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Protein

Endothelin-1 receptor

Gene

EDNRA

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-1 receptor
Alternative name(s):
Endothelin A receptor
Short name:
ET-A
Short name:
ET-AR
Gene namesi
Name:EDNRA
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 80ExtracellularSequence analysisAdd BLAST60
Transmembranei81 – 102Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini103 – 112CytoplasmicSequence analysis10
Transmembranei113 – 132Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini133 – 159ExtracellularSequence analysisAdd BLAST27
Transmembranei160 – 181Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini182 – 205CytoplasmicSequence analysisAdd BLAST24
Transmembranei206 – 229Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini230 – 256ExtracellularSequence analysisAdd BLAST27
Transmembranei257 – 278Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini279 – 306CytoplasmicSequence analysisAdd BLAST28
Transmembranei307 – 328Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini329 – 347ExtracellularSequence analysisAdd BLAST19
Transmembranei348 – 372Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini373 – 427CytoplasmicSequence analysisAdd BLAST55

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001272521 – 427Endothelin-1 receptorAdd BLAST407

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...)Sequence analysis1
Glycosylationi62N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi158 ↔ 239PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Interacts with HDAC7 and KAT5.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ95L55.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG051443.
KOiK04197.

Family and domain databases

InterProiIPR000499. Endthln_rcpt.
IPR002175. ETA_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00570. ENDOTHELINAR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q95L55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METFWLRVSF WVALVGGVIS DNPESYSTNL SIHVDSVTTF RGTELSFVVT
60 70 80 90 100
THQPTNLALP SNGSMHNYCP QQTKITSAFK YINTVISCTI FIVGMVGNAT
110 120 130 140 150
LLRIIYQNKC MRNGPNALIA SLALGDLIYV VIDLPINVFK LLAGRWPFEQ
160 170 180 190 200
NDFGVFLCKL FPFLQKSSVG ITVLNLCALS VDRYRAVASW SRVQGIGIPL
210 220 230 240 250
VTAIEIVSIW ILSFILAIPE AIGFVMVPFE YKGAQHRTCM LNATSKFMEF
260 270 280 290 300
YQDVKDWWLF GFYFCMPLVC TAIFYTLMTC EMLNRRNGSL RIALSEHLKQ
310 320 330 340 350
RREVAKTVFC LVVIFALCWF PLHLSRILKK TVYDEMDTNR CELLSFLLLM
360 370 380 390 400
DYIGINLATM NSCINPIALY FVSKKFKNCF QSCLCCCCYQ SKSLMTSVPM
410 420
NGTSIQWKNP EQNNHNTERS SHKDSIN
Length:427
Mass (Da):48,510
Last modified:December 1, 2001 - v1
Checksum:i1A8BA420E62D5F10
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF416703 mRNA. Translation: AAL08564.1.
RefSeqiNP_001009433.1. NM_001009433.1.
UniGeneiOar.776.

Genome annotation databases

GeneIDi443465.
KEGGioas:443465.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF416703 mRNA. Translation: AAL08564.1.
RefSeqiNP_001009433.1. NM_001009433.1.
UniGeneiOar.776.

3D structure databases

ProteinModelPortaliQ95L55.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi443465.
KEGGioas:443465.

Organism-specific databases

CTDi1909.

Phylogenomic databases

HOVERGENiHBG051443.
KOiK04197.

Family and domain databases

InterProiIPR000499. Endthln_rcpt.
IPR002175. ETA_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00570. ENDOTHELINAR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEDNRA_SHEEP
AccessioniPrimary (citable) accession number: Q95L55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: December 1, 2001
Last modified: October 14, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.