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Protein

Interleukin-13 receptor subunit alpha-2

Gene

IL13RA2

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds as a monomer with high affinity to interleukin-13 (IL13).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-13 receptor subunit alpha-2
Short name:
IL-13 receptor subunit alpha-2
Short name:
IL-13R subunit alpha-2
Short name:
IL-13R-alpha-2
Short name:
IL-13RA2
Alternative name(s):
CD_antigen: CD213a2
Gene namesi
Name:IL13RA2
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome X

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 338317ExtracellularSequence analysisAdd
BLAST
Transmembranei339 – 35921HelicalSequence analysisAdd
BLAST
Topological domaini360 – 38627CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 386365Interleukin-13 receptor subunit alpha-2PRO_0000010941Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi64 ↔ 112By similarity
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence analysis
Disulfide bondi144 ↔ 154By similarity
Disulfide bondi183 ↔ 196By similarity
Glycosylationi214 – 2141N-linked (GlcNAc...)Sequence analysis
Disulfide bondi268 ↔ 315By similarity
Glycosylationi298 – 2981N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ95LF0.

Expressioni

Tissue specificityi

Expressed in kidney, placenta, liver, skeletal muscle and thymus. Expression was not seen in whole blood and heart.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000026935.

Structurei

3D structure databases

ProteinModelPortaliQ95LF0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 133101Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini138 – 23497Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini239 – 338100Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi321 – 3255WSXWS motif

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

Sequence similaritiesi

Contains 3 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IUDW. Eukaryota.
ENOG4111JMU. LUCA.
GeneTreeiENSGT00530000063295.
HOGENOMiHOG000004823.
HOVERGENiHBG058972.
InParanoidiQ95LF0.
KOiK05077.
OMAiLFYWYEG.
OrthoDBiEOG71P2B1.
TreeFamiTF331549.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR003532. Short_hematopoietin_rcpt_2_CS.
IPR015321. TypeI_recpt_CBD.
[Graphical view]
PfamiPF09240. IL6Ra-bind. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 3 hits.
PS01356. HEMATOPO_REC_S_F2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q95LF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFIHLDVGF LYTLLVCTAF GSMLSNAEIK VNPPQDFEIV DPGYLGYLSL
60 70 80 90 100
QWQPPLFPDN FKECTIEYEL KYRNIDSENW KTIITKNLHY KDGFDLNKGI
110 120 130 140 150
EAKINTLLPA QCTNGSEVRS SWAETTYWTS PQGNRETKIQ DMDCVYYNWQ
160 170 180 190 200
YLVCSWKPGM GVHFDTNYQL FYWYEGLDHS AECTDYIKVN GKNMGCRFPY
210 220 230 240 250
LESSDYKDFY ICVNGSSESQ PIRPSYFIFQ LQNIVKPMPP DYLSLTVKNS
260 270 280 290 300
EEINLKWNMP KGPIPAKCFI YEIEFTEDGT TWVTTTVENE IQITRTSNES
310 320 330 340 350
QKLCFLVRSK VNIYCSDDGI WSEWSDEQCW KGDIWKETLV FFLIPFAFVS
360 370 380
IFVLVITCLL LYKQRALLKT IFHTKKEVFS HQDTFC
Length:386
Mass (Da):45,110
Last modified:December 1, 2001 - v1
Checksum:iA16FDF2DD023ED95
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF314533 mRNA. Translation: AAL14887.1.
DQ195087 mRNA. Translation: ABA40744.1.
RefSeqiNP_001003075.1. NM_001003075.1.
UniGeneiCfa.40284.

Genome annotation databases

EnsembliENSCAFT00000028961; ENSCAFP00000026935; ENSCAFG00000018230.
GeneIDi403622.
KEGGicfa:403622.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF314533 mRNA. Translation: AAL14887.1.
DQ195087 mRNA. Translation: ABA40744.1.
RefSeqiNP_001003075.1. NM_001003075.1.
UniGeneiCfa.40284.

3D structure databases

ProteinModelPortaliQ95LF0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000026935.

Proteomic databases

PaxDbiQ95LF0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000028961; ENSCAFP00000026935; ENSCAFG00000018230.
GeneIDi403622.
KEGGicfa:403622.

Organism-specific databases

CTDi3598.

Phylogenomic databases

eggNOGiENOG410IUDW. Eukaryota.
ENOG4111JMU. LUCA.
GeneTreeiENSGT00530000063295.
HOGENOMiHOG000004823.
HOVERGENiHBG058972.
InParanoidiQ95LF0.
KOiK05077.
OMAiLFYWYEG.
OrthoDBiEOG71P2B1.
TreeFamiTF331549.

Miscellaneous databases

NextBioi20817127.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR003532. Short_hematopoietin_rcpt_2_CS.
IPR015321. TypeI_recpt_CBD.
[Graphical view]
PfamiPF09240. IL6Ra-bind. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 3 hits.
PS01356. HEMATOPO_REC_S_F2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of canine IL-13 receptor alpha chain (alpha1 and alpha2) cDNAs and detection of corresponding mRNAs in canine tissues."
    Tang L.
    Vet. Immunol. Immunopathol. 79:181-195(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Immunopathogenic pathways in canine inflammatory myopathies resemble human myositis."
    Shelton G.D., Hoffman E.P., Ghimbovschi S., Peters I.R., Day M.J., Mullins M., Moore P.F., Nagaraju K.
    Vet. Immunol. Immunopathol. 113:200-214(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiI13R2_CANLF
AccessioniPrimary (citable) accession number: Q95LF0
Secondary accession number(s): Q3HTU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 1, 2001
Last modified: March 16, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.