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Q957T2 (COX1_SEPPH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 1

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene names
Name:COI
Encoded onMitochondrion
OrganismSepia pharaonis (Pharaoh cuttlefish)
Taxonomic identifier158019 [NCBI]
Taxonomic lineageEukaryotaMetazoaLophotrochozoaMolluscaCephalopodaColeoideaNeocoleoideaDecapodiformesSepiidaSepiinaSepiidaeSepia

Protein attributes

Sequence length219 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›219›219Cytochrome c oxidase subunit 1
PRO_0000183417

Regions

Topological domain‹1›1Mitochondrial matrix Potential
Transmembrane2 – 2221Helical; Name=1; Potential
Topological domain23 – 4624Mitochondrial intermembrane Potential
Transmembrane47 – 6721Helical; Name=2; Potential
Topological domain68 – 8518Mitochondrial matrix Potential
Transmembrane86 – 10621Helical; Name=3; Potential
Topological domain107 – 12822Mitochondrial intermembrane Potential
Transmembrane129 – 14921Helical; Name=4; Potential
Topological domain150 – 16617Mitochondrial matrix Potential
Transmembrane167 – 18721Helical; Name=5; Potential
Topological domain188 – 21932Mitochondrial intermembrane Potential

Sites

Metal binding451Iron (heme A axial ligand) Probable

Experimental info

Non-terminal residue11
Non-terminal residue2191

Sequences

Sequence LengthMass (Da)Tools
Q957T2 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 216FC605595D800B

FASTA21923,870
        10         20         30         40         50         60 
TLYFIFGIWS GLLGTSLSLM IRSELGKPGT LLNDDQLYNV VVTAHGFIMI FFLVMPIMIG 

        70         80         90        100        110        120 
GFGNWLVPLM LGAPDMAFPR MNNMSFWLLP PSLTLLLSSS AVESGAGTGW TVYPPLSSNL 

       130        140        150        160        170        180 
SHAGPSVDLA IFSLHLAGVS SILGAINFIT TILNMRWEGL QMERLPLFVW SVFITAILLL 

       190        200        210 
LSXPVLAGAI TMLLTDRNFN TTFFDPSGGG DPILYQHLF 

« Hide

References

[1]"Phylogeny of the cuttlefish (Mollusca: Cephalopoda) based on morphologic and mitochondrial DNA sequence data."
Zheng X.-D., Wang R.-C., Wang X.-F., Xiao S., Chen B.
Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF359555 Genomic DNA. Translation: AAK52490.1.

3D structure databases

ProteinModelPortalQ957T2.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. SSF81442. 1 hit.
PROSITEPS50855. COX1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX1_SEPPH
AccessionPrimary (citable) accession number: Q957T2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways