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Q95LA9

- TLR2_BOVIN

UniProt

Q95LA9 - TLR2_BOVIN

Protein

Toll-like receptor 2

Gene

TLR2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei349 – 3491Interaction with bacterial lipopeptideBy similarity

    GO - Molecular functioni

    1. transmembrane signaling receptor activity Source: InterPro

    GO - Biological processi

    1. inflammatory response Source: UniProtKB-KW
    2. innate immune response Source: UniProtKB-KW
    3. MyD88-dependent toll-like receptor signaling pathway Source: InterPro
    4. positive regulation of inflammatory response Source: InterPro
    5. regulation of cytokine secretion Source: InterPro
    6. response to molecule of bacterial origin Source: InterPro
    7. toll-like receptor 2 signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Immunity, Inflammatory response, Innate immunity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Toll-like receptor 2
    Alternative name(s):
    CD_antigen: CD282
    Gene namesi
    Name:TLR2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Membrane By similarity; Single-pass type I membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 784764Toll-like receptor 2PRO_0000034707Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi30 ↔ 36By similarity
    Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi353 ↔ 382By similarity
    Disulfide bondi432 ↔ 454By similarity
    Glycosylationi442 – 4421N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ95LA9.

    Interactioni

    Subunit structurei

    Interacts with LY96, TLR1 and TLR6 (via extracellular domain). Binds MYD88 (via TIR domain). Interacts with TICAM1. Ligand binding induces the formation of a heterodimer with TLR1 or TLR6. Interacts with CNPY3. Interacts with ATG16L1 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ95LA9.
    SMRiQ95LA9. Positions 27-543, 639-784.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 587567ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini609 – 784176CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei588 – 60821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati54 – 7724LRR 1Add
    BLAST
    Repeati78 – 10124LRR 2Add
    BLAST
    Repeati102 – 12524LRR 3Add
    BLAST
    Repeati126 – 15025LRR 4Add
    BLAST
    Repeati151 – 17525LRR 5Add
    BLAST
    Repeati176 – 19924LRR 6Add
    BLAST
    Repeati200 – 22324LRR 7Add
    BLAST
    Repeati224 – 25027LRR 8Add
    BLAST
    Repeati251 – 27828LRR 9Add
    BLAST
    Repeati279 – 30830LRR 10Add
    BLAST
    Repeati309 – 33729LRR 11Add
    BLAST
    Repeati338 – 36124LRR 12Add
    BLAST
    Repeati362 – 38827LRR 13Add
    BLAST
    Repeati389 – 41426LRR 14Add
    BLAST
    Repeati415 – 43723LRR 15Add
    BLAST
    Repeati438 – 45720LRR 16Add
    BLAST
    Repeati458 – 47821LRR 17Add
    BLAST
    Repeati479 – 50022LRR 18Add
    BLAST
    Repeati501 – 52424LRR 19Add
    BLAST
    Domaini525 – 57955LRRCTAdd
    BLAST
    Domaini639 – 784146TIRPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi761 – 77818ATG16L1-binding motifAdd
    BLAST

    Domaini

    Ester-bound lipid substrates are bound through a crevice formed between the LRR 11 and LRR 12.By similarity
    The ATG16L1-binding motif mediates interaction with ATG16L1.By similarity

    Sequence similaritiesi

    Belongs to the Toll-like receptor family.Curated
    Contains 19 LRR (leucine-rich) repeats.Curated
    Contains 1 LRRCT domain.Curated
    Contains 1 TIR domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG251801.
    HOGENOMiHOG000110611.
    HOVERGENiHBG108574.
    InParanoidiQ95LA9.
    KOiK10159.

    Family and domain databases

    Gene3Di3.40.50.10140. 1 hit.
    InterProiIPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000157. TIR_dom.
    IPR027185. TLR2.
    IPR017241. Toll-like_receptor.
    [Graphical view]
    PANTHERiPTHR24365:SF17. PTHR24365:SF17. 1 hit.
    PfamiPF13855. LRR_8. 2 hits.
    PF01582. TIR. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037595. Toll-like_receptor. 1 hit.
    SMARTiSM00369. LRR_TYP. 2 hits.
    SM00082. LRRCT. 1 hit.
    SM00255. TIR. 1 hit.
    [Graphical view]
    SUPFAMiSSF52200. SSF52200. 1 hit.
    PROSITEiPS51450. LRR. 11 hits.
    PS50104. TIR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q95LA9-1 [UniParc]FASTAAdd to Basket

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    MPRALWTAWV WAVIILSTEG ASDQASSLSC DPTGVCDGHS RSLNSIPSGL    50
    TAGVKSLDLS NNDITYVGNR DLQRCVNLKT LRLGANEIHT VEEDSFFHLR 100
    NLEYLDLSYN RLSNLSSSWF RSLYVLKFLN LLGNLYKTLG ETSLFSHLPN 150
    LRTLKVGNSN SFTEIHEKDF TGLTFLEELE ISAQNLQIYV PKSLKSIQNI 200
    SHLILHLKQP ILLVDILVDI VSSLDCFELR DTNLHTFHFS EASISEMSTS 250
    VKKLIFRNVQ FTDESFVEVV KLFNYVSGIL EVEFDDCTHD GIGDFRALSL 300
    DRIRHLGNVE TLTIRKLHIP QFFLFHDLSS IYPLTGRVKR VTIENSKVFL 350
    VPCLLSQHLK SLEYLDLSEN LMSEETLKNS ACKDAWPFLQ TLVLRQNRLK 400
    SLEKTGELLL TLENLNNLDI SKNNFLSMPE TCQWPGKMKQ LNLSSTRIHS 450
    LTQCLPQTLE ILDVSNNNLD SFSLILPQLK ELYISRNKLK TLPDASFLPV 500
    LSVMRISRNI INTFSKEQLD SFQQLKTLEA GGNNFICSCD FLSFTQGQQA 550
    LGRVLVDWPD DYRCDSPSHV RGQRVQDARL SLSECHRAAV VSAACCALFL 600
    LLLLTGVLCH RFHGLWYMKM MWAWLQAKRK PRKAPRRDIC YDAFVSYSER 650
    DSYWVENLMV QELEHFNPPF KLCLHKRDFI PGKWIIDNII DSIEKSHKTI 700
    FVLSENFVKS EWCKYELDFS HFRLFDENND AAILILLEPI DKKAIPQRFC 750
    KLRKIMNTKT YLEWPVDETQ QEGFWLNLRA AIRS 784
    Length:784
    Mass (Da):90,205
    Last modified:December 1, 2001 - v1
    Checksum:i59FDB9DFA7984C18
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti290 – 2901D → E.1 Publication
    Natural varianti783 – 7831R → K.1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF368419 mRNA. Translation: AAL16722.1.
    AF310951 mRNA. Translation: AAG32060.1.
    AY634629 mRNA. Translation: AAT48487.1.
    EU746459 Genomic DNA. Translation: ACH92788.1.
    EU746460 Genomic DNA. Translation: ACH92789.1.
    EU746464 Genomic DNA. Translation: ACH92793.1.
    EU746465 Genomic DNA. Translation: ACH92794.1.
    RefSeqiNP_776622.1. NM_174197.2.
    UniGeneiBt.8945.

    Genome annotation databases

    GeneIDi281534.
    KEGGibta:281534.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF368419 mRNA. Translation: AAL16722.1 .
    AF310951 mRNA. Translation: AAG32060.1 .
    AY634629 mRNA. Translation: AAT48487.1 .
    EU746459 Genomic DNA. Translation: ACH92788.1 .
    EU746460 Genomic DNA. Translation: ACH92789.1 .
    EU746464 Genomic DNA. Translation: ACH92793.1 .
    EU746465 Genomic DNA. Translation: ACH92794.1 .
    RefSeqi NP_776622.1. NM_174197.2.
    UniGenei Bt.8945.

    3D structure databases

    ProteinModelPortali Q95LA9.
    SMRi Q95LA9. Positions 27-543, 639-784.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q95LA9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 281534.
    KEGGi bta:281534.

    Organism-specific databases

    CTDi 7097.

    Phylogenomic databases

    eggNOGi NOG251801.
    HOGENOMi HOG000110611.
    HOVERGENi HBG108574.
    InParanoidi Q95LA9.
    KOi K10159.

    Miscellaneous databases

    NextBioi 20805489.

    Family and domain databases

    Gene3Di 3.40.50.10140. 1 hit.
    InterProi IPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000157. TIR_dom.
    IPR027185. TLR2.
    IPR017241. Toll-like_receptor.
    [Graphical view ]
    PANTHERi PTHR24365:SF17. PTHR24365:SF17. 1 hit.
    Pfami PF13855. LRR_8. 2 hits.
    PF01582. TIR. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037595. Toll-like_receptor. 1 hit.
    SMARTi SM00369. LRR_TYP. 2 hits.
    SM00082. LRRCT. 1 hit.
    SM00255. TIR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52200. SSF52200. 1 hit.
    PROSITEi PS51450. LRR. 11 hits.
    PS50104. TIR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Role of bovine TLR2, TLR4 and CD14 in the recognition of bacterial constituents."
      Guionaud C.T., Dubey C., Zumkehr J.R., Sonstegard T.S., Jungi T.W.
      Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Role of bovine TLRs in antigen presentation."
      Werling D., McGuire K., Glass E.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Analysis of sequence variability and protein domain architectures for bovine peptidoglycan recognition protein 1 and Toll-like receptors 2 and 6."
      Seabury C.M., Womack J.E.
      Genomics 92:235-245(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLU-290 AND LYS-783.
      Strain: Isolate 44, Isolate 74, Isolate 80 and Isolate JEW38.

    Entry informationi

    Entry nameiTLR2_BOVIN
    AccessioniPrimary (citable) accession number: Q95LA9
    Secondary accession number(s): B5T265
    , B5T266, B5T271, Q6GV20, Q9GL66
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 31, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3