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Q95365

- 1B38_HUMAN

UniProt

Q95365 - 1B38_HUMAN

Protein

HLA class I histocompatibility antigen, B-38 alpha chain

Gene

HLA-B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Involved in the presentation of foreign antigens to the immune system.

    GO - Molecular functioni

    1. peptide antigen binding Source: UniProt

    GO - Biological processi

    1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
    2. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
    3. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Source: Reactome
    4. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
    5. cytokine-mediated signaling pathway Source: Reactome
    6. innate immune response Source: Reactome
    7. interferon-gamma-mediated signaling pathway Source: Reactome
    8. positive regulation of T cell mediated cytotoxicity Source: InterPro
    9. regulation of immune response Source: Reactome
    10. type I interferon signaling pathway Source: Reactome
    11. viral process Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction, Immunity

    Enzyme and pathway databases

    ReactomeiREACT_111168. Endosomal/Vacuolar pathway.
    REACT_111178. ER-Phagosome pathway.
    REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_147694. DAP12 interactions.
    REACT_25078. Interferon gamma signaling.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HLA class I histocompatibility antigen, B-38 alpha chain
    Alternative name(s):
    Bw-4
    MHC class I antigen B*38
    Gene namesi
    Name:HLA-B
    Synonyms:HLAB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:4932. HLA-B.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: UniProt
    2. early endosome membrane Source: Reactome
    3. endoplasmic reticulum Source: UniProt
    4. ER to Golgi transport vesicle membrane Source: Reactome
    5. Golgi apparatus Source: UniProt
    6. Golgi membrane Source: Reactome
    7. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
    8. MHC class I protein complex Source: UniProt
    9. phagocytic vesicle membrane Source: Reactome
    10. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane, MHC I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Add
    BLAST
    Chaini25 – 362338HLA class I histocompatibility antigen, B-38 alpha chainPRO_0000018842Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi110 – 1101N-linked (GlcNAc...)By similarity
    Disulfide bondi125 ↔ 188PROSITE-ProRule annotation
    Disulfide bondi227 ↔ 283PROSITE-ProRule annotation

    Post-translational modificationi

    Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Ubl conjugation

    Proteomic databases

    PRIDEiQ95365.

    Expressioni

    Gene expression databases

    CleanExiHS_HLA-B.
    GenevestigatoriQ95365.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ95365.
    SMRiQ95365. Positions 25-300.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 308284ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini333 – 36230CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei309 – 33224HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini209 – 29587Ig-like C1-typeAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni25 – 11490Alpha-1Add
    BLAST
    Regioni115 – 20692Alpha-2Add
    BLAST
    Regioni207 – 29892Alpha-3Add
    BLAST
    Regioni299 – 30810Connecting peptide

    Sequence similaritiesi

    Belongs to the MHC class I family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG016709.
    InParanoidiQ95365.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    IPR010579. MHC_I_a_C.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    PF06623. MHC_I_C. 1 hit.
    [Graphical view]
    PRINTSiPR01638. MHCCLASSI.
    SMARTiSM00407. IGc1. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q95365-1 [UniParc]FASTAAdd to Basket

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    MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG    50
    YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI CKTNTQTYRE 100
    NLRIALRYYN QSEAGSHTLQ RMYGCDVGPD GRLLRGHNQF AYDGKDYIAL 150
    NEDLSSWTAA DTAAQITQRK WEAARVAEQL RTYLEGTCVE WLRRYLENGK 200
    ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ 250
    DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP 300
    SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAASS 350
    DSAQGSDVSL TA 362
    Length:362
    Mass (Da):40,416
    Last modified:February 1, 1997 - v1
    Checksum:i41F49A1A19DF21C7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti130 – 1312DG → ER in AAA36222. (PubMed:2777338)Curated
    Sequence conflicti191 – 1922WL → CV in AAA36222. (PubMed:2777338)Curated

    Polymorphismi

    The following alleles of B-38 are known: B*38:01, B*38:02, B*38:03, B*38:04, B*38:05, B*38:06, B*38:07 and B*38:08. The sequence shown is that of B*38:01.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti4 – 41M → T.
    Corresponds to variant rs1050458 [ dbSNP | Ensembl ].
    VAR_056347
    Natural varianti9 – 91V → L.
    Corresponds to variant rs1050462 [ dbSNP | Ensembl ].
    VAR_056348
    Natural varianti17 – 171L → V.
    Corresponds to variant rs1131165 [ dbSNP | Ensembl ].
    VAR_056349
    Natural varianti35 – 351S → A in allele B*38:05.
    Corresponds to variant rs1131170 [ dbSNP | Ensembl ].
    VAR_016411
    Natural varianti36 – 361V → M.
    Corresponds to variant rs1050486 [ dbSNP | Ensembl ].
    VAR_056350
    Natural varianti48 – 481S → A.
    Corresponds to variant rs713031 [ dbSNP | Ensembl ].
    VAR_061407
    Natural varianti48 – 481S → P.
    Corresponds to variant rs713031 [ dbSNP | Ensembl ].
    VAR_061408
    Natural varianti48 – 481S → T.
    Corresponds to variant rs713031 [ dbSNP | Ensembl ].
    VAR_061409
    Natural varianti65 – 651A → T.1 Publication
    Corresponds to variant rs1050529 [ dbSNP | Ensembl ].
    VAR_056351
    Natural varianti69 – 691E → T in allele B*38:06 and allele B*38:07; requires 2 nucleotide substitutions.
    VAR_016412
    Natural varianti82 – 821E → G in allele B*38:07.
    VAR_016413
    Natural varianti87 – 871N → D.
    Corresponds to variant rs1050570 [ dbSNP | Ensembl ].
    VAR_056352
    Natural varianti87 – 871N → E in allele B*38:03 and allele B*38:04; requires 2 nucleotide substitutions.
    VAR_016414
    Natural varianti87 – 871N → K.
    Corresponds to variant rs1065386 [ dbSNP | Ensembl ].
    VAR_059478
    Natural varianti91 – 911C → F in allele B*38:06 and allele B*38:07.
    VAR_016415
    Natural varianti91 – 911C → S in allele B*38:03.
    VAR_016416
    Natural varianti98 – 981Y → D in allele B*38:03.
    VAR_016417
    Natural varianti101 – 1011N → S in allele B*38:03.
    VAR_016418
    Natural varianti104 – 1041I → T in allele B*38:02, allele B*38:03, allele B*38:04 and allele B*38:08.
    VAR_016419
    Natural varianti187 – 1871T → M in allele B*38:08.
    VAR_016420
    Natural varianti306 – 3061V → I.
    Corresponds to variant rs1131500 [ dbSNP | Ensembl ].
    VAR_056353
    Natural varianti329 – 3291A → T.
    Corresponds to variant rs1051488 [ dbSNP | Ensembl ].
    VAR_056354

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L36591 mRNA. Translation: AAA73509.1.
    U40498 mRNA. Translation: AAD00010.1.
    L22028 mRNA. Translation: AAA59618.1.
    AJ297317 Genomic DNA. Translation: CAC29063.1.
    AH005604 Genomic DNA. Translation: AAB82305.1.
    AJ308991, AJ308992 Genomic DNA. Translation: CAC34965.1.
    AF081275 mRNA. Translation: AAC32198.1.
    AF081276 Genomic DNA. Translation: AAC32199.1.
    AH008211 Genomic DNA. Translation: AAD56222.1.
    AH009484 Genomic DNA. Translation: AAF78055.1.
    AH009277 Genomic DNA. Translation: AAF67340.1.
    AH010893 Genomic DNA. Translation: AAK69506.1.
    AH011066 Genomic DNA. Translation: AAL04500.1.
    M29864 Genomic DNA. Translation: AAA36222.1.
    PIRiA59028.
    I54463.
    UniGeneiHs.654404.
    Hs.77961.

    Genome annotation databases

    EnsembliENST00000425848; ENSP00000400842; ENSG00000223532.

    Polymorphism databases

    DMDMi34305608.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L36591 mRNA. Translation: AAA73509.1 .
    U40498 mRNA. Translation: AAD00010.1 .
    L22028 mRNA. Translation: AAA59618.1 .
    AJ297317 Genomic DNA. Translation: CAC29063.1 .
    AH005604 Genomic DNA. Translation: AAB82305.1 .
    AJ308991 , AJ308992 Genomic DNA. Translation: CAC34965.1 .
    AF081275 mRNA. Translation: AAC32198.1 .
    AF081276 Genomic DNA. Translation: AAC32199.1 .
    AH008211 Genomic DNA. Translation: AAD56222.1 .
    AH009484 Genomic DNA. Translation: AAF78055.1 .
    AH009277 Genomic DNA. Translation: AAF67340.1 .
    AH010893 Genomic DNA. Translation: AAK69506.1 .
    AH011066 Genomic DNA. Translation: AAL04500.1 .
    M29864 Genomic DNA. Translation: AAA36222.1 .
    PIRi A59028.
    I54463.
    UniGenei Hs.654404.
    Hs.77961.

    3D structure databases

    ProteinModelPortali Q95365.
    SMRi Q95365. Positions 25-300.
    ModBasei Search...
    MobiDBi Search...

    Polymorphism databases

    DMDMi 34305608.

    Proteomic databases

    PRIDEi Q95365.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000425848 ; ENSP00000400842 ; ENSG00000223532 .

    Organism-specific databases

    GeneCardsi GC06M031321.
    GC06Mj31312.
    HGNCi HGNC:4932. HLA-B.
    MIMi 142830. gene.
    neXtProti NX_Q95365.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG016709.
    InParanoidi Q95365.

    Enzyme and pathway databases

    Reactomei REACT_111168. Endosomal/Vacuolar pathway.
    REACT_111178. ER-Phagosome pathway.
    REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_147694. DAP12 interactions.
    REACT_25078. Interferon gamma signaling.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

    Miscellaneous databases

    ChiTaRSi HLA-B. human.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_HLA-B.
    Genevestigatori Q95365.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    IPR010579. MHC_I_a_C.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    PF06623. MHC_I_C. 1 hit.
    [Graphical view ]
    PRINTSi PR01638. MHCCLASSI.
    SMARTi SM00407. IGc1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "HLA-B16 antigens: sequence of the ST-16 antigen, further definition of two B38 subtypes and evidence for convergent evolution of B*3902."
      Adams E.J., Martinez-Naves E., Arnett K.L., Little A.-M., Tyan D.B., Parham P.
      Tissue Antigens 45:18-26(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*38:01).
    2. Morlighem G.
      Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*38:01).
    3. Little A.-M., Domena J.D., Hildebrand W.H., Parham P.
      Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*38:02).
    4. Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*38:02).
      Tissue: Blood.
    5. "HLA-B alleles associated with the B15 serologically defined antigens."
      Steiner N.K., Ng J., Bush J., Hartzman R.J., Johnston-Dow L., Hurley C.K.
      Hum. Immunol. 56:84-93(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*38:02).
    6. "Confirmatory sequence and serology of HLA-B*38021."
      Guttridge M.G., Hammond L., Darke C.
      Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*38:02).
    7. "Characterization of a new HLA-B*38 allele (B*3803) in a Spanish Caucasian individual which is closely related to the Oriental B*38021 and B*39021 alleles."
      Balas A., Santos S., Garcia-Sanchez F., Lillo R., Merino J.L., Vicario J.L.
      Tissue Antigens 53:374-377(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 26-206 (ALLELE B*38:03).
    8. Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELES B*38:04 AND B*38:06).
    9. "Two new HLA class I alleles recognised by PCR sequence-specific primer and sequencing based typing: B*3805 and Cw*0408."
      Garcia-Sanchez F., Fernandez-De-Velasco J., Lillo R., Alvarez-Doval A., Rodriguez M.A., Aviles M.J., Balas A., Vicario J.L.
      Tissue Antigens 59:47-48(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-298 (ALLELE B*38:05).
    10. Cavett J.W., Hildebrand W.H., Bennett T.T., Sparkman J.N.
      Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*38:07).
    11. "Novel HLA-B allele Identified by PCR SSO."
      Chapman G., Dodd R., Greville W.D., Dunckley H.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*38:08).
    12. "Genetic and serological heterogeneity of the supertypic HLA-B locus specificities Bw4 and Bw6."
      Mueller C.A., Engler-Blum G., Gekeler V., Steiert I., Weiss E., Schmidt H.
      Immunogenetics 30:200-207(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-298 (ALLELE B*38:01).
    13. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry namei1B38_HUMAN
    AccessioniPrimary (citable) accession number: Q95365
    Secondary accession number(s): O19779
    , O77959, O78160, Q29935, Q29936, Q95IB8, Q95IH5, Q9BCM8, Q9MY92, Q9MYG1, Q9TPT2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 22, 2003
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3