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Q95748

- NDUS3_ARATH

UniProt

Q95748 - NDUS3_ARATH

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Protein
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3
Gene
NAD9, AtMg00070
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.UniRule annotation

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).UniRule annotation
NADH + acceptor = NAD+ + reduced acceptor.UniRule annotation

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Enzyme and pathway databases

BioCyciARA:ATMG00070-MONOMER.
MetaCyc:ATMG00070-MONOMER.

Protein family/group databases

TCDBi3.D.1.6.3. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3 (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
NADH dehydrogenase subunit 9
Gene namesi
Name:NAD9
Ordered Locus Names:AtMg00070
Encoded oniMitochondrion
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Mitochondrion

Organism-specific databases

TAIRiATMG00070.

Subcellular locationi

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side 1 Publication

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB-SubCell
  2. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 190190NADH dehydrogenase [ubiquinone] iron-sulfur protein 3UniRule annotation
PRO_0000118637Add
BLAST

Proteomic databases

PaxDbiQ95748.
PRIDEiQ95748.

Expressioni

Gene expression databases

GenevestigatoriQ95748.

Interactioni

Subunit structurei

Complex I is composed of at least 49 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.

Protein-protein interaction databases

IntActiQ95748. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ95748.
SMRiQ95748. Positions 56-149.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0852.
HOGENOMiHOG000009797.
KOiK03936.

Family and domain databases

HAMAPiMF_01357. NDH1_NuoC.
InterProiIPR010218. NADH_DH_suC.
IPR001268. NADH_UbQ_OxRdtase_30kDa_su.
IPR020396. NADH_UbQ_OxRdtase_CS.
[Graphical view]
PfamiPF00329. Complex1_30kDa. 1 hit.
[Graphical view]
ProDomiPD001581. NADH_UbQ_OxRdtase_30kDa_su. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR01961. NuoC_fam. 1 hit.
PROSITEiPS00542. COMPLEX1_30K. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q95748-1 [UniParc]FASTAAdd to Basket

« Hide

MDNQFIFKYS WETLPKKWVK KMERSEHGNR FDTNTDYLFQ LLCFLKLHTY    50
TRVQVLIDIC GVDYPSRKRR FEVVYNLLST RYNSRIRVQT SADEVTRISS 100
VVSLFPSAGW WEREVWDMFG VSFINHPDLR RILTDYGFEG HPLRKDFPLS 150
GYVQVRYDDP EKRVVSEPIE MTQEFRYFDF ASPWEQRSDG 190
Length:190
Mass (Da):22,880
Last modified:January 16, 2004 - v2
Checksum:iFCF70F540E71BC70
GO

RNA editingi

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti130 – 1301R → P in BAA11532. 1 Publication
Sequence conflicti154 – 1541Q → E in ABS50639. 1 Publication
Sequence conflicti154 – 1541Q → E in ABS50638. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D82062 Genomic DNA. Translation: BAA11532.1. Sequence problems.
Y08501 Genomic DNA. Translation: CAA69753.3. Sequence problems.
EF488926 mRNA. Translation: ABS50638.1.
EF488927 mRNA. Translation: ABS50639.1.
RefSeqiNP_085479.1. NC_001284.2.

Genome annotation databases

EnsemblPlantsiATMG00070.1; ATMG00070.1; ATMG00070.
GeneIDi814568.
KEGGiath:ArthMp007.

Keywords - Coding sequence diversityi

RNA editing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D82062 Genomic DNA. Translation: BAA11532.1 . Sequence problems.
Y08501 Genomic DNA. Translation: CAA69753.3 . Sequence problems.
EF488926 mRNA. Translation: ABS50638.1 .
EF488927 mRNA. Translation: ABS50639.1 .
RefSeqi NP_085479.1. NC_001284.2.

3D structure databases

ProteinModelPortali Q95748.
SMRi Q95748. Positions 56-149.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q95748. 4 interactions.

Protein family/group databases

TCDBi 3.D.1.6.3. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Proteomic databases

PaxDbi Q95748.
PRIDEi Q95748.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi ATMG00070.1 ; ATMG00070.1 ; ATMG00070 .
GeneIDi 814568.
KEGGi ath:ArthMp007.

Organism-specific databases

TAIRi ATMG00070.

Phylogenomic databases

eggNOGi COG0852.
HOGENOMi HOG000009797.
KOi K03936.

Enzyme and pathway databases

BioCyci ARA:ATMG00070-MONOMER.
MetaCyc:ATMG00070-MONOMER.

Gene expression databases

Genevestigatori Q95748.

Family and domain databases

HAMAPi MF_01357. NDH1_NuoC.
InterProi IPR010218. NADH_DH_suC.
IPR001268. NADH_UbQ_OxRdtase_30kDa_su.
IPR020396. NADH_UbQ_OxRdtase_CS.
[Graphical view ]
Pfami PF00329. Complex1_30kDa. 1 hit.
[Graphical view ]
ProDomi PD001581. NADH_UbQ_OxRdtase_30kDa_su. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
TIGRFAMsi TIGR01961. NuoC_fam. 1 hit.
PROSITEi PS00542. COMPLEX1_30K. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Altered mitochondrial gene expression in a maternal distorted leaf mutant of Arabidopsis induced by chloroplast mutator."
    Sakamoto W., Kondo H., Murata M., Motoyoshi F.
    Plant Cell 8:1377-1390(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: cv. Landsberg erecta.
  2. "The mitochondrial genome of Arabidopsis thaliana contains 57 genes in 366,924 nucleotides."
    Unseld M., Marienfeld J.R., Brandt P., Brennicke A.
    Nat. Genet. 15:57-61(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. "RNA editing in Arabidopsis mitochondria effects 441 C to U changes in ORFs."
    Giege P., Brennicke A.
    Proc. Natl. Acad. Sci. U.S.A. 96:15324-15329(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], RNA EDITING.
  4. "Genetic architecture of mitochondrial editing in Arabidopsis thaliana."
    Bentolila S., Elliott L.E., Hanson M.R.
    Genetics 178:1693-1708(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-184, RNA EDITING.
    Strain: cv. Columbia and cv. Landsberg erecta.
    Tissue: Rosette leaf.
  5. "Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins."
    Heazlewood J.L., Tonti-Filippini J.S., Gout A.M., Day D.A., Whelan J., Millar A.H.
    Plant Cell 16:241-256(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Strain: cv. Landsberg erecta.

Entry informationi

Entry nameiNDUS3_ARATH
AccessioniPrimary (citable) accession number: Q95748
Secondary accession number(s): A7KNI3, P93279
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 16, 2004
Last modified: June 11, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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