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Q95LM1 (UBE2U_MACFA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin-conjugating enzyme E2 U

EC=6.3.2.19
Alternative name(s):
Ubiquitin carrier protein U
Ubiquitin-protein ligase U
Gene names
Name:UBE2U
ORF Names:QtsA-20104
OrganismMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifier9541 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length322 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the covalent attachment of ubiquitin to other proteins By similarity.

Catalytic activity

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathway

Protein modification; protein ubiquitination.

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
Gene Ontology (GO)
   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ubiquitin-protein transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 322322Ubiquitin-conjugating enzyme E2 U
PRO_0000082513

Sites

Active site891Glycyl thioester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q95LM1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: E94D9D0CBF1AA9F2

FASTA32237,760
        10         20         30         40         50         60 
MHGRAYLLLQ RDFYDLKENN YKGITARPVS EDMMEWEVEI EGLQNSVWQG LVFQLTIHFT 

        70         80         90        100        110        120 
SEYNYAPPVV KFVTIPFHPN VDPHTGQPCI DFLDNPKKWN TNYTLSSILL ALQVMLSNPV 

       130        140        150        160        170        180 
LENPVNLEAA RILTKDESLY RTILKLFNRP LQMKDDSQEL PKDPHKCIGP TKTTSFSDYY 

       190        200        210        220        230        240 
QAWSRIATSK ATEYYRTALL KDPNFIGQYY KWKKMDLQHH KEWNLKYSVI KCWLARKNRM 

       250        260        270        280        290        300 
PDEVRHSMEG IKLCPTQIPT TDEIFLESPT AINSVTNIYE TEEEGWKSDT SLYENNTDEP 

       310        320 
WEEEVEDLIS WINTLNTNTL ED 

« Hide

References

[1]"Cynomolgus monkey testicular cDNAs for discovery of novel human genes in the human genome sequence."
Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M., Terao K., Sugano S., Hashimoto K.
BMC Genomics 3:36-36(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB072767 mRNA. Translation: BAB69736.1.
RefSeqNP_001272035.1. NM_001285106.1.
UniGeneMfa.6612.

3D structure databases

ProteinModelPortalQ95LM1.
SMRQ95LM1. Positions 1-148.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID102126041.
KEGGmcf:102126041.

Organism-specific databases

CTD148581.

Phylogenomic databases

HOVERGENHBG080217.
KOK10584.

Enzyme and pathway databases

UniPathwayUPA00143.

Family and domain databases

Gene3D3.10.110.10. 1 hit.
InterProIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMSSF54495. SSF54495. 1 hit.
PROSITEPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBE2U_MACFA
AccessionPrimary (citable) accession number: Q95LM1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways