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Q95JC8 (ARGI1_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Arginase-1
EC=3.5.3.1
Alternative name(s):
Liver-type arginase
Type I arginase
Gene names
Name:ARG1
OrganismSus scrofa (Pig) [Complete proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length322 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

L-arginine + H2O = L-ornithine + urea.

Cofactor

Binds 2 manganese ions per subunit By similarity.

Pathway

Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.

Subunit structure

Homotrimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the arginase family.

Ontologies

Keywords
   Biological processArginine metabolism
Urea cycle
   Cellular componentCytoplasm
   LigandManganese
Metal-binding
   Molecular functionHydrolase
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

urea cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionarginase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 322322Arginase-1
PRO_0000173695

Regions

Region126 – 1305Substrate binding By similarity
Region137 – 1393Substrate binding By similarity

Sites

Metal binding1011Manganese 1 By similarity
Metal binding1241Manganese 1 By similarity
Metal binding1241Manganese 2 By similarity
Metal binding1261Manganese 2 By similarity
Metal binding1281Manganese 1 By similarity
Metal binding2321Manganese 1 By similarity
Metal binding2321Manganese 2 By similarity
Metal binding2341Manganese 2 By similarity
Binding site1831Substrate By similarity

Amino acid modifications

Modified residue2301Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q95JC8 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: D99FB071CE916B2F

FASTA32235,018
        10         20         30         40         50         60 
MSFKSQSIGI IGAPFSKGQP RGGVEEGPTA LRKAGLLEKL KEQECDVKDY GDLCFADVPN 

        70         80         90        100        110        120 
DTPFQIVKNP RSVGKANQQL ADVVAEIKKN GRTSLVLGGD HSMAIGSISG HARVHPDLCV 

       130        140        150        160        170        180 
IWVDAHTDIN TPLTTTTGNL HGQPVSFLLK ELKEKIPEVP GLSWVTPCLS AKDIVYIGLR 

       190        200        210        220        230        240 
DVDPAEHYIL KTLGIKYFSM IEVDKLGIGK VMEEAFSYLL GRKKRPIHLS FDVDGLDPFF 

       250        260        270        280        290        300 
TPATGTPVHG GLSYREGIYI TEEIYKTGLL SGLDIMEVNP SLGKTPEEVT RTVNTAVALV 

       310        320 
LACFGVAREG NHKPIDYLKP PK

« Hide

References

[1]"Sequence of pig arginase I."
Kepka-Lenhart D., Morris S.M. Jr.
Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY039112 mRNA. Translation: AAK91874.1.
RefSeqNP_999213.1. NM_214048.2.
UniGeneSsc.81816.

3D structure databases

ProteinModelPortalQ95JC8.
SMRQ95JC8. Positions 5-318.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ95JC8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID397115.
KEGGssc:397115.

Organism-specific databases

CTD383.

Phylogenomic databases

HOVERGENHBG003030.

Family and domain databases

InterProIPR014033. Arginase_subgr.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
Gene3DG3DSA:3.40.800.10. Ureohydrolase. 1 hit.
KOK01476.
PANTHERPTHR11358:SF2. Arginase_sub. 1 hit.
PTHR11358. Ureohydrolase. 1 hit.
PfamPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFPIRSF036979. Arginase. 1 hit.
PRINTSPR00116. ARGINASE.
TIGRFAMsTIGR01229. RocF_arginase. 1 hit.
PROSITEPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARGI1_PIG
AccessionPrimary (citable) accession number: Q95JC8
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: December 1, 2001
Last modified: November 16, 2011
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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