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Q95938 (Q95938_RAT) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 1 RuleBase RU000369
EC=1.9.3.1 RuleBase RU000369
Gene names
Name:Mt-co1 RGD 621871
Synonyms:Co I EMBL AAB00991.1, mt-Co3 RGD 621873, Mt-coi RGD 621871
Encoded onMitochondrion EMBL AAB00991.1
OrganismRattus norvegicus (Rat) EMBL AAB00991.1
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length514 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity. RuleBase RU000369

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O. RuleBase RU000369

Pathway

Energy metabolism; oxidative phosphorylation. RuleBase RU000369

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity RuleBase RU000369.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family. RuleBase RU000369

Sequences

Sequence LengthMass (Da)Tools
Q95938 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 57BCF9686236791A

FASTA51456,977
        10         20         30         40         50         60 
MFVNRWLFST NHKDIGTLYL LFGAWAGMVG TALSILIRAE LGQPGALLGD DQIYNVIVTA 

        70         80         90        100        110        120 
HAFVMIFFMV MPMMIGGFGN WLVPLMIGAP DMAFPRMNNM SFWLLPPSFL LLLASSMVEA 

       130        140        150        160        170        180 
GAGTGWTVYP PLAGNLAHAG VSVDLTIFSL HLAGVSSILG AINFITTIIN MKPPAMTQYQ 

       190        200        210        220        230        240 
TPLFVWSVLI TAVLLLLSLP VLAAGITMLL TDRNLNTTFF DPAGGGDPIL YQHLFWFFGH 

       250        260        270        280        290        300 
PEVYILILPG FGIISHVVTY YSGKKEPFGY MGMVWTMMSI GFLGFIVWAH HMFTVGLDVD 

       310        320        330        340        350        360 
TRAYFTSATM IIAIPTGVKV FSWLATLHGG NIKWSPAMLW ALGFIFLFTV GGLTGIVLSN 

       370        380        390        400        410        420 
SSLDIVLHDT YYVVAHFHYV LSMGAVFAIM AGFVHWFPLF SGYTLNDTWA KAHFAIMFVG 

       430        440        450        460        470        480 
VNMTFFPQHF LPLAGMPRRY SDYPDAYTTW NTVSSMGSFI SLTAVLVMIF MIWEAFASKR 

       490        500        510 
EVLSISYSST NLEWLHGCPP PYHTFEEPSY VKVK

« Hide

References

[1]"Non-random patterns of nucleotide substitutions and codon strategy in the mammalian mitochondrial genes coding for identified and unidentified reading frames."
Pepe G., Holtrop M., Gadaleta G., Kroon A.M., Cantatore P., Gallerani R., de Benedetto C., Quagliariello C., Sbisa E., Saccone C.
Biochem. Int. 6:553-563(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Wistar EMBL AAB00991.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M27315 Genomic DNA. Translation: AAB00991.1.
IPIIPI00200472.

3D structure databases

ProteinModelPortalQ95938.
SMRQ95938. Positions 1-514.
ModBaseSearch...

Proteomic databases

PRIDEQ95938.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

RGD621871. Mt-co1.

Phylogenomic databases

HOVERGENHBG003841.
InParanoidQ95938.

Enzyme and pathway databases

UniPathwayUPA00705.

Gene expression databases

ArrayExpressQ95938.
GenevestigatorQ95938.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. COX1. 1 hit.
PROSITEPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio35585030.

Entry information

Entry nameQ95938_RAT
AccessionPrimary (citable) accession number: Q95938
Entry history
Integrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: February 1, 1997
Last modified: May 29, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info