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Protein

Arginase-1

Gene

ARG1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-arginine + H2O = L-ornithine + urea.By similarity

Cofactori

Mn2+PROSITE-ProRule annotationNote: Binds 2 manganese ions per subunit.PROSITE-ProRule annotation

Pathwayi: urea cycle

This protein is involved in step 1 of the subpathway that synthesizes L-ornithine and urea from L-arginine.By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Arginase (ARG2), Arginase-1 (ARG1), Arginase (ARG2)
This subpathway is part of the pathway urea cycle, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-ornithine and urea from L-arginine, the pathway urea cycle and in Nitrogen metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi101Manganese 1PROSITE-ProRule annotation1
Metal bindingi124Manganese 1PROSITE-ProRule annotation1
Metal bindingi124Manganese 2PROSITE-ProRule annotation1
Metal bindingi126Manganese 2PROSITE-ProRule annotation1
Metal bindingi128Manganese 1PROSITE-ProRule annotation1
Binding sitei183SubstrateBy similarity1
Metal bindingi232Manganese 1PROSITE-ProRule annotation1
Metal bindingi232Manganese 2PROSITE-ProRule annotation1
Metal bindingi234Manganese 2PROSITE-ProRule annotation1
Binding sitei246SubstrateBy similarity1
Binding sitei277SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processArginine metabolism, Urea cycle
LigandManganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-SSC-6798695 Neutrophil degranulation
R-SSC-70635 Urea cycle
SABIO-RKiQ95JC8
UniPathwayiUPA00158; UER00270

Names & Taxonomyi

Protein namesi
Recommended name:
Arginase-1 (EC:3.5.3.1By similarity)
Alternative name(s):
Liver-type arginase
Type I arginase
Gene namesi
Name:ARG1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001736951 – 322Arginase-1Add BLAST322

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7PhosphoserineBy similarity1
Modified residuei17N6-succinyllysineBy similarity1
Modified residuei72PhosphoserineBy similarity1
Modified residuei75N6-succinyllysineBy similarity1
Modified residuei163PhosphoserineBy similarity1
Modified residuei217PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ95JC8
PeptideAtlasiQ95JC8
PRIDEiQ95JC8

Expressioni

Gene expression databases

BgeeiENSSSCG00000004195
ExpressionAtlasiQ95JC8 baseline and differential
GenevisibleiQ95JC8 SS

Interactioni

Subunit structurei

Homotrimer (By similarity). Interacts with CMTM6 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000004530

Structurei

3D structure databases

ProteinModelPortaliQ95JC8
SMRiQ95JC8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni126 – 130Substrate bindingBy similarity5
Regioni137 – 139Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the arginase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2965 Eukaryota
COG0010 LUCA
GeneTreeiENSGT00530000063082
HOVERGENiHBG003030
InParanoidiQ95JC8
KOiK01476
OMAiEQECDVK
OrthoDBiEOG091G0A38
TreeFamiTF300034

Family and domain databases

InterProiView protein in InterPro
IPR014033 Arginase
IPR006035 Ureohydrolase
IPR023696 Ureohydrolase_dom_sf
IPR020855 Ureohydrolase_Mn_BS
PfamiView protein in Pfam
PF00491 Arginase, 1 hit
PIRSFiPIRSF036979 Arginase, 1 hit
PRINTSiPR00116 ARGINASE
SUPFAMiSSF52768 SSF52768, 1 hit
TIGRFAMsiTIGR01229 rocF_arginase, 1 hit
PROSITEiView protein in PROSITE
PS01053 ARGINASE_1, 1 hit
PS51409 ARGINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q95JC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFKSQSIGI IGAPFSKGQP RGGVEEGPTA LRKAGLLEKL KEQECDVKDY
60 70 80 90 100
GDLCFADVPN DTPFQIVKNP RSVGKANQQL ADVVAEIKKN GRTSLVLGGD
110 120 130 140 150
HSMAIGSISG HARVHPDLCV IWVDAHTDIN TPLTTTTGNL HGQPVSFLLK
160 170 180 190 200
ELKEKIPEVP GLSWVTPCLS AKDIVYIGLR DVDPAEHYIL KTLGIKYFSM
210 220 230 240 250
IEVDKLGIGK VMEEAFSYLL GRKKRPIHLS FDVDGLDPFF TPATGTPVHG
260 270 280 290 300
GLSYREGIYI TEEIYKTGLL SGLDIMEVNP SLGKTPEEVT RTVNTAVALV
310 320
LACFGVAREG NHKPIDYLKP PK
Length:322
Mass (Da):35,018
Last modified:December 1, 2001 - v1
Checksum:iD99FB071CE916B2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY039112 mRNA Translation: AAK91874.1
RefSeqiNP_999213.1, NM_214048.2
XP_005659247.1, XM_005659190.2
UniGeneiSsc.81816

Genome annotation databases

EnsembliENSSSCT00000004636; ENSSSCP00000004530; ENSSSCG00000004195
ENSSSCT00000035404; ENSSSCP00000029011; ENSSSCG00000004195
GeneIDi397115
KEGGissc:397115

Similar proteinsi

Entry informationi

Entry nameiARGI1_PIG
AccessioniPrimary (citable) accession number: Q95JC8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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