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Q95LM0

- PDILT_MACFA

UniProt

Q95LM0 - PDILT_MACFA

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Protein
Protein disulfide-isomerase-like protein of the testis
Gene
PDILT, QtsA-10382, QtsA-15920, QtsA-20110
Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Probable redox-inactive chaperone involved in spermatogenesis By similarity.

GO - Molecular functioni

  1. isomerase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. cell redox homeostasis Source: InterPro
  3. multicellular organismal development Source: UniProtKB-KW
  4. spermatogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone, Developmental protein, Isomerase

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide-isomerase-like protein of the testis
Gene namesi
Name:PDILT
ORF Names:QtsA-10382, QtsA-15920, QtsA-20110
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Endoplasmic reticulum By similarity

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed prediction
Add
BLAST
Chaini18 – 583566Protein disulfide-isomerase-like protein of the testis
PRO_0000325850Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi58 – 581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi128 – 1281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi160 – 1601N-linked (GlcNAc...) Reviewed prediction
Glycosylationi340 – 3401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi540 – 5401N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

N-glycosylated By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Homodimer. The homodimer is not disulfide-linked. Interacts with ERO1L and CLGN By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ95LM0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini388 – 45164Thioredoxin
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi580 – 5834Prevents secretion from ER Reviewed prediction

Domaini

The thioredoxin domain lacks the conserved redox-active Cys at position 417 which is replaced by a Ser residue, suggesting that it lacks thioredoxin activity.

Sequence similaritiesi

Contains 1 thioredoxin domain.

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG108240.

Family and domain databases

Gene3Di3.40.30.10. 3 hits.
InterProiIPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 2 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 4 hits.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q95LM0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDLLWMPLLL VAARISAVHS SPEVNAGVSS IHITKPVHIL EERNLLVLTP    50
AGLTQMLNQT RFLMVLFHNP SSKQSRNLAE ELGKAVEIMG KGKNGIGFGK 100
VDITVEKELQ QEFGITKAPQ LKLFFEGNRS EPISCKGVVE STALVVWLRR 150
QISQKAFLFN SSLQVAEFVT SRPLVIVGFF QDLEEEVAEL FYDVIKDFPE 200
LTFGVITIGN AIGRFHVTLD SILVFKKGKI VNRQELINDS TNKQELNRVI 250
KQHLTDFVIE YNAENKDLIY ELYIMSHMLL FVSKSSESFG IIIQHYKLAS 300
KEFQNKILFI LVNADEPRNR RVIEYFRVTE VDIPSVQILN LSSDARYKMP 350
SDDITYENLK KFGRSFLSKN AKKHQSSEEI PKHWDQGLVK QLVGKNFNIV 400
VFDKEKDVFV MFYAPWSKKC KMLFPLLEEL GRKYQNHSTI IIAKIDITAN 450
DIQLVYLDRY PFFRLFPTDS QQAVLYKGEH TLKGFSDFLE SYIKTSIEDE 500
DELLSVEQNE VIEEEVRAKE KEVPMMKKEL PEQQSPELEN VTKHVSKLEE 550
SAGKKKTSEE VVVVAKPKGP PTQKKKPKVK EEL 583
Length:583
Mass (Da):66,848
Last modified:December 1, 2001 - v1
Checksum:iCAC54CF9A5F6369C
GO
Isoform 2 (identifier: Q95LM0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     527-553: Missing.

Note: No experimental confirmation available.

Show »
Length:556
Mass (Da):63,831
Checksum:iEE5DD333D60A367E
GO
Isoform 3 (identifier: Q95LM0-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-55: Missing.

Note: No experimental confirmation available.

Show »
Length:528
Mass (Da):60,913
Checksum:i57F2D7BF40991DF3
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5555Missing in isoform 3.
VSP_032447Add
BLAST
Alternative sequencei527 – 55327Missing in isoform 2.
VSP_032448Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti375 – 3751Q → R in BAB64435. 1 Publication
Sequence conflicti498 – 4981E → G in BAB64435. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB071042 mRNA. Translation: BAB64435.1.
AB071063 mRNA. Translation: BAB64456.1.
AB072768 mRNA. Translation: BAB69737.1.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB071042 mRNA. Translation: BAB64435.1 .
AB071063 mRNA. Translation: BAB64456.1 .
AB072768 mRNA. Translation: BAB69737.1 .

3D structure databases

ProteinModelPortali Q95LM0.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG108240.

Family and domain databases

Gene3Di 3.40.30.10. 3 hits.
InterProi IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view ]
Pfami PF00085. Thioredoxin. 2 hits.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 4 hits.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation of novel full-length cDNA clones from macaque testis cDNA libraries."
    Hashimoto K., Osada N., Hida M., Kusuda J., Tanuma R., Hirai M., Terao K., Sugano S.
    Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Testis.
  2. "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in the human genome sequence."
    Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M., Terao K., Sugano S., Hashimoto K.
    BMC Genomics 3:36-36(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.

Entry informationi

Entry nameiPDILT_MACFA
AccessioniPrimary (citable) accession number: Q95LM0
Secondary accession number(s): Q95LX8, Q95LZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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