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Q95KC9 (PCYOX_MACFA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Prenylcysteine oxidase

EC=1.8.3.5
Gene names
Name:PCYOX1
ORF Names:QmoA-10162
OrganismMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifier9541 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length505 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the degradation of prenylated proteins. Cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine By similarity.

Catalytic activity

An S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2.

Cofactor

FAD By similarity.

Subcellular location

Lysosome By similarity.

Sequence similarities

Belongs to the prenylcysteine oxidase family.

Ontologies

Keywords
   Cellular componentLysosome
   DomainSignal
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   PTMGlycoprotein
Isopeptide bond
Ubl conjugation
Gene Ontology (GO)
   Biological_processprenylcysteine catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentlysosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprenylcysteine oxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Chain28 – 505478Prenylcysteine oxidase
PRO_0000023299

Amino acid modifications

Glycosylation1961N-linked (GlcNAc...) Potential
Glycosylation3231N-linked (GlcNAc...) Potential
Glycosylation3531N-linked (GlcNAc...) Potential
Cross-link162Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q95KC9 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 9CC9A113FA132897

FASTA50556,517
        10         20         30         40         50         60 
MGRAVAELVS SLLGLWLLLC SCGCPEGAEL RAPPDKIAVI GAGIGGTSAA YYLRQKFGKD 

        70         80         90        100        110        120 
VKIDLFEREE VGGRLATMMV QGQEYEAGGS VIHPLNLHMK RFVKDLGLST VQASGGLLGI 

       130        140        150        160        170        180 
YNGEALVFEE SNWFIINVIK LVWRYGFQSL RMHMWVEDVL DKFMRIYRYQ SHDYAFSSVE 

       190        200        210        220        230        240 
KLLHALGGDD FLGMLNRTLL ETLQKAGFSE KFLNEMIAPV MRVDYGQSTD INAFVGAVSL 

       250        260        270        280        290        300 
SCSDSGLWAV EGGNKLVCSG LLQASKSNLI SGSVMYIEEK TKTKHTGNPT KMYEVVYQIG 

       310        320        330        340        350        360 
TETHSDFYDI VLVATPLNRK MSNITFLNFD PPIEEFHQYY QHIVTTLVKG ELNTSIFSSR 

       370        380        390        400        410        420 
PIDKFGLSTV LTTDNSDLFI NSIGIVSSVR EKEDPEPSTD GTYVWKIFSQ ETLTKAQILK 

       430        440        450        460        470        480 
LFLSYDYAVK KPWLAYPHYK PPEKCPSIIL HDRLYYLNGI ECAASAMEMS AIAAHNAALL 

       490        500 
AYHRWNGHTD MIDQDGLYEK LKTEL 

« Hide

References

[1]"Isolation of full-length cDNA clones from macaque brain cDNA libraries."
Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K., Suzuki Y., Sugano S., Hashimoto K.
Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Medulla oblongata.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB062961 mRNA. Translation: BAB60740.1.

3D structure databases

ProteinModelPortalQ95KC9.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ95KC9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG053532.

Family and domain databases

InterProIPR010795. Prenylcys_lyase.
IPR017046. Prenylcysteine_Oxase.
[Graphical view]
PfamPF07156. Prenylcys_lyase. 1 hit.
[Graphical view]
PIRSFPIRSF036292. Prenylcysteine_oxidase. 1 hit.
ProtoNetSearch...

Entry information

Entry namePCYOX_MACFA
AccessionPrimary (citable) accession number: Q95KC9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: December 1, 2001
Last modified: January 22, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families