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Q95LA9

- TLR2_BOVIN

UniProt

Q95LA9 - TLR2_BOVIN

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Protein

Toll-like receptor 2

Gene

TLR2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei349 – 3491Interaction with bacterial lipopeptideBy similarity

GO - Molecular functioni

  1. transmembrane signaling receptor activity Source: InterPro

GO - Biological processi

  1. inflammatory response Source: UniProtKB-KW
  2. innate immune response Source: UniProtKB-KW
  3. MyD88-dependent toll-like receptor signaling pathway Source: InterPro
  4. positive regulation of inflammatory response Source: InterPro
  5. regulation of cytokine secretion Source: InterPro
  6. response to molecule of bacterial origin Source: InterPro
  7. toll-like receptor 2 signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptor 2
Alternative name(s):
CD_antigen: CD282
Gene namesi
Name:TLR2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Membrane By similarity; Single-pass type I membrane protein By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 784764Toll-like receptor 2PRO_0000034707Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 36By similarity
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi353 ↔ 382By similarity
Disulfide bondi432 ↔ 454By similarity
Glycosylationi442 – 4421N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ95LA9.

Interactioni

Subunit structurei

Interacts with LY96, TLR1 and TLR6 (via extracellular domain). Binds MYD88 (via TIR domain). Interacts with TICAM1. Ligand binding induces the formation of a heterodimer with TLR1 or TLR6. Interacts with CNPY3. Interacts with ATG16L1 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ95LA9.
SMRiQ95LA9. Positions 27-543, 639-784.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 587567ExtracellularSequence AnalysisAdd
BLAST
Topological domaini609 – 784176CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei588 – 60821HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati54 – 7724LRR 1Add
BLAST
Repeati78 – 10124LRR 2Add
BLAST
Repeati102 – 12524LRR 3Add
BLAST
Repeati126 – 15025LRR 4Add
BLAST
Repeati151 – 17525LRR 5Add
BLAST
Repeati176 – 19924LRR 6Add
BLAST
Repeati200 – 22324LRR 7Add
BLAST
Repeati224 – 25027LRR 8Add
BLAST
Repeati251 – 27828LRR 9Add
BLAST
Repeati279 – 30830LRR 10Add
BLAST
Repeati309 – 33729LRR 11Add
BLAST
Repeati338 – 36124LRR 12Add
BLAST
Repeati362 – 38827LRR 13Add
BLAST
Repeati389 – 41426LRR 14Add
BLAST
Repeati415 – 43723LRR 15Add
BLAST
Repeati438 – 45720LRR 16Add
BLAST
Repeati458 – 47821LRR 17Add
BLAST
Repeati479 – 50022LRR 18Add
BLAST
Repeati501 – 52424LRR 19Add
BLAST
Domaini525 – 57955LRRCTAdd
BLAST
Domaini639 – 784146TIRPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi761 – 77818ATG16L1-binding motifAdd
BLAST

Domaini

Ester-bound lipid substrates are bound through a crevice formed between the LRR 11 and LRR 12.By similarity
The ATG16L1-binding motif mediates interaction with ATG16L1.By similarity

Sequence similaritiesi

Belongs to the Toll-like receptor family.Curated
Contains 19 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG251801.
HOGENOMiHOG000110611.
HOVERGENiHBG108574.
InParanoidiQ95LA9.
KOiK10159.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027185. TLR2.
IPR017241. Toll-like_receptor.
[Graphical view]
PANTHERiPTHR24365:SF17. PTHR24365:SF17. 1 hit.
PfamiPF13855. LRR_8. 2 hits.
PF01582. TIR. 1 hit.
[Graphical view]
PIRSFiPIRSF037595. Toll-like_receptor. 1 hit.
SMARTiSM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 11 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q95LA9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPRALWTAWV WAVIILSTEG ASDQASSLSC DPTGVCDGHS RSLNSIPSGL
60 70 80 90 100
TAGVKSLDLS NNDITYVGNR DLQRCVNLKT LRLGANEIHT VEEDSFFHLR
110 120 130 140 150
NLEYLDLSYN RLSNLSSSWF RSLYVLKFLN LLGNLYKTLG ETSLFSHLPN
160 170 180 190 200
LRTLKVGNSN SFTEIHEKDF TGLTFLEELE ISAQNLQIYV PKSLKSIQNI
210 220 230 240 250
SHLILHLKQP ILLVDILVDI VSSLDCFELR DTNLHTFHFS EASISEMSTS
260 270 280 290 300
VKKLIFRNVQ FTDESFVEVV KLFNYVSGIL EVEFDDCTHD GIGDFRALSL
310 320 330 340 350
DRIRHLGNVE TLTIRKLHIP QFFLFHDLSS IYPLTGRVKR VTIENSKVFL
360 370 380 390 400
VPCLLSQHLK SLEYLDLSEN LMSEETLKNS ACKDAWPFLQ TLVLRQNRLK
410 420 430 440 450
SLEKTGELLL TLENLNNLDI SKNNFLSMPE TCQWPGKMKQ LNLSSTRIHS
460 470 480 490 500
LTQCLPQTLE ILDVSNNNLD SFSLILPQLK ELYISRNKLK TLPDASFLPV
510 520 530 540 550
LSVMRISRNI INTFSKEQLD SFQQLKTLEA GGNNFICSCD FLSFTQGQQA
560 570 580 590 600
LGRVLVDWPD DYRCDSPSHV RGQRVQDARL SLSECHRAAV VSAACCALFL
610 620 630 640 650
LLLLTGVLCH RFHGLWYMKM MWAWLQAKRK PRKAPRRDIC YDAFVSYSER
660 670 680 690 700
DSYWVENLMV QELEHFNPPF KLCLHKRDFI PGKWIIDNII DSIEKSHKTI
710 720 730 740 750
FVLSENFVKS EWCKYELDFS HFRLFDENND AAILILLEPI DKKAIPQRFC
760 770 780
KLRKIMNTKT YLEWPVDETQ QEGFWLNLRA AIRS
Length:784
Mass (Da):90,205
Last modified:December 1, 2001 - v1
Checksum:i59FDB9DFA7984C18
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti290 – 2901D → E.1 Publication
Natural varianti783 – 7831R → K.1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF368419 mRNA. Translation: AAL16722.1.
AF310951 mRNA. Translation: AAG32060.1.
AY634629 mRNA. Translation: AAT48487.1.
EU746459 Genomic DNA. Translation: ACH92788.1.
EU746460 Genomic DNA. Translation: ACH92789.1.
EU746464 Genomic DNA. Translation: ACH92793.1.
EU746465 Genomic DNA. Translation: ACH92794.1.
RefSeqiNP_776622.1. NM_174197.2.
UniGeneiBt.8945.

Genome annotation databases

GeneIDi281534.
KEGGibta:281534.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF368419 mRNA. Translation: AAL16722.1 .
AF310951 mRNA. Translation: AAG32060.1 .
AY634629 mRNA. Translation: AAT48487.1 .
EU746459 Genomic DNA. Translation: ACH92788.1 .
EU746460 Genomic DNA. Translation: ACH92789.1 .
EU746464 Genomic DNA. Translation: ACH92793.1 .
EU746465 Genomic DNA. Translation: ACH92794.1 .
RefSeqi NP_776622.1. NM_174197.2.
UniGenei Bt.8945.

3D structure databases

ProteinModelPortali Q95LA9.
SMRi Q95LA9. Positions 27-543, 639-784.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q95LA9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 281534.
KEGGi bta:281534.

Organism-specific databases

CTDi 7097.

Phylogenomic databases

eggNOGi NOG251801.
HOGENOMi HOG000110611.
HOVERGENi HBG108574.
InParanoidi Q95LA9.
KOi K10159.

Miscellaneous databases

NextBioi 20805489.

Family and domain databases

Gene3Di 3.40.50.10140. 1 hit.
InterProi IPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027185. TLR2.
IPR017241. Toll-like_receptor.
[Graphical view ]
PANTHERi PTHR24365:SF17. PTHR24365:SF17. 1 hit.
Pfami PF13855. LRR_8. 2 hits.
PF01582. TIR. 1 hit.
[Graphical view ]
PIRSFi PIRSF037595. Toll-like_receptor. 1 hit.
SMARTi SM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view ]
SUPFAMi SSF52200. SSF52200. 1 hit.
PROSITEi PS51450. LRR. 11 hits.
PS50104. TIR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Role of bovine TLR2, TLR4 and CD14 in the recognition of bacterial constituents."
    Guionaud C.T., Dubey C., Zumkehr J.R., Sonstegard T.S., Jungi T.W.
    Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Role of bovine TLRs in antigen presentation."
    Werling D., McGuire K., Glass E.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Analysis of sequence variability and protein domain architectures for bovine peptidoglycan recognition protein 1 and Toll-like receptors 2 and 6."
    Seabury C.M., Womack J.E.
    Genomics 92:235-245(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLU-290 AND LYS-783.
    Strain: Isolate 44, Isolate 74, Isolate 80 and Isolate JEW38.

Entry informationi

Entry nameiTLR2_BOVIN
AccessioniPrimary (citable) accession number: Q95LA9
Secondary accession number(s): B5T265
, B5T266, B5T271, Q6GV20, Q9GL66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: December 1, 2001
Last modified: October 1, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3