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Protein

Ubiquitin-conjugating enzyme E2 U

Gene

UBE2U

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins.By similarity

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei89Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 U (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme U
Ubiquitin carrier protein U
Ubiquitin-protein ligase U
Gene namesi
Name:UBE2U
ORF Names:QtsA-20104
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000825131 – 322Ubiquitin-conjugating enzyme E2 UAdd BLAST322

Post-translational modificationi

Autoubiquitinated in vitro in the presence of UBR5.By similarity

Keywords - PTMi

Ubl conjugation

Structurei

3D structure databases

ProteinModelPortaliQ95LM1.
SMRiQ95LM1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG080217.
KOiK10584.

Family and domain databases

CDDicd00195. UBCc. 1 hit.
Gene3Di3.10.110.10. 1 hit.
InterProiView protein in InterPro
IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
PfamiView protein in Pfam
PF00179. UQ_con. 1 hit.
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiView protein in PROSITE
PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q95LM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHGRAYLLLQ RDFYDLKENN YKGITARPVS EDMMEWEVEI EGLQNSVWQG
60 70 80 90 100
LVFQLTIHFT SEYNYAPPVV KFVTIPFHPN VDPHTGQPCI DFLDNPKKWN
110 120 130 140 150
TNYTLSSILL ALQVMLSNPV LENPVNLEAA RILTKDESLY RTILKLFNRP
160 170 180 190 200
LQMKDDSQEL PKDPHKCIGP TKTTSFSDYY QAWSRIATSK ATEYYRTALL
210 220 230 240 250
KDPNFIGQYY KWKKMDLQHH KEWNLKYSVI KCWLARKNRM PDEVRHSMEG
260 270 280 290 300
IKLCPTQIPT TDEIFLESPT AINSVTNIYE TEEEGWKSDT SLYENNTDEP
310 320
WEEEVEDLIS WINTLNTNTL ED
Length:322
Mass (Da):37,760
Last modified:December 1, 2001 - v1
Checksum:iE94D9D0CBF1AA9F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072767 mRNA. Translation: BAB69736.1.
RefSeqiNP_001272035.1. NM_001285106.1.
UniGeneiMfa.6612.

Genome annotation databases

GeneIDi102126041.
KEGGimcf:102126041.

Similar proteinsi

Entry informationi

Entry nameiUBE2U_MACFA
AccessioniPrimary (citable) accession number: Q95LM1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: December 1, 2001
Last modified: September 27, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families