Q95HC2 (Q95HC2_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
HLA-C protein EMBL AAH07814.2

Gene names

Name:

HLA-C EMBL AAH07814.2

Organism

Homo sapiens (Human) EMBL AAH07814.2

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	365 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in the presentation of foreign antigens to the immune system By similarity. SAAS SAAS010579
Sequence similarities	Belongs to the MHC class I family. RuleBase RU004439 Contains 1 Ig-like C1-type (immunoglobulin-like) domain. SAAS SAAS010579

Ontologies

Keywords
Biological process	Immunity
Cellular component	MHC I SAAS SAAS010579 Membrane
Domain	Transmembrane Transmembrane helix SAAS SAAS010579
Gene Ontology (GO)
Biological_process	antigen processing and presentation of peptide antigen via MHC class I Inferred from electronic annotation. Source: UniProtKB-KW immune response Inferred from electronic annotation. Source: InterPro
Cellular_component	MHC class I protein complex Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAH07814.2

Sequences

	Sequence		Length	Mass (Da)
	Q95HC2 [UniParc]. Last modified March 29, 2005. Version 2. Checksum: 246B3241F2EAB52F	FASTA	365	40,517
	10 20 30 40 50 60 RVMAPRALLL LLSGGLALTE TWACSHSMRY FDTAVSRPGR GEPRFISVGY VDDTQFVRFD 70 80 90 100 110 120 SDAASPRGEP RAPWVEQEGP EYWDRETQKY KRQAQADRVS LRNLRGYYNQ SEDGSHTLQR 130 140 150 160 170 180 MSGCDLGPDG RLLRGYDQSA YDGKDYIALN EDLRSWTAAD TAAQITQRKL EAARAAEQLR 190 200 210 220 230 240 AYLEGTCVEW LRRYLENGKE TLQRAEPPKT HVTHHPLSDH EATLRCWALG FYPAEITLTW 250 260 270 280 290 300 QRDGEDQTQD TELVETRPAG DGTFQKWAAV VVPSGQEQRY TCHMQHEGLQ EPLTLSWEPS 310 320 330 340 350 360 SQPTIPIMGI VAGLAVLVVL AVLGAVVTAM MCRRKSSGGK GGSCSQAACS NSAQGSDESL ITCKA

References

[1]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J. Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye EMBL AAH07814.2.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC007814 mRNA. Translation: AAH07814.2.
IPI	IPI00642409.
RefSeq	NP_002108.4. NM_002117.5.
UniGene	Hs.654404. Hs.656020.
3D structure databases
ProteinModelPortal	Q95HC2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q95HC2.
Proteomic databases
PRIDE	Q95HC2.
Protocols and materials databases
DNASU	3107.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3107.
KEGG	hsa:3107.
Organism-specific databases
CTD	3107.
PharmGKB	PA35057.
Phylogenomic databases
HOVERGEN	HBG016709.
KO	K06751.
Gene expression databases
ArrayExpress	Q95HC2.
Bgee	Q95HC2.
Family and domain databases
Gene3D	2.60.40.10. 1 hit. 3.30.500.10. 1 hit.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003597. Ig_C1-set. IPR011161. MHC_I-like_Ag-recog. IPR011162. MHC_I/II-like_Ag-recog. IPR001039. MHC_I_a_a1/a2. IPR010579. MHC_I_a_C. [Graphical view]
Pfam	PF07654. C1-set. 1 hit. PF00129. MHC_I. 1 hit. PF06623. MHC_I_C. 1 hit. [Graphical view]
PRINTS	PR01638. MHCCLASSI.
SMART	SM00407. IGc1. 1 hit. [Graphical view]
SUPFAM	SSF54452. MHC_I/II-like_Ag-recog. 1 hit.
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	HLA-C. human.
GenomeRNAi	3107.
NextBio	12327.

Entry information

Entry name

Q95HC2_HUMAN

Accession

Primary (citable) accession number: Q95HC2

Entry history

Integrated into UniProtKB/TrEMBL:	December 1, 2001
Last sequence update:	March 29, 2005
Last modified:	March 6, 2013
This is version 90 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.