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Q95460 (HMR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Major histocompatibility complex class I-related gene protein

Short name=MHC class I-related gene protein
Alternative name(s):
Class I histocompatibility antigen-like protein
Gene names
Name:MR1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length341 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent. Ref.11 Ref.13

Subunit structure

Heterodimerizes with B2M, this interaction is required for surface expression. Associated with the peptide-loading complex, TAPBP, CALR and PDIA3. Isoform 3/MR1Bhomodimerizes and doesn't associates with B2M nor proteins of the peptide-loading complex. Ref.14

Subcellular location

Cell membrane; Single-pass membrane protein; Extracellular side. Endoplasmic reticulum Ref.11 Ref.12 Ref.14.

Isoform 4: Secreted Ref.11 Ref.12 Ref.14.

Isoform 3: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane. Note: The larger proportion remains in the ER in an immature state. The subset that reach cell surface does it through a B2M-independent pathway. Ref.11 Ref.12 Ref.14

Tissue specificity

Ubiquitous. Ref.1

Domain

The alpha-3 region and to a lesser extent the transmembrane and cytosolic domains regulate surface expression. The alpha-3 region mediates interaction with B2M (Ref.15).

The ligand-binding groove is ideally suited to present small organic compounds that can originate from vitamins rather than antigenic peptides (Ref.15).

Post-translational modification

N-glycosylated. Ref.11

Polymorphism

Several individuals from different ethnic background were analyzed for polymorphism. MR1 was identical in all individuals analyzed, except one. MR1 is not polymorphic.

Miscellaneous

MR1 is detected in an open versus folded conformation. Only the folded MR1 conformer activates MAIT cells.

Sequence similarities

Belongs to the MHC class I family.

Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Sequence caution

The sequence AAD01443.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Biological processImmunity
Innate immunity
   Cellular componentCell membrane
Endoplasmic reticulum
Membrane
MHC I
Secreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainImmunoglobulin domain
Signal
Transmembrane
Transmembrane helix
   PTMDisulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processantigen processing and presentation

Inferred from Biological aspect of Ancestor. Source: RefGenome

antigen processing and presentation of peptide antigen via MHC class I

Inferred from electronic annotation. Source: UniProtKB-KW

cytokine production involved in immune response

Inferred from electronic annotation. Source: Ensembl

defense response to Gram-negative bacterium

Inferred from electronic annotation. Source: Ensembl

immune response

Traceable author statement Ref.1. Source: ProtInc

innate immune response

Inferred from electronic annotation. Source: UniProtKB-KW

interleukin-1 beta production

Inferred from electronic annotation. Source: Ensembl

interleukin-17 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of T cell mediated cytotoxicity

Inferred from electronic annotation. Source: InterPro

signal transduction

Traceable author statement Ref.1. Source: GOC

   Cellular_componentMHC class I protein complex

Inferred from electronic annotation. Source: UniProtKB-KW

endoplasmic reticulum

Inferred from direct assay PubMed 21190736. Source: MGI

endoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionMHC class I receptor activity

Traceable author statement Ref.1. Source: UniProtKB

antigen binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

peptide antigen binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q95460-1)

Also known as: MR1A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q95460-2)

The sequence of this isoform differs from the canonical sequence as follows:
     110-154: Missing.
Isoform 3 (identifier: Q95460-3)

Also known as: MR1B; MR1D;

The sequence of this isoform differs from the canonical sequence as follows:
     203-294: Missing.
Isoform 4 (identifier: Q95460-4)

Also known as: MR1C;

The sequence of this isoform differs from the canonical sequence as follows:
     202-220: EPPLVRVNRKETFPGVTAL → GKEKEKASFPHCLNNCFYT
     221-341: Missing.
Isoform 5 (identifier: Q95460-5)

The sequence of this isoform differs from the canonical sequence as follows:
     202-328: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222
Chain23 – 341319Major histocompatibility complex class I-related gene protein
PRO_0000344441

Regions

Topological domain23 – 302280Extracellular Potential
Transmembrane303 – 32321Helical; Potential
Topological domain324 – 34118Cytoplasmic Potential
Domain203 – 29997Ig-like C1-type
Region23 – 201179Ligand-binding
Region23 – 10987Alpha-1
Region110 – 20192Alpha-2
Region202 – 29392Alpha-3
Region294 – 3029Connecting peptide

Sites

Binding site651Pathogen-derived ligand

Amino acid modifications

Glycosylation1071N-linked (GlcNAc...) Ref.11
Disulfide bond120 ↔ 183 Ref.15
Disulfide bond222 ↔ 278 Ref.15

Natural variations

Alternative sequence110 – 15445Missing in isoform 2.
VSP_034755
Alternative sequence202 – 328127Missing in isoform 5.
VSP_043479
Alternative sequence202 – 22019EPPLV…GVTAL → GKEKEKASFPHCLNNCFYT in isoform 4.
VSP_034756
Alternative sequence203 – 29492Missing in isoform 3.
VSP_034757
Alternative sequence221 – 341121Missing in isoform 4.
VSP_034758
Natural variant391H → R. Ref.10
Corresponds to variant rs2236410 [ dbSNP | Ensembl ].
VAR_045608
Natural variant631R → Q.
Corresponds to variant rs3897433 [ dbSNP | Ensembl ].
VAR_045609
Natural variant771A → V.
Corresponds to variant rs3897434 [ dbSNP | Ensembl ].
VAR_045610

Experimental info

Mutagenesis651K → R: Fails to refold in the presence of 6-FP.
Mutagenesis1691Q → L: Able to activate mouse MAIT cells. Ref.13
Mutagenesis2831C → G: No effect on cell surface expression. Ref.11
Sequence conflict1171M → V in BAF83063. Ref.3
Sequence conflict2001R → G in BAD96630. Ref.4
Sequence conflict3151L → P in BAD96630. Ref.4

Secondary structure

............................................... 341
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (MR1A) [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 2990C1F3F0A1CAD9

FASTA34139,366
        10         20         30         40         50         60 
MGELMAFLLP LIIVLMVKHS DSRTHSLRYF RLGVSDPIHG VPEFISVGYV DSHPITTYDS 

        70         80         90        100        110        120 
VTRQKEPRAP WMAENLAPDH WERYTQLLRG WQQMFKVELK RLQRHYNHSG SHTYQRMIGC 

       130        140        150        160        170        180 
ELLEDGSTTG FLQYAYDGQD FLIFNKDTLS WLAVDNVAHT IKQAWEANQH ELLYQKNWLE 

       190        200        210        220        230        240 
EECIAWLKRF LEYGKDTLQR TEPPLVRVNR KETFPGVTAL FCKAHGFYPP EIYMTWMKNG 

       250        260        270        280        290        300 
EEIVQEIDYG DILPSGDGTY QAWASIELDP QSSNLYSCHV EHCGVHMVLQ VPQESETIPL 

       310        320        330        340 
VMKAVSGSIV LVIVLAGVGV LVWRRRPREQ NGAIYLPTPD R 

« Hide

Isoform 2 [UniParc].

Checksum: 05ABC9CD4189F639
Show »

FASTA29634,278
Isoform 3 (MR1B) (MR1D) [UniParc].

Checksum: DED2E979686D6A8A
Show »

FASTA24928,973
Isoform 4 (MR1C) [UniParc].

Checksum: 529688A56159C475
Show »

FASTA22025,933
Isoform 5 [UniParc].

Checksum: B84A09E70B280E74
Show »

FASTA21425,190

References

« Hide 'large scale' references
[1]"A gene outside the human MHC related to classical HLA class I genes."
Hashimoto K., Hirai M., Kurosawa Y.
Science 269:693-695(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, TOPOLOGY.
Tissue: Thymus.
[2]"A study on the polymorphism of human MHC class I-related MR1 gene and identification of an MR1-like pseudogene."
Parra-Cuadrado J.F., Navarro P., Mirones I., Setien F., Oteo M., Martinez-Naves E.
Tissue Antigens 56:170-172(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), POLYMORPHISM.
Tissue: Peripheral blood.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 5).
Tissue: Tongue and Uterus.
[4]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Kidney proximal tubule.
[5]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Testis.
[8]"Genomics, isoforms, expression, and phylogeny of the MHC class I-related MR1 gene."
Riegert P., Wanner V., Bahram S.
J. Immunol. 161:4066-4077(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-11, NUCLEOTIDE SEQUENCE [MRNA] OF 5-341 (ISOFORM 3), NUCLEOTIDE SEQUENCE [MRNA] OF 6-229 (ISOFORM 4), TOPOLOGY, ALTERNATIVE SPLICING.
[9]"Expanded genomic organization of conserved mammalian MHC class I-related genes, human MR1 and its murine ortholog."
Yamaguchi H., Kurosawa Y., Hashimoto K.
Biochem. Biophys. Res. Commun. 250:558-564(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 8-341.
Tissue: Placenta.
[10]"Unrelated expression patterns of MHC class Ia, Ib and TCRA molecules."
Han M., Robinson M.A.
Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 23-109, VARIANT ARG-39.
[11]"Biochemical features of the MHC-related protein 1 consistent with an immunological function."
Miley M.J., Truscott S.M., Yu Y.Y., Gilfillan S., Fremont D.H., Hansen T.H., Lybarger L.
J. Immunol. 170:6090-6098(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, SIGNAL SEQUENCE CLEAVAGE SITE, GLYCOSYLATION AT ASN-107, INTERACTION WITH B2M; TAPBP; CALR AND PDIA3, MUTAGENESIS OF CYS-283.
[12]"Novel MHC class I-related molecule MR1 affects MHC class I expression in 293T cells."
Aldemir H.
Biochem. Biophys. Res. Commun. 366:328-334(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, INTERACTION WITH B2M.
[13]"MR1 antigen presentation to mucosal-associated invariant T cells was highly conserved in evolution."
Huang S., Martin E., Kim S., Yu L., Soudais C., Fremont D.H., Lantz O., Hansen T.H.
Proc. Natl. Acad. Sci. U.S.A. 106:8290-8295(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, MUTAGENESIS OF GLN-169.
[14]"MR1B, a natural spliced isoform of the MHC-related 1 protein, is expressed as homodimers at the cell surface and activates MAIT cells."
Lion J., Debuysscher V., Wlodarczyk A., Hodroge A., Serriari N.E., Choteau L., Ouled-haddou H., Plistat M., Lassoued K., Lantz O., Treiner E.
Eur. J. Immunol. 43:1363-1373(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION (ISOFORM 3), SUBUNIT (ISOFORM 3).
[15]"MR1 presents microbial vitamin B metabolites to MAIT cells."
Kjer-Nielsen L., Patel O., Corbett A.J., Le Nours J., Meehan B., Liu L., Bhati M., Chen Z., Kostenko L., Reantragoon R., Williamson N.A., Purcell A.W., Dudek N.L., McConville M.J., O'Hair R.A., Khairallah G.N., Godfrey D.I., Fairlie D.P., Rossjohn J., McCluskey J.
Nature 491:717-723(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 23-292 IN COMPLEX WITH VITAMIN B9 METABOLITE, LIGAND-BINDING SITES, DISULFIDE BONDS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U22963 mRNA. Translation: AAC50174.1.
AJ249778 mRNA. Translation: CAB77667.1.
AK290374 mRNA. Translation: BAF83063.1.
AK304645 mRNA. Translation: BAG65423.1.
AK222910 mRNA. Translation: BAD96630.1.
AL356267 Genomic DNA. Translation: CAH72302.1.
AL356267 Genomic DNA. Translation: CAH72303.1.
AL356267 Genomic DNA. Translation: CAH72304.1.
AL356267 Genomic DNA. Translation: CAH72305.1.
CH471067 Genomic DNA. Translation: EAW91097.1.
CH471067 Genomic DNA. Translation: EAW91098.1.
CH471067 Genomic DNA. Translation: EAW91095.1.
BC012485 mRNA. Translation: AAH12485.1.
AF010446 mRNA. Translation: AAD01442.1.
AF010447 mRNA. Translation: AAD01443.1. Different initiation.
AF031469 mRNA. Translation: AAD01933.1.
AF039526 Genomic DNA. Translation: AAD02172.1.
AH006983 Genomic DNA. Translation: AAC72900.1.
AF223407 Genomic DNA. Translation: AAF40170.1.
CCDSCCDS1342.1. [Q95460-1]
CCDS53440.1. [Q95460-3]
CCDS53441.1. [Q95460-5]
CCDS53442.1. [Q95460-2]
PIRA57136.
RefSeqNP_001181928.1. NM_001194999.1. [Q95460-2]
NP_001181929.1. NM_001195000.1. [Q95460-3]
NP_001181964.1. NM_001195035.1. [Q95460-5]
NP_001522.1. NM_001531.2. [Q95460-1]
UniGeneHs.13500.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4GUPX-ray3.20A/C23-292[»]
4L4TX-ray2.00A/C23-292[»]
4L4VX-ray1.90A/C23-292[»]
4LCWX-ray2.40A/C23-292[»]
4NQCX-ray2.50A/C23-292[»]
4NQDX-ray2.20A/C23-292[»]
4NQEX-ray2.10A/C23-292[»]
ProteinModelPortalQ95460.
SMRQ95460. Positions 24-292.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109385. 2 interactions.
DIPDIP-59986N.

Polymorphism databases

DMDM74751679.

Proteomic databases

PaxDbQ95460.
PRIDEQ95460.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000282990; ENSP00000282990; ENSG00000153029. [Q95460-3]
ENST00000367579; ENSP00000356551; ENSG00000153029. [Q95460-2]
ENST00000367580; ENSP00000356552; ENSG00000153029. [Q95460-1]
ENST00000434571; ENSP00000388504; ENSG00000153029. [Q95460-5]
GeneID3140.
KEGGhsa:3140.
UCSCuc001gop.3. human. [Q95460-4]
uc001goq.2. human. [Q95460-1]
uc001gor.2. human. [Q95460-2]
uc001gos.2. human. [Q95460-3]
uc010pns.2. human. [Q95460-5]

Organism-specific databases

CTD3140.
GeneCardsGC01P181003.
HGNCHGNC:4975. MR1.
MIM600764. gene.
neXtProtNX_Q95460.
PharmGKBPA29309.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42056.
HOGENOMHOG000296917.
HOVERGENHBG016709.
InParanoidQ95460.
OMAETECIAW.
OrthoDBEOG7JT6WQ.
PhylomeDBQ95460.
TreeFamTF336617.

Gene expression databases

BgeeQ95460.
CleanExHS_MR1.
GenevestigatorQ95460.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSPR01638. MHCCLASSI.
SMARTSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMSSF54452. SSF54452. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMR1. human.
GeneWikiMajor_histocompatibility_complex,_class_I-related.
GenomeRNAi3140.
NextBio12452.
PROQ95460.
SOURCESearch...

Entry information

Entry nameHMR1_HUMAN
AccessionPrimary (citable) accession number: Q95460
Secondary accession number(s): A8K2V9 expand/collapse secondary AC list , B4E3B1, O97985, O97986, Q53GM1, Q95HB8, Q9MY23, Q9NPL2, Q9TQB3, Q9TQB9, Q9TQK3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: February 1, 1997
Last modified: July 9, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM