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Protein
Submitted name:

MHC class I alpha chain 2

Gene

BFIV21

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • peptide antigen binding Source: AgBase

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-GGA-1236974. ER-Phagosome pathway.
R-GGA-1236977. Endosomal/Vacuolar pathway.
R-GGA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class I alpha chain 2Imported
Submitted name:
MHC class I antigenImported
Submitted name:
MHC class I glycoproteinImported
Submitted name:
MHC class I moleculeImported
Submitted name:
Major histocompatibility complex class I glycoprotein haplotype B21Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:BFIV21Imported
Synonyms:B-FIVImported, BF2Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 16

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei298 – 32326HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 355334Sequence analysisPRO_5007215606Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi120 ↔ 182Combined sources
Disulfide bondi220 ↔ 276Combined sources

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

ExpressionAtlasiQ95601. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000000138.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YEZX-ray2.90A1-291[»]
2YF1X-ray2.75A1-291[»]
3BEVX-ray2.10A22-291[»]
3BEWX-ray2.60A/D22-291[»]
4CVZX-ray2.39A1-291[»]
4D0BX-ray2.80A1-291[»]
4D0CX-ray2.81A1-291[»]
SMRiQ95601. Positions 22-291.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini203 – 28280Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotation
Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410II5V. Eukaryota.
ENOG4111K8F. LUCA.
GeneTreeiENSGT00760000118960.
HOVERGENiHBG016709.
KOiK06751.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q95601-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSCGALGLG LLLAAVCGAA AELHTLRYIR TAMTDPGPGL PWFVDVGYVD
60 70 80 90 100
GELFMHYNST ARRAVPRTEW IAANTDQQYW DRETQIVQGS EQINRENLDI
110 120 130 140 150
LRRRYNQTGG SHTVQWMSGC DILEDGTIRG YHQAAYDGRD FVAFDKGTMT
160 170 180 190 200
LTAAVPEAVP TKRKWEEGGY AEGLKQYLEE TCVEWLRRYV EYGKAELGRR
210 220 230 240 250
ERPEVRVWGK EADGILTLSC RAHGFYPRPI VVSWLKDGAV RGQDAQSGGI
260 270 280 290 300
VPNGDGTYHT WVTIDAQPGD GDKYQCRVEH ASLPQPGLYS WEPPQPNLVP
310 320 330 340 350
IVAGVAVAIV AIAIVVGVGF IIYRRHAGKK GKGYNIAPDR EGGSSSSSTG

SNPSI
Length:355
Mass (Da):38,960
Last modified:February 1, 1997 - v1
Checksum:iA751A09C46D94EE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN03007224 Genomic DNA. No translation available.
S78682 mRNA. Translation: AAB34945.1.
AF013493 mRNA. Translation: AAC17590.1.
AY234769 mRNA. Translation: AAP20110.1.
HQ435266 mRNA. Translation: ADZ31363.1.
KM014728 mRNA. Translation: AIP84343.1.
AB268588 Genomic DNA. Translation: BAF63006.1.
AB426152 Genomic DNA. Translation: BAG69455.1.
AM282697 Genomic DNA. Translation: CAK54658.1.
AM282700 Genomic DNA. Translation: CAK54661.1.
PIRiI51309.
RefSeqiNP_001026509.1. NM_001031338.1.
UniGeneiGga.33600.
Gga.4973.

Genome annotation databases

EnsembliENSGALT00000043207; ENSGALP00000042920; ENSGALG00000024372.
GeneIDi425389.
KEGGigga:425389.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN03007224 Genomic DNA. No translation available.
S78682 mRNA. Translation: AAB34945.1.
AF013493 mRNA. Translation: AAC17590.1.
AY234769 mRNA. Translation: AAP20110.1.
HQ435266 mRNA. Translation: ADZ31363.1.
KM014728 mRNA. Translation: AIP84343.1.
AB268588 Genomic DNA. Translation: BAF63006.1.
AB426152 Genomic DNA. Translation: BAG69455.1.
AM282697 Genomic DNA. Translation: CAK54658.1.
AM282700 Genomic DNA. Translation: CAK54661.1.
PIRiI51309.
RefSeqiNP_001026509.1. NM_001031338.1.
UniGeneiGga.33600.
Gga.4973.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YEZX-ray2.90A1-291[»]
2YF1X-ray2.75A1-291[»]
3BEVX-ray2.10A22-291[»]
3BEWX-ray2.60A/D22-291[»]
4CVZX-ray2.39A1-291[»]
4D0BX-ray2.80A1-291[»]
4D0CX-ray2.81A1-291[»]
SMRiQ95601. Positions 22-291.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000000138.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000043207; ENSGALP00000042920; ENSGALG00000024372.
GeneIDi425389.
KEGGigga:425389.

Organism-specific databases

CTDi425389.

Phylogenomic databases

eggNOGiENOG410II5V. Eukaryota.
ENOG4111K8F. LUCA.
GeneTreeiENSGT00760000118960.
HOVERGENiHBG016709.
KOiK06751.

Enzyme and pathway databases

ReactomeiR-GGA-1236974. ER-Phagosome pathway.
R-GGA-1236977. Endosomal/Vacuolar pathway.
R-GGA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Gene expression databases

ExpressionAtlasiQ95601. baseline and differential.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Functional analysis of avian class I (BFIV) glycoproteins by epitope tagging and mutagenesis in vitro."
    Fulton J.E., Thacker E.L., Bacon L.D., Hunt H.D.
    Eur. J. Immunol. 25:2069-2076(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Analysis of polymorphisms in the major expressed class I locus (B-FIV) of the chicken."
    Hunt H.D., Fulton J.E.
    Immunogenetics 47:456-467(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 15I5 B21 congenicImported and UCD BQImported.
  3. Park S.Y., Min B.W.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: UCD BQImported.
  4. "Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution."
    International Chicken Genome Sequencing Consortium
    Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A.
    , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K.
    Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Red jungle fowlImported.
  5. Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 22-291, DISULFIDE BONDS.
  6. "Different evolutionary histories of the two classical class I genes BF1 and BF2 illustrate drift and selection within the stable MHC haplotypes of chickens."
    Shaw I., Powell T.J., Marston D.A., Baker K., van Hateren A., Riegert P., Wiles M.V., Milne S., Beck S., Kaufman J.
    J. Immunol. 178:5744-5752(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 0Imported and NImported.
  7. "Extended gene map reveals tripartite motif, C-type lectin, and Ig superfamily type genes within a subregion of the chicken MHC-B affecting infectious disease."
    Shiina T., Briles W.E., Goto R.M., Hosomichi K., Yanagiya K., Shimizu S., Inoko H., Miller M.M.
    J. Immunol. 178:7162-7172(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  8. "Contribution of mutation, recombination, and gene conversion to chicken MHC-B haplotype diversity."
    Hosomichi K., Miller M.M., Goto R.M., Wang Y., Suzuki S., Kulski J.K., Nishibori M., Inoko H., Hanzawa K., Shiina T.
    J. Immunol. 181:3393-3399(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Cornell-NImported.
  9. "Polymorphic sites are mainly located in the 1 and 2 domains of MHC class I chain from several Chinese native chicken breeds."
    Dai Y., Liu X., Ye H., Liu S., Geng Z., Chen F., Yu W.
    Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: HBP-2Imported.
  10. "B21 Chicken Class I Mhc Molecules and Promiscuous Peptide Binding."
    Chappell P., Roversi P., Harrison M.C., Mears L.E., Kaufman J.F., Lea S.M.
    Submitted (MAR-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 1-291, DISULFIDE BONDS.
  11. Lai Y.H.
    Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: HNP-27Imported.
  12. Cited for: X-RAY CRYSTALLOGRAPHY (2.39 ANGSTROMS) OF 1-291, DISULFIDE BONDS.
  13. Ensembl
    Submitted (MAR-2016) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Red jungle fowlImported.

Entry informationi

Entry nameiQ95601_CHICK
AccessioniPrimary (citable) accession number: Q95601
Entry historyi
Integrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: February 1, 1997
Last modified: June 8, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.