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Q95365

- 1B38_HUMAN

UniProt

Q95365 - 1B38_HUMAN

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Protein

HLA class I histocompatibility antigen, B-38 alpha chain

Gene

HLA-B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

  1. peptide antigen binding Source: UniProt

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
  2. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
  3. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Source: Reactome
  4. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
  5. cytokine-mediated signaling pathway Source: Reactome
  6. innate immune response Source: Reactome
  7. interferon-gamma-mediated signaling pathway Source: Reactome
  8. positive regulation of T cell mediated cytotoxicity Source: InterPro
  9. regulation of immune response Source: Reactome
  10. type I interferon signaling pathway Source: Reactome
  11. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiREACT_111168. Endosomal/Vacuolar pathway.
REACT_111178. ER-Phagosome pathway.
REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_147694. DAP12 interactions.
REACT_25078. Interferon gamma signaling.
REACT_25162. Interferon alpha/beta signaling.
REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, B-38 alpha chain
Alternative name(s):
Bw-4
MHC class I antigen B*38
Gene namesi
Name:HLA-B
Synonyms:HLAB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:4932. HLA-B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 308284ExtracellularSequence AnalysisAdd
BLAST
Transmembranei309 – 33224HelicalSequence AnalysisAdd
BLAST
Topological domaini333 – 36230CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: UniProt
  2. early endosome membrane Source: Reactome
  3. endoplasmic reticulum Source: UniProt
  4. ER to Golgi transport vesicle membrane Source: Reactome
  5. Golgi apparatus Source: UniProt
  6. Golgi membrane Source: Reactome
  7. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
  8. MHC class I protein complex Source: UniProt
  9. phagocytic vesicle membrane Source: Reactome
  10. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Add
BLAST
Chaini25 – 362338HLA class I histocompatibility antigen, B-38 alpha chainPRO_0000018842Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi110 – 1101N-linked (GlcNAc...)By similarity
Disulfide bondi125 ↔ 188PROSITE-ProRule annotation
Disulfide bondi227 ↔ 283PROSITE-ProRule annotation

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PRIDEiQ95365.

Expressioni

Gene expression databases

CleanExiHS_HLA-B.
GenevestigatoriQ95365.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ95365.
SMRiQ95365. Positions 25-298.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini209 – 29587Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni25 – 11490Alpha-1Add
BLAST
Regioni115 – 20692Alpha-2Add
BLAST
Regioni207 – 29892Alpha-3Add
BLAST
Regioni299 – 30810Connecting peptide

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016709.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q95365-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG
60 70 80 90 100
YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI CKTNTQTYRE
110 120 130 140 150
NLRIALRYYN QSEAGSHTLQ RMYGCDVGPD GRLLRGHNQF AYDGKDYIAL
160 170 180 190 200
NEDLSSWTAA DTAAQITQRK WEAARVAEQL RTYLEGTCVE WLRRYLENGK
210 220 230 240 250
ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAASS
360
DSAQGSDVSL TA
Length:362
Mass (Da):40,416
Last modified:February 1, 1997 - v1
Checksum:i41F49A1A19DF21C7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti130 – 1312DG → ER in AAA36222. (PubMed:2777338)Curated
Sequence conflicti191 – 1922WL → CV in AAA36222. (PubMed:2777338)Curated

Polymorphismi

The following alleles of B-38 are known: B*38:01, B*38:02, B*38:03, B*38:04, B*38:05, B*38:06, B*38:07 and B*38:08. The sequence shown is that of B*38:01.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41M → T.
Corresponds to variant rs1050458 [ dbSNP | Ensembl ].
VAR_056347
Natural varianti9 – 91V → L.
Corresponds to variant rs1050462 [ dbSNP | Ensembl ].
VAR_056348
Natural varianti17 – 171L → V.
Corresponds to variant rs1131165 [ dbSNP | Ensembl ].
VAR_056349
Natural varianti35 – 351S → A in allele B*38:05.
Corresponds to variant rs1131170 [ dbSNP | Ensembl ].
VAR_016411
Natural varianti36 – 361V → M.
Corresponds to variant rs1050486 [ dbSNP | Ensembl ].
VAR_056350
Natural varianti48 – 481S → A.
Corresponds to variant rs713031 [ dbSNP | Ensembl ].
VAR_061407
Natural varianti48 – 481S → P.
Corresponds to variant rs713031 [ dbSNP | Ensembl ].
VAR_061408
Natural varianti48 – 481S → T.
Corresponds to variant rs713031 [ dbSNP | Ensembl ].
VAR_061409
Natural varianti65 – 651A → T.1 Publication
Corresponds to variant rs1050529 [ dbSNP | Ensembl ].
VAR_056351
Natural varianti69 – 691E → T in allele B*38:06 and allele B*38:07; requires 2 nucleotide substitutions.
VAR_016412
Natural varianti82 – 821E → G in allele B*38:07.
VAR_016413
Natural varianti87 – 871N → D.
Corresponds to variant rs1050570 [ dbSNP | Ensembl ].
VAR_056352
Natural varianti87 – 871N → E in allele B*38:03 and allele B*38:04; requires 2 nucleotide substitutions.
VAR_016414
Natural varianti87 – 871N → K.
Corresponds to variant rs1065386 [ dbSNP | Ensembl ].
VAR_059478
Natural varianti91 – 911C → F in allele B*38:06 and allele B*38:07.
VAR_016415
Natural varianti91 – 911C → S in allele B*38:03.
VAR_016416
Natural varianti98 – 981Y → D in allele B*38:03.
VAR_016417
Natural varianti101 – 1011N → S in allele B*38:03.
VAR_016418
Natural varianti104 – 1041I → T in allele B*38:02, allele B*38:03, allele B*38:04 and allele B*38:08.
VAR_016419
Natural varianti187 – 1871T → M in allele B*38:08.
VAR_016420
Natural varianti306 – 3061V → I.
Corresponds to variant rs1131500 [ dbSNP | Ensembl ].
VAR_056353
Natural varianti329 – 3291A → T.
Corresponds to variant rs1051488 [ dbSNP | Ensembl ].
VAR_056354

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36591 mRNA. Translation: AAA73509.1.
U40498 mRNA. Translation: AAD00010.1.
L22028 mRNA. Translation: AAA59618.1.
AJ297317 Genomic DNA. Translation: CAC29063.1.
AH005604 Genomic DNA. Translation: AAB82305.1.
AJ308991, AJ308992 Genomic DNA. Translation: CAC34965.1.
AF081275 mRNA. Translation: AAC32198.1.
AF081276 Genomic DNA. Translation: AAC32199.1.
AH008211 Genomic DNA. Translation: AAD56222.1.
AH009484 Genomic DNA. Translation: AAF78055.1.
AH009277 Genomic DNA. Translation: AAF67340.1.
AH010893 Genomic DNA. Translation: AAK69506.1.
AH011066 Genomic DNA. Translation: AAL04500.1.
M29864 Genomic DNA. Translation: AAA36222.1.
PIRiA59028.
I54463.
UniGeneiHs.654404.
Hs.77961.

Genome annotation databases

EnsembliENST00000425848; ENSP00000400842; ENSG00000223532.

Polymorphism databases

DMDMi34305608.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36591 mRNA. Translation: AAA73509.1 .
U40498 mRNA. Translation: AAD00010.1 .
L22028 mRNA. Translation: AAA59618.1 .
AJ297317 Genomic DNA. Translation: CAC29063.1 .
AH005604 Genomic DNA. Translation: AAB82305.1 .
AJ308991 , AJ308992 Genomic DNA. Translation: CAC34965.1 .
AF081275 mRNA. Translation: AAC32198.1 .
AF081276 Genomic DNA. Translation: AAC32199.1 .
AH008211 Genomic DNA. Translation: AAD56222.1 .
AH009484 Genomic DNA. Translation: AAF78055.1 .
AH009277 Genomic DNA. Translation: AAF67340.1 .
AH010893 Genomic DNA. Translation: AAK69506.1 .
AH011066 Genomic DNA. Translation: AAL04500.1 .
M29864 Genomic DNA. Translation: AAA36222.1 .
PIRi A59028.
I54463.
UniGenei Hs.654404.
Hs.77961.

3D structure databases

ProteinModelPortali Q95365.
SMRi Q95365. Positions 25-298.
ModBasei Search...
MobiDBi Search...

Polymorphism databases

DMDMi 34305608.

Proteomic databases

PRIDEi Q95365.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000425848 ; ENSP00000400842 ; ENSG00000223532 .

Organism-specific databases

GeneCardsi GC06M031321.
GC06Mj31312.
HGNCi HGNC:4932. HLA-B.
MIMi 142830. gene.
neXtProti NX_Q95365.
GenAtlasi Search...

Phylogenomic databases

HOVERGENi HBG016709.

Enzyme and pathway databases

Reactomei REACT_111168. Endosomal/Vacuolar pathway.
REACT_111178. ER-Phagosome pathway.
REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_147694. DAP12 interactions.
REACT_25078. Interferon gamma signaling.
REACT_25162. Interferon alpha/beta signaling.
REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSi HLA-B. human.
SOURCEi Search...

Gene expression databases

CleanExi HS_HLA-B.
Genevestigatori Q95365.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view ]
PRINTSi PR01638. MHCCLASSI.
SMARTi SM00407. IGc1. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "HLA-B16 antigens: sequence of the ST-16 antigen, further definition of two B38 subtypes and evidence for convergent evolution of B*3902."
    Adams E.J., Martinez-Naves E., Arnett K.L., Little A.-M., Tyan D.B., Parham P.
    Tissue Antigens 45:18-26(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*38:01).
  2. Morlighem G.
    Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*38:01).
  3. Little A.-M., Domena J.D., Hildebrand W.H., Parham P.
    Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*38:02).
  4. Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*38:02).
    Tissue: Blood.
  5. "HLA-B alleles associated with the B15 serologically defined antigens."
    Steiner N.K., Ng J., Bush J., Hartzman R.J., Johnston-Dow L., Hurley C.K.
    Hum. Immunol. 56:84-93(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*38:02).
  6. "Confirmatory sequence and serology of HLA-B*38021."
    Guttridge M.G., Hammond L., Darke C.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*38:02).
  7. "Characterization of a new HLA-B*38 allele (B*3803) in a Spanish Caucasian individual which is closely related to the Oriental B*38021 and B*39021 alleles."
    Balas A., Santos S., Garcia-Sanchez F., Lillo R., Merino J.L., Vicario J.L.
    Tissue Antigens 53:374-377(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 26-206 (ALLELE B*38:03).
  8. Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELES B*38:04 AND B*38:06).
  9. "Two new HLA class I alleles recognised by PCR sequence-specific primer and sequencing based typing: B*3805 and Cw*0408."
    Garcia-Sanchez F., Fernandez-De-Velasco J., Lillo R., Alvarez-Doval A., Rodriguez M.A., Aviles M.J., Balas A., Vicario J.L.
    Tissue Antigens 59:47-48(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-298 (ALLELE B*38:05).
  10. Cavett J.W., Hildebrand W.H., Bennett T.T., Sparkman J.N.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*38:07).
  11. "Novel HLA-B allele Identified by PCR SSO."
    Chapman G., Dodd R., Greville W.D., Dunckley H.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*38:08).
  12. "Genetic and serological heterogeneity of the supertypic HLA-B locus specificities Bw4 and Bw6."
    Mueller C.A., Engler-Blum G., Gekeler V., Steiert I., Weiss E., Schmidt H.
    Immunogenetics 30:200-207(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-298 (ALLELE B*38:01).
  13. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry namei1B38_HUMAN
AccessioniPrimary (citable) accession number: Q95365
Secondary accession number(s): O19779
, O77959, O78160, Q29935, Q29936, Q95IB8, Q95IH5, Q9BCM8, Q9MY92, Q9MYG1, Q9TPT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: February 1, 1997
Last modified: November 26, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3