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Protein

Beta-2-glycoprotein 1

Gene

APOH

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-2-glycoprotein 1
Alternative name(s):
Apolipoprotein H
Short name:
Apo-H
Beta-2-glycoprotein I
Short name:
B2GPI
Short name:
Beta(2)GPI
Gene namesi
Name:APOH
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 17

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919By similarityAdd
BLAST
Chaini20 – 345326Beta-2-glycoprotein 1PRO_0000002061Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi23 ↔ 66PROSITE-ProRule annotation
Glycosylationi33 – 331O-linked (GalNAc...)By similarity
Disulfide bondi51 ↔ 79PROSITE-ProRule annotation
Disulfide bondi84 ↔ 124PROSITE-ProRule annotation
Disulfide bondi110 ↔ 137PROSITE-ProRule annotation
Disulfide bondi142 ↔ 188PROSITE-ProRule annotation
Glycosylationi149 – 1491O-linked (GalNAc...)By similarity
Glycosylationi162 – 1621N-linked (GlcNAc...)Sequence analysis
Disulfide bondi174 ↔ 200PROSITE-ProRule annotation
Glycosylationi183 – 1831N-linked (GlcNAc...)Sequence analysis
Glycosylationi193 – 1931N-linked (GlcNAc...)Sequence analysis
Disulfide bondi205 ↔ 248PROSITE-ProRule annotation
Disulfide bondi234 ↔ 260PROSITE-ProRule annotation
Glycosylationi253 – 2531N-linked (GlcNAc...)Sequence analysis
Disulfide bondi264 ↔ 315PROSITE-ProRule annotation
Disulfide bondi300 ↔ 325PROSITE-ProRule annotation
Disulfide bondi307 ↔ 345PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ95LB0.

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.

Interactioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000016233.

Structurei

3D structure databases

ProteinModelPortaliQ95LB0.
SMRiQ95LB0. Positions 20-345.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 8161Sushi 1PROSITE-ProRule annotationAdd
BLAST
Domaini82 – 13958Sushi 2PROSITE-ProRule annotationAdd
BLAST
Domaini140 – 20263Sushi 3PROSITE-ProRule annotationAdd
BLAST
Domaini203 – 26260Sushi 4PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni263 – 34583Sushi-likeAdd
BLAST

Sequence similaritiesi

Contains 4 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00840000129714.
HOGENOMiHOG000034008.
HOVERGENiHBG004271.
InParanoidiQ95LB0.
KOiK17305.
OMAiRFTCPLT.
OrthoDBiEOG7K6PV8.
TreeFamiTF334137.

Family and domain databases

InterProiIPR015104. Sushi_2.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 4 hits.
PF09014. Sushi_2. 1 hit.
[Graphical view]
ProDomiPD012422. Sushi_2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00032. CCP. 4 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 5 hits.
PROSITEiPS50923. SUSHI. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q95LB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISPVLILFS SFLCHVAIAG RTCPKPDDLP FSTVVPLKTF YEPGEEITYS
60 70 80 90 100
CKPGYVSRGG MRKFICPLTG LWPINTLKCT PRVCPFAGIL ENGAVRYTTF
110 120 130 140 150
EYPNTISFSC NTGFYLNGAD SAKCTEEGKW SPELPVCAPI TCPPPSIPTF
160 170 180 190 200
ATLHVYKPSA GNNSLYRDTA VFECLPQHAM FGNDTITCTT HGNWTKLPEC
210 220 230 240 250
REVKCPFPSR PDNGFVNYPA KPTLYYKDKA TFGCHDGYSL DGPEEIECTK
260 270 280 290 300
LGNWSAMPSC KASCKVPVKK ATVVYQGERV KIQEKFKNGM LHGDKVSFFC
310 320 330 340
KNKEKKCSYT EDAQCIDGTI EVPKCFKEHS SLAFWKTDAS DVKPC
Length:345
Mass (Da):38,267
Last modified:December 1, 2001 - v1
Checksum:i712A3EDA2AD4FD36
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti229 – 2291K → E in allele APOH*4. 1 Publication
VAR_018697

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF358415
, AF358408, AF358409, AF358410, AF358411, AF358412, AF358413, AF358414 Genomic DNA. Translation: AAK71538.1.
RefSeqiNP_001009118.1. NM_001009118.3.

Genome annotation databases

EnsembliENSPTRT00000017524; ENSPTRP00000016233; ENSPTRG00000009556.
GeneIDi468459.
KEGGiptr:468459.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF358415
, AF358408, AF358409, AF358410, AF358411, AF358412, AF358413, AF358414 Genomic DNA. Translation: AAK71538.1.
RefSeqiNP_001009118.1. NM_001009118.3.

3D structure databases

ProteinModelPortaliQ95LB0.
SMRiQ95LB0. Positions 20-345.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000016233.

Proteomic databases

PaxDbiQ95LB0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000017524; ENSPTRP00000016233; ENSPTRG00000009556.
GeneIDi468459.
KEGGiptr:468459.

Organism-specific databases

CTDi350.

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00840000129714.
HOGENOMiHOG000034008.
HOVERGENiHBG004271.
InParanoidiQ95LB0.
KOiK17305.
OMAiRFTCPLT.
OrthoDBiEOG7K6PV8.
TreeFamiTF334137.

Family and domain databases

InterProiIPR015104. Sushi_2.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 4 hits.
PF09014. Sushi_2. 1 hit.
[Graphical view]
ProDomiPD012422. Sushi_2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00032. CCP. 4 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 5 hits.
PROSITEiPS50923. SUSHI. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Chimpanzee apolipoprotein H (beta2-glycoprotein I): report on the gene structure, a common polymorphism, and a high prevalence of antiphospholipid antibodies."
    Sanghera D.K., Nestlerode C.S., Ferrell R.E., Kamboh M.I.
    Hum. Genet. 109:63-72(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLU-229.

Entry informationi

Entry nameiAPOH_PANTR
AccessioniPrimary (citable) accession number: Q95LB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.