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Q95460

- HMR1_HUMAN

UniProt

Q95460 - HMR1_HUMAN

Protein

Major histocompatibility complex class I-related gene protein

Gene

MR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.2 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei65 – 651Pathogen-derived ligand

    GO - Molecular functioni

    1. MHC class I receptor activity Source: UniProtKB
    2. peptide antigen binding Source: InterPro

    GO - Biological processi

    1. antigen processing and presentation of peptide antigen via MHC class I Source: UniProtKB-KW
    2. cytokine production involved in immune response Source: Ensembl
    3. defense response to Gram-negative bacterium Source: Ensembl
    4. immune response Source: ProtInc
    5. innate immune response Source: UniProtKB-KW
    6. interleukin-17 production Source: Ensembl
    7. interleukin-1 beta production Source: Ensembl
    8. positive regulation of T cell mediated cytotoxicity Source: InterPro
    9. signal transduction Source: GOC

    Keywords - Biological processi

    Immunity, Innate immunity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Major histocompatibility complex class I-related gene protein
    Short name:
    MHC class I-related gene protein
    Alternative name(s):
    Class I histocompatibility antigen-like protein
    Gene namesi
    Name:MR1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:4975. MR1.

    Subcellular locationi

    Isoform 3 : Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Endoplasmic reticulum membrane 1 Publication
    Note: The larger proportion remains in the ER in an immature state. The subset that reach cell surface does it through a B2M-independent pathway.

    GO - Cellular componenti

    1. endoplasmic reticulum Source: MGI
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. extracellular region Source: UniProtKB-SubCell
    4. integral component of membrane Source: UniProtKB-KW
    5. MHC class I protein complex Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Endoplasmic reticulum, Membrane, MHC I, Secreted

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi65 – 651K → R: Fails to refold in the presence of 6-FP.
    Mutagenesisi169 – 1691Q → L: Able to activate mouse MAIT cells. 1 Publication
    Mutagenesisi283 – 2831C → G: No effect on cell surface expression. 1 Publication

    Organism-specific databases

    PharmGKBiPA29309.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 22221 PublicationAdd
    BLAST
    Chaini23 – 341319Major histocompatibility complex class I-related gene proteinPRO_0000344441Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi107 – 1071N-linked (GlcNAc...)1 Publication
    Disulfide bondi120 ↔ 1831 PublicationPROSITE-ProRule annotation
    Disulfide bondi222 ↔ 2781 PublicationPROSITE-ProRule annotation

    Post-translational modificationi

    N-glycosylated.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ95460.
    PRIDEiQ95460.

    Expressioni

    Tissue specificityi

    Ubiquitous.1 Publication

    Gene expression databases

    BgeeiQ95460.
    CleanExiHS_MR1.
    GenevestigatoriQ95460.

    Interactioni

    Subunit structurei

    Heterodimerizes with B2M, this interaction is required for surface expression. Associated with the peptide-loading complex, TAPBP, CALR and PDIA3. Isoform 3/MR1B homodimerizes and doesn't associates with B2M nor proteins of the peptide-loading complex.1 Publication

    Protein-protein interaction databases

    BioGridi109385. 2 interactions.
    DIPiDIP-59986N.

    Structurei

    Secondary structure

    1
    341
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi25 – 3612
    Beta strandi39 – 413
    Beta strandi43 – 508
    Beta strandi53 – 597
    Turni60 – 623
    Beta strandi66 – 694
    Helixi70 – 734
    Helixi78 – 10629
    Beta strandi113 – 12210
    Beta strandi128 – 1369
    Beta strandi139 – 1457
    Turni146 – 1494
    Beta strandi150 – 1556
    Helixi156 – 16611
    Helixi169 – 18012
    Helixi182 – 19312
    Helixi195 – 1984
    Beta strandi205 – 2128
    Beta strandi218 – 23013
    Beta strandi233 – 2386
    Helixi244 – 2463
    Beta strandi247 – 2493
    Beta strandi256 – 2583
    Beta strandi260 – 2678
    Beta strandi276 – 2827
    Beta strandi285 – 2906

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4GUPX-ray3.20A/C23-292[»]
    4L4TX-ray2.00A/C23-292[»]
    4L4VX-ray1.90A/C23-292[»]
    4LCWX-ray2.40A/C23-292[»]
    4NQCX-ray2.50A/C23-292[»]
    4NQDX-ray2.20A/C23-292[»]
    4NQEX-ray2.10A/C23-292[»]
    ProteinModelPortaliQ95460.
    SMRiQ95460. Positions 24-292.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 302280ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini324 – 34118CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei303 – 32321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini203 – 29997Ig-like C1-typeAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni23 – 201179Ligand-bindingAdd
    BLAST
    Regioni23 – 10987Alpha-1Add
    BLAST
    Regioni110 – 20192Alpha-2Add
    BLAST
    Regioni202 – 29392Alpha-3Add
    BLAST
    Regioni294 – 3029Connecting peptide

    Domaini

    The alpha-3 region and to a lesser extent the transmembrane and cytosolic domains regulate surface expression. The alpha-3 region mediates interaction with B2M (PubMed:23051753).1 Publication
    The ligand-binding groove is ideally suited to present small organic compounds that can originate from vitamins rather than antigenic peptides.1 Publication

    Sequence similaritiesi

    Belongs to the MHC class I family.Curated

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG42056.
    HOGENOMiHOG000296917.
    HOVERGENiHBG016709.
    InParanoidiQ95460.
    OMAiETECIAW.
    OrthoDBiEOG7JT6WQ.
    PhylomeDBiQ95460.
    TreeFamiTF336617.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    [Graphical view]
    PRINTSiPR01638. MHCCLASSI.
    SMARTiSM00407. IGc1. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q95460-1) [UniParc]FASTAAdd to Basket

    Also known as: MR1A

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGELMAFLLP LIIVLMVKHS DSRTHSLRYF RLGVSDPIHG VPEFISVGYV    50
    DSHPITTYDS VTRQKEPRAP WMAENLAPDH WERYTQLLRG WQQMFKVELK 100
    RLQRHYNHSG SHTYQRMIGC ELLEDGSTTG FLQYAYDGQD FLIFNKDTLS 150
    WLAVDNVAHT IKQAWEANQH ELLYQKNWLE EECIAWLKRF LEYGKDTLQR 200
    TEPPLVRVNR KETFPGVTAL FCKAHGFYPP EIYMTWMKNG EEIVQEIDYG 250
    DILPSGDGTY QAWASIELDP QSSNLYSCHV EHCGVHMVLQ VPQESETIPL 300
    VMKAVSGSIV LVIVLAGVGV LVWRRRPREQ NGAIYLPTPD R 341
    Length:341
    Mass (Da):39,366
    Last modified:February 1, 1997 - v1
    Checksum:i2990C1F3F0A1CAD9
    GO
    Isoform 2 (identifier: Q95460-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         110-154: Missing.

    Show »
    Length:296
    Mass (Da):34,278
    Checksum:i05ABC9CD4189F639
    GO
    Isoform 3 (identifier: Q95460-3) [UniParc]FASTAAdd to Basket

    Also known as: MR1B, MR1D

    The sequence of this isoform differs from the canonical sequence as follows:
         203-294: Missing.

    Show »
    Length:249
    Mass (Da):28,973
    Checksum:iDED2E979686D6A8A
    GO
    Isoform 4 (identifier: Q95460-4) [UniParc]FASTAAdd to Basket

    Also known as: MR1C

    The sequence of this isoform differs from the canonical sequence as follows:
         202-220: EPPLVRVNRKETFPGVTAL → GKEKEKASFPHCLNNCFYT
         221-341: Missing.

    Show »
    Length:220
    Mass (Da):25,933
    Checksum:i529688A56159C475
    GO
    Isoform 5 (identifier: Q95460-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         202-328: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:214
    Mass (Da):25,190
    Checksum:iB84A09E70B280E74
    GO

    Sequence cautioni

    The sequence AAD01443.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti117 – 1171M → V in BAF83063. (PubMed:14702039)Curated
    Sequence conflicti200 – 2001R → G in BAD96630. 1 PublicationCurated
    Sequence conflicti315 – 3151L → P in BAD96630. 1 PublicationCurated

    Polymorphismi

    Several individuals from different ethnic background were analyzed for polymorphism. MR1 was identical in all individuals analyzed, except one. MR1 is not polymorphic.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti39 – 391H → R.1 Publication
    Corresponds to variant rs2236410 [ dbSNP | Ensembl ].
    VAR_045608
    Natural varianti63 – 631R → Q.
    Corresponds to variant rs3897433 [ dbSNP | Ensembl ].
    VAR_045609
    Natural varianti77 – 771A → V.
    Corresponds to variant rs3897434 [ dbSNP | Ensembl ].
    VAR_045610

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei110 – 15445Missing in isoform 2. 1 PublicationVSP_034755Add
    BLAST
    Alternative sequencei202 – 328127Missing in isoform 5. 1 PublicationVSP_043479Add
    BLAST
    Alternative sequencei202 – 22019EPPLV…GVTAL → GKEKEKASFPHCLNNCFYT in isoform 4. 1 PublicationVSP_034756Add
    BLAST
    Alternative sequencei203 – 29492Missing in isoform 3. 2 PublicationsVSP_034757Add
    BLAST
    Alternative sequencei221 – 341121Missing in isoform 4. 1 PublicationVSP_034758Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U22963 mRNA. Translation: AAC50174.1.
    AJ249778 mRNA. Translation: CAB77667.1.
    AK290374 mRNA. Translation: BAF83063.1.
    AK304645 mRNA. Translation: BAG65423.1.
    AK222910 mRNA. Translation: BAD96630.1.
    AL356267 Genomic DNA. Translation: CAH72302.1.
    AL356267 Genomic DNA. Translation: CAH72303.1.
    AL356267 Genomic DNA. Translation: CAH72304.1.
    AL356267 Genomic DNA. Translation: CAH72305.1.
    CH471067 Genomic DNA. Translation: EAW91097.1.
    CH471067 Genomic DNA. Translation: EAW91098.1.
    CH471067 Genomic DNA. Translation: EAW91095.1.
    BC012485 mRNA. Translation: AAH12485.1.
    AF010446 mRNA. Translation: AAD01442.1.
    AF010447 mRNA. Translation: AAD01443.1. Different initiation.
    AF031469 mRNA. Translation: AAD01933.1.
    AF039526 Genomic DNA. Translation: AAD02172.1.
    AH006983 Genomic DNA. Translation: AAC72900.1.
    AF223407 Genomic DNA. Translation: AAF40170.1.
    CCDSiCCDS1342.1. [Q95460-1]
    CCDS53440.1. [Q95460-3]
    CCDS53441.1. [Q95460-5]
    CCDS53442.1. [Q95460-2]
    PIRiA57136.
    RefSeqiNP_001181928.1. NM_001194999.1. [Q95460-2]
    NP_001181929.1. NM_001195000.1. [Q95460-3]
    NP_001181964.1. NM_001195035.1. [Q95460-5]
    NP_001522.1. NM_001531.2. [Q95460-1]
    UniGeneiHs.13500.

    Genome annotation databases

    EnsembliENST00000282990; ENSP00000282990; ENSG00000153029. [Q95460-3]
    ENST00000367579; ENSP00000356551; ENSG00000153029. [Q95460-2]
    ENST00000367580; ENSP00000356552; ENSG00000153029. [Q95460-1]
    ENST00000434571; ENSP00000388504; ENSG00000153029. [Q95460-5]
    GeneIDi3140.
    KEGGihsa:3140.
    UCSCiuc001gop.3. human. [Q95460-4]
    uc001goq.2. human. [Q95460-1]
    uc001gor.2. human. [Q95460-2]
    uc001gos.2. human. [Q95460-3]
    uc010pns.2. human. [Q95460-5]

    Polymorphism databases

    DMDMi74751679.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U22963 mRNA. Translation: AAC50174.1 .
    AJ249778 mRNA. Translation: CAB77667.1 .
    AK290374 mRNA. Translation: BAF83063.1 .
    AK304645 mRNA. Translation: BAG65423.1 .
    AK222910 mRNA. Translation: BAD96630.1 .
    AL356267 Genomic DNA. Translation: CAH72302.1 .
    AL356267 Genomic DNA. Translation: CAH72303.1 .
    AL356267 Genomic DNA. Translation: CAH72304.1 .
    AL356267 Genomic DNA. Translation: CAH72305.1 .
    CH471067 Genomic DNA. Translation: EAW91097.1 .
    CH471067 Genomic DNA. Translation: EAW91098.1 .
    CH471067 Genomic DNA. Translation: EAW91095.1 .
    BC012485 mRNA. Translation: AAH12485.1 .
    AF010446 mRNA. Translation: AAD01442.1 .
    AF010447 mRNA. Translation: AAD01443.1 . Different initiation.
    AF031469 mRNA. Translation: AAD01933.1 .
    AF039526 Genomic DNA. Translation: AAD02172.1 .
    AH006983 Genomic DNA. Translation: AAC72900.1 .
    AF223407 Genomic DNA. Translation: AAF40170.1 .
    CCDSi CCDS1342.1. [Q95460-1 ]
    CCDS53440.1. [Q95460-3 ]
    CCDS53441.1. [Q95460-5 ]
    CCDS53442.1. [Q95460-2 ]
    PIRi A57136.
    RefSeqi NP_001181928.1. NM_001194999.1. [Q95460-2 ]
    NP_001181929.1. NM_001195000.1. [Q95460-3 ]
    NP_001181964.1. NM_001195035.1. [Q95460-5 ]
    NP_001522.1. NM_001531.2. [Q95460-1 ]
    UniGenei Hs.13500.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4GUP X-ray 3.20 A/C 23-292 [» ]
    4L4T X-ray 2.00 A/C 23-292 [» ]
    4L4V X-ray 1.90 A/C 23-292 [» ]
    4LCW X-ray 2.40 A/C 23-292 [» ]
    4NQC X-ray 2.50 A/C 23-292 [» ]
    4NQD X-ray 2.20 A/C 23-292 [» ]
    4NQE X-ray 2.10 A/C 23-292 [» ]
    ProteinModelPortali Q95460.
    SMRi Q95460. Positions 24-292.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109385. 2 interactions.
    DIPi DIP-59986N.

    Polymorphism databases

    DMDMi 74751679.

    Proteomic databases

    PaxDbi Q95460.
    PRIDEi Q95460.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000282990 ; ENSP00000282990 ; ENSG00000153029 . [Q95460-3 ]
    ENST00000367579 ; ENSP00000356551 ; ENSG00000153029 . [Q95460-2 ]
    ENST00000367580 ; ENSP00000356552 ; ENSG00000153029 . [Q95460-1 ]
    ENST00000434571 ; ENSP00000388504 ; ENSG00000153029 . [Q95460-5 ]
    GeneIDi 3140.
    KEGGi hsa:3140.
    UCSCi uc001gop.3. human. [Q95460-4 ]
    uc001goq.2. human. [Q95460-1 ]
    uc001gor.2. human. [Q95460-2 ]
    uc001gos.2. human. [Q95460-3 ]
    uc010pns.2. human. [Q95460-5 ]

    Organism-specific databases

    CTDi 3140.
    GeneCardsi GC01P181003.
    HGNCi HGNC:4975. MR1.
    MIMi 600764. gene.
    neXtProti NX_Q95460.
    PharmGKBi PA29309.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42056.
    HOGENOMi HOG000296917.
    HOVERGENi HBG016709.
    InParanoidi Q95460.
    OMAi ETECIAW.
    OrthoDBi EOG7JT6WQ.
    PhylomeDBi Q95460.
    TreeFami TF336617.

    Miscellaneous databases

    ChiTaRSi MR1. human.
    GeneWikii Major_histocompatibility_complex,_class_I-related.
    GenomeRNAii 3140.
    NextBioi 12452.
    PROi Q95460.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q95460.
    CleanExi HS_MR1.
    Genevestigatori Q95460.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    [Graphical view ]
    PRINTSi PR01638. MHCCLASSI.
    SMARTi SM00407. IGc1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A gene outside the human MHC related to classical HLA class I genes."
      Hashimoto K., Hirai M., Kurosawa Y.
      Science 269:693-695(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, TOPOLOGY.
      Tissue: Thymus.
    2. "A study on the polymorphism of human MHC class I-related MR1 gene and identification of an MR1-like pseudogene."
      Parra-Cuadrado J.F., Navarro P., Mirones I., Setien F., Oteo M., Martinez-Naves E.
      Tissue Antigens 56:170-172(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), POLYMORPHISM.
      Tissue: Peripheral blood.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 5).
      Tissue: Tongue and Uterus.
    4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Kidney proximal tubule.
    5. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    8. "Genomics, isoforms, expression, and phylogeny of the MHC class I-related MR1 gene."
      Riegert P., Wanner V., Bahram S.
      J. Immunol. 161:4066-4077(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-11, NUCLEOTIDE SEQUENCE [MRNA] OF 5-341 (ISOFORM 3), NUCLEOTIDE SEQUENCE [MRNA] OF 6-229 (ISOFORM 4), TOPOLOGY, ALTERNATIVE SPLICING.
    9. "Expanded genomic organization of conserved mammalian MHC class I-related genes, human MR1 and its murine ortholog."
      Yamaguchi H., Kurosawa Y., Hashimoto K.
      Biochem. Biophys. Res. Commun. 250:558-564(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 8-341.
      Tissue: Placenta.
    10. "Unrelated expression patterns of MHC class Ia, Ib and TCRA molecules."
      Han M., Robinson M.A.
      Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 23-109, VARIANT ARG-39.
    11. "Biochemical features of the MHC-related protein 1 consistent with an immunological function."
      Miley M.J., Truscott S.M., Yu Y.Y., Gilfillan S., Fremont D.H., Hansen T.H., Lybarger L.
      J. Immunol. 170:6090-6098(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, SIGNAL SEQUENCE CLEAVAGE SITE, GLYCOSYLATION AT ASN-107, INTERACTION WITH B2M; TAPBP; CALR AND PDIA3, MUTAGENESIS OF CYS-283.
    12. "Novel MHC class I-related molecule MR1 affects MHC class I expression in 293T cells."
      Aldemir H.
      Biochem. Biophys. Res. Commun. 366:328-334(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH B2M.
    13. "MR1 antigen presentation to mucosal-associated invariant T cells was highly conserved in evolution."
      Huang S., Martin E., Kim S., Yu L., Soudais C., Fremont D.H., Lantz O., Hansen T.H.
      Proc. Natl. Acad. Sci. U.S.A. 106:8290-8295(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MUTAGENESIS OF GLN-169.
    14. "MR1B, a natural spliced isoform of the MHC-related 1 protein, is expressed as homodimers at the cell surface and activates MAIT cells."
      Lion J., Debuysscher V., Wlodarczyk A., Hodroge A., Serriari N.E., Choteau L., Ouled-haddou H., Plistat M., Lassoued K., Lantz O., Treiner E.
      Eur. J. Immunol. 43:1363-1373(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION (ISOFORM 3), SUBUNIT (ISOFORM 3).
    15. Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 23-292 IN COMPLEX WITH VITAMIN B9 METABOLITE, LIGAND-BINDING SITES, DISULFIDE BONDS.

    Entry informationi

    Entry nameiHMR1_HUMAN
    AccessioniPrimary (citable) accession number: Q95460
    Secondary accession number(s): A8K2V9
    , B4E3B1, O97985, O97986, Q53GM1, Q95HB8, Q9MY23, Q9NPL2, Q9TQB3, Q9TQB9, Q9TQK3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 22, 2008
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 126 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    MR1 is detected in an open versus folded conformation. Only the folded MR1 conformer activates MAIT cells.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3