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Protein

Protein disulfide-isomerase-like protein of the testis

Gene

PDILT

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable redox-inactive chaperone involved in spermatogenesis.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone, Developmental protein, Isomerase
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide-isomerase-like protein of the testis
Gene namesi
Name:PDILT
ORF Names:QtsA-10382, QtsA-15920, QtsA-20110
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000032585018 – 583Protein disulfide-isomerase-like protein of the testisAdd BLAST566

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi58N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi128N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi160N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi340N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi540N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ95LM0

Interactioni

Subunit structurei

Homodimer. The homodimer is not disulfide-linked. Interacts with ERO1A and CLGN (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ95LM0
SMRiQ95LM0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini388 – 451ThioredoxinPROSITE-ProRule annotationAdd BLAST64

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi580 – 583Prevents secretion from ERPROSITE-ProRule annotation4

Domaini

The thioredoxin domain lacks the conserved redox-active Cys at position 417 which is replaced by a Ser residue, suggesting that it lacks thioredoxin activity.

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG108240

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 2 hits
SUPFAMiSSF52833 SSF52833, 4 hits
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q95LM0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLLWMPLLL VAARISAVHS SPEVNAGVSS IHITKPVHIL EERNLLVLTP
60 70 80 90 100
AGLTQMLNQT RFLMVLFHNP SSKQSRNLAE ELGKAVEIMG KGKNGIGFGK
110 120 130 140 150
VDITVEKELQ QEFGITKAPQ LKLFFEGNRS EPISCKGVVE STALVVWLRR
160 170 180 190 200
QISQKAFLFN SSLQVAEFVT SRPLVIVGFF QDLEEEVAEL FYDVIKDFPE
210 220 230 240 250
LTFGVITIGN AIGRFHVTLD SILVFKKGKI VNRQELINDS TNKQELNRVI
260 270 280 290 300
KQHLTDFVIE YNAENKDLIY ELYIMSHMLL FVSKSSESFG IIIQHYKLAS
310 320 330 340 350
KEFQNKILFI LVNADEPRNR RVIEYFRVTE VDIPSVQILN LSSDARYKMP
360 370 380 390 400
SDDITYENLK KFGRSFLSKN AKKHQSSEEI PKHWDQGLVK QLVGKNFNIV
410 420 430 440 450
VFDKEKDVFV MFYAPWSKKC KMLFPLLEEL GRKYQNHSTI IIAKIDITAN
460 470 480 490 500
DIQLVYLDRY PFFRLFPTDS QQAVLYKGEH TLKGFSDFLE SYIKTSIEDE
510 520 530 540 550
DELLSVEQNE VIEEEVRAKE KEVPMMKKEL PEQQSPELEN VTKHVSKLEE
560 570 580
SAGKKKTSEE VVVVAKPKGP PTQKKKPKVK EEL
Length:583
Mass (Da):66,848
Last modified:December 1, 2001 - v1
Checksum:iCAC54CF9A5F6369C
GO
Isoform 2 (identifier: Q95LM0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     527-553: Missing.

Note: No experimental confirmation available.
Show »
Length:556
Mass (Da):63,831
Checksum:iEE5DD333D60A367E
GO
Isoform 3 (identifier: Q95LM0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-55: Missing.

Note: No experimental confirmation available.
Show »
Length:528
Mass (Da):60,913
Checksum:i57F2D7BF40991DF3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti375Q → R in BAB64435 (PubMed:12498619).Curated1
Sequence conflicti498E → G in BAB64435 (PubMed:12498619).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0324471 – 55Missing in isoform 3. 1 PublicationAdd BLAST55
Alternative sequenceiVSP_032448527 – 553Missing in isoform 2. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB071042 mRNA Translation: BAB64435.1
AB071063 mRNA Translation: BAB64456.1
AB072768 mRNA Translation: BAB69737.1
UniGeneiMfa.2579

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPDILT_MACFA
AccessioniPrimary (citable) accession number: Q95LM0
Secondary accession number(s): Q95LX8, Q95LZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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