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Protein
Submitted name:

MHC class I alpha chain 2

Gene

BFIV21

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • peptide antigen binding Source: AgBase

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-GGA-1236974. ER-Phagosome pathway.
R-GGA-1236977. Endosomal/Vacuolar pathway.
R-GGA-6798695. Neutrophil degranulation.
R-GGA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class I alpha chain 2Imported
Submitted name:
MHC class I antigenImported
Submitted name:
MHC class I glycoproteinImported
Submitted name:
MHC class I moleculeImported
Submitted name:
Major histocompatibility complex class I glycoprotein haplotype B21Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:BFIV21Imported
Synonyms:B-FIVImported, BF2Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 16

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei298 – 323HelicalSequence analysisAdd BLAST26

GO - Cellular componenti

  • cell surface Source: AgBase
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500878539422 – 355Sequence analysisAdd BLAST334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi120 ↔ 182Combined sources
Disulfide bondi220 ↔ 276Combined sources

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSGALG00000024372.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000000138.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YEZX-ray2.90A1-291[»]
3BEVX-ray2.10A22-291[»]
3BEWX-ray2.60A/D22-291[»]
4CVZX-ray2.39A1-291[»]
4D0BX-ray2.80A1-291[»]
4D0CX-ray2.81A1-291[»]
5ACZX-ray2.69A1-291[»]
5AD0X-ray2.84A1-291[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini203 – 282Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST80

Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410II5V. Eukaryota.
ENOG4111K8F. LUCA.
GeneTreeiENSGT00760000118960.
HOVERGENiHBG016709.
KOiK06751.
OMAiTEWIAAN.
OrthoDBiEOG091G0K1X.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q95601-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSCGALGLG LLLAAVCGAA AELHTLRYIR TAMTDPGPGL PWFVDVGYVD
60 70 80 90 100
GELFMHYNST ARRAVPRTEW IAANTDQQYW DRETQIVQGS EQINRENLDI
110 120 130 140 150
LRRRYNQTGG SHTVQWMSGC DILEDGTIRG YHQAAYDGRD FVAFDKGTMT
160 170 180 190 200
LTAAVPEAVP TKRKWEEGGY AEGLKQYLEE TCVEWLRRYV EYGKAELGRR
210 220 230 240 250
ERPEVRVWGK EADGILTLSC RAHGFYPRPI VVSWLKDGAV RGQDAQSGGI
260 270 280 290 300
VPNGDGTYHT WVTIDAQPGD GDKYQCRVEH ASLPQPGLYS WEPPQPNLVP
310 320 330 340 350
IVAGVAVAIV AIAIVVGVGF IIYRRHAGKK GKGYNIAPDR EGGSSSSSTG

SNPSI
Length:355
Mass (Da):38,960
Last modified:February 1, 1997 - v1
Checksum:iA751A09C46D94EE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000555 Genomic DNA. No translation available.
S78682 mRNA. Translation: AAB34945.1.
AF013493 mRNA. Translation: AAC17590.1.
AY234769 mRNA. Translation: AAP20110.1.
HQ435266 mRNA. Translation: ADZ31363.1.
KM014728 mRNA. Translation: AIP84343.1.
AB268588 Genomic DNA. Translation: BAF63006.1.
AB426152 Genomic DNA. Translation: BAG69455.1.
AM282697 Genomic DNA. Translation: CAK54658.1.
AM282700 Genomic DNA. Translation: CAK54661.1.
PIRiI51309.
RefSeqiNP_001026509.1. NM_001031338.1.
UniGeneiGga.33600.
Gga.4973.

Genome annotation databases

EnsembliENSGALT00000079478; ENSGALP00000043493; ENSGALG00000041380.
GeneIDi425389.
KEGGigga:425389.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000555 Genomic DNA. No translation available.
S78682 mRNA. Translation: AAB34945.1.
AF013493 mRNA. Translation: AAC17590.1.
AY234769 mRNA. Translation: AAP20110.1.
HQ435266 mRNA. Translation: ADZ31363.1.
KM014728 mRNA. Translation: AIP84343.1.
AB268588 Genomic DNA. Translation: BAF63006.1.
AB426152 Genomic DNA. Translation: BAG69455.1.
AM282697 Genomic DNA. Translation: CAK54658.1.
AM282700 Genomic DNA. Translation: CAK54661.1.
PIRiI51309.
RefSeqiNP_001026509.1. NM_001031338.1.
UniGeneiGga.33600.
Gga.4973.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YEZX-ray2.90A1-291[»]
3BEVX-ray2.10A22-291[»]
3BEWX-ray2.60A/D22-291[»]
4CVZX-ray2.39A1-291[»]
4D0BX-ray2.80A1-291[»]
4D0CX-ray2.81A1-291[»]
5ACZX-ray2.69A1-291[»]
5AD0X-ray2.84A1-291[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000000138.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000079478; ENSGALP00000043493; ENSGALG00000041380.
GeneIDi425389.
KEGGigga:425389.

Organism-specific databases

CTDi425389.

Phylogenomic databases

eggNOGiENOG410II5V. Eukaryota.
ENOG4111K8F. LUCA.
GeneTreeiENSGT00760000118960.
HOVERGENiHBG016709.
KOiK06751.
OMAiTEWIAAN.
OrthoDBiEOG091G0K1X.

Enzyme and pathway databases

ReactomeiR-GGA-1236974. ER-Phagosome pathway.
R-GGA-1236977. Endosomal/Vacuolar pathway.
R-GGA-6798695. Neutrophil degranulation.
R-GGA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Gene expression databases

BgeeiENSGALG00000024372.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ95601_CHICK
AccessioniPrimary (citable) accession number: Q95601
Entry historyi
Integrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: February 1, 1997
Last modified: November 30, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.