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Q95604

- 1C17_HUMAN

UniProt

Q95604 - 1C17_HUMAN

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Protein

HLA class I histocompatibility antigen, Cw-17 alpha chain

Gene

HLA-C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

  1. peptide antigen binding Source: UniProt

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
  2. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
  3. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Source: Reactome
  4. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
  5. cytokine-mediated signaling pathway Source: Reactome
  6. interferon-gamma-mediated signaling pathway Source: Reactome
  7. positive regulation of T cell mediated cytotoxicity Source: InterPro
  8. regulation of immune response Source: Reactome
  9. type I interferon signaling pathway Source: Reactome
  10. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiREACT_111168. Endosomal/Vacuolar pathway.
REACT_111178. ER-Phagosome pathway.
REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_25078. Interferon gamma signaling.
REACT_25162. Interferon alpha/beta signaling.
REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, Cw-17 alpha chain
Alternative name(s):
MHC class I antigen Cw*17
Gene namesi
Name:HLA-C
Synonyms:D6S204, HLA-JY3, HLAC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:4933. HLA-C.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: UniProt
  2. early endosome membrane Source: Reactome
  3. endoplasmic reticulum Source: UniProt
  4. ER to Golgi transport vesicle membrane Source: Reactome
  5. Golgi apparatus Source: UniProt
  6. Golgi membrane Source: Reactome
  7. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
  8. MHC class I protein complex Source: UniProt
  9. phagocytic vesicle membrane Source: Reactome
  10. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Add
BLAST
Chaini25 – 372348HLA class I histocompatibility antigen, Cw-17 alpha chainPRO_0000018880Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi110 – 1101N-linked (GlcNAc...)1 Publication
Disulfide bondi125 ↔ 188PROSITE-ProRule annotation
Disulfide bondi227 ↔ 283PROSITE-ProRule annotation

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ95604.
PaxDbiQ95604.
PRIDEiQ95604.

Expressioni

Gene expression databases

CleanExiHS_HLA-C.
GenevestigatoriQ95604.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).By similarity

Protein-protein interaction databases

IntActiQ95604. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ95604.
SMRiQ95604. Positions 26-298.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 317293ExtracellularSequence AnalysisAdd
BLAST
Topological domaini339 – 37234CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei318 – 33821HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini209 – 29789Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni25 – 11490Alpha-1Add
BLAST
Regioni115 – 20692Alpha-2Add
BLAST
Regioni207 – 29892Alpha-3Add
BLAST
Regioni299 – 31719Connecting peptideAdd
BLAST

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42056.
HOVERGENiHBG016709.
InParanoidiQ95604.
PhylomeDBiQ95604.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q95604-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRVMAPQALL LLLSGALALI ETWAGSHSMR YFYTAVSRPG RGEPRFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQADRV
110 120 130 140 150
NLRKLRGYYN QSEAGSHTIQ RMYGCDLGPD GRLLRGYNQF AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DTAAQISQRK LEAAREAEQL RAYLEGECVE WLRGYLENGK
210 220 230 240 250
ETLQRAERPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHVQHEGL QEPCTLRWKP
310 320 330 340 350
SSQPTIPNLG IVSGPAVLAV LAVLAVLAVL GAVVAAVIHR RKSSGGKGGS
360 370
CSQAASSNSA QGSDESLIAC KA
Length:372
Mass (Da):41,238
Last modified:February 1, 1997 - v1
Checksum:iD5DDCE6361D93AA2
GO

Polymorphismi

Cw*17 appears at low frequencies in Caucasoid and Mongoloid populations (gene frequency 0.41 % in English Caucasoids, 0% in Japanese), but seems to be a common specificity in populations of African origin (PubMed:9098935). The following alleles of Cw-17 are known: Cw*17:01, Cw*17:02 and Cw*17:03. The sequence shown is that of Cw*17:01.1 Publication

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 82QA → RT in allele Cw*17:02.
VAR_016648
Natural varianti10 – 101L → I in allele Cw*17:02.
VAR_016649
Natural varianti24 – 241A → T in allele Cw*17:03.
VAR_016650
Natural varianti73 – 731A → E.
Corresponds to variant rs1050409 [ dbSNP | Ensembl ].
VAR_056512
Natural varianti76 – 761V → M.
Corresponds to variant rs1065382 [ dbSNP | Ensembl ].
VAR_056513
Natural varianti90 – 901K → N.
Corresponds to variant rs28626310 [ dbSNP | Ensembl ].
VAR_056514
Natural varianti97 – 971A → T.
Corresponds to variant rs41543814 [ dbSNP | Ensembl ].
VAR_056515
Natural varianti272 – 2721V → M.
Corresponds to variant rs1050276 [ dbSNP | Ensembl ].
VAR_056516

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U62824 mRNA. Translation: AAB67322.1.
X98742 mRNA. Translation: CAA67294.1.
Y10520 mRNA. Translation: CAA71531.1.
AJ420252 Genomic DNA. Translation: CAD12437.1.
D64149 mRNA. Translation: BAA20857.1.
Y18537
, Y18538, Y18539, Y18540, Y18541 Genomic DNA. Translation: CAB71837.1.
U06835 mRNA. Translation: AAA17674.1.
PIRiA59028.
UniGeneiHs.656020.
Hs.743218.
Hs.77961.

Genome annotation databases

EnsembliENST00000400341; ENSP00000383195; ENSG00000206435.
ENST00000400394; ENSP00000383244; ENSG00000206452.

Polymorphism databases

DMDMi34395506.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U62824 mRNA. Translation: AAB67322.1 .
X98742 mRNA. Translation: CAA67294.1 .
Y10520 mRNA. Translation: CAA71531.1 .
AJ420252 Genomic DNA. Translation: CAD12437.1 .
D64149 mRNA. Translation: BAA20857.1 .
Y18537
, Y18538 , Y18539 , Y18540 , Y18541 Genomic DNA. Translation: CAB71837.1 .
U06835 mRNA. Translation: AAA17674.1 .
PIRi A59028.
UniGenei Hs.656020.
Hs.743218.
Hs.77961.

3D structure databases

ProteinModelPortali Q95604.
SMRi Q95604. Positions 26-298.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q95604. 1 interaction.

Polymorphism databases

DMDMi 34395506.

Proteomic databases

MaxQBi Q95604.
PaxDbi Q95604.
PRIDEi Q95604.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000400341 ; ENSP00000383195 ; ENSG00000206435 .
ENST00000400394 ; ENSP00000383244 ; ENSG00000206452 .

Organism-specific databases

GeneCardsi GC06M031236.
GC06Mn31226.
GC06Mo31229.
HGNCi HGNC:4933. HLA-C.
MIMi 142840. gene.
neXtProti NX_Q95604.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42056.
HOVERGENi HBG016709.
InParanoidi Q95604.
PhylomeDBi Q95604.

Enzyme and pathway databases

Reactomei REACT_111168. Endosomal/Vacuolar pathway.
REACT_111178. ER-Phagosome pathway.
REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_25078. Interferon gamma signaling.
REACT_25162. Interferon alpha/beta signaling.
REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSi HLA-C. human.
SOURCEi Search...

Gene expression databases

CleanExi HS_HLA-C.
Genevestigatori Q95604.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view ]
PRINTSi PR01638. MHCCLASSI.
SMARTi SM00407. IGc1. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cw*1701 defines a divergent african HLA-C allelic lineage."
    Wells R.S., Seielstad M.T., Bunce M., Tyan D.B., Bekele E., Parham P.
    Immunogenetics 46:173-180(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*17:01).
  2. "The complete primary structure of Cw*1701 reveals a highly divergent HLA class I molecule."
    Herrero M.J., Vilches C., de Pablo R., Puente S., Kreisler M.
    Tissue Antigens 49:267-270(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*17:01).
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE CW*17:01).
  4. "HLA-C locus polymorphisms in Japanese."
    Wang H., Tokunaga K.
    Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-289 (ALLELE CW*17:02).
    Tissue: Peripheral blood.
  5. "There is more to HLA -C than exons 2 and 3: sequencing exons 1, 4 and 5."
    van der Vlies S.A., Voorter C.E., van den Berg-Loonen E.M.
    Tissue Antigens 54:169-177(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-338 (ALLELE CW*17:03).
  6. "Nucleotide sequence analysis of HLA-Cw blank alleles from seven B cell lines."
    Yang S., Cereb N.
    Submitted (APR-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 26-298 (ALLELE CW*17:01).
    Tissue: Blood.
  7. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-110.
    Tissue: Liver.

Entry informationi

Entry namei1C17_HUMAN
AccessioniPrimary (citable) accession number: Q95604
Secondary accession number(s): O02864
, O02958, Q29643, Q9MY30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: February 1, 1997
Last modified: October 29, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3