Eukaryotic translation initiation factor 4 gamma 2

Preferred order of sections

Names and origin

Protein names

Recommended name:
Eukaryotic translation initiation factor 4 gamma 2
Short name=eIF-4-gamma 2
Short name=eIF-4G 2
Short name=eIF4G 2

Alternative name(s):
p97

Gene names

Name:

EIF4G2

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	907 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases By similarity. UniProtKB P78344
Subunit structure	Interacts with the serine/threonine protein kinases MKNK1 and MKNK2. Binds EIF4A and EIF3. Interacts with MIF4GD By similarity.
Post-translational modification	Phosphorylation; hyperphosphorylated during mitosis By similarity. UniProtKB P78344
Sequence similarities	Belongs to the eukaryotic initiation factor 4G family. Contains 1 MI domain. Contains 1 MIF4G domain. Contains 1 W2 domain.

Ontologies

Keywords
Biological process	Protein biosynthesis Translation regulation
Molecular function	Initiation factor Repressor
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	RNA metabolic process Inferred from electronic annotation. Source: InterPro regulation of translational initiation Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	eukaryotic translation initiation factor 4F complex Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro translation initiation factor activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 907

907

Eukaryotic translation initiation factor 4 gamma 2

PRO_0000213324

Regions

Domain

78 – 308

231

MIF4G

Domain

543 – 666

124

MI

Domain

720 – 904

185

W2

Amino acid modifications

Modified residue

1

N-acetylmethionine By similarity

Modified residue

395

1

Phosphoserine By similarity

Modified residue

508

1

Phosphothreonine By similarity

Modified residue

514

1

Phosphothreonine By similarity

Modified residue

902

1

Phosphoserine By similarity

Experimental info

Sequence conflict

557

1

N → Y in AAI22632. Ref.1

Sequence conflict

628

1

Q → R in AAB64296. Ref.3

Sequences

Sequence

Length

Mass (Da)

Tools

Q95L46 [UniParc].

Last modified February 5, 2008. Version 2.
Checksum: 4EF050B5EEA4DF91
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FASTA

907

102,362

        10         20         30         40         50         60 
MESAIAEGGA SRFSASSGGG GSRGAPQHYP KTAGNSEFLG KTPGQNAQKW IPARSTRRDD 

        70         80         90        100        110        120 
NSAANNSANE KERHDAIFRK VRGILNKLTP EKFDKLCLEL LNVGVESKLI LKGVILLIVD 

       130        140        150        160        170        180 
KALEEPKYSS LYAQLCLRLA EDAPNFDGPA AEGQPGQKQS TTFRRLLISK LQDEFENRTR 

       190        200        210        220        230        240 
NVDVYDKREN PLLPEEEEQR AIAKIKMLGN IKFIGELGKL DLIHESILHK CIKTLLEKKK 

       250        260        270        280        290        300 
RVQLKDMGED LECLCQIMRT VGPRLDHERA KSLMDQYFAR MCSLMLSKEL PARIRFLLQD 

       310        320        330        340        350        360 
TVELREHHWV PRKAFLDNGP KTINQIRQDA VKDLGVFIPA PMAQGMRSDF FLEGPFMPPR 

       370        380        390        400        410        420 
MKMDRDPLGG LADMFGQMPG SGIGTGPGVI QDRFSPTMGR HRSNQLFNGH GGHIMPPTQS 

       430        440        450        460        470        480 
QFGEMGGKFM KSQGLSQLYH NQSQGLLSQL QGQSKDMPPR FSKKGQLNAD EISLRPAQSF 

       490        500        510        520        530        540 
LMNKNQVPKL QPQITMIPPS AQPPRTQTPP LGQTPQLGLK TNPPLIQEKP AKTSKKPPPS 

       550        560        570        580        590        600 
KEELLKLTET VVTEYLNSGN ANEAVNGVRE MRAPKHFLPE MLSKVIILSL DRSDEDKEKA 

       610        620        630        640        650        660 
SSLISLLKQE GIATSDNFMQ AFLNVLDQCP KLEVDIPLVK SYLAQFAARA IISELVSISE 

       670        680        690        700        710        720 
LAQPLESGTH FPLFLLCLQQ LAKLQDREWL TELFQQSKVN MQKMLPEIDQ NKDRMLEILE 

       730        740        750        760        770        780 
GKGLSFLFPL LKLEKELLKQ IKLDPSPQTI YKWIKDNISP KLHVDKGFVN ILMTSFLQYI 

       790        800        810        820        830        840 
SSEVNPPSDE TDSSSAPSKE QLEQEKQLLL SFKPVMQKFL HDHVDLQVSA LYALQVHCYN 

       850        860        870        880        890        900 
SNFPKGMLLR FFVHFYDMEI IEEEAFLAWK EDITQEFPGK GKALFQVNQW LTWLETAEEE 


ESEEEAD

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Brain cortex.
[2]	Smith T.P.L., Bennett G.L. Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 514-649.
[3]	"Differential gene expression of vascular smooth muscle cells. Detection by RNA arbitrarily primed polymerase chain reaction." Alfke H., Stumm G., Schnieder I., Klose K.J., Schlegel J. VASA 28:164-168(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 539-639. Tissue: Vascular smooth muscle.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC122631 mRNA. Translation: AAI22632.1. AF420315 Genomic DNA. Translation: AAL30507.1. AF011353 mRNA. Translation: AAB64296.1.
IPI	IPI00867192.
RefSeq	NP_001093329.1. NM_001099859.1.
UniGene	Bt.5471.
3D structure databases
ProteinModelPortal	Q95L46.
ModBase	Search...
Proteomic databases
PRIDE	Q95L46.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	286870.
KEGG	bta:286870.
Organism-specific databases
CTD	1982.
Phylogenomic databases
eggNOG	NOG301289.
HOGENOM	HOG000008096.
HOVERGEN	HBG052084.
KO	K03260.
Family and domain databases
Gene3D	1.25.40.180. 3 hits.
InterPro	IPR016024. ARM-type_fold. IPR003891. Initiation_fac_eIF4g_MI. IPR016021. MIF4-like_typ_1/2/3. IPR003890. MIF4G-like_typ-3. IPR003307. W2_domain. [Graphical view]
Pfam	PF02847. MA3. 1 hit. PF02854. MIF4G. 1 hit. PF02020. W2. 1 hit. [Graphical view]
SMART	SM00515. eIF5C. 1 hit. SM00544. MA3. 1 hit. SM00543. MIF4G. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 3 hits.
PROSITE	PS51366. MI. 1 hit. PS51363. W2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20806519.

Entry information

Entry name

IF4G2_BOVIN

Accession

Primary (citable) accession number: Q95L46
Secondary accession number(s): A8R456, O18948

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 30, 2003
Last sequence update:	February 5, 2008
Last modified:	May 1, 2013
This is version 77 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Other

Entry information

Relevant documents