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Protein

Prostaglandin E synthase

Gene

PTGES

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).By similarity

Catalytic activityi

(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate.

Cofactori

glutathioneBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei118 – 1181GlutathioneBy similarity
Binding sitei127 – 1271GlutathioneBy similarity
Binding sitei131 – 1311GlutathioneBy similarity
Binding sitei135 – 1351GlutathioneBy similarity

GO - Molecular functioni

GO - Biological processi

  • cellular response to interleukin-1 Source: AgBase
  • negative regulation of cell proliferation Source: Ensembl
  • prostaglandin biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism

Enzyme and pathway databases

BRENDAi5.3.99.3. 908.
ReactomeiR-BTA-2162123. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin E synthase (EC:5.3.99.3)
Alternative name(s):
Microsomal prostaglandin E synthase 1
Short name:
MPGES-1
Gene namesi
Name:PTGES
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1313LumenalBy similarityAdd
BLAST
Transmembranei14 – 4229HelicalBy similarityAdd
BLAST
Topological domaini43 – 6119CytoplasmicBy similarityAdd
BLAST
Transmembranei62 – 9130HelicalBy similarityAdd
BLAST
Topological domaini92 – 965LumenalBy similarity
Transmembranei97 – 12024HelicalBy similarityAdd
BLAST
Topological domaini121 – 1244CytoplasmicBy similarity
Transmembranei125 – 15329HelicalBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2502.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 153153Prostaglandin E synthasePRO_0000217743Add
BLAST

Proteomic databases

PaxDbiQ95L14.

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025912.

Structurei

3D structure databases

ProteinModelPortaliQ95L14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni29 – 3911Glutathione bindingBy similarityAdd
BLAST
Regioni71 – 788Glutathione bindingBy similarity
Regioni111 – 1144Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the MAPEG family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IY81. Eukaryota.
ENOG4111VJG. LUCA.
GeneTreeiENSGT00390000011980.
HOGENOMiHOG000231759.
HOVERGENiHBG052470.
InParanoidiQ95L14.
KOiK15729.
OMAiCFSMALQ.
OrthoDBiEOG7288T0.
TreeFamiTF105327.

Family and domain databases

Gene3Di1.20.120.550. 1 hit.
InterProiIPR023352. MAPEG-like_dom.
IPR001129. Membr-assoc_MAPEG.
[Graphical view]
PfamiPF01124. MAPEG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q95L14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPSGLELMN GQVLPAFLLC SALLVIKMYV VAVITGQVRL RKKAFANPED
60 70 80 90 100
AQRHGGLQYC RNDPDVERCL RAHRNDMETI YPFLFLGFVY SFLGPNPFVA
110 120 130 140 150
RMHFLVFFLG RMVHTVAYLG KLRAPTRSLA YTLAQLPCAS MALQIVWEAA

RHL
Length:153
Mass (Da):17,298
Last modified:December 1, 2001 - v1
Checksum:i2B8E3ABCFD01CE6F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 211S → G in AAI20229 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY032727 mRNA. Translation: AAK51127.1.
BC120228 mRNA. Translation: AAI20229.1.
RefSeqiNP_776868.1. NM_174443.2.
UniGeneiBt.8953.

Genome annotation databases

EnsembliENSBTAT00000025912; ENSBTAP00000025912; ENSBTAG00000019453.
GeneIDi282019.
KEGGibta:282019.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY032727 mRNA. Translation: AAK51127.1.
BC120228 mRNA. Translation: AAI20229.1.
RefSeqiNP_776868.1. NM_174443.2.
UniGeneiBt.8953.

3D structure databases

ProteinModelPortaliQ95L14.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025912.

Chemistry

ChEMBLiCHEMBL2502.

Proteomic databases

PaxDbiQ95L14.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000025912; ENSBTAP00000025912; ENSBTAG00000019453.
GeneIDi282019.
KEGGibta:282019.

Organism-specific databases

CTDi9536.

Phylogenomic databases

eggNOGiENOG410IY81. Eukaryota.
ENOG4111VJG. LUCA.
GeneTreeiENSGT00390000011980.
HOGENOMiHOG000231759.
HOVERGENiHBG052470.
InParanoidiQ95L14.
KOiK15729.
OMAiCFSMALQ.
OrthoDBiEOG7288T0.
TreeFamiTF105327.

Enzyme and pathway databases

BRENDAi5.3.99.3. 908.
ReactomeiR-BTA-2162123. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).

Family and domain databases

Gene3Di1.20.120.550. 1 hit.
InterProiIPR023352. MAPEG-like_dom.
IPR001129. Membr-assoc_MAPEG.
[Graphical view]
PfamiPF01124. MAPEG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and induction of bovine prostaglandin E synthase by gonadotropins in ovarian follicles prior to ovulation in vivo."
    Filion F., Bouchard N., Goff A.K., Lussier J.G., Sirois J.
    J. Biol. Chem. 276:34323-34330(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal medulla.

Entry informationi

Entry nameiPTGES_BOVIN
AccessioniPrimary (citable) accession number: Q95L14
Secondary accession number(s): Q0P5C8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.