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Protein

Interleukin-7

Gene

IL7

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokineUniRule annotation, Growth factorUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-7UniRule annotation
Short name:
IL-7UniRule annotation
Gene namesi
Name:IL7Imported
OrganismiMacaca mulatta (Rhesus macaque)Imported
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Chromosome 8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_501509959126 – 177Interleukin-7Sequence analysisAdd BLAST152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 166UniRule annotation
Disulfide bondi59 ↔ 154UniRule annotation
Disulfide bondi72 ↔ 117UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Interactioni

GO - Molecular functioni

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-7/IL-9 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

GeneTreeiENSGT00390000004451
HOVERGENiHBG004609
KOiK05431

Family and domain databases

Gene3Di1.20.1250.50, 1 hit
InterProiView protein in InterPro
IPR001181 IL-7
IPR000226 IL-7/IL-9_fam
IPR038325 IL7_sf
PANTHERiPTHR45542 PTHR45542, 1 hit
PfamiView protein in Pfam
PF01415 IL7, 1 hit
PIRSFiPIRSF001942 IL-7, 1 hit
PRINTSiPR00435 INTERLEUKIN7
SMARTiView protein in SMART
SM00127 IL7, 1 hit

Sequencei

Sequence statusi: Complete.

Q95J83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFHVSFRYIF GLPPLILVLL PVASSDCDIE GKDGKQYESV LMVSIDQLLD
60 70 80 90 100
SMKEIGSNCL NNEFNFFKRH LCDDNKEGMF LFRAARKLRQ FLKMNSTGDF
110 120 130 140 150
DLHLLKVSEG TTILLNCTGK VKGRKPAALG EPQPTKSLEE NKSLKEQKKL
160 170
NDSCFLKRLL QKIKTCWNKI LMGTKEH
Length:177
Mass (Da):20,230
Last modified:December 1, 2001 - v1
Checksum:i11D6717E8B633424
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JSUE03041800 Genomic DNA No translation available.
JSUE03041801 Genomic DNA No translation available.
AF401221 mRNA Translation: AAK83922.1
RefSeqiNP_001028018.1, NM_001032846.1
UniGeneiMmu.3574

Genome annotation databases

EnsembliENSMMUT00000063588; ENSMMUP00000053290; ENSMMUG00000001655
GeneIDi574168
KEGGimcc:574168

Similar proteinsi

Entry informationi

Entry nameiQ95J83_MACMU
AccessioniPrimary (citable) accession number: Q95J83
Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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