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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

Gene

NDUFA13

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) cell death pathway. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes (By similarity).By similarity

GO - Molecular functioni

  • NADH dehydrogenase (ubiquinone) activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.
R-BTA-6799198. Complex I biogenesis.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
Alternative name(s):
Cell death regulatory protein GRIM-19
Complex I-B16.6
Short name:
CI-B16.6
Gene associated with retinoic-interferon-induced mortality 19 protein
Short name:
GRIM-19
NADH-ubiquinone oxidoreductase B16.6 subunit
Gene namesi
Name:NDUFA13
Synonyms:GRIM19
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei30 – 51HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: Ensembl
  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial respiratory chain Source: UniProtKB
  • mitochondrial respiratory chain complex I Source: UniProtKB
  • mitochondrion Source: UniProtKB
  • nucleoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001188032 – 144NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13Add BLAST143

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ95KV7.
PRIDEiQ95KV7.

Expressioni

Gene expression databases

BgeeiENSBTAG00000007812.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits. Interacts with CARD15, but not with CARD4. Interacts with STAT3, but not with STAT1, STAT2 and STAT5A. Interacts with OLFM4 (By similarity).By similarity1 Publication

Protein-protein interaction databases

IntActiQ95KV7. 2 interactors.
STRINGi9913.ENSBTAP00000010276.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LC5electron microscopy4.35Z32-100[»]
5LDWelectron microscopy4.27Z32-100[»]
5LDXelectron microscopy5.60Z32-100[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFA13 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3300. Eukaryota.
ENOG4111KIB. LUCA.
GeneTreeiENSGT00390000000719.
HOGENOMiHOG000195836.
HOVERGENiHBG019074.
InParanoidiQ95KV7.
KOiK11353.
OMAiVFHTDRW.
OrthoDBiEOG091G0MHM.
TreeFamiTF315182.

Family and domain databases

InterProiIPR009346. GRIM-19.
[Graphical view]
PANTHERiPTHR12966. PTHR12966. 1 hit.
PfamiPF06212. GRIM-19. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q95KV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASKVKQDM PPVGGYGPID YKRNLPRRGL SGYSMFAVGI GALLFGYWSM
60 70 80 90 100
MKWNRERRRL QIEDFEARIA LMPLLQAEKD RRVLQMLREN LEEEATVMKD
110 120 130 140
VPGWKVGESV FHTTRWVTPM MGELYGLRAS EEVLSATYGF IWYT
Length:144
Mass (Da):16,673
Last modified:January 23, 2007 - v3
Checksum:i9AA885FFA4748347
GO

Mass spectrometryi

Molecular mass is 16585 Da from positions 2 - 144. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ316011 mRNA. Translation: CAC87049.1.
BC102406 mRNA. Translation: AAI02407.1.
RefSeqiNP_788845.1. NM_176672.2.
UniGeneiBt.49187.

Genome annotation databases

EnsembliENSBTAT00000010276; ENSBTAP00000010276; ENSBTAG00000007812.
GeneIDi338084.
KEGGibta:338084.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ316011 mRNA. Translation: CAC87049.1.
BC102406 mRNA. Translation: AAI02407.1.
RefSeqiNP_788845.1. NM_176672.2.
UniGeneiBt.49187.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LC5electron microscopy4.35Z32-100[»]
5LDWelectron microscopy4.27Z32-100[»]
5LDXelectron microscopy5.60Z32-100[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ95KV7. 2 interactors.
STRINGi9913.ENSBTAP00000010276.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Proteomic databases

PaxDbiQ95KV7.
PRIDEiQ95KV7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000010276; ENSBTAP00000010276; ENSBTAG00000007812.
GeneIDi338084.
KEGGibta:338084.

Organism-specific databases

CTDi51079.

Phylogenomic databases

eggNOGiKOG3300. Eukaryota.
ENOG4111KIB. LUCA.
GeneTreeiENSGT00390000000719.
HOGENOMiHOG000195836.
HOVERGENiHBG019074.
InParanoidiQ95KV7.
KOiK11353.
OMAiVFHTDRW.
OrthoDBiEOG091G0MHM.
TreeFamiTF315182.

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.
R-BTA-6799198. Complex I biogenesis.

Gene expression databases

BgeeiENSBTAG00000007812.

Family and domain databases

InterProiIPR009346. GRIM-19.
[Graphical view]
PANTHERiPTHR12966. PTHR12966. 1 hit.
PfamiPF06212. GRIM-19. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNDUAD_BOVIN
AccessioniPrimary (citable) accession number: Q95KV7
Secondary accession number(s): Q3T0G4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.