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Q95365 (1B38_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
HLA class I histocompatibility antigen, B-38 alpha chain
Alternative name(s):
Bw-4
MHC class I antigen B*38
Gene names
Name:HLA-B
Synonyms:HLAB
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the presentation of foreign antigens to the immune system.

Subunit structure

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Post-translational modification

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system By similarity.

Polymorphism

The following alleles of B-38 are known: B*38:01, B*38:02, B*38:03, B*38:04, B*38:05, B*38:06, B*38:07 and B*38:08. The sequence shown is that of B*38:01.

Sequence similarities

Belongs to the MHC class I family.

Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Ontologies

Keywords
   Biological processHost-virus interaction
Immunity
   Cellular componentMembrane
MHC I
   Coding sequence diversityPolymorphism
   DomainSignal
Transmembrane
Transmembrane helix
   PTMDisulfide bond
Glycoprotein
Ubl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I

Traceable author statement. Source: Reactome

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent

Traceable author statement. Source: Reactome

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent

Traceable author statement. Source: Reactome

antigen processing and presentation of peptide antigen via MHC class I

Traceable author statement. Source: Reactome

cytokine-mediated signaling pathway

Traceable author statement. Source: Reactome

innate immune response

Traceable author statement. Source: Reactome

interferon-gamma-mediated signaling pathway

Traceable author statement. Source: Reactome

positive regulation of T cell mediated cytotoxicity

Inferred from electronic annotation. Source: InterPro

regulation of immune response

Traceable author statement. Source: Reactome

type I interferon signaling pathway

Traceable author statement. Source: Reactome

viral process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentER to Golgi transport vesicle membrane

Traceable author statement. Source: Reactome

Golgi apparatus

Inferred from sequence or structural similarity. Source: UniProt

Golgi membrane

Traceable author statement. Source: Reactome

MHC class I protein complex

Inferred from sequence or structural similarity. Source: UniProt

cell surface

Inferred from sequence or structural similarity. Source: UniProt

early endosome membrane

Traceable author statement. Source: Reactome

endoplasmic reticulum

Inferred from sequence or structural similarity. Source: UniProt

integral component of lumenal side of endoplasmic reticulum membrane

Traceable author statement. Source: Reactome

phagocytic vesicle membrane

Traceable author statement. Source: Reactome

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionpeptide antigen binding

Inferred from sequence or structural similarity. Source: UniProt

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424
Chain25 – 362338HLA class I histocompatibility antigen, B-38 alpha chain
PRO_0000018842

Regions

Topological domain25 – 308284Extracellular Potential
Transmembrane309 – 33224Helical; Potential
Topological domain333 – 36230Cytoplasmic Potential
Domain209 – 29587Ig-like C1-type
Region25 – 11490Alpha-1
Region115 – 20692Alpha-2
Region207 – 29892Alpha-3
Region299 – 30810Connecting peptide

Amino acid modifications

Glycosylation1101N-linked (GlcNAc...) By similarity
Disulfide bond125 ↔ 188 By similarity
Disulfide bond227 ↔ 283 By similarity

Natural variations

Natural variant41M → T.
Corresponds to variant rs1050458 [ dbSNP | Ensembl ].
VAR_056347
Natural variant91V → L.
Corresponds to variant rs1050462 [ dbSNP | Ensembl ].
VAR_056348
Natural variant171L → V.
Corresponds to variant rs1131165 [ dbSNP | Ensembl ].
VAR_056349
Natural variant351S → A in allele B*38:05.
Corresponds to variant rs1131170 [ dbSNP | Ensembl ].
VAR_016411
Natural variant361V → M.
Corresponds to variant rs1050486 [ dbSNP | Ensembl ].
VAR_056350
Natural variant481S → A.
Corresponds to variant rs713031 [ dbSNP | Ensembl ].
VAR_061407
Natural variant481S → P.
Corresponds to variant rs713031 [ dbSNP | Ensembl ].
VAR_061408
Natural variant481S → T.
Corresponds to variant rs713031 [ dbSNP | Ensembl ].
VAR_061409
Natural variant651A → T. Ref.13
Corresponds to variant rs1050529 [ dbSNP | Ensembl ].
VAR_056351
Natural variant691E → T in allele B*38:06 and allele B*38:07; requires 2 nucleotide substitutions.
VAR_016412
Natural variant821E → G in allele B*38:07.
VAR_016413
Natural variant871N → D.
Corresponds to variant rs1050570 [ dbSNP | Ensembl ].
VAR_056352
Natural variant871N → E in allele B*38:03 and allele B*38:04; requires 2 nucleotide substitutions.
VAR_016414
Natural variant871N → K.
Corresponds to variant rs1065386 [ dbSNP | Ensembl ].
VAR_059478
Natural variant911C → F in allele B*38:06 and allele B*38:07.
VAR_016415
Natural variant911C → S in allele B*38:03.
VAR_016416
Natural variant981Y → D in allele B*38:03.
VAR_016417
Natural variant1011N → S in allele B*38:03.
VAR_016418
Natural variant1041I → T in allele B*38:02, allele B*38:03, allele B*38:04 and allele B*38:08.
VAR_016419
Natural variant1871T → M in allele B*38:08.
VAR_016420
Natural variant3061V → I.
Corresponds to variant rs1131500 [ dbSNP | Ensembl ].
VAR_056353
Natural variant3291A → T.
Corresponds to variant rs1051488 [ dbSNP | Ensembl ].
VAR_056354

Experimental info

Sequence conflict130 – 1312DG → ER in AAA36222. Ref.12
Sequence conflict191 – 1922WL → CV in AAA36222. Ref.12

Sequences

Sequence LengthMass (Da)Tools
Q95365 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 41F49A1A19DF21C7

FASTA36240,416
        10         20         30         40         50         60 
MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG YVDDTQFVRF 

        70         80         90        100        110        120 
DSDAASPREE PRAPWIEQEG PEYWDRNTQI CKTNTQTYRE NLRIALRYYN QSEAGSHTLQ 

       130        140        150        160        170        180 
RMYGCDVGPD GRLLRGHNQF AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAARVAEQL 

       190        200        210        220        230        240 
RTYLEGTCVE WLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT 

       250        260        270        280        290        300 
WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP 

       310        320        330        340        350        360 
SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAASS DSAQGSDVSL 


TA 

« Hide

References

« Hide 'large scale' references
[1]"HLA-B16 antigens: sequence of the ST-16 antigen, further definition of two B38 subtypes and evidence for convergent evolution of B*3902."
Adams E.J., Martinez-Naves E., Arnett K.L., Little A.-M., Tyan D.B., Parham P.
Tissue Antigens 45:18-26(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*38:01).
[2]Morlighem G.
Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*38:01).
[3]Little A.-M., Domena J.D., Hildebrand W.H., Parham P.
Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*38:02).
[4]"Cloning and sequencing full-length HLA-B and -C genes."
Cox S.T., McWhinnie A.J., Robinson J., Marsh S.G.E., Parham P., Madrigal J.A., Little A.-M.
Tissue Antigens 61:20-48(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*38:02).
Tissue: Blood.
[5]"HLA-B alleles associated with the B15 serologically defined antigens."
Steiner N.K., Ng J., Bush J., Hartzman R.J., Johnston-Dow L., Hurley C.K.
Hum. Immunol. 56:84-93(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*38:02).
[6]"Confirmatory sequence and serology of HLA-B*38021."
Guttridge M.G., Hammond L., Darke C.
Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*38:02).
[7]"Characterization of a new HLA-B*38 allele (B*3803) in a Spanish Caucasian individual which is closely related to the Oriental B*38021 and B*39021 alleles."
Balas A., Santos S., Garcia-Sanchez F., Lillo R., Merino J.L., Vicario J.L.
Tissue Antigens 53:374-377(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 26-206 (ALLELE B*38:03).
[8]"Novel HLA-B alleles associated with antigens in the 8C CREG."
Steiner N.K., Gans C.P., Kosman C., Baldassarre L.A., Edson S., Jones P.F., Rizzuto G., Pimtanothai N., Koester R., Mitton W., Ng J., Hartzman R.J., Hurley C.K.
Tissue Antigens 57:373-375(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELES B*38:04 AND B*38:06).
[9]"Two new HLA class I alleles recognised by PCR sequence-specific primer and sequencing based typing: B*3805 and Cw*0408."
Garcia-Sanchez F., Fernandez-De-Velasco J., Lillo R., Alvarez-Doval A., Rodriguez M.A., Aviles M.J., Balas A., Vicario J.L.
Tissue Antigens 59:47-48(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-298 (ALLELE B*38:05).
[10]Cavett J.W., Hildebrand W.H., Bennett T.T., Sparkman J.N.
Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*38:07).
[11]"Novel HLA-B allele Identified by PCR SSO."
Chapman G., Dodd R., Greville W.D., Dunckley H.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*38:08).
[12]"Genetic and serological heterogeneity of the supertypic HLA-B locus specificities Bw4 and Bw6."
Mueller C.A., Engler-Blum G., Gekeler V., Steiert I., Weiss E., Schmidt H.
Immunogenetics 30:200-207(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-298 (ALLELE B*38:01).
[13]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L36591 mRNA. Translation: AAA73509.1.
U40498 mRNA. Translation: AAD00010.1.
L22028 mRNA. Translation: AAA59618.1.
AJ297317 Genomic DNA. Translation: CAC29063.1.
AH005604 Genomic DNA. Translation: AAB82305.1.
AJ308991, AJ308992 Genomic DNA. Translation: CAC34965.1.
AF081275 mRNA. Translation: AAC32198.1.
AF081276 Genomic DNA. Translation: AAC32199.1.
AH008211 Genomic DNA. Translation: AAD56222.1.
AH009484 Genomic DNA. Translation: AAF78055.1.
AH009277 Genomic DNA. Translation: AAF67340.1.
AH010893 Genomic DNA. Translation: AAK69506.1.
AH011066 Genomic DNA. Translation: AAL04500.1.
M29864 Genomic DNA. Translation: AAA36222.1.
PIRA59028.
I54463.
UniGeneHs.654404.
Hs.77961.

3D structure databases

ProteinModelPortalQ95365.
SMRQ95365. Positions 25-300.
ModBaseSearch...
MobiDBSearch...

Polymorphism databases

DMDM34305608.

Proteomic databases

PRIDEQ95365.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000425848; ENSP00000400842; ENSG00000223532.

Organism-specific databases

GeneCardsGC06M031321.
GC06Mj31312.
HGNCHGNC:4932. HLA-B.
MIM142830. gene.
neXtProtNX_Q95365.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG016709.
InParanoidQ95365.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

CleanExHS_HLA-B.
GenevestigatorQ95365.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSPR01638. MHCCLASSI.
SMARTSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMSSF54452. SSF54452. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHLA-B. human.
SOURCESearch...

Entry information

Entry name1B38_HUMAN
AccessionPrimary (citable) accession number: Q95365
Secondary accession number(s): O19779 expand/collapse secondary AC list , O77959, O78160, Q29935, Q29936, Q95IB8, Q95IH5, Q9BCM8, Q9MY92, Q9MYG1, Q9TPT2
Entry history
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: February 1, 1997
Last modified: July 9, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM