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Q95L97

- S20A2_FELCA

UniProt

Q95L97 - S20A2_FELCA

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Protein

Sodium-dependent phosphate transporter 2

Gene

SLC20A2

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage calcification and vascular calcification (By similarity). Functions as a retroviral receptor for feline leukemia virus subgroup B (FeLV-B).By similarity1 Publication

GO - Molecular functioni

  1. inorganic phosphate transmembrane transporter activity Source: InterPro
  2. symporter activity Source: UniProtKB-KW
  3. virus receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. phosphate ion transport Source: UniProtKB-KW
  2. sodium ion transport Source: UniProtKB-KW
  3. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Host cell receptor for virus entry, Receptor

Keywords - Biological processi

Host-virus interaction, Ion transport, Phosphate transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent phosphate transporter 2
Alternative name(s):
Phosphate transporter 2
Short name:
FePit2
Short name:
PiT-2
Solute carrier family 20 member 2
Gene namesi
Name:SLC20A2
Synonyms:PIT2
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
ProteomesiUP000011712: Unplaced

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 653653Sodium-dependent phosphate transporter 2PRO_0000341267Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi81 – 811N-linked (GlcNAc...)Sequence Analysis
Modified residuei268 – 2681PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000009354.

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 55ExtracellularSequence Analysis
Topological domaini27 – 4620CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini68 – 8619ExtracellularSequence AnalysisAdd
BLAST
Topological domaini108 – 1092CytoplasmicSequence Analysis
Topological domaini131 – 14212ExtracellularSequence AnalysisAdd
BLAST
Topological domaini164 – 19027CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini212 – 2132ExtracellularSequence Analysis
Topological domaini235 – 483249CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini505 – 53127ExtracellularSequence AnalysisAdd
BLAST
Topological domaini553 – 57220CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini588 – 5947ExtracellularSequence Analysis
Topological domaini611 – 62212CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini644 – 65310ExtracellularSequence Analysis

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621HelicalSequence AnalysisAdd
BLAST
Transmembranei47 – 6721HelicalSequence AnalysisAdd
BLAST
Transmembranei87 – 10721HelicalSequence AnalysisAdd
BLAST
Transmembranei110 – 13021HelicalSequence AnalysisAdd
BLAST
Transmembranei143 – 16321HelicalSequence AnalysisAdd
BLAST
Transmembranei191 – 21121HelicalSequence AnalysisAdd
BLAST
Transmembranei214 – 23421HelicalSequence AnalysisAdd
BLAST
Transmembranei484 – 50421HelicalSequence AnalysisAdd
BLAST
Transmembranei532 – 55221HelicalSequence AnalysisAdd
BLAST
Transmembranei573 – 58715HelicalSequence AnalysisAdd
BLAST
Transmembranei595 – 61016HelicalSequence AnalysisAdd
BLAST
Transmembranei623 – 64321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0306.
HOGENOMiHOG000231892.
HOVERGENiHBG053358.
InParanoidiQ95L97.
KOiK14640.
OrthoDBiEOG79KPDT.
TreeFamiTF314426.

Family and domain databases

InterProiIPR001204. Phos_transporter.
[Graphical view]
PANTHERiPTHR11101. PTHR11101. 1 hit.
PfamiPF01384. PHO4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q95L97-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAIDGYLWMV ILGFIIAFIL AFSVGANDVA NSFGTAVGSG VVTLRQACIL
60 70 80 90 100
ASIFETTGSV LLGAKVGETI RKGIIDVNLY NETVETLMAG EVSAMVGSAV
110 120 130 140 150
WQLIASFLRL PISGTHCIVG STIGFSLVAI GTQGVQWMEL VKIVASWFIS
160 170 180 190 200
PLLSGFMSGV LFILIRIFIL KKEDPVPNGL RALPVFYAAT IAINVFSIMY
210 220 230 240 250
TGAPVLGLVL PIWAIALISF GVALLFALFV WLFVCPWMRR KIAGKLQKEA
260 270 280 290 300
ALSRVSDESL SKIQEVESPV FKELPGAKAN DDSTVPLTGS AGEPSGTSEG
310 320 330 340 350
TSVGNHPRAS YGRALSMTHG SAKSPVSNGT FGFDGHTRSD GHVYHTVHKD
360 370 380 390 400
SGLYKDLLHR IHSDRGPEER PAQENNYRFL RRNNSYTCYT AAICGMPVHS
410 420 430 440 450
TFKAADSSSA PEDSEKLVGD AVSYSKKRLR YDSYSSYCNA VAEAEIEADE
460 470 480 490 500
GGVEMKLASE LTDPDQPRDD PAEEEKEEKD TAEVHLLFHF LQVLTACFGS
510 520 530 540 550
FAHGGNDVSN AIGPLVALWL IYEQGAVLQE AVTPVWLLFY GGVGICTGLW
560 570 580 590 600
VWGRRVIQTM GKDLTPITPS SGFTIELASA FTVVIASNVG LPVSTTHCKV
610 620 630 640 650
GSVVAVGWIR SRKAVDWRLF RNIFVAWFVT VPVAGLFSAA IMALLMYGIL

PYV
Length:653
Mass (Da):70,492
Last modified:December 1, 2001 - v1
Checksum:i386C5D68D3B6C006
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF394194 mRNA. Translation: AAK73822.1.
RefSeqiNP_001009839.1. NM_001009839.1.

Genome annotation databases

GeneIDi493788.
KEGGifca:493788.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF394194 mRNA. Translation: AAK73822.1 .
RefSeqi NP_001009839.1. NM_001009839.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9685.ENSFCAP00000009354.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 493788.
KEGGi fca:493788.

Organism-specific databases

CTDi 6575.

Phylogenomic databases

eggNOGi COG0306.
HOGENOMi HOG000231892.
HOVERGENi HBG053358.
InParanoidi Q95L97.
KOi K14640.
OrthoDBi EOG79KPDT.
TreeFami TF314426.

Family and domain databases

InterProi IPR001204. Phos_transporter.
[Graphical view ]
PANTHERi PTHR11101. PTHR11101. 1 hit.
Pfami PF01384. PHO4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Feline Pit2 functions as a receptor for subgroup B feline leukemia viruses."
    Anderson M.M., Lauring A.S., Robertson S., Dirks C., Overbaugh J.
    J. Virol. 75:10563-10572(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION AS RETROVIRAL RECEPTOR.

Entry informationi

Entry nameiS20A2_FELCA
AccessioniPrimary (citable) accession number: Q95L97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3