Q95M61 (CP19A_CALJA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome P450 19A1
EC=1.14.14.1

Alternative name(s):
Aromatase
CYPXIX
Cytochrome P-450AROM
Estrogen synthase

Gene names

Name:	CYP19A1
Synonyms:	CYP19

Organism

Callithrix jacchus (White-tufted-ear marmoset) [Reference proteome]

Taxonomic identifier

9483 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Platyrrhini › Cebidae › Callitrichinae › Callithrix

Protein attributes

Sequence length	503 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the formation of aromatic C18 estrogens from C19 androgens By similarity.
Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Membrane; Peripheral membrane protein.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Membrane
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	aromatase activity Inferred from sequence or structural similarity. Source: UniProtKB electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from sequence or structural similarity. Source: UniProtKB iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 503	503	Cytochrome P450 19A1		PRO_0000051951
Sites
	Metal binding	437	1	Iron (heme axial ligand) By similarity
	Binding site	309	1	Substrate By similarity
	Binding site	374	1	Substrate; via amide nitrogen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q95M61 [UniParc]. Last modified October 1, 2002. Version 2. Checksum: 775E8F1734412099	FASTA	503	57,794
	10 20 30 40 50 60 MVLEMLNPMH YNITSMVPEA MPAATMPILL LTGLFLLVWN YEGTSSIPGP GYCMGIGPLI 70 80 90 100 110 120 SHGRFLWMGI GNACNYYNRM YGEFMRVWIS GEETLIISKS SSMFHVMKHN HYSSRFGSKL 130 140 150 160 170 180 GLQCIGMHEK GIIFNNNPDL WKTTRPLFMK ALSGPGLVRM VTVCAESLNT HLDRLEEVTN 190 200 210 220 230 240 ESGFIDVLTL LRCVMLDTSN TLFLRIPLDE NAIVFKIQGY FDAWQALLIK PDIFFKISWL 250 260 270 280 290 300 YKKYEKSVKD LKDAIEVLMA EKRRRISAEE KLEEHIDFAT ELILAEKRGD LTRENVNQCM 310 320 330 340 350 360 LEMLIAAPDT MSVSLFFMLF LIAKHPNVEE AIMKEIQTVV GERDVKIDDI QKLKVVENFI 370 380 390 400 410 420 YESMRYQPVV DLVMRKALED DVIDGYPVKK GTNIILNIGR MHRLEFFPKP NEFTLENFAK 430 440 450 460 470 480 NVPYRYFQPF GFGPRSCAGK YIAMVMMKSI LVTLLRRFHV KTLGGECVES LQKTNDLALH 490 500 PDHTKSMLEM IFTPRNSGWC LEH

References

[1]	"Regulation of 17-beta-hydroxysteroid dehydrogenases type 1 and type 7 during pregnancy in the marmoset monkey." Husen B., Einspanier A. Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY034779 mRNA. Translation: AAK58465.2.
RefSeq	NP_001254691.1. NM_001267762.1.
3D structure databases
ProteinModelPortal	Q95M61.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100411557.
Organism-specific databases
CTD	1588.
Phylogenomic databases
HOGENOM	HOG000111912.
HOVERGEN	HBG050750.
OrthoDB	EOG4ZCT4K.
Family and domain databases
Gene3D	1.10.630.10. 1 hit.
InterPro	IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view]
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR00385. P450.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CP19A_CALJA

Accession

Primary (citable) accession number: Q95M61

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	October 1, 2002
Last modified:	April 3, 2013
This is version 67 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program