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Q95328

- CP17A_HORSE

UniProt

Q95328 - CP17A_HORSE

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Protein
Steroid 17-alpha-hydroxylase/17,20 lyase
Gene
CYP17A1, CYP17
Organism
Equus caballus (Horse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction.

Catalytic activityi

A C(21)-steroid + (reduced NADPH--hemoprotein reductase) + O2 = a 17-alpha-hydroxy-C(21)-steroid + (oxidized NADPH--hemoprotein reductase) + H2O.
17-alpha-hydroxyprogesterone = androst-4-ene-3,17-dione + acetaldehyde.

Cofactori

Heme group By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi442 – 4421Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. 17-alpha-hydroxyprogesterone aldolase activity Source: UniProtKB-EC
  2. heme binding Source: UniProtKB
  3. iron ion binding Source: InterPro
  4. steroid 17-alpha-monooxygenase activity Source: UniProtKB

GO - Biological processi

  1. glucocorticoid biosynthetic process Source: Ensembl
  2. hormone biosynthetic process Source: UniProtKB
  3. progesterone metabolic process Source: UniProtKB
  4. steroid metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Lyase, Monooxygenase, Oxidoreductase

Keywords - Biological processi

Steroidogenesis

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00062.

Names & Taxonomyi

Protein namesi
Recommended name:
Steroid 17-alpha-hydroxylase/17,20 lyase (EC:1.14.99.9, EC:4.1.2.30)
Alternative name(s):
17-alpha-hydroxyprogesterone aldolase
CYPXVII
Cytochrome P450 17A1
Cytochrome P450-C17
Short name:
Cytochrome P450c17
Gene namesi
Name:CYP17A1
Synonyms:CYP17
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
ProteomesiUP000002281: Chromosome 1

Subcellular locationi

Membrane Reviewed prediction

GO - Cellular componenti

  1. axon Source: Ensembl
  2. membrane Source: UniProtKB-SubCell
  3. mitochondrion Source: Ensembl
  4. neuronal cell body Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508Steroid 17-alpha-hydroxylase/17,20 lyase
PRO_0000051930Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ95328.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00750000117317.
HOGENOMiHOG000036991.
HOVERGENiHBG106944.
InParanoidiQ95328.
KOiK00512.
OrthoDBiEOG7RBZ85.
TreeFamiTF105095.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q95328-1 [UniParc]FASTAAdd to Basket

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MWELLAFLLL AIAYFFRPKV KCPGAKYPKS LPYLPLVGSL PFLPRHGHPH    50
VNFFKLQKKY GPIYSLRMGT KTTVMVGHYQ LAKEVLIKKG KEFSGRPQVA 100
TLNILSDNQK GVAFADHGAP WQLHRKLVRA AFALFKDGNQ KLEKIICHET 150
SLLCDLLATQ NGQTIDLSSP LFLAVTNVIC WICFNSSYMK GDPALETMQN 200
YHKGILETLE KDNVVDIFPA LKIFPNKSLE KMRHCVNIRN ELLSKIFEKH 250
KENFNSDSIT SMLDLLIQAK KNSDNNNTGP DQDSKLLSDK HILATIGDIF 300
GAGVETTTSV VKWIVAFLLH DPQLKKKIQE EIDQNVGFSR TPTLSDRNRL 350
LLLEATIREV LRIRPVAPML IPHKALVDSS IGEFAVDDGT NVIINLWALH 400
HNEKEWHQPD RFMPERFLDP TGSQLISPSL SYLPFGAGPR SCIGELLARQ 450
ELFLFTAWLL QRFNLEVPDD GQLPSLEGHP TAVFLIDSFK VKINVRQAWR 500
EAQAEGST 508
Length:508
Mass (Da):57,394
Last modified:February 1, 1997 - v1
Checksum:i71862C8B50AC4BE5
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti388 – 3881D → E in BAA06350. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D30688 mRNA. Translation: BAA06350.1.
D88184 Genomic DNA. Translation: BAA13551.1.
RefSeqiNP_001075992.1. NM_001082523.1.
UniGeneiEca.12075.

Genome annotation databases

EnsembliENSECAT00000011028; ENSECAP00000008577; ENSECAG00000010022.
GeneIDi100034232.
KEGGiecb:100034232.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D30688 mRNA. Translation: BAA06350.1 .
D88184 Genomic DNA. Translation: BAA13551.1 .
RefSeqi NP_001075992.1. NM_001082523.1.
UniGenei Eca.12075.

3D structure databases

ProteinModelPortali Q95328.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSECAT00000011028 ; ENSECAP00000008577 ; ENSECAG00000010022 .
GeneIDi 100034232.
KEGGi ecb:100034232.

Organism-specific databases

CTDi 1586.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00750000117317.
HOGENOMi HOG000036991.
HOVERGENi HBG106944.
InParanoidi Q95328.
KOi K00512.
OrthoDBi EOG7RBZ85.
TreeFami TF105095.

Enzyme and pathway databases

UniPathwayi UPA00062 .

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and nucleotide sequence of equine testicular cytochrome P-450 steroid 17alpha-hydroxylase/C17,20-lyase messenger ribonucleic acid."
    Hasegawa T., Mukoyama H., Yoshida S., Takahashi M.
    (In) Sharp D.C., Bazer F.W. (eds.); Biology of Reproduction Monograph Series 1: Equine Reproduction, pp.VI:615-622, The Society for the Study of Reproduction, Madison (1995)
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Testis.
  2. "Exon/intron structure of equine P450c17."
    Hasegawa T.
    Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Thoroughbred.
    Tissue: Leukocyte.

Entry informationi

Entry nameiCP17A_HORSE
AccessioniPrimary (citable) accession number: Q95328
Secondary accession number(s): Q29483
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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