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Protein

DnaJ homolog subfamily C member 14

Gene

DNAJC14

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface (By similarity). Promotes cleavage of pestivirus polyprotein.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Host-virus interaction, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 14
Alternative name(s):
J domain protein interacting with viral protein
Short name:
Jiv
Gene namesi
Name:DNAJC14
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei251 – 27121HelicalSequence analysisAdd
BLAST
Transmembranei301 – 32121HelicalSequence analysisAdd
BLAST
Transmembranei327 – 34721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 699699DnaJ homolog subfamily C member 14PRO_0000247492Add
BLAST

Proteomic databases

PaxDbiQ95J56.
PRIDEiQ95J56.

Interactioni

Subunit structurei

Interacts with the FxxxFxxxF motif of DRD1 via its C-terminal domain (By similarity). Interacts with pestivirus nonstructural protein NS2.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
P197112EBI-9612178,EBI-9612504From a different organism.

Protein-protein interaction databases

IntActiQ95J56. 1 interaction.
STRINGi9913.ENSBTAP00000027541.

Structurei

3D structure databases

ProteinModelPortaliQ95J56.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini444 – 50865JPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 J domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0720. Eukaryota.
ENOG410Z2TP. LUCA.
GeneTreeiENSGT00840000129767.
HOGENOMiHOG000290199.
HOVERGENiHBG059561.
InParanoidiQ95J56.
KOiK09534.
OMAiPPGQMSN.
OrthoDBiEOG7HTHGK.
TreeFamiTF105173.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR032843. Jiv.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF14901. Jiv90. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q95J56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQKHPGEGG LCGAHHSGGA SLRTLGPSVD PDILSFSGLR DSAGSAPNGT
60 70 80 90 100
RCLTEHSSPK YTQPPNPAHW SDPSHGPPRG PGPPLAEEDP DQSEASSEES
110 120 130 140 150
GVDQELSREN ETGYQDDGNS SFLSIPSTCN CQGTPGIPEG PYSEGRDSSS
160 170 180 190 200
SNFCHHCTSP ALGEDEELEG EYDEEEPLKF PSDVSRVPSE KKPAPRRQRH
210 220 230 240 250
RVPAKEDTRE GGRRDPRSPG RHRLGRKRSQ ADKRRGLGLW GAEELCQLGQ
260 270 280 290 300
AGFWWLIELL VLVGEYVETC GHLIYACRQL KGSDLDLLRV WVGVWAGRLR
310 320 330 340 350
GWAQVMFQFL SQGFCYGAGL FTRFLRLVGA LLLLALALLL GCLQLGWRFL
360 370 380 390 400
VGLSDRLGWR DKATWIFSWL ASPTWQRCLI LLRESRPWQQ LVRIVQWGWL
410 420 430 440 450
ELPWVKQRTN RQANAPVAGG RYCQPEEEVA RLLTMAGVPE DELNPFHVLG
460 470 480 490 500
VEATASDVEL KKAYRQLAVM VHPDKNHHPR AEEAFKVLRA AWDIVSNPER
510 520 530 540 550
RKEYEMKRMA ENELSRSVNE FLSKLQEAMN TMMCSRCQGK HRRFEMDREP
560 570 580 590 600
KSARYCAECN RLHPAEEGDF WAESSMLGLK ITYFALMDGK VYDITEWAGC
610 620 630 640 650
QRVGISPDTH RVPYHISFGS RMPGTSGRQR ATPDAPPADL QDFLSRIFQV
660 670 680 690
PPGQMSNGNF FAAPQPGPGA TAASKPNSTV PKGEAKPKRR KKVRRPFQR
Length:699
Mass (Da):78,178
Last modified:December 1, 2001 - v1
Checksum:i370F62297595F516
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY027881 mRNA. Translation: AAK28650.1.
AY027882 mRNA. Translation: AAK28651.1.
BT025444 mRNA. Translation: ABF57400.1.
BC151599 mRNA. Translation: AAI51600.1.
RefSeqiNP_776699.1. NM_174274.1.
UniGeneiBt.7218.

Genome annotation databases

EnsembliENSBTAT00000027541; ENSBTAP00000027541; ENSBTAG00000020664.
GeneIDi281691.
KEGGibta:281691.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY027881 mRNA. Translation: AAK28650.1.
AY027882 mRNA. Translation: AAK28651.1.
BT025444 mRNA. Translation: ABF57400.1.
BC151599 mRNA. Translation: AAI51600.1.
RefSeqiNP_776699.1. NM_174274.1.
UniGeneiBt.7218.

3D structure databases

ProteinModelPortaliQ95J56.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ95J56. 1 interaction.
STRINGi9913.ENSBTAP00000027541.

Proteomic databases

PaxDbiQ95J56.
PRIDEiQ95J56.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000027541; ENSBTAP00000027541; ENSBTAG00000020664.
GeneIDi281691.
KEGGibta:281691.

Organism-specific databases

CTDi85406.

Phylogenomic databases

eggNOGiKOG0720. Eukaryota.
ENOG410Z2TP. LUCA.
GeneTreeiENSGT00840000129767.
HOGENOMiHOG000290199.
HOVERGENiHBG059561.
InParanoidiQ95J56.
KOiK09534.
OMAiPPGQMSN.
OrthoDBiEOG7HTHGK.
TreeFamiTF105173.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR032843. Jiv.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF14901. Jiv90. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A cellular J-domain protein modulates polyprotein processing and cytopathogenicity of a pestivirus."
    Rinck G., Birghan C., Harada T., Meyers G., Thiel H.-J., Tautz N.
    J. Virol. 75:9470-9482(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, INTERACTION WITH PESTIVIRUS NS2.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Thymus.

Entry informationi

Entry nameiDJC14_BOVIN
AccessioniPrimary (citable) accession number: Q95J56
Secondary accession number(s): B0JYR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.