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Protein

Interleukin-13

Gene

IL13

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-SSC-6785807 Interleukin-4 and 13 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-13
Short name:
IL-13
Gene namesi
Name:IL13
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20By similarityAdd BLAST20
ChainiPRO_000001555221 – 131Interleukin-13Add BLAST111

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi49 ↔ 78By similarity
Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi58N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi66 ↔ 92By similarity
Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ95J68

Expressioni

Gene expression databases

BgeeiENSSSCG00000014281
GenevisibleiQ95J68 SS

Interactioni

Subunit structurei

Interacts with IL13RA2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000015192

Structurei

3D structure databases

ProteinModelPortaliQ95J68
SMRiQ95J68
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-4/IL-13 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JCI3 Eukaryota
ENOG4111BX2 LUCA
GeneTreeiENSGT00390000003225
HOGENOMiHOG000113028
HOVERGENiHBG006140
InParanoidiQ95J68
KOiK05435
OMAiVYCAALE
OrthoDBiEOG091G10SR
TreeFamiTF336383

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR020470 IL-13
IPR001325 IL-4/IL-13
IPR018096 IL-4/IL-13_CS
PANTHERiPTHR45413 PTHR45413, 1 hit
PfamiView protein in Pfam
PF03487 IL13, 1 hit
PRINTSiPR01929 INTRLEUKIN13
SMARTiView protein in SMART
SM00190 IL4_13, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00838 INTERLEUKIN_4_13, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q95J68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALWLTLVIA LTCFGGLASP GPVPPHSTAL KELIEELVNI TQNQKTPLCN
60 70 80 90 100
GSMVWSVNLT TSMQYCAALE SLINISDCSA IQKTQRMLSA LCSHKPPSEQ
110 120 130
VPGKHIRDTK IEVAQFVKDL LKHLRMIFRH G
Length:131
Mass (Da):14,452
Last modified:December 1, 2001 - v1
Checksum:i27F8352DCCBEE51A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF385625 Genomic DNA Translation: AAK68108.1
AF385626 mRNA Translation: AAK68109.2
RefSeqiNP_998968.1, NM_213803.1
UniGeneiSsc.15877

Genome annotation databases

EnsembliENSSSCT00000033118; ENSSSCP00000030285; ENSSSCG00000014281
GeneIDi396721
KEGGissc:396721

Similar proteinsi

Entry informationi

Entry nameiIL13_PIG
AccessioniPrimary (citable) accession number: Q95J68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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