Q95KZ0 (PE2R4_PANTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Prostaglandin E2 receptor EP4 subtype
Short name=PGE receptor EP4 subtype
Short name=PGE2 receptor EP4 subtype

Alternative name(s):
Prostanoid EP4 receptor

Gene names

Name:

PTGER4

Organism

Pan troglodytes (Chimpanzee) [Reference proteome]

Taxonomic identifier

9598 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Pan

Protein attributes

Sequence length	490 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function By similarity.
Subunit structure	Interacts with FEM1A By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Post-translational modification	Phosphorylation mediates agonist-mediated desensitization by promoting cytoplasmic retention By similarity.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	T-helper cell differentiation Inferred from electronic annotation. Source: Compara adenylate cyclase-modulating G-protein coupled receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB cellular response to mechanical stimulus Inferred from electronic annotation. Source: Compara negative regulation of cytokine secretion Inferred from electronic annotation. Source: Compara negative regulation of eosinophil extravasation Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of inflammatory response Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of integrin activation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of cytokine secretion Inferred from electronic annotation. Source: Compara positive regulation of inflammatory response Inferred from electronic annotation. Source: Compara regulation of ossification Inferred from electronic annotation. Source: Compara regulation of stress fiber assembly Inferred from electronic annotation. Source: Compara response to lipopolysaccharide Inferred from electronic annotation. Source: Compara
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	prostaglandin E receptor activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 490	490	Prostaglandin E2 receptor EP4 subtype		PRO_0000070066
Regions
	Topological domain	1 – 19	19	Extracellular Potential
	Transmembrane	20 – 43	24	Helical; Name=1; Potential
	Topological domain	44 – 55	12	Cytoplasmic Potential
	Transmembrane	56 – 79	24	Helical; Name=2; Potential
	Topological domain	80 – 96	17	Extracellular Potential
	Transmembrane	97 – 115	19	Helical; Name=3; Potential
	Topological domain	116 – 135	20	Cytoplasmic Potential
	Transmembrane	136 – 160	25	Helical; Name=4; Potential
	Topological domain	161 – 184	24	Extracellular Potential
	Transmembrane	185 – 211	27	Helical; Name=5; Potential
	Topological domain	212 – 269	58	Cytoplasmic Potential
	Transmembrane	270 – 297	28	Helical; Name=6; Potential
	Topological domain	298 – 314	17	Extracellular Potential
	Transmembrane	315 – 334	20	Helical; Name=7; Potential
	Topological domain	335 – 490	156	Cytoplasmic Potential
Amino acid modifications
	Modified residue	376	1	Phosphoserine By similarity
	Modified residue	379	1	Phosphoserine By similarity
	Modified residue	381	1	Phosphoserine By similarity
	Modified residue	384	1	Phosphoserine By similarity
	Glycosylation	7	1	N-linked (GlcNAc...) Potential
	Disulfide bond	92 ↔ 170		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q95KZ0 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 2074ACAE9CBF87D0	FASTA	490	53,304
	10 20 30 40 50 60 MSTPGVNASA SLSPDRLNSP VTIPAVMFIF GVVGNLVAIV VLCKSRKEQK ETTFYTLVCG 70 80 90 100 110 120 LAVTDLLGTL LVSPVTIATY MKGQWPGGQP LCEYSTFILL FFSLSGLSII CAMSVERYLA 130 140 150 160 170 180 INHAYFYSHY VDKRLAGLTL FAVYASNVLF CALPNMGLGS SRLQYPDTWC FIDWTTNVTA 190 200 210 220 230 240 HAAYSYMYAG FSSFLILATV LCNVLVCGAL LRMHRQFMRR TSLGTEQHHA AAAAVTSVAS 250 260 270 280 290 300 RGHPAASPAL PRLSDFRRRR SFRRIAGAEI QMVILLIATS LVVLICSIPL VVRVFVNQLY 310 320 330 340 350 360 QPSLEREVSK NPDLQAIRIA SVNPILDPWI YILLRKTVLS KAIEKIKCLF CRIGGSRRER 370 380 390 400 410 420 SGQHCSDSQR TSSAMSGHSR SFISRELKEI SSTSQTLLPD LSLPDLSENG LGGRNLLPGV 430 440 450 460 470 480 PGMGLAQEDT TSLRTLRISE TSDSSQGQDS ESVLLVDEAG GSGRAGPAPK GSSLQVTFPS 490 ETLNLSEKCI

References

[1]	"Pan troglodytes prostaglandin E2 subtype EP4 receptor." Smock S.L., Castleberry T.A., Lu B., Owen T.A. Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY052641 mRNA. Translation: AAL15039.1.
RefSeq	NP_001009078.1. NM_001009078.1.
UniGene	Ptr.6406.
3D structure databases
ProteinModelPortal	Q95KZ0.
ModBase	Search...
Protein-protein interaction databases
STRING	9598.ENSPTRP00000028838.
Protein family/group databases
GPCRDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSPTRT00000031222; ENSPTRP00000028838; ENSPTRG00000016819.
GeneID	450195.
KEGG	ptr:450195.
Organism-specific databases
CTD	5734.
Phylogenomic databases
eggNOG	NOG295140.
GeneTree	ENSGT00690000101953.
HOGENOM	HOG000251595.
HOVERGEN	HBG053556.
InParanoid	Q95KZ0.
KO	K04261.
OMA	HCSDSRR.
OrthoDB	EOG495ZS1.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR001758. Prost_EP4_rcpt. IPR008365. Prostanoid_rcpt. IPR001244. Prostglndn_DP_rcpt. [Graphical view]
PANTHER	PTHR11866. PTHR11866. 1 hit. PTHR11866:SF6. PTHR11866:SF6. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00428. PROSTAGLNDNR. PR01788. PROSTANOIDR. PR00586. PRSTNOIDEP4R.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20833154.

Entry information

Entry name

PE2R4_PANTR

Accession

Primary (citable) accession number: Q95KZ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 21, 2003
Last sequence update:	December 1, 2001
Last modified:	April 3, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program