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Protein

Arginase-1

Gene

ARG1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-arginine + H2O = L-ornithine + urea.By similarity

Cofactori

Mn2+PROSITE-ProRule annotationNote: Binds 2 manganese ions per subunit.PROSITE-ProRule annotation

Pathwayi: urea cycle

This protein is involved in step 1 of the subpathway that synthesizes L-ornithine and urea from L-arginine.By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Arginase (ARG2), Arginase-1 (ARG1)
This subpathway is part of the pathway urea cycle, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-ornithine and urea from L-arginine, the pathway urea cycle and in Nitrogen metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi101 – 1011Manganese 1PROSITE-ProRule annotation
Metal bindingi124 – 1241Manganese 1PROSITE-ProRule annotation
Metal bindingi124 – 1241Manganese 2PROSITE-ProRule annotation
Metal bindingi126 – 1261Manganese 2PROSITE-ProRule annotation
Metal bindingi128 – 1281Manganese 1PROSITE-ProRule annotation
Binding sitei183 – 1831SubstrateBy similarity
Metal bindingi232 – 2321Manganese 1PROSITE-ProRule annotation
Metal bindingi232 – 2321Manganese 2PROSITE-ProRule annotation
Metal bindingi234 – 2341Manganese 2PROSITE-ProRule annotation
Binding sitei246 – 2461SubstrateBy similarity
Binding sitei277 – 2771SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Arginine metabolism, Urea cycle

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-SSC-70635. Urea cycle.
SABIO-RKQ95JC8.
UniPathwayiUPA00158; UER00270.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginase-1 (EC:3.5.3.1By similarity)
Alternative name(s):
Liver-type arginase
Type I arginase
Gene namesi
Name:ARG1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322Arginase-1PRO_0000173695Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei7 – 71PhosphoserineBy similarity
Modified residuei17 – 171N6-succinyllysineBy similarity
Modified residuei72 – 721PhosphoserineBy similarity
Modified residuei75 – 751N6-succinyllysineBy similarity
Modified residuei163 – 1631PhosphoserineBy similarity
Modified residuei217 – 2171PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ95JC8.
PeptideAtlasiQ95JC8.

Expressioni

Gene expression databases

BgeeiENSSSCG00000004195.
GenevisibleiQ95JC8. SS.

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000004530.

Structurei

3D structure databases

ProteinModelPortaliQ95JC8.
SMRiQ95JC8. Positions 5-318.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni126 – 1305Substrate bindingBy similarity
Regioni137 – 1393Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the arginase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2965. Eukaryota.
COG0010. LUCA.
GeneTreeiENSGT00530000063082.
HOVERGENiHBG003030.
InParanoidiQ95JC8.
KOiK01476.
OMAiEQECDVK.
OrthoDBiEOG091G0A38.
TreeFamiTF300034.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
InterProiIPR014033. Arginase.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
PRINTSiPR00116. ARGINASE.
TIGRFAMsiTIGR01229. rocF_arginase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q95JC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFKSQSIGI IGAPFSKGQP RGGVEEGPTA LRKAGLLEKL KEQECDVKDY
60 70 80 90 100
GDLCFADVPN DTPFQIVKNP RSVGKANQQL ADVVAEIKKN GRTSLVLGGD
110 120 130 140 150
HSMAIGSISG HARVHPDLCV IWVDAHTDIN TPLTTTTGNL HGQPVSFLLK
160 170 180 190 200
ELKEKIPEVP GLSWVTPCLS AKDIVYIGLR DVDPAEHYIL KTLGIKYFSM
210 220 230 240 250
IEVDKLGIGK VMEEAFSYLL GRKKRPIHLS FDVDGLDPFF TPATGTPVHG
260 270 280 290 300
GLSYREGIYI TEEIYKTGLL SGLDIMEVNP SLGKTPEEVT RTVNTAVALV
310 320
LACFGVAREG NHKPIDYLKP PK
Length:322
Mass (Da):35,018
Last modified:December 1, 2001 - v1
Checksum:iD99FB071CE916B2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY039112 mRNA. Translation: AAK91874.1.
RefSeqiNP_999213.1. NM_214048.2.
XP_005659247.1. XM_005659190.2.
UniGeneiSsc.81816.

Genome annotation databases

EnsembliENSSSCT00000004636; ENSSSCP00000004530; ENSSSCG00000004195.
GeneIDi397115.
KEGGissc:397115.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY039112 mRNA. Translation: AAK91874.1.
RefSeqiNP_999213.1. NM_214048.2.
XP_005659247.1. XM_005659190.2.
UniGeneiSsc.81816.

3D structure databases

ProteinModelPortaliQ95JC8.
SMRiQ95JC8. Positions 5-318.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000004530.

Proteomic databases

PaxDbiQ95JC8.
PeptideAtlasiQ95JC8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000004636; ENSSSCP00000004530; ENSSSCG00000004195.
GeneIDi397115.
KEGGissc:397115.

Organism-specific databases

CTDi383.

Phylogenomic databases

eggNOGiKOG2965. Eukaryota.
COG0010. LUCA.
GeneTreeiENSGT00530000063082.
HOVERGENiHBG003030.
InParanoidiQ95JC8.
KOiK01476.
OMAiEQECDVK.
OrthoDBiEOG091G0A38.
TreeFamiTF300034.

Enzyme and pathway databases

UniPathwayiUPA00158; UER00270.
ReactomeiR-SSC-70635. Urea cycle.
SABIO-RKQ95JC8.

Gene expression databases

BgeeiENSSSCG00000004195.
GenevisibleiQ95JC8. SS.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
InterProiIPR014033. Arginase.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
PRINTSiPR00116. ARGINASE.
TIGRFAMsiTIGR01229. rocF_arginase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARGI1_PIG
AccessioniPrimary (citable) accession number: Q95JC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.