Q95KP4 (Q95KP4_HORSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Pancreatic lipase-related protein type 2 EMBL AAK38605.1

Gene names

Name:

PLRP2 EMBL AAK38605.1

Organism

Equus caballus (Horse) EMBL AAK38605.1

Taxonomic identifier

9796 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus

Protein attributes

Sequence length	452 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the AB hydrolase superfamily. Lipase family. RuleBase RU004262

Ontologies

Keywords
Cellular component	Secreted SAAS SAAS016272
Ligand	Calcium PDB 1W52 Metal-binding PDB 1W52
Molecular function	Hydrolase RuleBase RU004263
Technical term	3D-structure PDB 1W52
Gene Ontology (GO)
Biological process	lipid metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW triglyceride lipase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 452	›452	pancreatic lipase-related protein type 2 EMBL AAK38605.1		PRO_5000060254
Sites
	Metal binding	189	1	Calcium 1; via carbonyl oxygen PDB 1W52
	Metal binding	194	1	Calcium 1 PDB 1W52
	Metal binding	197	1	Calcium 1 PDB 1W52
	Metal binding	314	1	Calcium 2 PDB 1W52
Experimental info
	Non-terminal residue	1	1	EMBL AAK38605.1

Sequences

	Sequence		Length	Mass (Da)
	Q95KP4 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 386AFA5732D69AD9	FASTA	452	50,063
	10 20 30 40 50 60 KEVCYTPLGC FSDDKPWAGT LQRPLKSLPW SPEEVNTRFL LYTNKNPDSY QLITARDVAT 70 80 90 100 110 120 IKSSNFQSSR KTHFVIHGFR DRGEDSWPSD MCKKILQVET TNCISVDWSS GAKAEYTQAV 130 140 150 160 170 180 QNIRIVGAET AYLIQQLLTE LSYNPENVHI IGHSLGAHTA GEAGRRLEGR VGRVTGLDPA 190 200 210 220 230 240 EPCFQDASEE VRLDPSDAQF VDVIHTDASP MLPSLGFGMS QKVGHMDFFP NGGKQMPGCK 250 260 270 280 290 300 RSSFSTFIDI NGIWQGAQDY LACNHLKSFE YYSSSILNPD GFLAYPCDSY DKFQENGCFP 310 320 330 340 350 360 CPAGGCPKMG HYADQYKEKT SAVEQTFFLN TGESGDYTSW RYRVSITLAG SGKANGYLKV 370 380 390 400 410 420 TLRGSNGNSK QYEIFKGSLQ PDSSYTLDVD VNFIIGKIQE VKFVWNKTVL NLSKPQLGAS 430 440 450 RITVQSGADG TEYKFCGSGT VQDNVEQSLY PC

References

[1]	"High expression in adult horse of PLRP2 displaying a low phospholipase activity." Jayne S., Kerfelec B., Foglizzo E., Chapus C., Crenon I. Biochim. Biophys. Acta 1594:255-265(2002) [PubMed: 11904221] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Crystallization of a proteolyzed form of the horse pancreatic lipase-related protein 2: structural basis for the specific detergent requirement." Mancheno J.M., Jayne S., Kerfelec B., Chapus C., Crenon I., Hermoso J.A. Acta Crystallogr. D Biol. Crystallogr. 60:2107-2109(2004) [PubMed: 15502342] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.99 ANGSTROMS) IN COMPLEX WITH CALCIUM.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF359386 mRNA. Translation: AAK38605.1.

UniGene

Eca.12952.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1W52	X-ray	2.99	X	1-452	[»]

ProteinModelPortal

Q95KP4.

ModBase

Search...

Protein-protein interaction databases

STRING

Q95KP4.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Phylogenomic databases

GeneTree

ENSGT00560000076769.

HOVERGEN

HBG003243.

InParanoid

Q95KP4.

OrthoDB

EOG4WH8KM.

Family and domain databases

InterPro

IPR000734. Lipase.
IPR008976. Lipase_LipOase.
IPR013818. Lipase_N.
IPR002331. Lipase_panc.
IPR001024. LipOase_LH2.
IPR016272. Lipoprotein_lipase_LIPH.
[Graphical view]

Gene3D

G3DSA:2.60.60.20. Lipase_LipOase. 1 hit.

PANTHER

PTHR11610. Lipase. 1 hit.
PTHR11610:SF8. Lipase_panc. 1 hit.

Pfam

PF00151. Lipase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]

PIRSF

PIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.

PRINTS

PR00823. PANCLIPASE.
PR00821. TAGLIPASE.

SMART

SM00308. LH2. 1 hit.
[Graphical view]

SUPFAM

SSF49723. Lipase_LipOase. 1 hit.

PROSITE

PS50095. PLAT. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Q95KP4_HORSE

Accession

Primary (citable) accession number: Q95KP4

Entry history

Integrated into UniProtKB/TrEMBL:	December 1, 2001
Last sequence update:	December 1, 2001
Last modified:	January 25, 2012
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)