Reviewed,
UniProtKB/Swiss-Prot Q95JH5 (AK1C4_MACFA)
Last modified
June 16, 2009.
Version 40.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Aldo-keto reductase family 1 member C4 EC=1.1.1.- Alternative name(s): Chlordecone reductase Short name=CDR EC=1.1.1.225 3-alpha-hydroxysteroid dehydrogenase type I EC=1.1.1.50 3-alpha-HSD1 Dihydrodiol dehydrogenase 4 Short name=DD-4 Short name=DD4 | ||
| Gene names |
| ||
| Organism | Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) | ||
| Taxonomic identifier | 9541 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca |
Protein attributes
| Sequence length | 323 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route. |
| Catalytic activity | Chlordecone alcohol + NADP+ = chlordecone + NADPH. Androsterone + NAD(P)+ = 5-alpha-androstane-3,17-dione + NAD(P)H. |
| Subunit structure | Monomer By similarity. |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the aldo/keto reductase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| PTM | Phosphoprotein |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | 3-alpha-hydroxysteroid dehydrogenase (B-specific) activity Inferred from electronic annotation. Source: EC chlordecone reductase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 323 | 323 | Aldo-keto reductase family 1 member C4 | PRO_0000124641 | |||||
Regions | |||||||||
| Nucleotide binding | 13 – 22 | 10 | NADP Potential | ||||||
| Nucleotide binding | 217 – 280 | 64 | NADP By similarity | ||||||
Sites | |||||||||
| Active site | 55 | 1 | Proton donor By similarity | ||||||
| Binding site | 117 | 1 | Substrate By similarity | ||||||
| Site | 54 | 1 | Important for substrate specificity By similarity | ||||||
| Site | 84 | 1 | Lowers pKa of active site Tyr By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 196 | 1 | Phosphotyrosine By similarity | ||||||
Sequences
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References
| [1] | "Molecular characterization of two monkey dihydrodiol dehydrogenases." Higaki Y., Kamiya T., Usami N., Shintani S., Shiraishi H., Ishikura S., Yamamoto I., Hara A. Drug Metab. Pharmacokinet. 17:348-356(2002) [PubMed: 15618685] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-23; 69-116; 137-153; 184-246 AND 250-323. Tissue: Liver. |
Cross-references
Sequence databases | |
|---|---|
| AB070211 mRNA. Translation: BAB63208.1. | |
3D structure databases | |
| HSSP | HSSP built from PDB template 1MRQ based on UniProtKB Q04828. |
| SMR | Q95JH5. Positions 1-323. |
| ModBase | Search... |
Phylogenomic databases | |
| HOVERGEN | Q95JH5. |
Enzyme and pathway databases | |
| BRENDA | 1.1.1.225. 3438. 1.1.1.50. 3438. 1.3.1.20. 3438. |
Family and domain databases | |
| InterPro | IPR001395. Aldo/ket_red. IPR018170. Aldo/ket_reductase_CS. [Graphical view] |
| Gene3D | G3DSA:3.20.20.100. Aldo/ket_red. 1 hit. |
| PANTHER | PTHR11732. Aldo/ket_red. 1 hit. |
| Pfam | PF00248. Aldo_ket_red. 1 hit. [Graphical view] |
| ProDom | PD000288. Aldo/ket_red. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| PROSITE | PS00798. ALDOKETO_REDUCTASE_1. 1 hit. PS00062. ALDOKETO_REDUCTASE_2. 1 hit. PS00063. ALDOKETO_REDUCTASE_3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | AK1C4_MACFA | ||||||||
| Accession | Primary (citable) accession number: Q95JH5 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

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