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Q95L97

- S20A2_FELCA

UniProt

Q95L97 - S20A2_FELCA

Protein

Sodium-dependent phosphate transporter 2

Gene

SLC20A2

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage calcification and vascular calcification By similarity. Functions as a retroviral receptor for feline leukemia virus subgroup B (FeLV-B).By similarity1 Publication

    GO - Molecular functioni

    1. inorganic phosphate transmembrane transporter activity Source: InterPro
    2. symporter activity Source: UniProtKB-KW
    3. virus receptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. phosphate ion transport Source: UniProtKB-KW
    2. sodium ion transport Source: UniProtKB-KW
    3. viral process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Host cell receptor for virus entry, Receptor

    Keywords - Biological processi

    Host-virus interaction, Ion transport, Phosphate transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium-dependent phosphate transporter 2
    Alternative name(s):
    Phosphate transporter 2
    Short name:
    FePit2
    Short name:
    PiT-2
    Solute carrier family 20 member 2
    Gene namesi
    Name:SLC20A2
    Synonyms:PIT2
    OrganismiFelis catus (Cat) (Felis silvestris catus)
    Taxonomic identifieri9685 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
    ProteomesiUP000011712: Unplaced

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 653653Sodium-dependent phosphate transporter 2PRO_0000341267Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi81 – 811N-linked (GlcNAc...)Sequence Analysis
    Modified residuei268 – 2681PhosphoserineBy similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi9685.ENSFCAP00000009354.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 55ExtracellularSequence Analysis
    Topological domaini27 – 4620CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini68 – 8619ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini108 – 1092CytoplasmicSequence Analysis
    Topological domaini131 – 14212ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini164 – 19027CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini212 – 2132ExtracellularSequence Analysis
    Topological domaini235 – 483249CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini505 – 53127ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini553 – 57220CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini588 – 5947ExtracellularSequence Analysis
    Topological domaini611 – 62212CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini644 – 65310ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei6 – 2621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei47 – 6721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei87 – 10721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei110 – 13021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei143 – 16321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei191 – 21121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei214 – 23421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei484 – 50421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei532 – 55221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei573 – 58715HelicalSequence AnalysisAdd
    BLAST
    Transmembranei595 – 61016HelicalSequence AnalysisAdd
    BLAST
    Transmembranei623 – 64321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0306.
    HOGENOMiHOG000231892.
    HOVERGENiHBG053358.
    KOiK14640.
    OrthoDBiEOG79KPDT.
    TreeFamiTF314426.

    Family and domain databases

    InterProiIPR001204. Phos_transporter.
    [Graphical view]
    PANTHERiPTHR11101. PTHR11101. 1 hit.
    PfamiPF01384. PHO4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q95L97-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAIDGYLWMV ILGFIIAFIL AFSVGANDVA NSFGTAVGSG VVTLRQACIL    50
    ASIFETTGSV LLGAKVGETI RKGIIDVNLY NETVETLMAG EVSAMVGSAV 100
    WQLIASFLRL PISGTHCIVG STIGFSLVAI GTQGVQWMEL VKIVASWFIS 150
    PLLSGFMSGV LFILIRIFIL KKEDPVPNGL RALPVFYAAT IAINVFSIMY 200
    TGAPVLGLVL PIWAIALISF GVALLFALFV WLFVCPWMRR KIAGKLQKEA 250
    ALSRVSDESL SKIQEVESPV FKELPGAKAN DDSTVPLTGS AGEPSGTSEG 300
    TSVGNHPRAS YGRALSMTHG SAKSPVSNGT FGFDGHTRSD GHVYHTVHKD 350
    SGLYKDLLHR IHSDRGPEER PAQENNYRFL RRNNSYTCYT AAICGMPVHS 400
    TFKAADSSSA PEDSEKLVGD AVSYSKKRLR YDSYSSYCNA VAEAEIEADE 450
    GGVEMKLASE LTDPDQPRDD PAEEEKEEKD TAEVHLLFHF LQVLTACFGS 500
    FAHGGNDVSN AIGPLVALWL IYEQGAVLQE AVTPVWLLFY GGVGICTGLW 550
    VWGRRVIQTM GKDLTPITPS SGFTIELASA FTVVIASNVG LPVSTTHCKV 600
    GSVVAVGWIR SRKAVDWRLF RNIFVAWFVT VPVAGLFSAA IMALLMYGIL 650
    PYV 653
    Length:653
    Mass (Da):70,492
    Last modified:December 1, 2001 - v1
    Checksum:i386C5D68D3B6C006
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF394194 mRNA. Translation: AAK73822.1.
    RefSeqiNP_001009839.1. NM_001009839.1.

    Genome annotation databases

    GeneIDi493788.
    KEGGifca:493788.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF394194 mRNA. Translation: AAK73822.1 .
    RefSeqi NP_001009839.1. NM_001009839.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9685.ENSFCAP00000009354.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 493788.
    KEGGi fca:493788.

    Organism-specific databases

    CTDi 6575.

    Phylogenomic databases

    eggNOGi COG0306.
    HOGENOMi HOG000231892.
    HOVERGENi HBG053358.
    KOi K14640.
    OrthoDBi EOG79KPDT.
    TreeFami TF314426.

    Family and domain databases

    InterProi IPR001204. Phos_transporter.
    [Graphical view ]
    PANTHERi PTHR11101. PTHR11101. 1 hit.
    Pfami PF01384. PHO4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Feline Pit2 functions as a receptor for subgroup B feline leukemia viruses."
      Anderson M.M., Lauring A.S., Robertson S., Dirks C., Overbaugh J.
      J. Virol. 75:10563-10572(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION AS RETROVIRAL RECEPTOR.

    Entry informationi

    Entry nameiS20A2_FELCA
    AccessioniPrimary (citable) accession number: Q95L97
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3