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Q95748

- NDUS3_ARATH

UniProt

Q95748 - NDUS3_ARATH

Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 3

Gene

NAD9

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (16 Jan 2004)
      Previous versions | rss
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    Functioni

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.By similarity

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
    NADH + acceptor = NAD+ + reduced acceptor.

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    NAD, Ubiquinone

    Enzyme and pathway databases

    BioCyciARA:ATMG00070-MONOMER.
    MetaCyc:ATMG00070-MONOMER.

    Protein family/group databases

    TCDBi3.D.1.6.3. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH dehydrogenase [ubiquinone] iron-sulfur protein 3 (EC:1.6.5.3, EC:1.6.99.3)
    Alternative name(s):
    NADH dehydrogenase subunit 9
    Gene namesi
    Name:NAD9
    Ordered Locus Names:AtMg00070
    Encoded oniMitochondrion
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Mitochondrion

    Organism-specific databases

    TAIRiATMG00070.

    Subcellular locationi

    Mitochondrion inner membrane 1 Publication; Peripheral membrane protein 1 Publication; Matrix side 1 Publication

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB-SubCell
    2. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 190190NADH dehydrogenase [ubiquinone] iron-sulfur protein 3PRO_0000118637Add
    BLAST

    Proteomic databases

    PaxDbiQ95748.
    PRIDEiQ95748.

    Expressioni

    Gene expression databases

    GenevestigatoriQ95748.

    Interactioni

    Subunit structurei

    Complex I is composed of at least 49 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.

    Protein-protein interaction databases

    IntActiQ95748. 4 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ95748.
    SMRiQ95748. Positions 56-149.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I 30 kDa subunit family.Curated

    Phylogenomic databases

    eggNOGiCOG0852.
    HOGENOMiHOG000009797.
    KOiK03936.

    Family and domain databases

    HAMAPiMF_01357. NDH1_NuoC.
    InterProiIPR010218. NADH_DH_suC.
    IPR001268. NADH_UbQ_OxRdtase_30kDa_su.
    IPR020396. NADH_UbQ_OxRdtase_CS.
    [Graphical view]
    PfamiPF00329. Complex1_30kDa. 1 hit.
    [Graphical view]
    ProDomiPD001581. NADH_UbQ_OxRdtase_30kDa_su. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    TIGRFAMsiTIGR01961. NuoC_fam. 1 hit.
    PROSITEiPS00542. COMPLEX1_30K. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q95748-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDNQFIFKYS WETLPKKWVK KMERSEHGNR FDTNTDYLFQ LLCFLKLHTY    50
    TRVQVLIDIC GVDYPSRKRR FEVVYNLLST RYNSRIRVQT SADEVTRISS 100
    VVSLFPSAGW WEREVWDMFG VSFINHPDLR RILTDYGFEG HPLRKDFPLS 150
    GYVQVRYDDP EKRVVSEPIE MTQEFRYFDF ASPWEQRSDG 190
    Length:190
    Mass (Da):22,880
    Last modified:January 16, 2004 - v2
    Checksum:iFCF70F540E71BC70
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti130 – 1301R → P in BAA11532. (PubMed:8776901)Curated
    Sequence conflicti154 – 1541Q → E in ABS50639. (PubMed:17565941)Curated
    Sequence conflicti154 – 1541Q → E in ABS50638. (PubMed:17565941)Curated

    RNA editingi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D82062 Genomic DNA. Translation: BAA11532.1. Sequence problems.
    Y08501 Genomic DNA. Translation: CAA69753.3. Sequence problems.
    EF488926 mRNA. Translation: ABS50638.1.
    EF488927 mRNA. Translation: ABS50639.1.
    RefSeqiNP_085479.1. NC_001284.2.

    Genome annotation databases

    EnsemblPlantsiATMG00070.1; ATMG00070.1; ATMG00070.
    GeneIDi814568.
    KEGGiath:ArthMp007.

    Keywords - Coding sequence diversityi

    RNA editing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D82062 Genomic DNA. Translation: BAA11532.1 . Sequence problems.
    Y08501 Genomic DNA. Translation: CAA69753.3 . Sequence problems.
    EF488926 mRNA. Translation: ABS50638.1 .
    EF488927 mRNA. Translation: ABS50639.1 .
    RefSeqi NP_085479.1. NC_001284.2.

    3D structure databases

    ProteinModelPortali Q95748.
    SMRi Q95748. Positions 56-149.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q95748. 4 interactions.

    Protein family/group databases

    TCDBi 3.D.1.6.3. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

    Proteomic databases

    PaxDbi Q95748.
    PRIDEi Q95748.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi ATMG00070.1 ; ATMG00070.1 ; ATMG00070 .
    GeneIDi 814568.
    KEGGi ath:ArthMp007.

    Organism-specific databases

    TAIRi ATMG00070.

    Phylogenomic databases

    eggNOGi COG0852.
    HOGENOMi HOG000009797.
    KOi K03936.

    Enzyme and pathway databases

    BioCyci ARA:ATMG00070-MONOMER.
    MetaCyc:ATMG00070-MONOMER.

    Gene expression databases

    Genevestigatori Q95748.

    Family and domain databases

    HAMAPi MF_01357. NDH1_NuoC.
    InterProi IPR010218. NADH_DH_suC.
    IPR001268. NADH_UbQ_OxRdtase_30kDa_su.
    IPR020396. NADH_UbQ_OxRdtase_CS.
    [Graphical view ]
    Pfami PF00329. Complex1_30kDa. 1 hit.
    [Graphical view ]
    ProDomi PD001581. NADH_UbQ_OxRdtase_30kDa_su. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    TIGRFAMsi TIGR01961. NuoC_fam. 1 hit.
    PROSITEi PS00542. COMPLEX1_30K. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Altered mitochondrial gene expression in a maternal distorted leaf mutant of Arabidopsis induced by chloroplast mutator."
      Sakamoto W., Kondo H., Murata M., Motoyoshi F.
      Plant Cell 8:1377-1390(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: cv. Landsberg erecta.
    2. "The mitochondrial genome of Arabidopsis thaliana contains 57 genes in 366,924 nucleotides."
      Unseld M., Marienfeld J.R., Brandt P., Brennicke A.
      Nat. Genet. 15:57-61(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. "RNA editing in Arabidopsis mitochondria effects 441 C to U changes in ORFs."
      Giege P., Brennicke A.
      Proc. Natl. Acad. Sci. U.S.A. 96:15324-15329(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], RNA EDITING.
    4. "Genetic architecture of mitochondrial editing in Arabidopsis thaliana."
      Bentolila S., Elliott L.E., Hanson M.R.
      Genetics 178:1693-1708(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-184, RNA EDITING.
      Strain: cv. Columbia and cv. Landsberg erecta.
      Tissue: Rosette leaf.
    5. "Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins."
      Heazlewood J.L., Tonti-Filippini J.S., Gout A.M., Day D.A., Whelan J., Millar A.H.
      Plant Cell 16:241-256(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Strain: cv. Landsberg erecta.

    Entry informationi

    Entry nameiNDUS3_ARATH
    AccessioniPrimary (citable) accession number: Q95748
    Secondary accession number(s): A7KNI3, P93279
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: January 16, 2004
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3