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Protein

Transcription factor GATA-6

Gene

GATA6

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional activator that regulates SEMA3C and PLXNA2. May regulate genes that protect epithelial cells from bacterial infection. Involved in gene regulation specifically in the gastric epithelium. Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri246 – 270GATA-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri300 – 324GATA-type 2PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor GATA-6
Alternative name(s):
GATA-binding factor 6
Gene namesi
Name:GATA6
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000083425‹1 – 451Transcription factor GATA-6Add BLAST›451

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei126PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ95JA5.
PRIDEiQ95JA5.

Interactioni

Subunit structurei

Interacts with LMCD1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000004009.

Structurei

3D structure databases

ProteinModelPortaliQ95JA5.
SMRiQ95JA5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi32 – 42Poly-AlaAdd BLAST11
Compositional biasi183 – 189Poly-His7
Compositional biasi305 – 309Poly-Thr5

Domaini

The GATA-type zinc fingers mediate interaction with LMCD1.By similarity

Sequence similaritiesi

Contains 2 GATA-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri246 – 270GATA-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri300 – 324GATA-type 2PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1601. Eukaryota.
COG5641. LUCA.
HOGENOMiHOG000047700.
HOVERGENiHBG051703.
InParanoidiQ95JA5.
KOiK17897.

Family and domain databases

Gene3Di3.30.50.10. 2 hits.
InterProiIPR008013. GATA_N.
IPR016375. TF_GATA_4/5/6.
IPR028437. TF_GATA_6.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERiPTHR10071:SF23. PTHR10071:SF23. 1 hit.
PfamiPF00320. GATA. 2 hits.
PF05349. GATA-N. 1 hit.
[Graphical view]
PIRSFiPIRSF003028. TF_GATA_4/5/6. 1 hit.
PRINTSiPR00619. GATAZNFINGER.
SMARTiSM00401. ZnF_GATA. 2 hits.
[Graphical view]
PROSITEiPS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q95JA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
EQPEEMYQTL AALSSQGPAA YDGAPGGFVH SAAAAAAAAA AASSPVYVPT
60 70 80 90 100
TRVGSMLPGL PYLQGAGSGP ANHAGGAGSH PGWPQASADS PPYGSGGGTA
110 120 130 140 150
GGGAAGPGSA GSAAAHVSAR FPYSPSPPMA NGAARDPGGY AAAGGGGAGG
160 170 180 190 200
VSGGSGGGLA AMGSREHQYS SLSAARPLNG TYHHHHHHHP SAYSPYVGAP
210 220 230 240 250
LTPAWPAGPF ETPVLHSLQS RAGAPLPVPR GPSADLLEDL PESRECVNCG
260 270 280 290 300
SIQTPLWRRD GTGHYLCNRC GLYSKMNGLS GPLIKPQKPV PSSRRLGLSC
310 320 330 340 350
ANCHTTTTTL WRRNAEGEPV CNACGLYMKL HGVPRPLAMK KEGIQTRKRK
360 370 380 390 400
PKSINKSKAC SGNSNNSVPM TPTSTSSNSD DCSKNTSPTT QTPASGAGAS
410 420 430 440 450
VMSGTGESAN PENSELKYSG QDGLYIGVSL ASPAEVTSSV RQDSWCALAL

A
Length:451
Mass (Da):45,410
Last modified:November 25, 2008 - v2
Checksum:i95607C32BD837E03
GO

Sequence cautioni

The sequence AAL09304 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF295687 mRNA. Translation: AAL09304.1. Different initiation.
RefSeqiNP_999493.2. NM_214328.2.
UniGeneiSsc.2258.

Genome annotation databases

GeneIDi397600.
KEGGissc:397600.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF295687 mRNA. Translation: AAL09304.1. Different initiation.
RefSeqiNP_999493.2. NM_214328.2.
UniGeneiSsc.2258.

3D structure databases

ProteinModelPortaliQ95JA5.
SMRiQ95JA5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000004009.

Proteomic databases

PaxDbiQ95JA5.
PRIDEiQ95JA5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397600.
KEGGissc:397600.

Organism-specific databases

CTDi2627.

Phylogenomic databases

eggNOGiKOG1601. Eukaryota.
COG5641. LUCA.
HOGENOMiHOG000047700.
HOVERGENiHBG051703.
InParanoidiQ95JA5.
KOiK17897.

Family and domain databases

Gene3Di3.30.50.10. 2 hits.
InterProiIPR008013. GATA_N.
IPR016375. TF_GATA_4/5/6.
IPR028437. TF_GATA_6.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERiPTHR10071:SF23. PTHR10071:SF23. 1 hit.
PfamiPF00320. GATA. 2 hits.
PF05349. GATA-N. 1 hit.
[Graphical view]
PIRSFiPIRSF003028. TF_GATA_4/5/6. 1 hit.
PRINTSiPR00619. GATAZNFINGER.
SMARTiSM00401. ZnF_GATA. 2 hits.
[Graphical view]
PROSITEiPS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGATA6_PIG
AccessioniPrimary (citable) accession number: Q95JA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: November 25, 2008
Last modified: November 2, 2016
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.