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Protein

Beta-2-glycoprotein 1

Gene

APOH

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-2-glycoprotein 1
Alternative name(s):
Apolipoprotein H
Short name:
Apo-H
Beta-2-glycoprotein I
Short name:
B2GPI
Short name:
Beta(2)GPI
Gene namesi
Name:APOH
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000000206120 – 345Beta-2-glycoprotein 1Add BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi23 ↔ 66PROSITE-ProRule annotation
Glycosylationi33O-linked (GalNAc...) threonineBy similarity1
Disulfide bondi51 ↔ 79PROSITE-ProRule annotation
Disulfide bondi84 ↔ 124PROSITE-ProRule annotation
Disulfide bondi110 ↔ 137PROSITE-ProRule annotation
Disulfide bondi142 ↔ 188PROSITE-ProRule annotation
Glycosylationi149O-linked (GalNAc...) threonineBy similarity1
Glycosylationi162N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi174 ↔ 200PROSITE-ProRule annotation
Glycosylationi183N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi193N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi205 ↔ 248PROSITE-ProRule annotation
Disulfide bondi234 ↔ 260PROSITE-ProRule annotation
Glycosylationi253N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi264 ↔ 315PROSITE-ProRule annotation
Disulfide bondi300 ↔ 325PROSITE-ProRule annotation
Disulfide bondi307 ↔ 345PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ95LB0.

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.

Gene expression databases

BgeeiENSPTRG00000009556.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000016233.

Structurei

3D structure databases

ProteinModelPortaliQ95LB0.
SMRiQ95LB0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 81Sushi 1PROSITE-ProRule annotationAdd BLAST61
Domaini82 – 139Sushi 2PROSITE-ProRule annotationAdd BLAST58
Domaini140 – 202Sushi 3PROSITE-ProRule annotationAdd BLAST63
Domaini203 – 262Sushi 4PROSITE-ProRule annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni263 – 345Sushi-likeAdd BLAST83

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00870000136398.
HOGENOMiHOG000034008.
HOVERGENiHBG004271.
InParanoidiQ95LB0.
KOiK17305.
OMAiKNKEKKC.
OrthoDBiEOG091G0AFE.
TreeFamiTF334137.

Family and domain databases

CDDicd00033. CCP. 4 hits.
InterProiView protein in InterPro
IPR015104. Sushi_2.
IPR000436. Sushi_SCR_CCP_dom.
PfamiView protein in Pfam
PF00084. Sushi. 4 hits.
PF09014. Sushi_2. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD012422. Sushi_2. 1 hit.
SMARTiView protein in SMART
SM00032. CCP. 4 hits.
SUPFAMiSSF57535. SSF57535. 5 hits.
PROSITEiView protein in PROSITE
PS50923. SUSHI. 4 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q95LB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISPVLILFS SFLCHVAIAG RTCPKPDDLP FSTVVPLKTF YEPGEEITYS
60 70 80 90 100
CKPGYVSRGG MRKFICPLTG LWPINTLKCT PRVCPFAGIL ENGAVRYTTF
110 120 130 140 150
EYPNTISFSC NTGFYLNGAD SAKCTEEGKW SPELPVCAPI TCPPPSIPTF
160 170 180 190 200
ATLHVYKPSA GNNSLYRDTA VFECLPQHAM FGNDTITCTT HGNWTKLPEC
210 220 230 240 250
REVKCPFPSR PDNGFVNYPA KPTLYYKDKA TFGCHDGYSL DGPEEIECTK
260 270 280 290 300
LGNWSAMPSC KASCKVPVKK ATVVYQGERV KIQEKFKNGM LHGDKVSFFC
310 320 330 340
KNKEKKCSYT EDAQCIDGTI EVPKCFKEHS SLAFWKTDAS DVKPC
Length:345
Mass (Da):38,267
Last modified:December 1, 2001 - v1
Checksum:i712A3EDA2AD4FD36
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_018697229K → E in allele APOH*4. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF358415
, AF358408, AF358409, AF358410, AF358411, AF358412, AF358413, AF358414 Genomic DNA. Translation: AAK71538.1.
RefSeqiNP_001009118.1. NM_001009118.3.

Genome annotation databases

EnsembliENSPTRT00000017524; ENSPTRP00000016233; ENSPTRG00000009556.
GeneIDi468459.
KEGGiptr:468459.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAPOH_PANTR
AccessioniPrimary (citable) accession number: Q95LB0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: December 1, 2001
Last modified: September 27, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome