Q95365 (1B38_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
HLA class I histocompatibility antigen, B-38 alpha chain

Alternative name(s):
Bw-4
MHC class I antigen B*38

Gene names

Name:	HLA-B
Synonyms:	HLAB

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in the presentation of foreign antigens to the immune system.
Subunit structure	Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Post-translational modification	Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system By similarity.
Polymorphism	The following alleles of B-38 are known: B*38:01, B*38:02, B*38:03, B*38:04, B*38:05, B*38:06, B*38:07 and B*38:08. The sequence shown is that of B*38:01.
Sequence similarities	Belongs to the MHC class I family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Ontologies

Keywords
Biological process	Host-virus interaction Immunity
Cellular component	MHC I Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Traceable author statement. Source: Reactome antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Traceable author statement. Source: Reactome interferon-gamma-mediated signaling pathway Traceable author statement. Source: Reactome regulation of immune response Traceable author statement. Source: Reactome type I interferon-mediated signaling pathway Traceable author statement. Source: Reactome virus-host interaction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	ER to Golgi transport vesicle membrane Traceable author statement. Source: Reactome Golgi membrane Traceable author statement. Source: Reactome MHC class I protein complex Inferred from electronic annotation. Source: UniProtKB-KW early endosome membrane Traceable author statement. Source: Reactome integral to lumenal side of endoplasmic reticulum membrane Traceable author statement. Source: Reactome phagocytic vesicle membrane Traceable author statement. Source: Reactome plasma membrane Traceable author statement. Source: Reactome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24
	Chain	25 – 362	338	HLA class I histocompatibility antigen, B-38 alpha chain		PRO_0000018842
Regions
	Topological domain	25 – 308	284	Extracellular Potential
	Transmembrane	309 – 332	24	Helical; Potential
	Topological domain	333 – 362	30	Cytoplasmic Potential
	Domain	209 – 295	87	Ig-like C1-type
	Region	25 – 114	90	Alpha-1
	Region	115 – 206	92	Alpha-2
	Region	207 – 298	92	Alpha-3
	Region	299 – 308	10	Connecting peptide
Amino acid modifications
	Glycosylation	110	1	N-linked (GlcNAc...) By similarity
	Disulfide bond	125 ↔ 188		By similarity
	Disulfide bond	227 ↔ 283		By similarity
Natural variations
	Natural variant	4	1	M → T. Corresponds to variant rs1050458 [ dbSNP | Ensembl ].		VAR_056347
	Natural variant	9	1	V → L. Corresponds to variant rs1050462 [ dbSNP | Ensembl ].		VAR_056348
	Natural variant	17	1	L → V. Corresponds to variant rs1131165 [ dbSNP | Ensembl ].		VAR_056349
	Natural variant	35	1	S → A in allele B*38:05. Corresponds to variant rs1131170 [ dbSNP | Ensembl ].		VAR_016411
	Natural variant	36	1	V → M. Corresponds to variant rs1050486 [ dbSNP | Ensembl ].		VAR_056350
	Natural variant	48	1	S → A. Corresponds to variant rs713031 [ dbSNP | Ensembl ].		VAR_061407
	Natural variant	48	1	S → P. Corresponds to variant rs713031 [ dbSNP | Ensembl ].		VAR_061408
	Natural variant	48	1	S → T. Corresponds to variant rs713031 [ dbSNP | Ensembl ].		VAR_061409
	Natural variant	65	1	A → T. Corresponds to variant rs1050529 [ dbSNP | Ensembl ].		VAR_056351
	Natural variant	69	1	E → T in allele B*38:06 and allele B*38:07; requires 2 nucleotide substitutions.		VAR_016412
	Natural variant	82	1	E → G in allele B*38:07.		VAR_016413
	Natural variant	87	1	N → D. Corresponds to variant rs1050570 [ dbSNP | Ensembl ].		VAR_056352
	Natural variant	87	1	N → E in allele B*38:03 and allele B*38:04; requires 2 nucleotide substitutions.		VAR_016414
	Natural variant	87	1	N → K. Corresponds to variant rs1065386 [ dbSNP | Ensembl ].		VAR_059478
	Natural variant	91	1	C → F in allele B*38:06 and allele B*38:07.		VAR_016415
	Natural variant	91	1	C → S in allele B*38:03.		VAR_016416
	Natural variant	98	1	Y → D in allele B*38:03.		VAR_016417
	Natural variant	101	1	N → S in allele B*38:03.		VAR_016418
	Natural variant	104	1	I → T in allele B*38:02, allele B*38:03, allele B*38:04 and allele B*38:08.		VAR_016419
	Natural variant	187	1	T → M in allele B*38:08.		VAR_016420
	Natural variant	306	1	V → I. Corresponds to variant rs1131500 [ dbSNP | Ensembl ].		VAR_056353
	Natural variant	329	1	A → T. Corresponds to variant rs1051488 [ dbSNP | Ensembl ].		VAR_056354
Experimental info
	Sequence conflict	130 – 131	2	DG → ER in AAA36222. Ref.12
	Sequence conflict	191 – 192	2	WL → CV in AAA36222. Ref.12

Sequences

	Sequence		Length	Mass (Da)
	Q95365 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 41F49A1A19DF21C7	FASTA	362	40,416
	10 20 30 40 50 60 MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG YVDDTQFVRF 70 80 90 100 110 120 DSDAASPREE PRAPWIEQEG PEYWDRNTQI CKTNTQTYRE NLRIALRYYN QSEAGSHTLQ 130 140 150 160 170 180 RMYGCDVGPD GRLLRGHNQF AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAARVAEQL 190 200 210 220 230 240 RTYLEGTCVE WLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT 250 260 270 280 290 300 WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP 310 320 330 340 350 360 SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAASS DSAQGSDVSL TA

References

[1]	"HLA-B16 antigens: sequence of the ST-16 antigen, further definition of two B38 subtypes and evidence for convergent evolution of B*3902." Adams E.J., Martinez-Naves E., Arnett K.L., Little A.-M., Tyan D.B., Parham P. Tissue Antigens 45:18-26(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*38:01).
[2]	Morlighem G. Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*38:01).
[3]	Little A.-M., Domena J.D., Hildebrand W.H., Parham P. Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*38:02).
[4]	"Cloning and sequencing full-length HLA-B and -C genes." Cox S.T., McWhinnie A.J., Robinson J., Marsh S.G.E., Parham P., Madrigal J.A., Little A.-M. Tissue Antigens 61:20-48(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*38:02). Tissue: Blood.
[5]	"HLA-B alleles associated with the B15 serologically defined antigens." Steiner N.K., Ng J., Bush J., Hartzman R.J., Johnston-Dow L., Hurley C.K. Hum. Immunol. 56:84-93(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*38:02).
[6]	"Confirmatory sequence and serology of HLA-B*38021." Guttridge M.G., Hammond L., Darke C. Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*38:02).
[7]	"Characterization of a new HLA-B*38 allele (B*3803) in a Spanish Caucasian individual which is closely related to the Oriental B*38021 and B*39021 alleles." Balas A., Santos S., Garcia-Sanchez F., Lillo R., Merino J.L., Vicario J.L. Tissue Antigens 53:374-377(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 26-206 (ALLELE B*38:03).
[8]	"Novel HLA-B alleles associated with antigens in the 8C CREG." Steiner N.K., Gans C.P., Kosman C., Baldassarre L.A., Edson S., Jones P.F., Rizzuto G., Pimtanothai N., Koester R., Mitton W., Ng J., Hartzman R.J., Hurley C.K. Tissue Antigens 57:373-375(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELES B*38:04 AND B*38:06).
[9]	"Two new HLA class I alleles recognised by PCR sequence-specific primer and sequencing based typing: B*3805 and Cw*0408." Garcia-Sanchez F., Fernandez-De-Velasco J., Lillo R., Alvarez-Doval A., Rodriguez M.A., Aviles M.J., Balas A., Vicario J.L. Tissue Antigens 59:47-48(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-298 (ALLELE B*38:05).
[10]	Cavett J.W., Hildebrand W.H., Bennett T.T., Sparkman J.N. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*38:07).
[11]	"Novel HLA-B allele Identified by PCR SSO." Chapman G., Dodd R., Greville W.D., Dunckley H. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*38:08).
[12]	"Genetic and serological heterogeneity of the supertypic HLA-B locus specificities Bw4 and Bw6." Mueller C.A., Engler-Blum G., Gekeler V., Steiert I., Weiss E., Schmidt H. Immunogenetics 30:200-207(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-298 (ALLELE B*38:01).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L36591 mRNA. Translation: AAA73509.1. U40498 mRNA. Translation: AAD00010.1. L22028 mRNA. Translation: AAA59618.1. AJ297317 Genomic DNA. Translation: CAC29063.1. AH005604 Genomic DNA. Translation: AAB82305.1. AJ308991, AJ308992 Genomic DNA. Translation: CAC34965.1. AF081275 mRNA. Translation: AAC32198.1. AF081276 Genomic DNA. Translation: AAC32199.1. AH008211 Genomic DNA. Translation: AAD56222.1. AH009484 Genomic DNA. Translation: AAF78055.1. AH009277 Genomic DNA. Translation: AAF67340.1. AH010893 Genomic DNA. Translation: AAK69506.1. AH011066 Genomic DNA. Translation: AAL04500.1. M29864 Genomic DNA. Translation: AAA36222.1.
IPI	IPI00473068.
PIR	A59028. I54463.
UniGene	Hs.654404. Hs.77961.
3D structure databases
ProteinModelPortal	Q95365.
ModBase	Search...
Polymorphism databases
DMDM	34305608.
Proteomic databases
PRIDE	Q95365.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000425848; ENSP00000400842; ENSG00000223532.
Organism-specific databases
GeneCards	GC06M031321.
HGNC	HGNC:4932. HLA-B.
MIM	142830. gene.
neXtProt	NX_Q95365.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG016709.
InParanoid	Q95365.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
ArrayExpress	Q95365.
CleanEx	HS_HLA-B.
Genevestigator	Q95365.
Family and domain databases
Gene3D	2.60.40.10. 1 hit. 3.30.500.10. 1 hit.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003006. Ig/MHC_CS. IPR003597. Ig_C1-set. IPR011161. MHC_I-like_Ag-recog. IPR011162. MHC_I/II-like_Ag-recog. IPR001039. MHC_I_a_a1/a2. IPR010579. MHC_I_a_C. [Graphical view]
Pfam	PF07654. C1-set. 1 hit. PF00129. MHC_I. 1 hit. PF06623. MHC_I_C. 1 hit. [Graphical view]
PRINTS	PR01638. MHCCLASSI.
SMART	SM00407. IGc1. 1 hit. [Graphical view]
SUPFAM	SSF54452. MHC_I/II-like_Ag-recog. 1 hit.
PROSITE	PS50835. IG_LIKE. 1 hit. PS00290. IG_MHC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	HLA-B. human.
SOURCE	Search...

Entry information

Entry name

1B38_HUMAN

Accession

Primary (citable) accession number: Q95365
Secondary accession number(s): O19779 , O77959, O78160, Q29935, Q29936, Q95IB8, Q95IH5, Q9BCM8, Q9MY92, Q9MYG1, Q9TPT2

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 22, 2003
Last sequence update:	February 1, 1997
Last modified:	May 1, 2013
This is version 104 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.