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Q95L97 (S20A2_FELCA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Sodium-dependent phosphate transporter 2
Alternative name(s):
Phosphate transporter 2
Short name=FePit2
Short name=PiT-2
Solute carrier family 20 member 2
Gene names
Name:SLC20A2
Synonyms:PIT2
OrganismFelis catus (Cat) (Felis silvestris catus) [Reference proteome]
Taxonomic identifier9685 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis

Protein attributes

Sequence length653 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage calcification and vascular calcification By similarity. Functions as a retroviral receptor for feline leukemia virus subgroup B (FeLV-B). Ref.1

Subunit structure

Homodimer By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 653653Sodium-dependent phosphate transporter 2
PRO_0000341267

Regions

Topological domain1 – 55Extracellular Potential
Transmembrane6 – 2621Helical; Potential
Topological domain27 – 4620Cytoplasmic Potential
Transmembrane47 – 6721Helical; Potential
Topological domain68 – 8619Extracellular Potential
Transmembrane87 – 10721Helical; Potential
Topological domain108 – 1092Cytoplasmic Potential
Transmembrane110 – 13021Helical; Potential
Topological domain131 – 14212Extracellular Potential
Transmembrane143 – 16321Helical; Potential
Topological domain164 – 19027Cytoplasmic Potential
Transmembrane191 – 21121Helical; Potential
Topological domain212 – 2132Extracellular Potential
Transmembrane214 – 23421Helical; Potential
Topological domain235 – 483249Cytoplasmic Potential
Transmembrane484 – 50421Helical; Potential
Topological domain505 – 53127Extracellular Potential
Transmembrane532 – 55221Helical; Potential
Topological domain553 – 57220Cytoplasmic Potential
Transmembrane573 – 58715Helical; Potential
Topological domain588 – 5947Extracellular Potential
Transmembrane595 – 61016Helical; Potential
Topological domain611 – 62212Cytoplasmic Potential
Transmembrane623 – 64321Helical; Potential
Topological domain644 – 65310Extracellular Potential

Amino acid modifications

Modified residue2681Phosphoserine By similarity
Glycosylation811N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q95L97 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 386C5D68D3B6C006

FASTA65370,492
        10         20         30         40         50         60 
MAIDGYLWMV ILGFIIAFIL AFSVGANDVA NSFGTAVGSG VVTLRQACIL ASIFETTGSV 

        70         80         90        100        110        120 
LLGAKVGETI RKGIIDVNLY NETVETLMAG EVSAMVGSAV WQLIASFLRL PISGTHCIVG 

       130        140        150        160        170        180 
STIGFSLVAI GTQGVQWMEL VKIVASWFIS PLLSGFMSGV LFILIRIFIL KKEDPVPNGL 

       190        200        210        220        230        240 
RALPVFYAAT IAINVFSIMY TGAPVLGLVL PIWAIALISF GVALLFALFV WLFVCPWMRR 

       250        260        270        280        290        300 
KIAGKLQKEA ALSRVSDESL SKIQEVESPV FKELPGAKAN DDSTVPLTGS AGEPSGTSEG 

       310        320        330        340        350        360 
TSVGNHPRAS YGRALSMTHG SAKSPVSNGT FGFDGHTRSD GHVYHTVHKD SGLYKDLLHR 

       370        380        390        400        410        420 
IHSDRGPEER PAQENNYRFL RRNNSYTCYT AAICGMPVHS TFKAADSSSA PEDSEKLVGD 

       430        440        450        460        470        480 
AVSYSKKRLR YDSYSSYCNA VAEAEIEADE GGVEMKLASE LTDPDQPRDD PAEEEKEEKD 

       490        500        510        520        530        540 
TAEVHLLFHF LQVLTACFGS FAHGGNDVSN AIGPLVALWL IYEQGAVLQE AVTPVWLLFY 

       550        560        570        580        590        600 
GGVGICTGLW VWGRRVIQTM GKDLTPITPS SGFTIELASA FTVVIASNVG LPVSTTHCKV 

       610        620        630        640        650 
GSVVAVGWIR SRKAVDWRLF RNIFVAWFVT VPVAGLFSAA IMALLMYGIL PYV 

« Hide

References

[1]"Feline Pit2 functions as a receptor for subgroup B feline leukemia viruses."
Anderson M.M., Lauring A.S., Robertson S., Dirks C., Overbaugh J.
J. Virol. 75:10563-10572(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION AS RETROVIRAL RECEPTOR.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF394194 mRNA. Translation: AAK73822.1.
RefSeqNP_001009839.1. NM_001009839.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9685.ENSFCAP00000009354.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID493788.
KEGGfca:493788.

Organism-specific databases

CTD6575.

Phylogenomic databases

eggNOGCOG0306.
HOGENOMHOG000231892.
HOVERGENHBG053358.
KOK14640.
OrthoDBEOG79KPDT.
TreeFamTF314426.

Family and domain databases

InterProIPR001204. Phos_transporter.
[Graphical view]
PANTHERPTHR11101. PTHR11101. 1 hit.
PfamPF01384. PHO4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameS20A2_FELCA
AccessionPrimary (citable) accession number: Q95L97
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families