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Q95L97

- S20A2_FELCA

UniProt

Q95L97 - S20A2_FELCA

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Protein
Sodium-dependent phosphate transporter 2
Gene
SLC20A2, PIT2
Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage calcification and vascular calcification By similarity. Functions as a retroviral receptor for feline leukemia virus subgroup B (FeLV-B).1 Publication

GO - Molecular functioni

  1. inorganic phosphate transmembrane transporter activity Source: InterPro
  2. symporter activity Source: UniProtKB-KW
  3. virus receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. phosphate ion transport Source: UniProtKB-KW
  2. sodium ion transport Source: UniProtKB-KW
  3. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Host cell receptor for virus entry, Receptor

Keywords - Biological processi

Host-virus interaction, Ion transport, Phosphate transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent phosphate transporter 2
Alternative name(s):
Phosphate transporter 2
Short name:
FePit2
Short name:
PiT-2
Solute carrier family 20 member 2
Gene namesi
Name:SLC20A2
Synonyms:PIT2
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
ProteomesiUP000011712: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 55Extracellular Reviewed prediction
Transmembranei6 – 2621Helical; Reviewed prediction
Add
BLAST
Topological domaini27 – 4620Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei47 – 6721Helical; Reviewed prediction
Add
BLAST
Topological domaini68 – 8619Extracellular Reviewed prediction
Add
BLAST
Transmembranei87 – 10721Helical; Reviewed prediction
Add
BLAST
Topological domaini108 – 1092Cytoplasmic Reviewed prediction
Transmembranei110 – 13021Helical; Reviewed prediction
Add
BLAST
Topological domaini131 – 14212Extracellular Reviewed prediction
Add
BLAST
Transmembranei143 – 16321Helical; Reviewed prediction
Add
BLAST
Topological domaini164 – 19027Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei191 – 21121Helical; Reviewed prediction
Add
BLAST
Topological domaini212 – 2132Extracellular Reviewed prediction
Transmembranei214 – 23421Helical; Reviewed prediction
Add
BLAST
Topological domaini235 – 483249Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei484 – 50421Helical; Reviewed prediction
Add
BLAST
Topological domaini505 – 53127Extracellular Reviewed prediction
Add
BLAST
Transmembranei532 – 55221Helical; Reviewed prediction
Add
BLAST
Topological domaini553 – 57220Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei573 – 58715Helical; Reviewed prediction
Add
BLAST
Topological domaini588 – 5947Extracellular Reviewed prediction
Transmembranei595 – 61016Helical; Reviewed prediction
Add
BLAST
Topological domaini611 – 62212Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei623 – 64321Helical; Reviewed prediction
Add
BLAST
Topological domaini644 – 65310Extracellular Reviewed prediction

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 653653Sodium-dependent phosphate transporter 2
PRO_0000341267Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi81 – 811N-linked (GlcNAc...) Reviewed prediction
Modified residuei268 – 2681Phosphoserine By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000009354.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0306.
HOGENOMiHOG000231892.
HOVERGENiHBG053358.
KOiK14640.
OrthoDBiEOG79KPDT.
TreeFamiTF314426.

Family and domain databases

InterProiIPR001204. Phos_transporter.
[Graphical view]
PANTHERiPTHR11101. PTHR11101. 1 hit.
PfamiPF01384. PHO4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q95L97-1 [UniParc]FASTAAdd to Basket

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MAIDGYLWMV ILGFIIAFIL AFSVGANDVA NSFGTAVGSG VVTLRQACIL    50
ASIFETTGSV LLGAKVGETI RKGIIDVNLY NETVETLMAG EVSAMVGSAV 100
WQLIASFLRL PISGTHCIVG STIGFSLVAI GTQGVQWMEL VKIVASWFIS 150
PLLSGFMSGV LFILIRIFIL KKEDPVPNGL RALPVFYAAT IAINVFSIMY 200
TGAPVLGLVL PIWAIALISF GVALLFALFV WLFVCPWMRR KIAGKLQKEA 250
ALSRVSDESL SKIQEVESPV FKELPGAKAN DDSTVPLTGS AGEPSGTSEG 300
TSVGNHPRAS YGRALSMTHG SAKSPVSNGT FGFDGHTRSD GHVYHTVHKD 350
SGLYKDLLHR IHSDRGPEER PAQENNYRFL RRNNSYTCYT AAICGMPVHS 400
TFKAADSSSA PEDSEKLVGD AVSYSKKRLR YDSYSSYCNA VAEAEIEADE 450
GGVEMKLASE LTDPDQPRDD PAEEEKEEKD TAEVHLLFHF LQVLTACFGS 500
FAHGGNDVSN AIGPLVALWL IYEQGAVLQE AVTPVWLLFY GGVGICTGLW 550
VWGRRVIQTM GKDLTPITPS SGFTIELASA FTVVIASNVG LPVSTTHCKV 600
GSVVAVGWIR SRKAVDWRLF RNIFVAWFVT VPVAGLFSAA IMALLMYGIL 650
PYV 653
Length:653
Mass (Da):70,492
Last modified:December 1, 2001 - v1
Checksum:i386C5D68D3B6C006
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF394194 mRNA. Translation: AAK73822.1.
RefSeqiNP_001009839.1. NM_001009839.1.

Genome annotation databases

GeneIDi493788.
KEGGifca:493788.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF394194 mRNA. Translation: AAK73822.1 .
RefSeqi NP_001009839.1. NM_001009839.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9685.ENSFCAP00000009354.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 493788.
KEGGi fca:493788.

Organism-specific databases

CTDi 6575.

Phylogenomic databases

eggNOGi COG0306.
HOGENOMi HOG000231892.
HOVERGENi HBG053358.
KOi K14640.
OrthoDBi EOG79KPDT.
TreeFami TF314426.

Family and domain databases

InterProi IPR001204. Phos_transporter.
[Graphical view ]
PANTHERi PTHR11101. PTHR11101. 1 hit.
Pfami PF01384. PHO4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Feline Pit2 functions as a receptor for subgroup B feline leukemia viruses."
    Anderson M.M., Lauring A.S., Robertson S., Dirks C., Overbaugh J.
    J. Virol. 75:10563-10572(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION AS RETROVIRAL RECEPTOR.

Entry informationi

Entry nameiS20A2_FELCA
AccessioniPrimary (citable) accession number: Q95L97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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