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Protein

Liver-expressed antimicrobial peptide 2

Gene

LEAP2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Has an antimicrobial activity.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Names & Taxonomyi

Protein namesi
Recommended name:
Liver-expressed antimicrobial peptide 2
Short name:
LEAP-2
Gene namesi
Name:LEAP2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Propeptidei23 – 3715Sequence analysisPRO_0000017351Add
BLAST
Chaini38 – 7740Liver-expressed antimicrobial peptide 2PRO_0000017352Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 ↔ 65By similarity
Disulfide bondi60 ↔ 70By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ95JC3.
PRIDEiQ95JC3.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025186.

Family & Domainsi

Sequence similaritiesi

Belongs to the LEAP2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J7PZ. Eukaryota.
ENOG410Y6EA. LUCA.
GeneTreeiENSGT00390000013467.
HOGENOMiHOG000037938.
HOVERGENiHBG052319.
InParanoidiQ95JC3.
OMAiMWHLKLL.
OrthoDBiEOG7673F2.
TreeFamiTF336274.

Family and domain databases

InterProiIPR009955. LEAP-2.
[Graphical view]
PANTHERiPTHR21007. PTHR21007. 1 hit.
PfamiPF07359. LEAP-2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q95JC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWHLKLFAVL MICLLLLAQV DGSPIPQQSS AKRRPRRMTP FWRAVSLRPI
60 70
GASCRDDSEC ITRLCRKRRC SLSVAQE
Length:77
Mass (Da):8,856
Last modified:December 1, 2001 - v1
Checksum:iBB70BB721F0B25B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ409014 mRNA. Translation: CAC51470.1.
BC108204 mRNA. Translation: AAI08205.1.
RefSeqiNP_776984.1. NM_174559.4.
UniGeneiBt.8954.

Genome annotation databases

EnsembliENSBTAT00000025186; ENSBTAP00000025186; ENSBTAG00000018926.
GeneIDi282270.
KEGGibta:282270.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ409014 mRNA. Translation: CAC51470.1.
BC108204 mRNA. Translation: AAI08205.1.
RefSeqiNP_776984.1. NM_174559.4.
UniGeneiBt.8954.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025186.

Proteomic databases

PaxDbiQ95JC3.
PRIDEiQ95JC3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000025186; ENSBTAP00000025186; ENSBTAG00000018926.
GeneIDi282270.
KEGGibta:282270.

Organism-specific databases

CTDi116842.

Phylogenomic databases

eggNOGiENOG410J7PZ. Eukaryota.
ENOG410Y6EA. LUCA.
GeneTreeiENSGT00390000013467.
HOGENOMiHOG000037938.
HOVERGENiHBG052319.
InParanoidiQ95JC3.
OMAiMWHLKLL.
OrthoDBiEOG7673F2.
TreeFamiTF336274.

Miscellaneous databases

NextBioi20806081.

Family and domain databases

InterProiIPR009955. LEAP-2.
[Graphical view]
PANTHERiPTHR21007. PTHR21007. 1 hit.
PfamiPF07359. LEAP-2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and biochemical characterization of LEAP-2, a novel blood peptide expressed in the liver."
    Krause A., Sillard R., Kleemeier B., Kluever E., Maronde E., Conejo-Garcia J.-R., Forssmann W.-G., Schulz-Knappe P., Nehls M.C., Wattler F., Wattler S., Adermann K.
    Protein Sci. 12:143-152(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Small intestine.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.

Entry informationi

Entry nameiLEAP2_BOVIN
AccessioniPrimary (citable) accession number: Q95JC3
Secondary accession number(s): Q32P98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: December 1, 2001
Last modified: November 11, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.