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Q957T2

- COX1_SEPPH

UniProt

Q957T2 - COX1_SEPPH

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Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Sepia pharaonis (Pharaoh cuttlefish)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi45 – 451Iron (heme A axial ligand)Curated

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Encoded oniMitochondrion
OrganismiSepia pharaonis (Pharaoh cuttlefish)
Taxonomic identifieri158019 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaCephalopodaColeoideaNeocoleoideaDecapodiformesSepiidaSepiinaSepiidaeSepia

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini‹1 – 1›1Mitochondrial matrixSequence Analysis
Transmembranei2 – 2221Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini23 – 4624Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Transmembranei47 – 6721Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini68 – 8518Mitochondrial matrixSequence AnalysisAdd
BLAST
Transmembranei86 – 10621Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini107 – 12822Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Transmembranei129 – 14921Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini150 – 16617Mitochondrial matrixSequence AnalysisAdd
BLAST
Transmembranei167 – 18721Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini188 – 21932Mitochondrial intermembraneSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›219›219Cytochrome c oxidase subunit 1PRO_0000183417Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ957T2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q957T2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
TLYFIFGIWS GLLGTSLSLM IRSELGKPGT LLNDDQLYNV VVTAHGFIMI
60 70 80 90 100
FFLVMPIMIG GFGNWLVPLM LGAPDMAFPR MNNMSFWLLP PSLTLLLSSS
110 120 130 140 150
AVESGAGTGW TVYPPLSSNL SHAGPSVDLA IFSLHLAGVS SILGAINFIT
160 170 180 190 200
TILNMRWEGL QMERLPLFVW SVFITAILLL LSXPVLAGAI TMLLTDRNFN
210
TTFFDPSGGG DPILYQHLF
Length:219
Mass (Da):23,870
Last modified:December 1, 2001 - v1
Checksum:i216FC605595D800B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei219 – 2191

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF359555 Genomic DNA. Translation: AAK52490.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF359555 Genomic DNA. Translation: AAK52490.1 .

3D structure databases

ProteinModelPortali Q957T2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Phylogeny of the cuttlefish (Mollusca: Cephalopoda) based on morphologic and mitochondrial DNA sequence data."
    Zheng X.-D., Wang R.-C., Wang X.-F., Xiao S., Chen B.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX1_SEPPH
AccessioniPrimary (citable) accession number: Q957T2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3