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Q95938

- Q95938_RAT

UniProt

Q95938 - Q95938_RAT

Protein

Cytochrome c oxidase subunit 1

Gene

Mt-co1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.UniRule annotation

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Electron transport, Respiratory chainUniRule annotation, Transport

    Keywords - Ligandi

    CopperUniRule annotation, HemeUniRule annotation, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1UniRule annotation (EC:1.9.3.1UniRule annotation)
    Gene namesi
    Name:Mt-co1Imported
    Synonyms:Co IImported, mt-Co3Imported, Mt-coiImported
    Encoded oniMitochondrionImported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    Organism-specific databases

    RGDi621871. Mt-co1.

    Subcellular locationi

    Mitochondrion inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

    PTM / Processingi

    Proteomic databases

    PRIDEiQ95938.

    Expressioni

    Gene expression databases

    GenevestigatoriQ95938.

    Structurei

    3D structure databases

    ProteinModelPortaliQ95938.
    SMRiQ95938. Positions 1-514.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the heme-copper respiratory oxidase family.UniRule annotation

    Keywords - Domaini

    TransmembraneUniRule annotation

    Phylogenomic databases

    HOVERGENiHBG003841.
    InParanoidiQ95938.

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q95938-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFVNRWLFST NHKDIGTLYL LFGAWAGMVG TALSILIRAE LGQPGALLGD    50
    DQIYNVIVTA HAFVMIFFMV MPMMIGGFGN WLVPLMIGAP DMAFPRMNNM 100
    SFWLLPPSFL LLLASSMVEA GAGTGWTVYP PLAGNLAHAG VSVDLTIFSL 150
    HLAGVSSILG AINFITTIIN MKPPAMTQYQ TPLFVWSVLI TAVLLLLSLP 200
    VLAAGITMLL TDRNLNTTFF DPAGGGDPIL YQHLFWFFGH PEVYILILPG 250
    FGIISHVVTY YSGKKEPFGY MGMVWTMMSI GFLGFIVWAH HMFTVGLDVD 300
    TRAYFTSATM IIAIPTGVKV FSWLATLHGG NIKWSPAMLW ALGFIFLFTV 350
    GGLTGIVLSN SSLDIVLHDT YYVVAHFHYV LSMGAVFAIM AGFVHWFPLF 400
    SGYTLNDTWA KAHFAIMFVG VNMTFFPQHF LPLAGMPRRY SDYPDAYTTW 450
    NTVSSMGSFI SLTAVLVMIF MIWEAFASKR EVLSISYSST NLEWLHGCPP 500
    PYHTFEEPSY VKVK 514
    Length:514
    Mass (Da):56,977
    Last modified:February 1, 1997 - v1
    Checksum:i57BCF9686236791A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M27315 Genomic DNA. Translation: AAB00991.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M27315 Genomic DNA. Translation: AAB00991.1 .

    3D structure databases

    ProteinModelPortali Q95938.
    SMRi Q95938. Positions 1-514.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q95938.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    RGDi 621871. Mt-co1.

    Phylogenomic databases

    HOVERGENi HBG003841.
    InParanoidi Q95938.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Miscellaneous databases

    NextBioi 35585030.

    Gene expression databases

    Genevestigatori Q95938.

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Non-random patterns of nucleotide substitutions and codon strategy in the mammalian mitochondrial genes coding for identified and unidentified reading frames."
      Pepe G., Holtrop M., Gadaleta G., Kroon A.M., Cantatore P., Gallerani R., de Benedetto C., Quagliariello C., Sbisa E., Saccone C.
      Biochem. Int. 6:553-563(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: WistarImported.

    Entry informationi

    Entry nameiQ95938_RAT
    AccessioniPrimary (citable) accession number: Q95938
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)