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Q95LM1

- UBE2U_MACFA

UniProt

Q95LM1 - UBE2U_MACFA

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Protein

Ubiquitin-conjugating enzyme E2 U

Gene
UBE2U, QtsA-20104
Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins By similarity.

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891Glycyl thioester intermediate By similarity

GO - Molecular functioni

  1. acid-amino acid ligase activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 U (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein U
Ubiquitin-protein ligase U
Gene namesi
Name:UBE2U
ORF Names:QtsA-20104
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322Ubiquitin-conjugating enzyme E2 UPRO_0000082513Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ95LM1.
SMRiQ95LM1. Positions 1-148.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG080217.
KOiK10584.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q95LM1-1 [UniParc]FASTAAdd to Basket

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MHGRAYLLLQ RDFYDLKENN YKGITARPVS EDMMEWEVEI EGLQNSVWQG    50
LVFQLTIHFT SEYNYAPPVV KFVTIPFHPN VDPHTGQPCI DFLDNPKKWN 100
TNYTLSSILL ALQVMLSNPV LENPVNLEAA RILTKDESLY RTILKLFNRP 150
LQMKDDSQEL PKDPHKCIGP TKTTSFSDYY QAWSRIATSK ATEYYRTALL 200
KDPNFIGQYY KWKKMDLQHH KEWNLKYSVI KCWLARKNRM PDEVRHSMEG 250
IKLCPTQIPT TDEIFLESPT AINSVTNIYE TEEEGWKSDT SLYENNTDEP 300
WEEEVEDLIS WINTLNTNTL ED 322
Length:322
Mass (Da):37,760
Last modified:December 1, 2001 - v1
Checksum:iE94D9D0CBF1AA9F2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB072767 mRNA. Translation: BAB69736.1.
RefSeqiNP_001272035.1. NM_001285106.1.
UniGeneiMfa.6612.

Genome annotation databases

GeneIDi102126041.
KEGGimcf:102126041.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB072767 mRNA. Translation: BAB69736.1 .
RefSeqi NP_001272035.1. NM_001285106.1.
UniGenei Mfa.6612.

3D structure databases

ProteinModelPortali Q95LM1.
SMRi Q95LM1. Positions 1-148.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 102126041.
KEGGi mcf:102126041.

Organism-specific databases

CTDi 148581.

Phylogenomic databases

HOVERGENi HBG080217.
KOi K10584.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in the human genome sequence."
    Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M., Terao K., Sugano S., Hashimoto K.
    BMC Genomics 3:36-36(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiUBE2U_MACFA
AccessioniPrimary (citable) accession number: Q95LM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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