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Q95L46

- IF4G2_BOVIN

UniProt

Q95L46 - IF4G2_BOVIN

Protein

Eukaryotic translation initiation factor 4 gamma 2

Gene

EIF4G2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 2 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases By similarity.By similarity

    GO - Molecular functioni

    1. translation factor activity, nucleic acid binding Source: UniProtKB
    2. translation initiation factor activity Source: UniProtKB

    GO - Biological processi

    1. regulation of translational initiation Source: UniProtKB

    Keywords - Molecular functioni

    Initiation factor, Repressor

    Keywords - Biological processi

    Protein biosynthesis, Translation regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Eukaryotic translation initiation factor 4 gamma 2
    Short name:
    eIF-4-gamma 2
    Short name:
    eIF-4G 2
    Short name:
    eIF4G 2
    Alternative name(s):
    p97
    Gene namesi
    Name:EIF4G2
    OrganismiBos taurus (Bovine)Imported
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. eukaryotic translation initiation factor 4F complex Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 907907Eukaryotic translation initiation factor 4 gamma 2PRO_0000213324Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei395 – 3951PhosphoserineBy similarity
    Modified residuei508 – 5081PhosphothreonineBy similarity
    Modified residuei514 – 5141PhosphothreonineBy similarity
    Modified residuei902 – 9021PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylation; hyperphosphorylated during mitosis.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PRIDEiQ95L46.

    Interactioni

    Subunit structurei

    Interacts with the serine/threonine protein kinases MKNK1 and MKNK2. Binds EIF4A and EIF3. Interacts with MIF4GD By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ95L46.
    SMRiQ95L46. Positions 78-311, 540-897.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini78 – 308231MIF4GPROSITE-ProRule annotationAdd
    BLAST
    Domaini543 – 666124MIPROSITE-ProRule annotationAdd
    BLAST
    Domaini720 – 904185W2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 MI domain.PROSITE-ProRule annotation
    Contains 1 MIF4G domain.Curated
    Contains 1 W2 domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG301289.
    HOGENOMiHOG000008096.
    HOVERGENiHBG052084.
    KOiK03260.

    Family and domain databases

    Gene3Di1.25.40.180. 3 hits.
    InterProiIPR016024. ARM-type_fold.
    IPR003891. Initiation_fac_eIF4g_MI.
    IPR016021. MIF4-like_typ_1/2/3.
    IPR003890. MIF4G-like_typ-3.
    IPR003307. W2_domain.
    [Graphical view]
    PfamiPF02847. MA3. 1 hit.
    PF02854. MIF4G. 1 hit.
    PF02020. W2. 1 hit.
    [Graphical view]
    SMARTiSM00515. eIF5C. 1 hit.
    SM00544. MA3. 1 hit.
    SM00543. MIF4G. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 3 hits.
    PROSITEiPS51366. MI. 1 hit.
    PS51363. W2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q95L46-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESAIAEGGA SRFSASSGGG GSRGAPQHYP KTAGNSEFLG KTPGQNAQKW    50
    IPARSTRRDD NSAANNSANE KERHDAIFRK VRGILNKLTP EKFDKLCLEL 100
    LNVGVESKLI LKGVILLIVD KALEEPKYSS LYAQLCLRLA EDAPNFDGPA 150
    AEGQPGQKQS TTFRRLLISK LQDEFENRTR NVDVYDKREN PLLPEEEEQR 200
    AIAKIKMLGN IKFIGELGKL DLIHESILHK CIKTLLEKKK RVQLKDMGED 250
    LECLCQIMRT VGPRLDHERA KSLMDQYFAR MCSLMLSKEL PARIRFLLQD 300
    TVELREHHWV PRKAFLDNGP KTINQIRQDA VKDLGVFIPA PMAQGMRSDF 350
    FLEGPFMPPR MKMDRDPLGG LADMFGQMPG SGIGTGPGVI QDRFSPTMGR 400
    HRSNQLFNGH GGHIMPPTQS QFGEMGGKFM KSQGLSQLYH NQSQGLLSQL 450
    QGQSKDMPPR FSKKGQLNAD EISLRPAQSF LMNKNQVPKL QPQITMIPPS 500
    AQPPRTQTPP LGQTPQLGLK TNPPLIQEKP AKTSKKPPPS KEELLKLTET 550
    VVTEYLNSGN ANEAVNGVRE MRAPKHFLPE MLSKVIILSL DRSDEDKEKA 600
    SSLISLLKQE GIATSDNFMQ AFLNVLDQCP KLEVDIPLVK SYLAQFAARA 650
    IISELVSISE LAQPLESGTH FPLFLLCLQQ LAKLQDREWL TELFQQSKVN 700
    MQKMLPEIDQ NKDRMLEILE GKGLSFLFPL LKLEKELLKQ IKLDPSPQTI 750
    YKWIKDNISP KLHVDKGFVN ILMTSFLQYI SSEVNPPSDE TDSSSAPSKE 800
    QLEQEKQLLL SFKPVMQKFL HDHVDLQVSA LYALQVHCYN SNFPKGMLLR 850
    FFVHFYDMEI IEEEAFLAWK EDITQEFPGK GKALFQVNQW LTWLETAEEE 900
    ESEEEAD 907
    Length:907
    Mass (Da):102,362
    Last modified:February 5, 2008 - v2
    Checksum:i4EF050B5EEA4DF91
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti557 – 5571N → Y in AAI22632. 1 PublicationCurated
    Sequence conflicti628 – 6281Q → R in AAB64296. (PubMed:10483320)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC122631 mRNA. Translation: AAI22632.1.
    AF420315 Genomic DNA. Translation: AAL30507.1.
    AF011353 mRNA. Translation: AAB64296.1.
    RefSeqiNP_001093329.1. NM_001099859.1.
    UniGeneiBt.5471.

    Genome annotation databases

    GeneIDi286870.
    KEGGibta:286870.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC122631 mRNA. Translation: AAI22632.1 .
    AF420315 Genomic DNA. Translation: AAL30507.1 .
    AF011353 mRNA. Translation: AAB64296.1 .
    RefSeqi NP_001093329.1. NM_001099859.1.
    UniGenei Bt.5471.

    3D structure databases

    ProteinModelPortali Q95L46.
    SMRi Q95L46. Positions 78-311, 540-897.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q95L46.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 286870.
    KEGGi bta:286870.

    Organism-specific databases

    CTDi 1982.

    Phylogenomic databases

    eggNOGi NOG301289.
    HOGENOMi HOG000008096.
    HOVERGENi HBG052084.
    KOi K03260.

    Miscellaneous databases

    NextBioi 20806519.

    Family and domain databases

    Gene3Di 1.25.40.180. 3 hits.
    InterProi IPR016024. ARM-type_fold.
    IPR003891. Initiation_fac_eIF4g_MI.
    IPR016021. MIF4-like_typ_1/2/3.
    IPR003890. MIF4G-like_typ-3.
    IPR003307. W2_domain.
    [Graphical view ]
    Pfami PF02847. MA3. 1 hit.
    PF02854. MIF4G. 1 hit.
    PF02020. W2. 1 hit.
    [Graphical view ]
    SMARTi SM00515. eIF5C. 1 hit.
    SM00544. MA3. 1 hit.
    SM00543. MIF4G. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 3 hits.
    PROSITEi PS51366. MI. 1 hit.
    PS51363. W2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Brain cortex.
    2. Smith T.P.L., Bennett G.L.
      Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 514-649.
    3. "Differential gene expression of vascular smooth muscle cells. Detection by RNA arbitrarily primed polymerase chain reaction."
      Alfke H., Stumm G., Schnieder I., Klose K.J., Schlegel J.
      VASA 28:164-168(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 539-639.
      Tissue: Vascular smooth muscle.

    Entry informationi

    Entry nameiIF4G2_BOVIN
    AccessioniPrimary (citable) accession number: Q95L46
    Secondary accession number(s): A8R456, O18948
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 30, 2003
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3