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Protein

Mitochondrial folate transporter/carrier

Gene

SLC25A32

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Transports folate across the inner membranes of mitochondria.By similarity

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial folate transporter/carrier
Alternative name(s):
Solute carrier family 25 member 32
Gene namesi
Name:SLC25A32
Synonyms:MFTC
ORF Names:QmoA-10785, QtrA-13024
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei26 – 43Helical; Name=1Sequence analysisAdd BLAST18
Transmembranei89 – 106Helical; Name=2Sequence analysisAdd BLAST18
Transmembranei123 – 143Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei186 – 203Helical; Name=4Sequence analysisAdd BLAST18
Transmembranei227 – 243Helical; Name=5Sequence analysisAdd BLAST17
Transmembranei281 – 300Helical; Name=6Sequence analysisAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906421 – 315Mitochondrial folate transporter/carrierAdd BLAST315

Structurei

3D structure databases

ProteinModelPortaliQ95J75.
SMRiQ95J75.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati20 – 109Solcar 1Add BLAST90
Repeati118 – 209Solcar 2Add BLAST92
Repeati222 – 306Solcar 3Add BLAST85

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG101979.
KOiK15115.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiView protein in InterPro
IPR002030. Mit_uncoupling_UCP-like.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
PfamiView protein in Pfam
PF00153. Mito_carr. 3 hits.
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiView protein in PROSITE
PS50920. SOLCAR. 3 hits.

Sequencei

Sequence statusi: Complete.

Q95J75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGQGHSASG SSAWSTVFRH VRYENLVAGV SGGVLSNLAL HPLDLVKIRF
60 70 80 90 100
AVSDGLELRP KYNGILHCLT TIWKLDGLRG LYQGVTPNVW GAGLSWGLYF
110 120 130 140 150
FFYNAIKSYK TEGRAERLEA TEYLVSAAEA GAMTLCITNP LWVTKTRLML
160 170 180 190 200
QYDAVINSPH RQYKGMFDTL VKIYKYEGVR GLYKGFVPGL FGTSHGALQF
210 220 230 240 250
MAYELLKLKY NQHINRLPEA QLSTVEYISV AALSKIFAVA ATYPYQVVRA
260 270 280 290 300
RLQDQHMFYS GVIDVITKTW RKEGIGGFYK GIAPNLIRVT PACCITFVVY
310
ENVSHFLLDL REKRK
Length:315
Mass (Da):35,416
Last modified:December 1, 2001 - v1
Checksum:i00AE5B0A774590F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB060884 mRNA. Translation: BAB46890.1.
AB062992 mRNA. Translation: BAB60754.1.
RefSeqiXP_005563951.1. XM_005563894.2.
UniGeneiMfa.2396.

Genome annotation databases

GeneIDi102144981.
KEGGimcf:102144981.

Similar proteinsi

Entry informationi

Entry nameiMFTC_MACFA
AccessioniPrimary (citable) accession number: Q95J75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: December 1, 2001
Last modified: June 7, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families