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Protein

Calpain-10

Gene

CAPN10

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake (By similarity).By similarity

Catalytic activityi

Broad endopeptidase specificity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei73 – 731By similarity
Active sitei238 – 2381By similarity
Active sitei263 – 2631By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Enzyme and pathway databases

BRENDAi3.4.22.B30. 1793.

Protein family/group databases

MEROPSiC02.018.

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain-10 (EC:3.4.22.-)
Alternative name(s):
Calcium-activated neutral proteinase 10
Short name:
CANP 10
Gene namesi
Name:CAPN10
ORF Names:QtsA-15844
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 653653Calpain-10PRO_0000207726Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ95LP4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 321309Calpain catalyticPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni322 – 494173Domain III 1Add
BLAST
Regioni513 – 653141Domain III 2Add
BLAST

Sequence similaritiesi

Belongs to the peptidase C2 family.Curated
Contains 1 calpain catalytic domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG050787.
KOiK08579.

Family and domain databases

InterProiIPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR028791. CAPN10.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PANTHERiPTHR10183:SF30. PTHR10183:SF30. 2 hits.
PfamiPF01067. Calpain_III. 2 hits.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00720. calpain_III. 2 hits.
SM00230. CysPc. 1 hit.
[Graphical view]
SUPFAMiSSF49758. SSF49758. 2 hits.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q95LP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAGRGATPA RELFRDAAFP AADSSLFCDL STPLAQFRED ITWRRPQEIC
60 70 80 90 100
AMPRLFPDDP QEGQVKQGLL GDCWFLCACA ALQKSRHLLE QVIPPGQPSW
110 120 130 140 150
ADQEYQGSFT CRIWQFGRWV EVTTDDRLPC LAGRLCFSRC QREDVFWLPL
160 170 180 190 200
LEKVYAKVHG SYEHLWAGQV ADALVDLTGG LAERWSLKGV AGSGGQQDRL
210 220 230 240 250
GRWEHRTCRQ LLRLKDQSLI SCSVLSPRAG ARELGEFHAF IVSDLRELQD
260 270 280 290 300
QAGQSILLLR IQNPWGRRCW QGLWREGGEG WSQVDAAVTS ELLSQLQEGE
310 320 330 340 350
FWVEEEEFLR EFDEITIGYP ITEAGHLQSL YTEKLLCHTR ALPGAWVKGQ
360 370 380 390 400
SAGGCRNNSG FPSNPKFWLR VSEPSEVYIA VLQRSRLRAV DWAGRARALV
410 420 430 440 450
GDSHTSWSPA SIPGKHYQAV GLHLWKVEKR RVNLPRVLST PPVAGTACHA
460 470 480 490 500
YDREVHLRCE LSPGYYLAVP STFLKDAPGE FLLRVFSTGR VSLSAIRAVA
510 520 530 540 550
KNASPRAALP AGEWGTVQLR GSWRAGQTAG GSRNFASYPT NPCFPFSVPE
560 570 580 590 600
GPGPRCVRIT LHQHCQPRDT EFHPIGFHIF QVPEGGRSQD APPLLLQEPL
610 620 630 640 650
LSCVPHRYAQ EVSQLCLLPP GTYRVVPSTY LPDTEGAFTV TIATRIDRSP

SWQ
Length:653
Mass (Da):72,998
Last modified:December 1, 2001 - v1
Checksum:i47812497BB315971
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072744 mRNA. Translation: BAB69713.1.
AB179239 mRNA. Translation: BAE02290.1.
RefSeqiNP_001270318.1. NM_001283389.1.
UniGeneiMfa.6606.

Genome annotation databases

GeneIDi101866540.
KEGGimcf:101866540.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072744 mRNA. Translation: BAB69713.1.
AB179239 mRNA. Translation: BAE02290.1.
RefSeqiNP_001270318.1. NM_001283389.1.
UniGeneiMfa.6606.

3D structure databases

ProteinModelPortaliQ95LP4.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiC02.018.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101866540.
KEGGimcf:101866540.

Organism-specific databases

CTDi11132.

Phylogenomic databases

HOVERGENiHBG050787.
KOiK08579.

Enzyme and pathway databases

BRENDAi3.4.22.B30. 1793.

Family and domain databases

InterProiIPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR028791. CAPN10.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PANTHERiPTHR10183:SF30. PTHR10183:SF30. 2 hits.
PfamiPF01067. Calpain_III. 2 hits.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00720. calpain_III. 2 hits.
SM00230. CysPc. 1 hit.
[Graphical view]
SUPFAMiSSF49758. SSF49758. 2 hits.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAN10_MACFA
AccessioniPrimary (citable) accession number: Q95LP4
Secondary accession number(s): Q4R3M7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: December 1, 2001
Last modified: November 11, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.