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Protein

Prostaglandin E synthase

Gene

PTGES

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).By similarity

Catalytic activityi

(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate.

Cofactori

glutathioneBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei118GlutathioneBy similarity1
Binding sitei127GlutathioneBy similarity1
Binding sitei131GlutathioneBy similarity1
Binding sitei135GlutathioneBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cellular response to interleukin-1 Source: AgBase
  • negative regulation of cell proliferation Source: Ensembl
  • prostaglandin biosynthetic process Source: UniProtKB

Keywordsi

Molecular functionIsomerase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism

Enzyme and pathway databases

BRENDAi5.3.99.3 908
ReactomeiR-BTA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin E synthase (EC:5.3.99.3)
Alternative name(s):
Microsomal prostaglandin E synthase 1
Short name:
MPGES-1
Gene namesi
Name:PTGES
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Organism-specific databases

VGNCiVGNC:33505 PTGES

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13LumenalBy similarityAdd BLAST13
Transmembranei14 – 42HelicalBy similarityAdd BLAST29
Topological domaini43 – 61CytoplasmicBy similarityAdd BLAST19
Transmembranei62 – 91HelicalBy similarityAdd BLAST30
Topological domaini92 – 96LumenalBy similarity5
Transmembranei97 – 120HelicalBy similarityAdd BLAST24
Topological domaini121 – 124CytoplasmicBy similarity4
Transmembranei125 – 153HelicalBy similarityAdd BLAST29

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2502

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002177431 – 153Prostaglandin E synthaseAdd BLAST153

Proteomic databases

PaxDbiQ95L14

Expressioni

Gene expression databases

BgeeiENSBTAG00000019453

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025912

Structurei

3D structure databases

ProteinModelPortaliQ95L14
SMRiQ95L14
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 39Glutathione bindingBy similarityAdd BLAST11
Regioni71 – 78Glutathione bindingBy similarity8
Regioni111 – 114Glutathione bindingBy similarity4

Sequence similaritiesi

Belongs to the MAPEG family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IY81 Eukaryota
ENOG4111VJG LUCA
GeneTreeiENSGT00390000011980
HOGENOMiHOG000231759
HOVERGENiHBG052470
InParanoidiQ95L14
KOiK15729
OMAiCFSMALQ
OrthoDBiEOG091G14I4
TreeFamiTF105327

Family and domain databases

Gene3Di1.20.120.550, 1 hit
InterProiView protein in InterPro
IPR023352 MAPEG-like_dom_sf
IPR001129 Membr-assoc_MAPEG
PfamiView protein in Pfam
PF01124 MAPEG, 1 hit
SUPFAMiSSF161084 SSF161084, 1 hit

Sequencei

Sequence statusi: Complete.

Q95L14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPSGLELMN GQVLPAFLLC SALLVIKMYV VAVITGQVRL RKKAFANPED
60 70 80 90 100
AQRHGGLQYC RNDPDVERCL RAHRNDMETI YPFLFLGFVY SFLGPNPFVA
110 120 130 140 150
RMHFLVFFLG RMVHTVAYLG KLRAPTRSLA YTLAQLPCAS MALQIVWEAA

RHL
Length:153
Mass (Da):17,298
Last modified:December 1, 2001 - v1
Checksum:i2B8E3ABCFD01CE6F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21S → G in AAI20229 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY032727 mRNA Translation: AAK51127.1
BC120228 mRNA Translation: AAI20229.1
RefSeqiNP_776868.1, NM_174443.2
UniGeneiBt.8953

Genome annotation databases

EnsembliENSBTAT00000025912; ENSBTAP00000025912; ENSBTAG00000019453
GeneIDi282019
KEGGibta:282019

Similar proteinsi

Entry informationi

Entry nameiPTGES_BOVIN
AccessioniPrimary (citable) accession number: Q95L14
Secondary accession number(s): Q0P5C8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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