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Q95LM0

- PDILT_MACFA

UniProt

Q95LM0 - PDILT_MACFA

Protein

Protein disulfide-isomerase-like protein of the testis

Gene

PDILT

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Probable redox-inactive chaperone involved in spermatogenesis.By similarity

    GO - Molecular functioni

    1. isomerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. cell redox homeostasis Source: InterPro
    3. multicellular organismal development Source: UniProtKB-KW
    4. spermatogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chaperone, Developmental protein, Isomerase

    Keywords - Biological processi

    Differentiation, Spermatogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein disulfide-isomerase-like protein of the testis
    Gene namesi
    Name:PDILT
    ORF Names:QtsA-10382, QtsA-15920, QtsA-20110
    OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
    Taxonomic identifieri9541 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

    Subcellular locationi

    Endoplasmic reticulum PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 583566Protein disulfide-isomerase-like protein of the testisPRO_0000325850Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi58 – 581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi340 – 3401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi540 – 5401N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Subunit structurei

    Homodimer. The homodimer is not disulfide-linked. Interacts with ERO1L and CLGN By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ95LM0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini388 – 45164ThioredoxinPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi580 – 5834Prevents secretion from ERPROSITE-ProRule annotation

    Domaini

    The thioredoxin domain lacks the conserved redox-active Cys at position 417 which is replaced by a Ser residue, suggesting that it lacks thioredoxin activity.

    Sequence similaritiesi

    Belongs to the protein disulfide isomerase family.Curated
    Contains 1 thioredoxin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG108240.

    Family and domain databases

    Gene3Di3.40.30.10. 3 hits.
    InterProiIPR012336. Thioredoxin-like_fold.
    IPR013766. Thioredoxin_domain.
    [Graphical view]
    PfamiPF00085. Thioredoxin. 2 hits.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 4 hits.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q95LM0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDLLWMPLLL VAARISAVHS SPEVNAGVSS IHITKPVHIL EERNLLVLTP    50
    AGLTQMLNQT RFLMVLFHNP SSKQSRNLAE ELGKAVEIMG KGKNGIGFGK 100
    VDITVEKELQ QEFGITKAPQ LKLFFEGNRS EPISCKGVVE STALVVWLRR 150
    QISQKAFLFN SSLQVAEFVT SRPLVIVGFF QDLEEEVAEL FYDVIKDFPE 200
    LTFGVITIGN AIGRFHVTLD SILVFKKGKI VNRQELINDS TNKQELNRVI 250
    KQHLTDFVIE YNAENKDLIY ELYIMSHMLL FVSKSSESFG IIIQHYKLAS 300
    KEFQNKILFI LVNADEPRNR RVIEYFRVTE VDIPSVQILN LSSDARYKMP 350
    SDDITYENLK KFGRSFLSKN AKKHQSSEEI PKHWDQGLVK QLVGKNFNIV 400
    VFDKEKDVFV MFYAPWSKKC KMLFPLLEEL GRKYQNHSTI IIAKIDITAN 450
    DIQLVYLDRY PFFRLFPTDS QQAVLYKGEH TLKGFSDFLE SYIKTSIEDE 500
    DELLSVEQNE VIEEEVRAKE KEVPMMKKEL PEQQSPELEN VTKHVSKLEE 550
    SAGKKKTSEE VVVVAKPKGP PTQKKKPKVK EEL 583
    Length:583
    Mass (Da):66,848
    Last modified:December 1, 2001 - v1
    Checksum:iCAC54CF9A5F6369C
    GO
    Isoform 2 (identifier: Q95LM0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         527-553: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:556
    Mass (Da):63,831
    Checksum:iEE5DD333D60A367E
    GO
    Isoform 3 (identifier: Q95LM0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-55: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:528
    Mass (Da):60,913
    Checksum:i57F2D7BF40991DF3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti375 – 3751Q → R in BAB64435. (PubMed:12498619)Curated
    Sequence conflicti498 – 4981E → G in BAB64435. (PubMed:12498619)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 5555Missing in isoform 3. 1 PublicationVSP_032447Add
    BLAST
    Alternative sequencei527 – 55327Missing in isoform 2. 1 PublicationVSP_032448Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB071042 mRNA. Translation: BAB64435.1.
    AB071063 mRNA. Translation: BAB64456.1.
    AB072768 mRNA. Translation: BAB69737.1.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB071042 mRNA. Translation: BAB64435.1 .
    AB071063 mRNA. Translation: BAB64456.1 .
    AB072768 mRNA. Translation: BAB69737.1 .

    3D structure databases

    ProteinModelPortali Q95LM0.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG108240.

    Family and domain databases

    Gene3Di 3.40.30.10. 3 hits.
    InterProi IPR012336. Thioredoxin-like_fold.
    IPR013766. Thioredoxin_domain.
    [Graphical view ]
    Pfami PF00085. Thioredoxin. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 4 hits.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of novel full-length cDNA clones from macaque testis cDNA libraries."
      Hashimoto K., Osada N., Hida M., Kusuda J., Tanuma R., Hirai M., Terao K., Sugano S.
      Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Testis.
    2. "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in the human genome sequence."
      Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M., Terao K., Sugano S., Hashimoto K.
      BMC Genomics 3:36-36(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.

    Entry informationi

    Entry nameiPDILT_MACFA
    AccessioniPrimary (citable) accession number: Q95LM0
    Secondary accession number(s): Q95LX8, Q95LZ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3