFMLF LIAKHPNVEE AIMKEIQTVV GERDVKIDDI QKLKVVENFI 

       370        380        390        400        410        420 
YESMRYQPVV DLVMRKALED DVIDGYPVKK GTNIILNIGR MHRLEFFPKP NEFTLENFAK 

       430        440        450        460        470        480 
NVPYRYFQPF GFGPRSCAGK YIAMVMMKSI LVTLLRRFHV KTLGGECVES LQKTNDLALH 

       490        500 
PDHTKSMLEM IFTPRNSGWC LEH 

« Hide

References

[1]"Regulation of 17-beta-hydroxysteroid dehydrogenases type 1 and type 7 during pregnancy in the marmoset monkey."
Husen B., Einspanier A.
Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY034779 mRNA. Translation: AAK58465.2.
RefSeqNP_001254691.1. NM_001267762.1.

3D structure databases

ProteinModelPortalQ95M61.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100411557.

Organism-specific databases

CTD1588.

Phylogenomic databases

HOGENOMHOG000111912.
HOVERGENHBG050750.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP19A_CALJA
AccessionPrimary (citable) accession number: Q95M61
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2002
Last modified: December 11, 2013
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families