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Protein

Transcription factor GATA-6

Gene

GATA6

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional activator that regulates SEMA3C and PLXNA2. May regulate genes that protect epithelial cells from bacterial infection. Involved in gene regulation specifically in the gastric epithelium. Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri246 – 270GATA-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri300 – 324GATA-type 2PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor GATA-6
Alternative name(s):
GATA-binding factor 6
Gene namesi
Name:GATA6
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000083425‹1 – 451Transcription factor GATA-6Add BLAST›451

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei126PhosphoserineBy similarity1
Cross-linki285Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki329Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki340Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ95JA5
PRIDEiQ95JA5

Interactioni

Subunit structurei

Interacts with LMCD1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000004009

Structurei

3D structure databases

SMRiQ95JA5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi32 – 42Poly-AlaAdd BLAST11
Compositional biasi183 – 189Poly-His7
Compositional biasi305 – 309Poly-Thr5

Domaini

The GATA-type zinc fingers mediate interaction with LMCD1.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri246 – 270GATA-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri300 – 324GATA-type 2PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1601 Eukaryota
COG5641 LUCA
HOGENOMiHOG000047700
HOVERGENiHBG051703
InParanoidiQ95JA5
KOiK17897

Family and domain databases

Gene3Di3.30.50.102 hits
InterProiView protein in InterPro
IPR008013 GATA_N
IPR016375 TF_GATA_4/5/6
IPR000679 Znf_GATA
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00320 GATA, 2 hits
PF05349 GATA-N, 1 hit
PIRSFiPIRSF003028 TF_GATA_4/5/6, 1 hit
PRINTSiPR00619 GATAZNFINGER
SMARTiView protein in SMART
SM00401 ZnF_GATA, 2 hits
PROSITEiView protein in PROSITE
PS00344 GATA_ZN_FINGER_1, 2 hits
PS50114 GATA_ZN_FINGER_2, 2 hits

Sequencei

Sequence statusi: Fragment.

Q95JA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
EQPEEMYQTL AALSSQGPAA YDGAPGGFVH SAAAAAAAAA AASSPVYVPT
60 70 80 90 100
TRVGSMLPGL PYLQGAGSGP ANHAGGAGSH PGWPQASADS PPYGSGGGTA
110 120 130 140 150
GGGAAGPGSA GSAAAHVSAR FPYSPSPPMA NGAARDPGGY AAAGGGGAGG
160 170 180 190 200
VSGGSGGGLA AMGSREHQYS SLSAARPLNG TYHHHHHHHP SAYSPYVGAP
210 220 230 240 250
LTPAWPAGPF ETPVLHSLQS RAGAPLPVPR GPSADLLEDL PESRECVNCG
260 270 280 290 300
SIQTPLWRRD GTGHYLCNRC GLYSKMNGLS GPLIKPQKPV PSSRRLGLSC
310 320 330 340 350
ANCHTTTTTL WRRNAEGEPV CNACGLYMKL HGVPRPLAMK KEGIQTRKRK
360 370 380 390 400
PKSINKSKAC SGNSNNSVPM TPTSTSSNSD DCSKNTSPTT QTPASGAGAS
410 420 430 440 450
VMSGTGESAN PENSELKYSG QDGLYIGVSL ASPAEVTSSV RQDSWCALAL

A
Length:451
Mass (Da):45,410
Last modified:November 25, 2008 - v2
Checksum:i95607C32BD837E03
GO

Sequence cautioni

The sequence AAL09304 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF295687 mRNA Translation: AAL09304.1 Different initiation.
RefSeqiNP_999493.2, NM_214328.2
UniGeneiSsc.2258

Genome annotation databases

GeneIDi397600
KEGGissc:397600

Similar proteinsi

Entry informationi

Entry nameiGATA6_PIG
AccessioniPrimary (citable) accession number: Q95JA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: November 25, 2008
Last modified: February 28, 2018
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome