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Protein

Beta-galactosidase-1-like protein

Gene

GLB1L

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable glycosyl hydrolase.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei186Proton donorSequence analysis1
Active sitei264NucleophileSequence analysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Protein family/group databases

CAZyiGH35. Glycoside Hydrolase Family 35.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase-1-like protein (EC:3.2.1.-)
Gene namesi
Name:GLB1L
ORF Names:QtsA-15875, QtsA-16327, QtsA-17830
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000031360528 – 654Beta-galactosidase-1-like proteinAdd BLAST627

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi243N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ95LV1.
SMRiQ95LV1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 35 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG004841.

Family and domain databases

Gene3Di2.60.120.260. 2 hits.
InterProiView protein in InterPro
IPR026283. B-gal_1-like.
IPR008979. Galactose-bd-like_sf.
IPR031330. Gly_Hdrlase_35_cat.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
PANTHERiPTHR23421. PTHR23421. 1 hit.
PfamiView protein in Pfam
PF01301. Glyco_hydro_35. 1 hit.
PIRSFiPIRSF006336. B-gal. 1 hit.
PRINTSiPR00742. GLHYDRLASE35.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q95LV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKKPSCLR SLLLPLSLTL LLPQADTRSF IVDRDHDRFL LDGAPFRYVS
60 70 80 90 100
GSLHYFRVPR VLWADRLLKM RWSGLNAIQF YVPWNYHEPQ PGVYNFNGSR
110 120 130 140 150
DLIAFLNEAA LANLLVILRP GPYICAEWEM GGLPSWLLRK PEIRLRTSDP
160 170 180 190 200
DFLAAVDSWF KVLLPKIYPW LYHNGGNIIS IQVENEYGSY GACDFSYMRH
210 220 230 240 250
LAGLFRALLG EKILLFTTDG PEGLKCGSLQ GLYTTVDFGP ADNMTKIFTL
260 270 280 290 300
LRKYEPHGPL VNSEYYTGWL DYWGQNHSTR SVSAVTKGLE NMLKLGASVN
310 320 330 340 350
MYMFHGGTNF GYWNGADKKG RFLSITTSYD YDAPISEAGD PTPKLFALRD
360 370 380 390 400
VISKFQEVPL GPLPPPSPKM MVGPLTLHLV GHLLAFLDLL CPSGPIRSIL
410 420 430 440 450
PMTFEAVKQD RGFMLYRTYM THTIFEPTPF WVPNNGVHDR AYVMVDGVFQ
460 470 480 490 500
GVLERNMRDK LFLMGKVGSK LDILVENMGR LSFGSNSSDF KGLLEPPILG
510 520 530 540 550
QTILTQWMMF PLKIDNLVKW WFLLQLPKWP YPQAPSGPTF YSKTFPILGS
560 570 580 590 600
VGDTFLHLPG WTKGQVWING FNLGRYWTKR GPQQTLYVPR FLLFPRGALN
610 620 630 640 650
KITLLELENV PLQPQVQFLD KPILNSTSTL HRTHINSLSA DTLSASEPME

LSGH
Length:654
Mass (Da):74,113
Last modified:December 1, 2001 - v1
Checksum:iE0815FB08856919E
GO

Sequence cautioni

The sequence BAE01075 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33D → N in BAB64453 (PubMed:12498619).Curated1
Sequence conflicti627T → A in BAB64453 (PubMed:12498619).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB071060 mRNA. Translation: BAB64453.1.
AB071090 mRNA. Translation: BAB64484.1.
AB168978 mRNA. Translation: BAE01075.1. Different initiation.
RefSeqiNP_001271478.1. NM_001284549.1.
XP_005574408.1. XM_005574351.2.
XP_015287616.1. XM_015432130.1.
UniGeneiMfa.6590.

Genome annotation databases

GeneIDi102141964.
KEGGimcf:102141964.

Similar proteinsi

Entry informationi

Entry nameiGLB1L_MACFA
AccessioniPrimary (citable) accession number: Q95LV1
Secondary accession number(s): Q4R748, Q95LY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 1, 2001
Last modified: November 22, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families