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Protein

Modulator of apoptosis 1

Gene

MOAP1

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Modulator of apoptosis 1
Short name:
MAP-1
Gene namesi
Name:MOAP1
ORF Names:QtrA-11392
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001552061 – 351Modulator of apoptosis 1Add BLAST351

Post-translational modificationi

Ubiquitinated and degraded during mitotic exit by APC/C-Cdh1, this modification is inhibited by TRIM39.By similarity

Keywords - PTMi

Ubl conjugation

Interactioni

Subunit structurei

Homodimer. Under normal circumstances, held in an inactive conformation by an intramolecular interaction. Binding to RASSF1 isoform A (RASSF1A) relieves this inhibitory interaction and allows further binding to BAX. Binds also to BCL2 and BCLX. Recruited to the TNFRSF1A and TNFRSF10A complexes in response to their respective cognate ligand, after internalization (By similarity). Interacts with TRIM39 (By similarity). Interacts with RASSF6 (By similarity).By similarity

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni120 – 127BH3-like8
Regioni202 – 205RASSF1-bindingBy similarity4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi336 – 339Poly-Glu4

Domaini

The BH3-like domain is required for association with BAX and for mediating apoptosis. The three BH domains (BH1, BH2, and BH3) of BAX are all required for mediating protein-protein interaction (By similarity).By similarity

Sequence similaritiesi

Belongs to the PNMA family.Curated

Phylogenomic databases

HOVERGENiHBG052488.

Family and domain databases

InterProiView protein in InterPro
IPR026523. PNMA.
PANTHERiPTHR23095. PTHR23095. 1 hit.
PfamiView protein in Pfam
PF14893. PNMA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q95KI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLRLLEDWC RGMDMNPRKA LLIAGISQSC SVAEIEEALQ AGLAPLGEYR
60 70 80 90 100
LLGRMFRRDE NRKVALVGLT AETSHALVPK EIPGKGGIWR VIFKPPDSDN
110 120 130 140 150
TFLSRLNEFL AGEGMTVGEL TRALAHENGS LDLEQGMIPE MWAPMLAQAL
160 170 180 190 200
EALQPALQCL KYKKLRVFSG REPPEPGEEE FGRWMFHTTQ MIKAWQVPDV
210 220 230 240 250
EKRRRLLESL RGPALDVIRV LKINNPLITV DECLQALEEV FGVTDNPREL
260 270 280 290 300
QVKYLTTYQK DEEKLSAYVL RLEPLLQKLV QRGAIERDAV NQARLDQVIA
310 320 330 340 350
GAVHKTIRRE LNLPEDGPAP GFLQLLVLIK DYEAAEEEEA LLQEVLEGHF

T
Length:351
Mass (Da):39,624
Last modified:December 1, 2001 - v1
Checksum:iC7530E4496A6FFB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB060854 mRNA. Translation: BAB46873.1.
RefSeqiNP_001274595.1. NM_001287666.1.
UniGeneiMfa.13703.

Genome annotation databases

GeneIDi102133169.
KEGGimcf:102133169.

Similar proteinsi

Entry informationi

Entry nameiMOAP1_MACFA
AccessioniPrimary (citable) accession number: Q95KI4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: December 1, 2001
Last modified: October 1, 2014
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families