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Q95IE3

- 2B1C_HUMAN

UniProt

Q95IE3 - 2B1C_HUMAN

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Protein

HLA class II histocompatibility antigen, DRB1-12 beta chain

Gene
HLA-DRB1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
  2. cytokine-mediated signaling pathway Source: Reactome
  3. interferon-gamma-mediated signaling pathway Source: Reactome
  4. T cell costimulation Source: Reactome
  5. T cell receptor signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiREACT_121399. MHC class II antigen presentation.
REACT_12555. Downstream TCR signaling.
REACT_12582. Phosphorylation of CD3 and TCR zeta chains.
REACT_12596. Translocation of ZAP-70 to Immunological synapse.
REACT_12623. Generation of second messenger molecules.
REACT_19324. PD-1 signaling.
REACT_25078. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class II histocompatibility antigen, DRB1-12 beta chain
Alternative name(s):
MHC class II antigen DRB1*12
Short name:
DR-12
Short name:
DR12
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:4948. HLA-DRB1.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein
Note: The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei228 – 24821Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. clathrin-coated endocytic vesicle membrane Source: Reactome
  2. endocytic vesicle membrane Source: Reactome
  3. ER to Golgi transport vesicle membrane Source: Reactome
  4. Golgi membrane Source: Reactome
  5. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
  6. late endosome membrane Source: UniProtKB
  7. lysosomal membrane Source: UniProtKB
  8. MHC class II protein complex Source: UniProtKB-KW
  9. plasma membrane Source: Reactome
  10. trans-Golgi network membrane Source: Reactome
  11. transport vesicle membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, MHC II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929 Reviewed predictionAdd
BLAST
Chaini30 – 266237HLA class II histocompatibility antigen, DRB1-12 beta chainPRO_0000391832Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi48 – 481N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi146 ↔ 202 By similarity
Cross-linki254 – 254Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Post-translational modificationi

Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHC class II Inferred.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

PRIDEiQ95IE3.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.

Structurei

3D structure databases

ProteinModelPortaliQ95IE3.
SMRiQ95IE3. Positions 34-220.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini126 – 21489Ig-like C1-typeAdd
BLAST

Sequence similaritiesi

Belongs to the MHC class II family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG012730.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q95IE3-1 [UniParc]FASTAAdd to Basket

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MVCLRLPGGS CMAVLTVTLM VLSSPLALAG DTRPRFLEYS TGECYFFNGT    50
ERVRLLERHF HNQEELLRFD SDVGEFRAVT ELGRPVAESW NSQKDILEDR 100
RAAVDTYCRH NYGAVESFTV QRRVHPKVTV YPSKTQPLQH HNLLVCSVSG 150
FYPGSIEVRW FRNGQEEKTG VVSTGLIHNG DWTFQTLVML ETVPRSGEVY 200
TCQVEHPSVT SPLTVEWRAR SESAQSKMLS GVGGFVLGLL FLGAGLFIYF 250
RNQKGHSGLQ PRGFLS 266
Length:266
Mass (Da):29,878
Last modified:December 1, 2001 - v1
Checksum:iFFDD0001C2F0BAF9
GO

Polymorphismi

The following alleles of DRB1-12 are known: DRB1*12:01, DRB1*12:02, DRB1*12:03, DRB1*12:04, DRB1*12:05, DRB1*12:06, DRB1*12:07, DRB1*12:08, DRB1*12:09, DRB1*12:10, DRB1*12:11, DRB1*12:12, DRB1*12:13, DRB1*12:14, DRB1*12:15, DRB1*12:16, DRB1*12:17, DRB1*12:18 and DRB1*12:19. The sequence shown is that of DRB1*12:01.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5 – 51R → K in allele DRB1*12:17.
VAR_062818
Natural varianti13 – 131A → T in allele DRB1*12:17.
VAR_062819
Natural varianti14 – 141V → A in allele DRB1*12:17.
VAR_062820
Natural varianti14 – 141V → I in allele DRB1*12:10.
VAR_062821
Natural varianti54 – 541R → L in allele DRB1*12:13.
VAR_062822
Natural varianti55 – 551L → F in allele DRB1*12:08.
VAR_062823
Natural varianti66 – 661L → F in allele DRB1*12:05, allele DRB1*12:14 and allele DRB1*12:15.
VAR_062824
Natural varianti67 – 671L → V in allele DRB1*12:14.
VAR_062825
Natural varianti76 – 761F → L in allele DRB1*12:11.
VAR_062826
Natural varianti86 – 861V → D in allele DRB1*12:04 and allele DRB1*12:09.
VAR_062827
Natural varianti87 – 871A → E in allele DRB1*12:04.
VAR_062828
Natural varianti88 – 881E → Q in allele DRB1*12:18.
VAR_062829
Natural varianti89 – 891S → Y in allele DRB1*12:04 and allele DRB1*12:09.
VAR_062830
Natural varianti96 – 961I → F in allele DRB1*12:02, allele DRB1*12:13, allele DRB1*12:15, allele DRB1*12:16, allele DRB1*12:18 and allele DRB1*12:19.
VAR_062831
Natural varianti96 – 961I → L in allele DRB1*12:12.
VAR_062832
Natural varianti98 – 981E → G in allele DRB1*12:07.
VAR_062833
Natural varianti114 – 1141A → V in allele DRB1*12:03, allele DRB1*12:16 and allele DRB1*12:19.
VAR_062834
Natural varianti115 – 1151V → G in allele DRB1*12:16.
VAR_062835
Natural varianti125 – 1251H → E in allele DRB1*12:17; requires 2 nucleotide substitutions.
VAR_062836
Natural varianti169 – 1691T → A in allele DRB1*12:17.
VAR_062837
Natural varianti178 – 1781H → Q in allele DRB1*12:06 and allele DRB1*12:17.
VAR_062838
Natural varianti262 – 2621R → T in allele DRB1*12:17.
Corresponds to variant rs9269744 [ dbSNP | Ensembl ].
VAR_062839

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ302075 mRNA. Translation: CAC44379.1.
AY626551 mRNA. Translation: AAV34808.1.
EU375850 mRNA. Translation: ABY78039.1.
AY663396 Genomic DNA. Translation: AAU87983.1.
AH010330 Genomic DNA. Translation: AAK07563.1.
AJ870921 Genomic DNA. Translation: CAI35044.1.
AY033428 Genomic DNA. Translation: AAK55114.1.
DQ533486 Genomic DNA. Translation: ABF74752.1.
FJ374889 Genomic DNA. Translation: ACJ09136.1.
FJ481086 Genomic DNA. Translation: ACK77491.1.
D86503 Genomic DNA. Translation: BAA13098.1.
AB112911 Genomic DNA. Translation: BAD02942.1.
AY339246 Genomic DNA. Translation: AAQ18913.1.
AY899825 Genomic DNA. Translation: AAW82078.1.
DQ250650 Genomic DNA. Translation: ABC59072.1.
DQ343834 Genomic DNA. Translation: ABC70992.1.
EF688603 Genomic DNA. Translation: ABS11697.1.
X83455 Genomic DNA. No translation available.
AY174091 Genomic DNA. Translation: AAO20088.1.
AF017439 mRNA. Translation: AAB70553.1.
PIRiC60748.
F60748.
PH0154.
UniGeneiHs.534322.
Hs.696211.
Hs.716081.
Hs.723344.
Hs.736560.

Genome annotation databases

EnsembliENST00000328980; ENSP00000331343; ENSG00000206306.
ENST00000399450; ENSP00000382378; ENSG00000206240.
ENST00000412634; ENSP00000408795; ENSG00000228080.
ENST00000415796; ENSP00000412168; ENSG00000206306.
ENST00000419393; ENSP00000403458; ENSG00000228080.
ENST00000428566; ENSP00000392280; ENSG00000206240.

Polymorphism databases

DMDMi74760669.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ302075 mRNA. Translation: CAC44379.1 .
AY626551 mRNA. Translation: AAV34808.1 .
EU375850 mRNA. Translation: ABY78039.1 .
AY663396 Genomic DNA. Translation: AAU87983.1 .
AH010330 Genomic DNA. Translation: AAK07563.1 .
AJ870921 Genomic DNA. Translation: CAI35044.1 .
AY033428 Genomic DNA. Translation: AAK55114.1 .
DQ533486 Genomic DNA. Translation: ABF74752.1 .
FJ374889 Genomic DNA. Translation: ACJ09136.1 .
FJ481086 Genomic DNA. Translation: ACK77491.1 .
D86503 Genomic DNA. Translation: BAA13098.1 .
AB112911 Genomic DNA. Translation: BAD02942.1 .
AY339246 Genomic DNA. Translation: AAQ18913.1 .
AY899825 Genomic DNA. Translation: AAW82078.1 .
DQ250650 Genomic DNA. Translation: ABC59072.1 .
DQ343834 Genomic DNA. Translation: ABC70992.1 .
EF688603 Genomic DNA. Translation: ABS11697.1 .
X83455 Genomic DNA. No translation available.
AY174091 Genomic DNA. Translation: AAO20088.1 .
AF017439 mRNA. Translation: AAB70553.1 .
PIRi C60748.
F60748.
PH0154.
UniGenei Hs.534322.
Hs.696211.
Hs.716081.
Hs.723344.
Hs.736560.

3D structure databases

ProteinModelPortali Q95IE3.
SMRi Q95IE3. Positions 34-220.
ModBasei Search...
MobiDBi Search...

Polymorphism databases

DMDMi 74760669.

Proteomic databases

PRIDEi Q95IE3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000328980 ; ENSP00000331343 ; ENSG00000206306 .
ENST00000399450 ; ENSP00000382378 ; ENSG00000206240 .
ENST00000412634 ; ENSP00000408795 ; ENSG00000228080 .
ENST00000415796 ; ENSP00000412168 ; ENSG00000206306 .
ENST00000419393 ; ENSP00000403458 ; ENSG00000228080 .
ENST00000428566 ; ENSP00000392280 ; ENSG00000206240 .

Organism-specific databases

GeneCardsi GC06M032546.
GC06Mj32477.
GC06Mn32480.
GC06Mo32593.
HGNCi HGNC:4948. HLA-DRB1.
neXtProti NX_Q95IE3.
GenAtlasi Search...

Phylogenomic databases

HOVERGENi HBG012730.

Enzyme and pathway databases

Reactomei REACT_121399. MHC class II antigen presentation.
REACT_12555. Downstream TCR signaling.
REACT_12582. Phosphorylation of CD3 and TCR zeta chains.
REACT_12596. Translocation of ZAP-70 to Immunological synapse.
REACT_12623. Generation of second messenger molecules.
REACT_19324. PD-1 signaling.
REACT_25078. Interferon gamma signaling.

Miscellaneous databases

ChiTaRSi HLA-DRB1. human.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view ]
ProDomi PD000328. MHC_II_b_N. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence of a new DR12 allele with two silent mutations that affect PCR-SSP typing."
    Zanone R., Bettens F., Tiercy J.M.
    Tissue Antigens 59:165-167(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB1*12:01).
  2. "Identification of a novel HLA-DRB1*12 allele (DRB1*1210) in the Korean population."
    Kim E., Lee E.J., Lim Y.H., Lee J.Y., Koh I.S., Kimm K., Ji G.E., Kwack K.
    Tissue Antigens 64:518-519(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB1*12:10).
  3. "Identification of a novel HLA-DRB1 allele, HLA-DRB1*1217, in a Korean individual."
    Park M.H., Kim Y., Lee J.Y.
    Tissue Antigens 73:627-628(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB1*12:17).
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-262 (ALLELE DRB1*12:01).
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-208 (ALLELE DRB1*12:07).
  6. "The replacement mutation in HLA-DRB1*1211 affects a likely keystone position."
    Horn P.A., DeLuca D.S., Jindra P., Blasczyk R.
    Hum. Immunol. 66:1254-1257(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*12:11).
    Tissue: Peripheral blood.
  7. "Identification of two new alleles in a single Korean individual, HLA-B*1568 and HLA-DRB1*1208."
    Sheldon M.H., Bunce M., Dunn P.P., Day S., Lee G.D., Park Y.J., Bang B.K., Kim B.K., Oh E.J.
    Tissue Antigens 59:430-432(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*12:08).
  8. "Identification of two novel HLA-DRB1 alleles, HLA-DRB1*1214 and HLA-DRB1*1215, in two Taiwanese individuals."
    Lee H.L., Chu C.C., Trejaut J.A., Yang K.L., Lin M.
    Int. J. Immunogenet. 35:423-426(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*12:15).
  9. "A novel HLA-DRB1 allele, DRB1*1219, was identified by sequence-based typing in a Chinese leukaemia family."
    Nie X.M., Fang Y.H., Zhang Y., He W.D., Zhu C.F.
    Tissue Antigens 74:352-354(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*12:19).
  10. "Identification of a novel HLA-DRB1*12 allele, DRB1*1218, in Chinese population."
    Gao S.Q., Deng Z.H., Xu Y.P.
    Tissue Antigens 74:265-267(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*12:18).
  11. "Sequence of new allele."
    Kashiwase K., Tokunaga K., Akaza T., Tadokoro K., Juji T.
    Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*12:05).
  12. "A new HLA-DR12V allele detected by PCR-RFLP."
    Ono A.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*12:09).
  13. Gedil M.A., Steiner N.K., Hurley C.K.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*12:04).
  14. "Identification a novel HLA-DRB1*12 in Chinese by sequence-based typed."
    Zhu F., Lu Q., Zhang W.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*12:12).
  15. "Novel HLA-DRB1*120201 variant allele."
    Hur S.S., Lee M.N., Park S.Y., Kwon O.J.
    Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*12:13).
  16. "A novel HLA-DRB1 allele."
    Chu C.-C.
    Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*12:14).
  17. Zhang C., Liu J.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*12:16).
  18. "Sequence analysis of three novel HLA-DRB1 alleles: DRB1*1113, DRB1*1114 and DRB1*12032."
    Hashemi S., Couture C., Buyse I., Cole R., Aye M.T.
    Tissue Antigens 47:155-158(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-122 (ALLELE DRB1*12:03).
  19. "HLA class II DRB1*120201 confirmatory sequence."
    Lo B.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 36-123 (ALLELE DRB1*12:02).
  20. "A novel HLA-DR12 allele (DRB1*1206) found in a Korean B-cell line."
    Maeng C.Y., Kim K.H., Kang J.H., Han H., Kim K.L.
    Tissue Antigens 53:516-518(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 88-197 (ALLELE DRB1*12:06).
  21. "Invariant chain structure and MHC class II function."
    Cresswell P.
    Cell 84:505-507(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  22. "Presentation of antigens by MHC class II molecules: getting the most out of them."
    Villadangos J.A.
    Mol. Immunol. 38:329-346(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  23. "Autophagy in MHC class II presentation: sampling from within."
    Menendez-Benito V., Neefjes J.
    Immunity 26:1-3(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  24. "MHC class II molecules on the move for successful antigen presentation."
    Rocha N., Neefjes J.
    EMBO J. 27:1-5(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  25. "MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation."
    De Gassart A., Camosseto V., Thibodeau J., Ceppi M., Catalan N., Pierre P., Gatti E.
    Proc. Natl. Acad. Sci. U.S.A. 105:3491-3496(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION BY MARCH1, SUBCELLULAR LOCATION.
  26. "MHC class II transport at a glance."
    Berger A.C., Roche P.A.
    J. Cell Sci. 122:1-4(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  27. "CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract."
    Beswick E.J., Reyes V.E.
    World J. Gastroenterol. 15:2855-2861(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry namei2B1C_HUMAN
AccessioniPrimary (citable) accession number: Q95IE3
Secondary accession number(s): A7LA26
, B0LUZ6, B6VCX2, B7UDB2, O19585, Q19AF2, Q29771, Q2L9H4, Q2MZ92, Q5EER6, Q5NDB9, Q5UT58, Q5Y7G0, Q768U4, Q7YP04, Q861H8, Q95IT6, Q9BD40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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