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Protein

Interleukin-13

Gene

IL13

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

ReactomeiR-SSC-449147. Signaling by Interleukins.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-13
Short name:
IL-13
Gene namesi
Name:IL13
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020By similarityAdd
BLAST
Chaini21 – 131111Interleukin-13PRO_0000015552Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi39 – 391N-linked (GlcNAc...)Sequence analysis
Disulfide bondi49 ↔ 78By similarity
Glycosylationi50 – 501N-linked (GlcNAc...)Sequence analysis
Glycosylationi58 – 581N-linked (GlcNAc...)Sequence analysis
Disulfide bondi66 ↔ 92By similarity
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ95J68.

Expressioni

Gene expression databases

GenevisibleiQ95J68. SS.

Interactioni

Subunit structurei

Interacts with IL13RA2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000015192.

Structurei

3D structure databases

ProteinModelPortaliQ95J68.
SMRiQ95J68. Positions 21-131.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-4/IL-13 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JCI3. Eukaryota.
ENOG4111BX2. LUCA.
GeneTreeiENSGT00390000003225.
HOGENOMiHOG000113028.
HOVERGENiHBG006140.
InParanoidiQ95J68.
KOiK05435.
OMAiVYCAALE.
OrthoDBiEOG091G10SR.
TreeFamiTF336383.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020470. IL-13.
IPR001325. IL-4/IL-13.
IPR018096. IL-4/IL-13_CS.
[Graphical view]
PANTHERiPTHR11322. PTHR11322. 1 hit.
PfamiPF03487. IL13. 1 hit.
[Graphical view]
PRINTSiPR01929. INTRLEUKIN13.
SMARTiSM00190. IL4_13. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00838. INTERLEUKIN_4_13. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q95J68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALWLTLVIA LTCFGGLASP GPVPPHSTAL KELIEELVNI TQNQKTPLCN
60 70 80 90 100
GSMVWSVNLT TSMQYCAALE SLINISDCSA IQKTQRMLSA LCSHKPPSEQ
110 120 130
VPGKHIRDTK IEVAQFVKDL LKHLRMIFRH G
Length:131
Mass (Da):14,452
Last modified:December 1, 2001 - v1
Checksum:i27F8352DCCBEE51A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF385625 Genomic DNA. Translation: AAK68108.1.
AF385626 mRNA. Translation: AAK68109.2.
RefSeqiNP_998968.1. NM_213803.1.
UniGeneiSsc.15877.

Genome annotation databases

EnsembliENSSSCT00000015604; ENSSSCP00000015192; ENSSSCG00000014281.
GeneIDi396721.
KEGGissc:396721.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF385625 Genomic DNA. Translation: AAK68108.1.
AF385626 mRNA. Translation: AAK68109.2.
RefSeqiNP_998968.1. NM_213803.1.
UniGeneiSsc.15877.

3D structure databases

ProteinModelPortaliQ95J68.
SMRiQ95J68. Positions 21-131.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000015192.

Proteomic databases

PaxDbiQ95J68.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000015604; ENSSSCP00000015192; ENSSSCG00000014281.
GeneIDi396721.
KEGGissc:396721.

Organism-specific databases

CTDi3596.

Phylogenomic databases

eggNOGiENOG410JCI3. Eukaryota.
ENOG4111BX2. LUCA.
GeneTreeiENSGT00390000003225.
HOGENOMiHOG000113028.
HOVERGENiHBG006140.
InParanoidiQ95J68.
KOiK05435.
OMAiVYCAALE.
OrthoDBiEOG091G10SR.
TreeFamiTF336383.

Enzyme and pathway databases

ReactomeiR-SSC-449147. Signaling by Interleukins.

Gene expression databases

GenevisibleiQ95J68. SS.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020470. IL-13.
IPR001325. IL-4/IL-13.
IPR018096. IL-4/IL-13_CS.
[Graphical view]
PANTHERiPTHR11322. PTHR11322. 1 hit.
PfamiPF03487. IL13. 1 hit.
[Graphical view]
PRINTSiPR01929. INTRLEUKIN13.
SMARTiSM00190. IL4_13. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00838. INTERLEUKIN_4_13. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL13_PIG
AccessioniPrimary (citable) accession number: Q95J68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.