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Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 3

Gene

NAD9

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandNAD, Ubiquinone

Enzyme and pathway databases

BioCyciARA:ATMG00070-MONOMER
MetaCyc:ATMG00070-MONOMER
ReactomeiR-ATH-6799198 Complex I biogenesis

Protein family/group databases

TCDBi3.D.1.6.3 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3 (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
NADH dehydrogenase subunit 9
Gene namesi
Name:NAD9
Ordered Locus Names:AtMg00070
Encoded oniMitochondrion
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Mitochondrion

Organism-specific databases

AraportiATMG00070

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001186371 – 190NADH dehydrogenase [ubiquinone] iron-sulfur protein 3Add BLAST190

Proteomic databases

PaxDbiQ95748
PRIDEiQ95748

Expressioni

Gene expression databases

ExpressionAtlasiQ95748 baseline and differential
GenevisibleiQ95748 AT

Interactioni

Subunit structurei

Complex I is composed of at least 49 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.

Protein-protein interaction databases

IntActiQ95748, 4 interactors
STRINGi3702.ATMG00070.1

Structurei

3D structure databases

ProteinModelPortaliQ95748
SMRiQ95748
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 30 kDa subunit family.Curated

Phylogenomic databases

eggNOGiKOG1713 Eukaryota
COG0852 LUCA
HOGENOMiHOG000009797
InParanoidiQ95748
KOiK03936
OrthoDBiEOG09360N2P

Family and domain databases

Gene3Di3.30.460.80, 1 hit
HAMAPiMF_01357 NDH1_NuoC, 1 hit
InterProiView protein in InterPro
IPR010218 NADH_DH_suC
IPR037232 NADH_quin_OxRdtase_su_C/D-like
IPR001268 NADH_UbQ_OxRdtase_30kDa_su
IPR020396 NADH_UbQ_OxRdtase_CS
PfamiView protein in Pfam
PF00329 Complex1_30kDa, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001581 NADH_UbQ_OxRdtase_30kDa_su, 1 hit
SUPFAMiSSF143243 SSF143243, 1 hit
TIGRFAMsiTIGR01961 NuoC_fam, 1 hit
PROSITEiView protein in PROSITE
PS00542 COMPLEX1_30K, 1 hit

Sequencei

Sequence statusi: Complete.

Q95748-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNQFIFKYS WETLPKKWVK KMERSEHGNR FDTNTDYLFQ LLCFLKLHTY
60 70 80 90 100
TRVQVLIDIC GVDYPSRKRR FEVVYNLLST RYNSRIRVQT SADEVTRISS
110 120 130 140 150
VVSLFPSAGW WEREVWDMFG VSFINHPDLR RILTDYGFEG HPLRKDFPLS
160 170 180 190
GYVQVRYDDP EKRVVSEPIE MTQEFRYFDF ASPWEQRSDG
Length:190
Mass (Da):22,880
Last modified:January 16, 2004 - v2
Checksum:iFCF70F540E71BC70
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti130R → P in BAA11532 (PubMed:8776901).Curated1
Sequence conflicti154Q → E in ABS50639 (PubMed:17565941).Curated1
Sequence conflicti154Q → E in ABS50638 (PubMed:17565941).Curated1

RNA editingi

Edited at positions 31, 56, 64, 100, 110, 133 and 147.2 Publications

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D82062 Genomic DNA Translation: BAA11532.1 Sequence problems.
Y08501 Genomic DNA Translation: CAA69753.3 Sequence problems.
EF488926 mRNA Translation: ABS50638.1
EF488927 mRNA Translation: ABS50639.1
RefSeqiNP_085479.1, NC_001284.2

Genome annotation databases

GeneIDi814568
KEGGiath:ArthMp007

Keywords - Coding sequence diversityi

RNA editing

Similar proteinsi

Entry informationi

Entry nameiNDUS3_ARATH
AccessioniPrimary (citable) accession number: Q95748
Secondary accession number(s): A7KNI3, P93279
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 16, 2004
Last modified: March 28, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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