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Q95L46 (IF4G2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Eukaryotic translation initiation factor 4 gamma 2

Short name=eIF-4-gamma 2
Short name=eIF-4G 2
Short name=eIF4G 2
Alternative name(s):
p97
Gene names
Name:EIF4G2
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length907 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases By similarity. UniProtKB P78344

Subunit structure

Interacts with the serine/threonine protein kinases MKNK1 and MKNK2. Binds EIF4A and EIF3. Interacts with MIF4GD By similarity.

Post-translational modification

Phosphorylation; hyperphosphorylated during mitosis By similarity. UniProtKB P78344

Sequence similarities

Belongs to the eukaryotic initiation factor 4G family.

Contains 1 MI domain.

Contains 1 MIF4G domain.

Contains 1 W2 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 907907Eukaryotic translation initiation factor 4 gamma 2
PRO_0000213324

Regions

Domain78 – 308231MIF4G
Domain543 – 666124MI
Domain720 – 904185W2

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue3951Phosphoserine By similarity
Modified residue5081Phosphothreonine By similarity
Modified residue5141Phosphothreonine By similarity
Modified residue9021Phosphoserine By similarity

Experimental info

Sequence conflict5571N → Y in AAI22632. Ref.1
Sequence conflict6281Q → R in AAB64296. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q95L46 [UniParc].

Last modified February 5, 2008. Version 2.
Checksum: 4EF050B5EEA4DF91

FASTA907102,362
        10         20         30         40         50         60 
MESAIAEGGA SRFSASSGGG GSRGAPQHYP KTAGNSEFLG KTPGQNAQKW IPARSTRRDD 

        70         80         90        100        110        120 
NSAANNSANE KERHDAIFRK VRGILNKLTP EKFDKLCLEL LNVGVESKLI LKGVILLIVD 

       130        140        150        160        170        180 
KALEEPKYSS LYAQLCLRLA EDAPNFDGPA AEGQPGQKQS TTFRRLLISK LQDEFENRTR 

       190        200        210        220        230        240 
NVDVYDKREN PLLPEEEEQR AIAKIKMLGN IKFIGELGKL DLIHESILHK CIKTLLEKKK 

       250        260        270        280        290        300 
RVQLKDMGED LECLCQIMRT VGPRLDHERA KSLMDQYFAR MCSLMLSKEL PARIRFLLQD 

       310        320        330        340        350        360 
TVELREHHWV PRKAFLDNGP KTINQIRQDA VKDLGVFIPA PMAQGMRSDF FLEGPFMPPR 

       370        380        390        400        410        420 
MKMDRDPLGG LADMFGQMPG SGIGTGPGVI QDRFSPTMGR HRSNQLFNGH GGHIMPPTQS 

       430        440        450        460        470        480 
QFGEMGGKFM KSQGLSQLYH NQSQGLLSQL QGQSKDMPPR FSKKGQLNAD EISLRPAQSF 

       490        500        510        520        530        540 
LMNKNQVPKL QPQITMIPPS AQPPRTQTPP LGQTPQLGLK TNPPLIQEKP AKTSKKPPPS 

       550        560        570        580        590        600 
KEELLKLTET VVTEYLNSGN ANEAVNGVRE MRAPKHFLPE MLSKVIILSL DRSDEDKEKA 

       610        620        630        640        650        660 
SSLISLLKQE GIATSDNFMQ AFLNVLDQCP KLEVDIPLVK SYLAQFAARA IISELVSISE 

       670        680        690        700        710        720 
LAQPLESGTH FPLFLLCLQQ LAKLQDREWL TELFQQSKVN MQKMLPEIDQ NKDRMLEILE 

       730        740        750        760        770        780 
GKGLSFLFPL LKLEKELLKQ IKLDPSPQTI YKWIKDNISP KLHVDKGFVN ILMTSFLQYI 

       790        800        810        820        830        840 
SSEVNPPSDE TDSSSAPSKE QLEQEKQLLL SFKPVMQKFL HDHVDLQVSA LYALQVHCYN 

       850        860        870        880        890        900 
SNFPKGMLLR FFVHFYDMEI IEEEAFLAWK EDITQEFPGK GKALFQVNQW LTWLETAEEE 


ESEEEAD 

« Hide

References

« Hide 'large scale' references
[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Brain cortex.
[2]Smith T.P.L., Bennett G.L.
Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 514-649.
[3]"Differential gene expression of vascular smooth muscle cells. Detection by RNA arbitrarily primed polymerase chain reaction."
Alfke H., Stumm G., Schnieder I., Klose K.J., Schlegel J.
VASA 28:164-168(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 539-639.
Tissue: Vascular smooth muscle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC122631 mRNA. Translation: AAI22632.1.
AF420315 Genomic DNA. Translation: AAL30507.1.
AF011353 mRNA. Translation: AAB64296.1.
RefSeqNP_001093329.1. NM_001099859.1.
UniGeneBt.5471.

3D structure databases

ProteinModelPortalQ95L46.
SMRQ95L46. Positions 78-311, 540-897.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ95L46.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID286870.
KEGGbta:286870.

Organism-specific databases

CTD1982.

Phylogenomic databases

eggNOGNOG301289.
HOGENOMHOG000008096.
HOVERGENHBG052084.
KOK03260.

Family and domain databases

Gene3D1.25.40.180. 3 hits.
InterProIPR016024. ARM-type_fold.
IPR003891. Initiation_fac_eIF4g_MI.
IPR016021. MIF4-like_typ_1/2/3.
IPR003890. MIF4G-like_typ-3.
IPR003307. W2_domain.
[Graphical view]
PfamPF02847. MA3. 1 hit.
PF02854. MIF4G. 1 hit.
PF02020. W2. 1 hit.
[Graphical view]
SMARTSM00515. eIF5C. 1 hit.
SM00544. MA3. 1 hit.
SM00543. MIF4G. 1 hit.
[Graphical view]
SUPFAMSSF48371. SSF48371. 3 hits.
PROSITEPS51366. MI. 1 hit.
PS51363. W2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20806519.

Entry information

Entry nameIF4G2_BOVIN
AccessionPrimary (citable) accession number: Q95L46
Secondary accession number(s): A8R456, O18948
Entry history
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: February 5, 2008
Last modified: April 16, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families