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Protein

Lysyl oxidase homolog 1

Gene

LOXL1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Active on elastin and collagen substrates.1 Publication

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi466 – 4661CopperSequence analysis
Metal bindingi468 – 4681CopperSequence analysis
Metal bindingi470 – 4701CopperSequence analysis

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lysyl oxidase homolog 1 (EC:1.4.3.-)
Alternative name(s):
Lysyl oxidase-like protein 1
Gene namesi
Name:LOXL1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Propeptidei23 – 9169PRO_0000045438Add
BLAST
Chaini92 – 591500Lysyl oxidase homolog 1PRO_0000045439Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi412 ↔ 418By similarity
Disulfide bondi465 ↔ 514By similarity
Cross-linki494 ↔ 529Lysine tyrosylquinone (Lys-Tyr)By similarity
Disulfide bondi498 ↔ 504By similarity
Disulfide bondi525 ↔ 535By similarity
Modified residuei529 – 52912',4',5'-topaquinoneBy similarity
Disulfide bondi572 ↔ 586By similarity

Post-translational modificationi

The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, LTQ, TPQ

Proteomic databases

PaxDbiQ95L39.
PRIDEiQ95L39.

Miscellaneous databases

PMAP-CutDBQ95L39.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011978.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni387 – 591205Lysyl-oxidase likeAdd
BLAST

Sequence similaritiesi

Belongs to the lysyl oxidase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHTH. Eukaryota.
ENOG41101E4. LUCA.
HOVERGENiHBG000226.
InParanoidiQ95L39.
KOiK14678.

Family and domain databases

InterProiIPR001695. Lysyl_oxidase.
IPR019828. Lysyl_oxidase_CS.
[Graphical view]
PfamiPF01186. Lysyl_oxidase. 1 hit.
[Graphical view]
PRINTSiPR00074. LYSYLOXIDASE.
PROSITEiPS00926. LYSYL_OXIDASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q95L39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALALTGWQL VWGACVCVLV HGQQAPPGQG SDPGRWRQLI QWENNGQVYS
60 70 80 90 100
LLNSGAEYVP PGPQGSEANS RVLLAGAPQA PPRRRGGLRR RQAPSLPLPG
110 120 130 140 150
RVGSDTVRGQ ARHPFGFGQV PDNWREVAVG DSTGMARART SVSQQRHGGS
160 170 180 190 200
ASSVSASASA FASTYRQPSS FPQQQFPYPQ APFVSQYETY DPSTRTYDQG
210 220 230 240 250
YVYYRSASGG LGAAAVASAG VVYPFQPRAR YEEYGGGGGE EQPEYPPQGF
260 270 280 290 300
YPAAPERPYA PQPADGLDRR YSHSLYHEGT AGLEPAYPDP GPDAAQPNGG
310 320 330 340 350
GGGGTYGGGG GDPRLGWYPP YGNMPPEAYS PPRVVEPQPP FRVLEPPYLP
360 370 380 390 400
VRSSDAPPPG SERNGAQQGR LSVGSVYRPN QNGRGLPDLV PDPNYVQAST
410 420 430 440 450
YVQRAHLYSL RCAAEEKCLA STAYAPEATD YDVRVLLRFP QRVKNQGTAD
460 470 480 490 500
FLPNRPRHTW EWHSCHQHYH SMDEFSHYDL LDAATGKKVA EGHKASFCLE
510 520 530 540 550
DSTCDFGNLK RYACTSHTQG LSPGCYDTYN ADIDCQWIDI TDVQPGNYIL
560 570 580 590
KVHVNPKYIV LESDFTNNVV RCNIHYTGRY VSTTNCKIVQ S
Length:591
Mass (Da):64,496
Last modified:December 1, 2001 - v1
Checksum:i337A344E64F0FC73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF421185 mRNA. Translation: AAL13312.1.
RefSeqiNP_776808.1. NM_174383.2.
UniGeneiBt.8963.

Genome annotation databases

GeneIDi281903.
KEGGibta:281903.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF421185 mRNA. Translation: AAL13312.1.
RefSeqiNP_776808.1. NM_174383.2.
UniGeneiBt.8963.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011978.

Proteomic databases

PaxDbiQ95L39.
PRIDEiQ95L39.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281903.
KEGGibta:281903.

Organism-specific databases

CTDi4016.

Phylogenomic databases

eggNOGiENOG410IHTH. Eukaryota.
ENOG41101E4. LUCA.
HOVERGENiHBG000226.
InParanoidiQ95L39.
KOiK14678.

Miscellaneous databases

PMAP-CutDBQ95L39.

Family and domain databases

InterProiIPR001695. Lysyl_oxidase.
IPR019828. Lysyl_oxidase_CS.
[Graphical view]
PfamiPF01186. Lysyl_oxidase. 1 hit.
[Graphical view]
PRINTSiPR00074. LYSYLOXIDASE.
PROSITEiPS00926. LYSYL_OXIDASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLOXL1_BOVIN
AccessioniPrimary (citable) accession number: Q95L39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.