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Q95L46

- IF4G2_BOVIN

UniProt

Q95L46 - IF4G2_BOVIN

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Protein

Eukaryotic translation initiation factor 4 gamma 2

Gene
EIF4G2
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases By similarity.By similarity

GO - Molecular functioni

  1. translation factor activity, nucleic acid binding Source: UniProtKB
  2. translation initiation factor activity Source: UniProtKB

GO - Biological processi

  1. regulation of translational initiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor, Repressor

Keywords - Biological processi

Protein biosynthesis, Translation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4 gamma 2
Short name:
eIF-4-gamma 2
Short name:
eIF-4G 2
Short name:
eIF4G 2
Alternative name(s):
p97
Gene namesi
Name:EIF4G2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. eukaryotic translation initiation factor 4F complex Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 907907Eukaryotic translation initiation factor 4 gamma 2PRO_0000213324Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity
Modified residuei395 – 3951Phosphoserine By similarity
Modified residuei508 – 5081Phosphothreonine By similarity
Modified residuei514 – 5141Phosphothreonine By similarity
Modified residuei902 – 9021Phosphoserine By similarity

Post-translational modificationi

Phosphorylation; hyperphosphorylated during mitosis By similarity.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ95L46.

Interactioni

Subunit structurei

Interacts with the serine/threonine protein kinases MKNK1 and MKNK2. Binds EIF4A and EIF3. Interacts with MIF4GD By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ95L46.
SMRiQ95L46. Positions 78-311, 540-897.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini78 – 308231MIF4GAdd
BLAST
Domaini543 – 666124MIAdd
BLAST
Domaini720 – 904185W2Add
BLAST

Sequence similaritiesi

Contains 1 MI domain.
Contains 1 MIF4G domain.
Contains 1 W2 domain.

Phylogenomic databases

eggNOGiNOG301289.
HOGENOMiHOG000008096.
HOVERGENiHBG052084.
KOiK03260.

Family and domain databases

Gene3Di1.25.40.180. 3 hits.
InterProiIPR016024. ARM-type_fold.
IPR003891. Initiation_fac_eIF4g_MI.
IPR016021. MIF4-like_typ_1/2/3.
IPR003890. MIF4G-like_typ-3.
IPR003307. W2_domain.
[Graphical view]
PfamiPF02847. MA3. 1 hit.
PF02854. MIF4G. 1 hit.
PF02020. W2. 1 hit.
[Graphical view]
SMARTiSM00515. eIF5C. 1 hit.
SM00544. MA3. 1 hit.
SM00543. MIF4G. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
PROSITEiPS51366. MI. 1 hit.
PS51363. W2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q95L46-1 [UniParc]FASTAAdd to Basket

« Hide

MESAIAEGGA SRFSASSGGG GSRGAPQHYP KTAGNSEFLG KTPGQNAQKW    50
IPARSTRRDD NSAANNSANE KERHDAIFRK VRGILNKLTP EKFDKLCLEL 100
LNVGVESKLI LKGVILLIVD KALEEPKYSS LYAQLCLRLA EDAPNFDGPA 150
AEGQPGQKQS TTFRRLLISK LQDEFENRTR NVDVYDKREN PLLPEEEEQR 200
AIAKIKMLGN IKFIGELGKL DLIHESILHK CIKTLLEKKK RVQLKDMGED 250
LECLCQIMRT VGPRLDHERA KSLMDQYFAR MCSLMLSKEL PARIRFLLQD 300
TVELREHHWV PRKAFLDNGP KTINQIRQDA VKDLGVFIPA PMAQGMRSDF 350
FLEGPFMPPR MKMDRDPLGG LADMFGQMPG SGIGTGPGVI QDRFSPTMGR 400
HRSNQLFNGH GGHIMPPTQS QFGEMGGKFM KSQGLSQLYH NQSQGLLSQL 450
QGQSKDMPPR FSKKGQLNAD EISLRPAQSF LMNKNQVPKL QPQITMIPPS 500
AQPPRTQTPP LGQTPQLGLK TNPPLIQEKP AKTSKKPPPS KEELLKLTET 550
VVTEYLNSGN ANEAVNGVRE MRAPKHFLPE MLSKVIILSL DRSDEDKEKA 600
SSLISLLKQE GIATSDNFMQ AFLNVLDQCP KLEVDIPLVK SYLAQFAARA 650
IISELVSISE LAQPLESGTH FPLFLLCLQQ LAKLQDREWL TELFQQSKVN 700
MQKMLPEIDQ NKDRMLEILE GKGLSFLFPL LKLEKELLKQ IKLDPSPQTI 750
YKWIKDNISP KLHVDKGFVN ILMTSFLQYI SSEVNPPSDE TDSSSAPSKE 800
QLEQEKQLLL SFKPVMQKFL HDHVDLQVSA LYALQVHCYN SNFPKGMLLR 850
FFVHFYDMEI IEEEAFLAWK EDITQEFPGK GKALFQVNQW LTWLETAEEE 900
ESEEEAD 907
Length:907
Mass (Da):102,362
Last modified:February 5, 2008 - v2
Checksum:i4EF050B5EEA4DF91
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti557 – 5571N → Y in AAI22632. 1 Publication
Sequence conflicti628 – 6281Q → R in AAB64296. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC122631 mRNA. Translation: AAI22632.1.
AF420315 Genomic DNA. Translation: AAL30507.1.
AF011353 mRNA. Translation: AAB64296.1.
RefSeqiNP_001093329.1. NM_001099859.1.
UniGeneiBt.5471.

Genome annotation databases

GeneIDi286870.
KEGGibta:286870.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC122631 mRNA. Translation: AAI22632.1 .
AF420315 Genomic DNA. Translation: AAL30507.1 .
AF011353 mRNA. Translation: AAB64296.1 .
RefSeqi NP_001093329.1. NM_001099859.1.
UniGenei Bt.5471.

3D structure databases

ProteinModelPortali Q95L46.
SMRi Q95L46. Positions 78-311, 540-897.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q95L46.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 286870.
KEGGi bta:286870.

Organism-specific databases

CTDi 1982.

Phylogenomic databases

eggNOGi NOG301289.
HOGENOMi HOG000008096.
HOVERGENi HBG052084.
KOi K03260.

Miscellaneous databases

NextBioi 20806519.

Family and domain databases

Gene3Di 1.25.40.180. 3 hits.
InterProi IPR016024. ARM-type_fold.
IPR003891. Initiation_fac_eIF4g_MI.
IPR016021. MIF4-like_typ_1/2/3.
IPR003890. MIF4G-like_typ-3.
IPR003307. W2_domain.
[Graphical view ]
Pfami PF02847. MA3. 1 hit.
PF02854. MIF4G. 1 hit.
PF02020. W2. 1 hit.
[Graphical view ]
SMARTi SM00515. eIF5C. 1 hit.
SM00544. MA3. 1 hit.
SM00543. MIF4G. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 3 hits.
PROSITEi PS51366. MI. 1 hit.
PS51363. W2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Brain cortex.
  2. Smith T.P.L., Bennett G.L.
    Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 514-649.
  3. "Differential gene expression of vascular smooth muscle cells. Detection by RNA arbitrarily primed polymerase chain reaction."
    Alfke H., Stumm G., Schnieder I., Klose K.J., Schlegel J.
    VASA 28:164-168(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 539-639.
    Tissue: Vascular smooth muscle.

Entry informationi

Entry nameiIF4G2_BOVIN
AccessioniPrimary (citable) accession number: Q95L46
Secondary accession number(s): A8R456, O18948
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: February 5, 2008
Last modified: April 16, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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