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Protein

Major histocompatibility complex class I-related gene protein

Gene

MR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei65Pathogen-derived ligand1

GO - Molecular functioni

  • antigen binding Source: GO_Central
  • MHC class I receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Major histocompatibility complex class I-related gene protein
Short name:
MHC class I-related gene protein
Alternative name(s):
Class I histocompatibility antigen-like protein
Gene namesi
Name:MR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:4975. MR1.

Subcellular locationi

Isoform 3 :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 302ExtracellularSequence analysisAdd BLAST280
Transmembranei303 – 323HelicalSequence analysisAdd BLAST21
Topological domaini324 – 341CytoplasmicSequence analysisAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane, MHC I, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi65K → R: Fails to refold in the presence of 6-FP. 1
Mutagenesisi169Q → L: Able to activate mouse MAIT cells. 1 Publication1
Mutagenesisi283C → G: No effect on cell surface expression. 1 Publication1

Organism-specific databases

DisGeNETi3140.
MalaCardsiMR1.
OpenTargetsiENSG00000153029.
PharmGKBiPA29309.

Chemistry databases

DrugBankiDB00098. Anti-thymocyte Globulin (Rabbit).

Polymorphism and mutation databases

BioMutaiMR1.
DMDMi74751679.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000034444123 – 341Major histocompatibility complex class I-related gene proteinAdd BLAST319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi107N-linked (GlcNAc...)1 Publication1
Disulfide bondi120 ↔ 183PROSITE-ProRule annotation1 Publication
Disulfide bondi222 ↔ 278PROSITE-ProRule annotation1 Publication

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ95460.
PeptideAtlasiQ95460.
PRIDEiQ95460.

PTM databases

iPTMnetiQ95460.
PhosphoSitePlusiQ95460.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000153029.
CleanExiHS_MR1.
GenevisibleiQ95460. HS.

Interactioni

Subunit structurei

Heterodimerizes with B2M, this interaction is required for surface expression. Associated with the peptide-loading complex, TAPBP, CALR and PDIA3. Isoform 3/MR1B homodimerizes and doesn't associates with B2M nor proteins of the peptide-loading complex.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
FATE1Q969F03EBI-10280401,EBI-743099

Protein-protein interaction databases

BioGridi109385. 17 interactors.
DIPiDIP-59986N.
IntActiQ95460. 1 interactor.
STRINGi9606.ENSP00000356552.

Structurei

Secondary structure

1341
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi25 – 36Combined sources12
Beta strandi39 – 41Combined sources3
Beta strandi43 – 50Combined sources8
Beta strandi53 – 59Combined sources7
Turni60 – 62Combined sources3
Beta strandi66 – 69Combined sources4
Helixi70 – 73Combined sources4
Beta strandi74 – 76Combined sources3
Helixi78 – 106Combined sources29
Beta strandi113 – 122Combined sources10
Beta strandi128 – 136Combined sources9
Beta strandi139 – 145Combined sources7
Turni146 – 149Combined sources4
Beta strandi150 – 155Combined sources6
Helixi156 – 166Combined sources11
Helixi169 – 180Combined sources12
Helixi182 – 193Combined sources12
Helixi195 – 198Combined sources4
Beta strandi205 – 212Combined sources8
Beta strandi214 – 216Combined sources3
Beta strandi218 – 230Combined sources13
Beta strandi233 – 238Combined sources6
Turni239 – 241Combined sources3
Helixi244 – 246Combined sources3
Beta strandi248 – 254Combined sources7
Beta strandi256 – 258Combined sources3
Beta strandi260 – 267Combined sources8
Beta strandi270 – 272Combined sources3
Beta strandi276 – 282Combined sources7
Beta strandi285 – 290Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GUPX-ray3.20A/C23-292[»]
4L4TX-ray2.00A/C23-292[»]
4L4VX-ray1.90A/C23-292[»]
4LCWX-ray2.40A/C23-292[»]
4NQCX-ray2.50A/C23-292[»]
4NQDX-ray2.20A/C23-292[»]
4NQEX-ray2.10A/C23-292[»]
4PJ5X-ray2.00A/C23-292[»]
4PJ7X-ray2.50A/C23-292[»]
4PJ8X-ray3.30A23-292[»]
4PJ9X-ray2.00A23-292[»]
4PJAX-ray2.68A/C23-292[»]
4PJBX-ray2.85A/C23-292[»]
4PJCX-ray2.50A/C23-292[»]
4PJDX-ray2.78A/C23-292[»]
4PJEX-ray1.95A/C23-292[»]
4PJFX-ray2.45A/C23-292[»]
4PJGX-ray2.40A/C23-292[»]
4PJHX-ray2.00A/C23-292[»]
4PJIX-ray2.50A/C23-292[»]
4PJXX-ray2.25A/C23-292[»]
5D5MX-ray2.20A/C23-292[»]
5D7IX-ray2.00A/C23-292[»]
5D7JX-ray1.97C/E23-292[»]
5D7LX-ray3.40A/C23-292[»]
ProteinModelPortaliQ95460.
SMRiQ95460.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini203 – 299Ig-like C1-typeAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni23 – 201Ligand-bindingAdd BLAST179
Regioni23 – 109Alpha-1Add BLAST87
Regioni110 – 201Alpha-2Add BLAST92
Regioni202 – 293Alpha-3Add BLAST92
Regioni294 – 302Connecting peptide9

Domaini

The alpha-3 region and to a lesser extent the transmembrane and cytosolic domains regulate surface expression. The alpha-3 region mediates interaction with B2M (PubMed:23051753).1 Publication
The ligand-binding groove is ideally suited to present small organic compounds that can originate from vitamins rather than antigenic peptides.1 Publication

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II5V. Eukaryota.
ENOG4111K8F. LUCA.
GeneTreeiENSGT00760000118960.
HOGENOMiHOG000296917.
HOVERGENiHBG016709.
InParanoidiQ95460.
OMAiTWMKNGE.
OrthoDBiEOG091G0K1X.
PhylomeDBiQ95460.
TreeFamiTF336617.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q95460-1) [UniParc]FASTAAdd to basket
Also known as: MR1A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGELMAFLLP LIIVLMVKHS DSRTHSLRYF RLGVSDPIHG VPEFISVGYV
60 70 80 90 100
DSHPITTYDS VTRQKEPRAP WMAENLAPDH WERYTQLLRG WQQMFKVELK
110 120 130 140 150
RLQRHYNHSG SHTYQRMIGC ELLEDGSTTG FLQYAYDGQD FLIFNKDTLS
160 170 180 190 200
WLAVDNVAHT IKQAWEANQH ELLYQKNWLE EECIAWLKRF LEYGKDTLQR
210 220 230 240 250
TEPPLVRVNR KETFPGVTAL FCKAHGFYPP EIYMTWMKNG EEIVQEIDYG
260 270 280 290 300
DILPSGDGTY QAWASIELDP QSSNLYSCHV EHCGVHMVLQ VPQESETIPL
310 320 330 340
VMKAVSGSIV LVIVLAGVGV LVWRRRPREQ NGAIYLPTPD R
Length:341
Mass (Da):39,366
Last modified:February 1, 1997 - v1
Checksum:i2990C1F3F0A1CAD9
GO
Isoform 2 (identifier: Q95460-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     110-154: Missing.

Show »
Length:296
Mass (Da):34,278
Checksum:i05ABC9CD4189F639
GO
Isoform 3 (identifier: Q95460-3) [UniParc]FASTAAdd to basket
Also known as: MR1B, MR1D

The sequence of this isoform differs from the canonical sequence as follows:
     203-294: Missing.

Show »
Length:249
Mass (Da):28,973
Checksum:iDED2E979686D6A8A
GO
Isoform 4 (identifier: Q95460-4) [UniParc]FASTAAdd to basket
Also known as: MR1C

The sequence of this isoform differs from the canonical sequence as follows:
     202-220: EPPLVRVNRKETFPGVTAL → GKEKEKASFPHCLNNCFYT
     221-341: Missing.

Show »
Length:220
Mass (Da):25,933
Checksum:i529688A56159C475
GO
Isoform 5 (identifier: Q95460-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     202-328: Missing.

Note: No experimental confirmation available.
Show »
Length:214
Mass (Da):25,190
Checksum:iB84A09E70B280E74
GO

Sequence cautioni

The sequence AAD01443 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti117M → V in BAF83063 (PubMed:14702039).Curated1
Sequence conflicti200R → G in BAD96630 (Ref. 4) Curated1
Sequence conflicti315L → P in BAD96630 (Ref. 4) Curated1

Polymorphismi

Several individuals from different ethnic background were analyzed for polymorphism. MR1 was identical in all individuals analyzed, except one. MR1 is not polymorphic.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04560839H → R.1 PublicationCorresponds to variant rs2236410dbSNPEnsembl.1
Natural variantiVAR_04560963R → Q.Corresponds to variant rs3897433dbSNPEnsembl.1
Natural variantiVAR_04561077A → V.Corresponds to variant rs3897434dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_034755110 – 154Missing in isoform 2. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_043479202 – 328Missing in isoform 5. 1 PublicationAdd BLAST127
Alternative sequenceiVSP_034756202 – 220EPPLV…GVTAL → GKEKEKASFPHCLNNCFYT in isoform 4. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_034757203 – 294Missing in isoform 3. 2 PublicationsAdd BLAST92
Alternative sequenceiVSP_034758221 – 341Missing in isoform 4. 1 PublicationAdd BLAST121

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22963 mRNA. Translation: AAC50174.1.
AJ249778 mRNA. Translation: CAB77667.1.
AK290374 mRNA. Translation: BAF83063.1.
AK304645 mRNA. Translation: BAG65423.1.
AK222910 mRNA. Translation: BAD96630.1.
AL356267 Genomic DNA. Translation: CAH72302.1.
AL356267 Genomic DNA. Translation: CAH72303.1.
AL356267 Genomic DNA. Translation: CAH72304.1.
AL356267 Genomic DNA. Translation: CAH72305.1.
CH471067 Genomic DNA. Translation: EAW91097.1.
CH471067 Genomic DNA. Translation: EAW91098.1.
CH471067 Genomic DNA. Translation: EAW91095.1.
BC012485 mRNA. Translation: AAH12485.1.
AF010446 mRNA. Translation: AAD01442.1.
AF010447 mRNA. Translation: AAD01443.1. Different initiation.
AF031469 mRNA. Translation: AAD01933.1.
AF039526 Genomic DNA. Translation: AAD02172.1.
AH006983 Genomic DNA. Translation: AAC72900.1.
AF223407 Genomic DNA. Translation: AAF40170.1.
CCDSiCCDS1342.1. [Q95460-1]
CCDS53440.1. [Q95460-3]
CCDS53441.1. [Q95460-5]
CCDS53442.1. [Q95460-2]
PIRiA57136.
RefSeqiNP_001181928.1. NM_001194999.1. [Q95460-2]
NP_001181929.1. NM_001195000.1. [Q95460-3]
NP_001181964.1. NM_001195035.1. [Q95460-5]
NP_001522.1. NM_001531.2. [Q95460-1]
UniGeneiHs.13500.

Genome annotation databases

EnsembliENST00000282990; ENSP00000282990; ENSG00000153029. [Q95460-3]
ENST00000367579; ENSP00000356551; ENSG00000153029. [Q95460-2]
ENST00000367580; ENSP00000356552; ENSG00000153029. [Q95460-1]
ENST00000434571; ENSP00000388504; ENSG00000153029. [Q95460-5]
ENST00000614012; ENSP00000477563; ENSG00000153029. [Q95460-1]
ENST00000617803; ENSP00000478976; ENSG00000153029. [Q95460-3]
GeneIDi3140.
KEGGihsa:3140.
UCSCiuc001goq.2. human. [Q95460-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22963 mRNA. Translation: AAC50174.1.
AJ249778 mRNA. Translation: CAB77667.1.
AK290374 mRNA. Translation: BAF83063.1.
AK304645 mRNA. Translation: BAG65423.1.
AK222910 mRNA. Translation: BAD96630.1.
AL356267 Genomic DNA. Translation: CAH72302.1.
AL356267 Genomic DNA. Translation: CAH72303.1.
AL356267 Genomic DNA. Translation: CAH72304.1.
AL356267 Genomic DNA. Translation: CAH72305.1.
CH471067 Genomic DNA. Translation: EAW91097.1.
CH471067 Genomic DNA. Translation: EAW91098.1.
CH471067 Genomic DNA. Translation: EAW91095.1.
BC012485 mRNA. Translation: AAH12485.1.
AF010446 mRNA. Translation: AAD01442.1.
AF010447 mRNA. Translation: AAD01443.1. Different initiation.
AF031469 mRNA. Translation: AAD01933.1.
AF039526 Genomic DNA. Translation: AAD02172.1.
AH006983 Genomic DNA. Translation: AAC72900.1.
AF223407 Genomic DNA. Translation: AAF40170.1.
CCDSiCCDS1342.1. [Q95460-1]
CCDS53440.1. [Q95460-3]
CCDS53441.1. [Q95460-5]
CCDS53442.1. [Q95460-2]
PIRiA57136.
RefSeqiNP_001181928.1. NM_001194999.1. [Q95460-2]
NP_001181929.1. NM_001195000.1. [Q95460-3]
NP_001181964.1. NM_001195035.1. [Q95460-5]
NP_001522.1. NM_001531.2. [Q95460-1]
UniGeneiHs.13500.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GUPX-ray3.20A/C23-292[»]
4L4TX-ray2.00A/C23-292[»]
4L4VX-ray1.90A/C23-292[»]
4LCWX-ray2.40A/C23-292[»]
4NQCX-ray2.50A/C23-292[»]
4NQDX-ray2.20A/C23-292[»]
4NQEX-ray2.10A/C23-292[»]
4PJ5X-ray2.00A/C23-292[»]
4PJ7X-ray2.50A/C23-292[»]
4PJ8X-ray3.30A23-292[»]
4PJ9X-ray2.00A23-292[»]
4PJAX-ray2.68A/C23-292[»]
4PJBX-ray2.85A/C23-292[»]
4PJCX-ray2.50A/C23-292[»]
4PJDX-ray2.78A/C23-292[»]
4PJEX-ray1.95A/C23-292[»]
4PJFX-ray2.45A/C23-292[»]
4PJGX-ray2.40A/C23-292[»]
4PJHX-ray2.00A/C23-292[»]
4PJIX-ray2.50A/C23-292[»]
4PJXX-ray2.25A/C23-292[»]
5D5MX-ray2.20A/C23-292[»]
5D7IX-ray2.00A/C23-292[»]
5D7JX-ray1.97C/E23-292[»]
5D7LX-ray3.40A/C23-292[»]
ProteinModelPortaliQ95460.
SMRiQ95460.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109385. 17 interactors.
DIPiDIP-59986N.
IntActiQ95460. 1 interactor.
STRINGi9606.ENSP00000356552.

Chemistry databases

DrugBankiDB00098. Anti-thymocyte Globulin (Rabbit).

PTM databases

iPTMnetiQ95460.
PhosphoSitePlusiQ95460.

Polymorphism and mutation databases

BioMutaiMR1.
DMDMi74751679.

Proteomic databases

PaxDbiQ95460.
PeptideAtlasiQ95460.
PRIDEiQ95460.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000282990; ENSP00000282990; ENSG00000153029. [Q95460-3]
ENST00000367579; ENSP00000356551; ENSG00000153029. [Q95460-2]
ENST00000367580; ENSP00000356552; ENSG00000153029. [Q95460-1]
ENST00000434571; ENSP00000388504; ENSG00000153029. [Q95460-5]
ENST00000614012; ENSP00000477563; ENSG00000153029. [Q95460-1]
ENST00000617803; ENSP00000478976; ENSG00000153029. [Q95460-3]
GeneIDi3140.
KEGGihsa:3140.
UCSCiuc001goq.2. human. [Q95460-1]

Organism-specific databases

CTDi3140.
DisGeNETi3140.
GeneCardsiMR1.
HGNCiHGNC:4975. MR1.
MalaCardsiMR1.
MIMi600764. gene.
neXtProtiNX_Q95460.
OpenTargetsiENSG00000153029.
PharmGKBiPA29309.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II5V. Eukaryota.
ENOG4111K8F. LUCA.
GeneTreeiENSGT00760000118960.
HOGENOMiHOG000296917.
HOVERGENiHBG016709.
InParanoidiQ95460.
OMAiTWMKNGE.
OrthoDBiEOG091G0K1X.
PhylomeDBiQ95460.
TreeFamiTF336617.

Miscellaneous databases

ChiTaRSiMR1. human.
GeneWikiiMajor_histocompatibility_complex,_class_I-related.
GenomeRNAii3140.
PROiQ95460.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000153029.
CleanExiHS_MR1.
GenevisibleiQ95460. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHMR1_HUMAN
AccessioniPrimary (citable) accession number: Q95460
Secondary accession number(s): A8K2V9
, B4E3B1, O97985, O97986, Q53GM1, Q95HB8, Q9MY23, Q9NPL2, Q9TQB3, Q9TQB9, Q9TQK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

MR1 is detected in an open versus folded conformation. Only the folded MR1 conformer activates MAIT cells.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.