ID   VWC2L_MACFA             Reviewed;         138 AA.
AC   Q95K75;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   24-JAN-2024, entry version 56.
DE   RecName: Full=von Willebrand factor C domain-containing protein 2-like;
DE   Flags: Precursor;
GN   Name=VWC2L; Synonyms=QtrA-13554;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Temporal cortex;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K.,
RA   Suzuki Y., Sugano S., Hashimoto K.;
RT   "Isolation of full-length cDNA clones from macaque brain cDNA libraries.";
RL   Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in neurogenesis. May play a role in bone
CC       differentiation and matrix mineralization. {ECO:0000250}.
CC   -!- SUBUNIT: Peripherally associated with AMPAR complex. AMPAR complex
CC       consists of an inner core made of 4 pore-forming GluA/GRIA proteins
CC       (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged
CC       in a twofold symmetry. One of the two pairs of distinct binding sites
CC       is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors
CC       CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR
CC       complex is complemented by outer core constituents binding directly to
CC       the GluA/GRIA proteins at sites distinct from the interaction sites of
CC       the inner core constituents. Outer core constituents include at least
CC       PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the
CC       inner and outer core serve as a platform for other, more peripherally
CC       associated AMPAR constituents, including VWC2L. Alone or in
CC       combination, these auxiliary subunits control the gating and
CC       pharmacology of the AMPAR complex and profoundly impact their
CC       biogenesis and protein processing (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Synapse {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB063096; BAB60802.1; -; mRNA.
DR   AlphaFoldDB; Q95K75; -.
DR   STRING; 9541.ENSMFAP00000009893; -.
DR   eggNOG; ENOG502RAAU; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR   InterPro; IPR042979; VWC2/VWC2L.
DR   PANTHER; PTHR46252; BRORIN FAMILY MEMBER; 1.
DR   PANTHER; PTHR46252:SF2; VON WILLEBRAND FACTOR C DOMAIN-CONTAINING PROTEIN 2-LIKE; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Reference proteome; Secreted; Signal; Synapse.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..138
FT                   /note="von Willebrand factor C domain-containing protein 2-
FT                   like"
FT                   /id="PRO_0000348061"
FT   DOMAIN          51..110
FT                   /note="VWFC"
SQ   SEQUENCE   138 AA;  15382 MW;  A6F3AB068821A555 CRC64;
     MALHIHEACI LLLVIPGLVT SAAISHEDYP ADEGDQISSN DNLIFDDYRG KGCVDDSGFV
     YKLGERFFPG HSNCPCVCAL DGPVCDQPEC PKIHPKCTKV EHNGCCPECK EVKNFCEYHG
     KNYKILEEFK VCVTLHTY
//