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Q95LM1

- UBE2U_MACFA

UniProt

Q95LM1 - UBE2U_MACFA

Protein

Ubiquitin-conjugating enzyme E2 U

Gene

UBE2U

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the covalent attachment of ubiquitin to other proteins.PROSITE-ProRule annotation

    Catalytic activityi

    ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei89 – 891Glycyl thioester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. protein ubiquitination Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-conjugating enzyme E2 U (EC:6.3.2.19)
    Alternative name(s):
    Ubiquitin carrier protein U
    Ubiquitin-protein ligase U
    Gene namesi
    Name:UBE2U
    ORF Names:QtsA-20104
    OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
    Taxonomic identifieri9541 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 322322Ubiquitin-conjugating enzyme E2 UPRO_0000082513Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ95LM1.
    SMRiQ95LM1. Positions 1-148.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG080217.
    KOiK10584.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF00179. UQ_con. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 1 hit.
    PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q95LM1-1 [UniParc]FASTAAdd to Basket

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    MHGRAYLLLQ RDFYDLKENN YKGITARPVS EDMMEWEVEI EGLQNSVWQG    50
    LVFQLTIHFT SEYNYAPPVV KFVTIPFHPN VDPHTGQPCI DFLDNPKKWN 100
    TNYTLSSILL ALQVMLSNPV LENPVNLEAA RILTKDESLY RTILKLFNRP 150
    LQMKDDSQEL PKDPHKCIGP TKTTSFSDYY QAWSRIATSK ATEYYRTALL 200
    KDPNFIGQYY KWKKMDLQHH KEWNLKYSVI KCWLARKNRM PDEVRHSMEG 250
    IKLCPTQIPT TDEIFLESPT AINSVTNIYE TEEEGWKSDT SLYENNTDEP 300
    WEEEVEDLIS WINTLNTNTL ED 322
    Length:322
    Mass (Da):37,760
    Last modified:December 1, 2001 - v1
    Checksum:iE94D9D0CBF1AA9F2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB072767 mRNA. Translation: BAB69736.1.
    RefSeqiNP_001272035.1. NM_001285106.1.
    UniGeneiMfa.6612.

    Genome annotation databases

    GeneIDi102126041.
    KEGGimcf:102126041.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB072767 mRNA. Translation: BAB69736.1 .
    RefSeqi NP_001272035.1. NM_001285106.1.
    UniGenei Mfa.6612.

    3D structure databases

    ProteinModelPortali Q95LM1.
    SMRi Q95LM1. Positions 1-148.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 102126041.
    KEGGi mcf:102126041.

    Organism-specific databases

    CTDi 148581.

    Phylogenomic databases

    HOVERGENi HBG080217.
    KOi K10584.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 1 hit.
    PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in the human genome sequence."
      Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M., Terao K., Sugano S., Hashimoto K.
      BMC Genomics 3:36-36(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiUBE2U_MACFA
    AccessioniPrimary (citable) accession number: Q95LM1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2005
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3