Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q95460

- HMR1_HUMAN

UniProt

Q95460 - HMR1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Major histocompatibility complex class I-related gene protein

Gene

MR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei65 – 651Pathogen-derived ligand

GO - Molecular functioni

  1. MHC class I receptor activity Source: UniProtKB
  2. peptide antigen binding Source: InterPro

GO - Biological processi

  1. antigen processing and presentation of peptide antigen via MHC class I Source: UniProtKB-KW
  2. immune response Source: ProtInc
  3. innate immune response Source: UniProtKB-KW
  4. positive regulation of T cell mediated cytotoxicity Source: InterPro
  5. signal transduction Source: GOC
Complete GO annotation...

Keywords - Biological processi

Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Major histocompatibility complex class I-related gene protein
Short name:
MHC class I-related gene protein
Alternative name(s):
Class I histocompatibility antigen-like protein
Gene namesi
Name:MR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:4975. MR1.

Subcellular locationi

Isoform 3 : Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Endoplasmic reticulum membrane 1 Publication
Note: The larger proportion remains in the ER in an immature state. The subset that reach cell surface does it through a B2M-independent pathway.

GO - Cellular componenti

  1. endoplasmic reticulum Source: MGI
  2. extracellular region Source: UniProtKB-KW
  3. integral component of membrane Source: UniProtKB-KW
  4. MHC class I protein complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane, MHC I, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi65 – 651K → R: Fails to refold in the presence of 6-FP.
Mutagenesisi169 – 1691Q → L: Able to activate mouse MAIT cells. 1 Publication
Mutagenesisi283 – 2831C → G: No effect on cell surface expression. 1 Publication

Organism-specific databases

PharmGKBiPA29309.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22221 PublicationAdd
BLAST
Chaini23 – 341319Major histocompatibility complex class I-related gene proteinPRO_0000344441Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi107 – 1071N-linked (GlcNAc...)1 Publication
Disulfide bondi120 ↔ 1831 PublicationPROSITE-ProRule annotation
Disulfide bondi222 ↔ 2781 PublicationPROSITE-ProRule annotation

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ95460.
PRIDEiQ95460.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiQ95460.
CleanExiHS_MR1.
GenevestigatoriQ95460.

Interactioni

Subunit structurei

Heterodimerizes with B2M, this interaction is required for surface expression. Associated with the peptide-loading complex, TAPBP, CALR and PDIA3. Isoform 3/MR1B homodimerizes and doesn't associates with B2M nor proteins of the peptide-loading complex.1 Publication

Protein-protein interaction databases

BioGridi109385. 11 interactions.
DIPiDIP-59986N.

Structurei

Secondary structure

1
341
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi25 – 3612
Beta strandi39 – 413
Beta strandi43 – 508
Beta strandi53 – 597
Turni60 – 623
Beta strandi66 – 694
Helixi70 – 734
Helixi78 – 10629
Beta strandi113 – 12210
Beta strandi128 – 1369
Beta strandi139 – 1457
Turni146 – 1494
Beta strandi150 – 1556
Helixi156 – 16611
Helixi169 – 18012
Helixi182 – 19312
Helixi195 – 1984
Beta strandi205 – 2128
Beta strandi218 – 23013
Beta strandi233 – 2386
Helixi244 – 2463
Beta strandi247 – 2493
Beta strandi256 – 2583
Beta strandi260 – 2678
Beta strandi276 – 2827
Beta strandi285 – 2906

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GUPX-ray3.20A/C23-292[»]
4L4TX-ray2.00A/C23-292[»]
4L4VX-ray1.90A/C23-292[»]
4LCWX-ray2.40A/C23-292[»]
4NQCX-ray2.50A/C23-292[»]
4NQDX-ray2.20A/C23-292[»]
4NQEX-ray2.10A/C23-292[»]
4PJ5X-ray2.00A/C23-292[»]
4PJ7X-ray2.50A/C23-292[»]
4PJ8X-ray3.30A23-292[»]
4PJ9X-ray2.00A23-292[»]
4PJAX-ray2.68A/C23-292[»]
4PJBX-ray2.85A/C23-292[»]
4PJCX-ray2.50A/C23-292[»]
4PJDX-ray2.78A/C23-292[»]
4PJEX-ray1.95A/C23-292[»]
4PJFX-ray2.45A/C23-292[»]
4PJGX-ray2.40A/C23-292[»]
4PJHX-ray2.00A/C23-292[»]
4PJIX-ray2.50A/C23-292[»]
4PJXX-ray2.25A/C23-292[»]
ProteinModelPortaliQ95460.
SMRiQ95460. Positions 23-291.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 302280ExtracellularSequence AnalysisAdd
BLAST
Topological domaini324 – 34118CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei303 – 32321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini203 – 29997Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni23 – 201179Ligand-bindingAdd
BLAST
Regioni23 – 10987Alpha-1Add
BLAST
Regioni110 – 20192Alpha-2Add
BLAST
Regioni202 – 29392Alpha-3Add
BLAST
Regioni294 – 3029Connecting peptide

Domaini

The alpha-3 region and to a lesser extent the transmembrane and cytosolic domains regulate surface expression. The alpha-3 region mediates interaction with B2M (PubMed:23051753).1 Publication
The ligand-binding groove is ideally suited to present small organic compounds that can originate from vitamins rather than antigenic peptides.1 Publication

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42056.
GeneTreeiENSGT00760000118960.
HOGENOMiHOG000296917.
HOVERGENiHBG016709.
InParanoidiQ95460.
OMAiETECIAW.
OrthoDBiEOG7JT6WQ.
PhylomeDBiQ95460.
TreeFamiTF336617.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q95460-1) [UniParc]FASTAAdd to Basket

Also known as: MR1A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGELMAFLLP LIIVLMVKHS DSRTHSLRYF RLGVSDPIHG VPEFISVGYV
60 70 80 90 100
DSHPITTYDS VTRQKEPRAP WMAENLAPDH WERYTQLLRG WQQMFKVELK
110 120 130 140 150
RLQRHYNHSG SHTYQRMIGC ELLEDGSTTG FLQYAYDGQD FLIFNKDTLS
160 170 180 190 200
WLAVDNVAHT IKQAWEANQH ELLYQKNWLE EECIAWLKRF LEYGKDTLQR
210 220 230 240 250
TEPPLVRVNR KETFPGVTAL FCKAHGFYPP EIYMTWMKNG EEIVQEIDYG
260 270 280 290 300
DILPSGDGTY QAWASIELDP QSSNLYSCHV EHCGVHMVLQ VPQESETIPL
310 320 330 340
VMKAVSGSIV LVIVLAGVGV LVWRRRPREQ NGAIYLPTPD R
Length:341
Mass (Da):39,366
Last modified:February 1, 1997 - v1
Checksum:i2990C1F3F0A1CAD9
GO
Isoform 2 (identifier: Q95460-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     110-154: Missing.

Show »
Length:296
Mass (Da):34,278
Checksum:i05ABC9CD4189F639
GO
Isoform 3 (identifier: Q95460-3) [UniParc]FASTAAdd to Basket

Also known as: MR1B, MR1D

The sequence of this isoform differs from the canonical sequence as follows:
     203-294: Missing.

Show »
Length:249
Mass (Da):28,973
Checksum:iDED2E979686D6A8A
GO
Isoform 4 (identifier: Q95460-4) [UniParc]FASTAAdd to Basket

Also known as: MR1C

The sequence of this isoform differs from the canonical sequence as follows:
     202-220: EPPLVRVNRKETFPGVTAL → GKEKEKASFPHCLNNCFYT
     221-341: Missing.

Show »
Length:220
Mass (Da):25,933
Checksum:i529688A56159C475
GO
Isoform 5 (identifier: Q95460-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     202-328: Missing.

Note: No experimental confirmation available.

Show »
Length:214
Mass (Da):25,190
Checksum:iB84A09E70B280E74
GO

Sequence cautioni

The sequence AAD01443.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti117 – 1171M → V in BAF83063. (PubMed:14702039)Curated
Sequence conflicti200 – 2001R → G in BAD96630. 1 PublicationCurated
Sequence conflicti315 – 3151L → P in BAD96630. 1 PublicationCurated

Polymorphismi

Several individuals from different ethnic background were analyzed for polymorphism. MR1 was identical in all individuals analyzed, except one. MR1 is not polymorphic.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti39 – 391H → R.1 Publication
Corresponds to variant rs2236410 [ dbSNP | Ensembl ].
VAR_045608
Natural varianti63 – 631R → Q.
Corresponds to variant rs3897433 [ dbSNP | Ensembl ].
VAR_045609
Natural varianti77 – 771A → V.
Corresponds to variant rs3897434 [ dbSNP | Ensembl ].
VAR_045610

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei110 – 15445Missing in isoform 2. 1 PublicationVSP_034755Add
BLAST
Alternative sequencei202 – 328127Missing in isoform 5. 1 PublicationVSP_043479Add
BLAST
Alternative sequencei202 – 22019EPPLV…GVTAL → GKEKEKASFPHCLNNCFYT in isoform 4. 1 PublicationVSP_034756Add
BLAST
Alternative sequencei203 – 29492Missing in isoform 3. 2 PublicationsVSP_034757Add
BLAST
Alternative sequencei221 – 341121Missing in isoform 4. 1 PublicationVSP_034758Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U22963 mRNA. Translation: AAC50174.1.
AJ249778 mRNA. Translation: CAB77667.1.
AK290374 mRNA. Translation: BAF83063.1.
AK304645 mRNA. Translation: BAG65423.1.
AK222910 mRNA. Translation: BAD96630.1.
AL356267 Genomic DNA. Translation: CAH72302.1.
AL356267 Genomic DNA. Translation: CAH72303.1.
AL356267 Genomic DNA. Translation: CAH72304.1.
AL356267 Genomic DNA. Translation: CAH72305.1.
CH471067 Genomic DNA. Translation: EAW91097.1.
CH471067 Genomic DNA. Translation: EAW91098.1.
CH471067 Genomic DNA. Translation: EAW91095.1.
BC012485 mRNA. Translation: AAH12485.1.
AF010446 mRNA. Translation: AAD01442.1.
AF010447 mRNA. Translation: AAD01443.1. Different initiation.
AF031469 mRNA. Translation: AAD01933.1.
AF039526 Genomic DNA. Translation: AAD02172.1.
AH006983 Genomic DNA. Translation: AAC72900.1.
AF223407 Genomic DNA. Translation: AAF40170.1.
CCDSiCCDS1342.1. [Q95460-1]
CCDS53440.1. [Q95460-3]
CCDS53441.1. [Q95460-5]
CCDS53442.1. [Q95460-2]
PIRiA57136.
RefSeqiNP_001181928.1. NM_001194999.1. [Q95460-2]
NP_001181929.1. NM_001195000.1. [Q95460-3]
NP_001181964.1. NM_001195035.1. [Q95460-5]
NP_001522.1. NM_001531.2. [Q95460-1]
UniGeneiHs.13500.

Genome annotation databases

EnsembliENST00000282990; ENSP00000282990; ENSG00000153029. [Q95460-3]
ENST00000367579; ENSP00000356551; ENSG00000153029. [Q95460-2]
ENST00000367580; ENSP00000356552; ENSG00000153029. [Q95460-1]
ENST00000434571; ENSP00000388504; ENSG00000153029. [Q95460-5]
ENST00000614012; ENSP00000477563; ENSG00000153029. [Q95460-1]
ENST00000617803; ENSP00000478976; ENSG00000153029. [Q95460-3]
GeneIDi3140.
KEGGihsa:3140.
UCSCiuc001gop.3. human. [Q95460-4]
uc001goq.2. human. [Q95460-1]
uc001gor.2. human. [Q95460-2]
uc001gos.2. human. [Q95460-3]
uc010pns.2. human. [Q95460-5]

Polymorphism databases

DMDMi74751679.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U22963 mRNA. Translation: AAC50174.1 .
AJ249778 mRNA. Translation: CAB77667.1 .
AK290374 mRNA. Translation: BAF83063.1 .
AK304645 mRNA. Translation: BAG65423.1 .
AK222910 mRNA. Translation: BAD96630.1 .
AL356267 Genomic DNA. Translation: CAH72302.1 .
AL356267 Genomic DNA. Translation: CAH72303.1 .
AL356267 Genomic DNA. Translation: CAH72304.1 .
AL356267 Genomic DNA. Translation: CAH72305.1 .
CH471067 Genomic DNA. Translation: EAW91097.1 .
CH471067 Genomic DNA. Translation: EAW91098.1 .
CH471067 Genomic DNA. Translation: EAW91095.1 .
BC012485 mRNA. Translation: AAH12485.1 .
AF010446 mRNA. Translation: AAD01442.1 .
AF010447 mRNA. Translation: AAD01443.1 . Different initiation.
AF031469 mRNA. Translation: AAD01933.1 .
AF039526 Genomic DNA. Translation: AAD02172.1 .
AH006983 Genomic DNA. Translation: AAC72900.1 .
AF223407 Genomic DNA. Translation: AAF40170.1 .
CCDSi CCDS1342.1. [Q95460-1 ]
CCDS53440.1. [Q95460-3 ]
CCDS53441.1. [Q95460-5 ]
CCDS53442.1. [Q95460-2 ]
PIRi A57136.
RefSeqi NP_001181928.1. NM_001194999.1. [Q95460-2 ]
NP_001181929.1. NM_001195000.1. [Q95460-3 ]
NP_001181964.1. NM_001195035.1. [Q95460-5 ]
NP_001522.1. NM_001531.2. [Q95460-1 ]
UniGenei Hs.13500.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4GUP X-ray 3.20 A/C 23-292 [» ]
4L4T X-ray 2.00 A/C 23-292 [» ]
4L4V X-ray 1.90 A/C 23-292 [» ]
4LCW X-ray 2.40 A/C 23-292 [» ]
4NQC X-ray 2.50 A/C 23-292 [» ]
4NQD X-ray 2.20 A/C 23-292 [» ]
4NQE X-ray 2.10 A/C 23-292 [» ]
4PJ5 X-ray 2.00 A/C 23-292 [» ]
4PJ7 X-ray 2.50 A/C 23-292 [» ]
4PJ8 X-ray 3.30 A 23-292 [» ]
4PJ9 X-ray 2.00 A 23-292 [» ]
4PJA X-ray 2.68 A/C 23-292 [» ]
4PJB X-ray 2.85 A/C 23-292 [» ]
4PJC X-ray 2.50 A/C 23-292 [» ]
4PJD X-ray 2.78 A/C 23-292 [» ]
4PJE X-ray 1.95 A/C 23-292 [» ]
4PJF X-ray 2.45 A/C 23-292 [» ]
4PJG X-ray 2.40 A/C 23-292 [» ]
4PJH X-ray 2.00 A/C 23-292 [» ]
4PJI X-ray 2.50 A/C 23-292 [» ]
4PJX X-ray 2.25 A/C 23-292 [» ]
ProteinModelPortali Q95460.
SMRi Q95460. Positions 23-291.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109385. 11 interactions.
DIPi DIP-59986N.

Chemistry

DrugBanki DB00098. Antithymocyte globulin.

Polymorphism databases

DMDMi 74751679.

Proteomic databases

PaxDbi Q95460.
PRIDEi Q95460.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000282990 ; ENSP00000282990 ; ENSG00000153029 . [Q95460-3 ]
ENST00000367579 ; ENSP00000356551 ; ENSG00000153029 . [Q95460-2 ]
ENST00000367580 ; ENSP00000356552 ; ENSG00000153029 . [Q95460-1 ]
ENST00000434571 ; ENSP00000388504 ; ENSG00000153029 . [Q95460-5 ]
ENST00000614012 ; ENSP00000477563 ; ENSG00000153029 . [Q95460-1 ]
ENST00000617803 ; ENSP00000478976 ; ENSG00000153029 . [Q95460-3 ]
GeneIDi 3140.
KEGGi hsa:3140.
UCSCi uc001gop.3. human. [Q95460-4 ]
uc001goq.2. human. [Q95460-1 ]
uc001gor.2. human. [Q95460-2 ]
uc001gos.2. human. [Q95460-3 ]
uc010pns.2. human. [Q95460-5 ]

Organism-specific databases

CTDi 3140.
GeneCardsi GC01P181003.
HGNCi HGNC:4975. MR1.
MIMi 600764. gene.
neXtProti NX_Q95460.
PharmGKBi PA29309.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42056.
GeneTreei ENSGT00760000118960.
HOGENOMi HOG000296917.
HOVERGENi HBG016709.
InParanoidi Q95460.
OMAi ETECIAW.
OrthoDBi EOG7JT6WQ.
PhylomeDBi Q95460.
TreeFami TF336617.

Miscellaneous databases

ChiTaRSi MR1. human.
GeneWikii Major_histocompatibility_complex,_class_I-related.
GenomeRNAii 3140.
NextBioi 12452.
PROi Q95460.
SOURCEi Search...

Gene expression databases

Bgeei Q95460.
CleanExi HS_MR1.
Genevestigatori Q95460.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view ]
PRINTSi PR01638. MHCCLASSI.
SMARTi SM00407. IGc1. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A gene outside the human MHC related to classical HLA class I genes."
    Hashimoto K., Hirai M., Kurosawa Y.
    Science 269:693-695(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, TOPOLOGY.
    Tissue: Thymus.
  2. "A study on the polymorphism of human MHC class I-related MR1 gene and identification of an MR1-like pseudogene."
    Parra-Cuadrado J.F., Navarro P., Mirones I., Setien F., Oteo M., Martinez-Naves E.
    Tissue Antigens 56:170-172(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), POLYMORPHISM.
    Tissue: Peripheral blood.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 5).
    Tissue: Tongue and Uterus.
  4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney proximal tubule.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  8. "Genomics, isoforms, expression, and phylogeny of the MHC class I-related MR1 gene."
    Riegert P., Wanner V., Bahram S.
    J. Immunol. 161:4066-4077(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-11, NUCLEOTIDE SEQUENCE [MRNA] OF 5-341 (ISOFORM 3), NUCLEOTIDE SEQUENCE [MRNA] OF 6-229 (ISOFORM 4), TOPOLOGY, ALTERNATIVE SPLICING.
  9. "Expanded genomic organization of conserved mammalian MHC class I-related genes, human MR1 and its murine ortholog."
    Yamaguchi H., Kurosawa Y., Hashimoto K.
    Biochem. Biophys. Res. Commun. 250:558-564(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 8-341.
    Tissue: Placenta.
  10. "Unrelated expression patterns of MHC class Ia, Ib and TCRA molecules."
    Han M., Robinson M.A.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 23-109, VARIANT ARG-39.
  11. "Biochemical features of the MHC-related protein 1 consistent with an immunological function."
    Miley M.J., Truscott S.M., Yu Y.Y., Gilfillan S., Fremont D.H., Hansen T.H., Lybarger L.
    J. Immunol. 170:6090-6098(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, SIGNAL SEQUENCE CLEAVAGE SITE, GLYCOSYLATION AT ASN-107, INTERACTION WITH B2M; TAPBP; CALR AND PDIA3, MUTAGENESIS OF CYS-283.
  12. "Novel MHC class I-related molecule MR1 affects MHC class I expression in 293T cells."
    Aldemir H.
    Biochem. Biophys. Res. Commun. 366:328-334(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH B2M.
  13. "MR1 antigen presentation to mucosal-associated invariant T cells was highly conserved in evolution."
    Huang S., Martin E., Kim S., Yu L., Soudais C., Fremont D.H., Lantz O., Hansen T.H.
    Proc. Natl. Acad. Sci. U.S.A. 106:8290-8295(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF GLN-169.
  14. "MR1B, a natural spliced isoform of the MHC-related 1 protein, is expressed as homodimers at the cell surface and activates MAIT cells."
    Lion J., Debuysscher V., Wlodarczyk A., Hodroge A., Serriari N.E., Choteau L., Ouled-haddou H., Plistat M., Lassoued K., Lantz O., Treiner E.
    Eur. J. Immunol. 43:1363-1373(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION (ISOFORM 3), SUBUNIT (ISOFORM 3).
  15. Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 23-292 IN COMPLEX WITH VITAMIN B9 METABOLITE, LIGAND-BINDING SITES, DISULFIDE BONDS.

Entry informationi

Entry nameiHMR1_HUMAN
AccessioniPrimary (citable) accession number: Q95460
Secondary accession number(s): A8K2V9
, B4E3B1, O97985, O97986, Q53GM1, Q95HB8, Q9MY23, Q9NPL2, Q9TQB3, Q9TQB9, Q9TQK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: February 1, 1997
Last modified: October 29, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

MR1 is detected in an open versus folded conformation. Only the folded MR1 conformer activates MAIT cells.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3