Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

MHC class I antigen

Gene

LA-A11

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class I antigenImported
Gene namesi
Name:LA-A11Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei305 – 328HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane, MHC ISAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_500432341325 – 361Sequence analysisAdd BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi125 ↔ 188Combined sources
Disulfide bondi227 ↔ 283Combined sources

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).SAAS annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PWUX-ray1.90A26-299[»]
3PWVX-ray2.70A/D26-299[»]
ProteinModelPortaliQ95477.
SMRiQ95477.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 295Ig-likeInterPro annotationAdd BLAST87

Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOVERGENiHBG016709.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR037055. MHC_I-like_Ag-recog_sf.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
PfamiView protein in Pfam
PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
PRINTSiPR01638. MHCCLASSI.
SMARTiView protein in SMART
SM00407. IGc1. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q95477-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVMRPRTLL LLLSRVLVLT ETLAGSHSLR YFYTAVSRPG LGEPRFIAVG
60 70 80 90 100
YVDDTQFTRF DSDAPNPRDE PRVPWMEQEG PEYWDRNTRI YKDTAQIFRA
110 120 130 140 150
NLNTALGYYN QSEAGSHTFQ EMYGCYVGPD GRLLLGFMQF AYDGRDYIAL
160 170 180 190 200
NEDLRSWTAA DTAAQITKRK WEAAGEAERQ RNYLEGRCVE GLRRYLENGK
210 220 230 240 250
DTLLRADPPK AHVTHHPISD REVTLRCWAL GFYPEEISLT WQHEGEDQTQ
260 270 280 290 300
DMELVETRPS GDGTFQKWAA LVVPSGEEQR YTCRVQHEGL QEPLTLRWEP
310 320 330 340 350
PQTSFLTMGI IVGLVLLVVA VVAGAVIWRK KRSGEKGRIY TQAASSDSAQ
360
GSDVSLTVPK V
Length:361
Mass (Da):41,030
Last modified:February 1, 1997 - v1
Checksum:iA3406BBA75D16D0F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82671
, X82672, X82673, X82674, X82675 Genomic DNA. Translation: CAA57992.1.
PIRiI46030.
UniGeneiBt.12775.
Bt.65666.
Bt.91164.

Similar proteinsi

Entry informationi

Entry nameiQ95477_BOVIN
AccessioniPrimary (citable) accession number: Q95477
Entry historyiIntegrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: February 1, 1997
Last modified: October 25, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources