SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q957T2

- COX1_SEPPH

UniProt

Q957T2 - COX1_SEPPH

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Cytochrome c oxidase subunit 1
Gene
COI
Organism
Sepia pharaonis (Pharaoh cuttlefish)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi45 – 451Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Encoded oniMitochondrion
OrganismiSepia pharaonis (Pharaoh cuttlefish)
Taxonomic identifieri158019 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaCephalopodaColeoideaNeocoleoideaDecapodiformesSepiidaSepiinaSepiidaeSepia

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini‹1 – 1›1Mitochondrial matrix Reviewed prediction
Transmembranei2 – 2221Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini23 – 4624Mitochondrial intermembrane Reviewed prediction
Add
BLAST
Transmembranei47 – 6721Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini68 – 8518Mitochondrial matrix Reviewed prediction
Add
BLAST
Transmembranei86 – 10621Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini107 – 12822Mitochondrial intermembrane Reviewed prediction
Add
BLAST
Transmembranei129 – 14921Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini150 – 16617Mitochondrial matrix Reviewed prediction
Add
BLAST
Transmembranei167 – 18721Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini188 – 21932Mitochondrial intermembrane Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›219›219Cytochrome c oxidase subunit 1
PRO_0000183417Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ957T2.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q957T2-1 [UniParc]FASTAAdd to Basket

« Hide

TLYFIFGIWS GLLGTSLSLM IRSELGKPGT LLNDDQLYNV VVTAHGFIMI    50
FFLVMPIMIG GFGNWLVPLM LGAPDMAFPR MNNMSFWLLP PSLTLLLSSS 100
AVESGAGTGW TVYPPLSSNL SHAGPSVDLA IFSLHLAGVS SILGAINFIT 150
TILNMRWEGL QMERLPLFVW SVFITAILLL LSXPVLAGAI TMLLTDRNFN 200
TTFFDPSGGG DPILYQHLF 219
Length:219
Mass (Da):23,870
Last modified:December 1, 2001 - v1
Checksum:i216FC605595D800B
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei219 – 2191

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF359555 Genomic DNA. Translation: AAK52490.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF359555 Genomic DNA. Translation: AAK52490.1 .

3D structure databases

ProteinModelPortali Q957T2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Phylogeny of the cuttlefish (Mollusca: Cephalopoda) based on morphologic and mitochondrial DNA sequence data."
    Zheng X.-D., Wang R.-C., Wang X.-F., Xiao S., Chen B.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX1_SEPPH
AccessioniPrimary (citable) accession number: Q957T2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi