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Protein

Carbonic anhydrase 4

Gene

CA4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 (By similarity).By similarity

Catalytic activityi

H2CO3 = CO2 + H2O.

Cofactori

Zn2+By similarity

Enzyme regulationi

Inhibited by acetazolamide.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei88Proton acceptorBy similarity1
Metal bindingi115Zinc; catalyticBy similarity1
Metal bindingi117Zinc; catalyticBy similarity1
Metal bindingi140Zinc; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-BTA-1237044 Erythrocytes take up carbon dioxide and release oxygen
R-BTA-1247673 Erythrocytes take up oxygen and release carbon dioxide
R-BTA-1475029 Reversible hydration of carbon dioxide

Names & Taxonomyi

Protein namesi
Recommended name:
Carbonic anhydrase 4 (EC:4.2.1.1)
Alternative name(s):
Carbonate dehydratase IV
Carbonic anhydrase IV
Short name:
CA-IV
Gene namesi
Name:CA4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Organism-specific databases

VGNCiVGNC:26654 CA4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL281

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000000422419 – 284Carbonic anhydrase 4Add BLAST266
PropeptideiPRO_0000004225285 – 312Removed in mature formBy similarityAdd BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 36By similarity
Glycosylationi33N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi46 ↔ 229By similarity
Glycosylationi152N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi195N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi265N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi284GPI-anchor amidated serineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ95323
PRIDEiQ95323

Expressioni

Gene expression databases

BgeeiENSBTAG00000017969

Interactioni

Subunit structurei

Interacts with SLC4A4.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000023909

Chemistry databases

BindingDBiQ95323

Structurei

3D structure databases

ProteinModelPortaliQ95323
SMRiQ95323
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 285Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST265

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni225 – 226Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the alpha-carbonic anhydrase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0382 Eukaryota
COG3338 LUCA
GeneTreeiENSGT00910000144074
HOGENOMiHOG000112637
HOVERGENiHBG002837
InParanoidiQ95323
KOiK18246
OMAiAESHWCY
OrthoDBiEOG091G0XFM
TreeFamiTF316425

Family and domain databases

Gene3Di3.10.200.10, 1 hit
InterProiView protein in InterPro
IPR001148 CA_dom
IPR036398 CA_dom_sf
IPR023561 Carbonic_anhydrase_a-class
IPR018343 Carbonic_anhydrase_CA4
PANTHERiPTHR18952 PTHR18952, 1 hit
PTHR18952:SF95 PTHR18952:SF95, 1 hit
PfamiView protein in Pfam
PF00194 Carb_anhydrase, 1 hit
SMARTiView protein in SMART
SM01057 Carb_anhydrase, 1 hit
SUPFAMiSSF51069 SSF51069, 1 hit
PROSITEiView protein in PROSITE
PS51144 ALPHA_CA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q95323-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLLALLVL AAAPPQARAA SHWCYQIQVK PSNYTCLEPD EWEGSCQNNR
60 70 80 90 100
QSPVNIVTAK TQLDPNLGRF SFSGYNMKHQ WVVQNNGHTV MVLLENKPSI
110 120 130 140 150
AGGGLSTRYQ ATQLHLHWSR AMDRGSEHSF DGERFAMEMH IVHEKEKGLS
160 170 180 190 200
GNASQNQFAE DEIAVLAFMV EDGSKNVNFQ PLVEALSDIP RPNMNTTMKE
210 220 230 240 250
GVSLFDLLPE EESLRHYFRY LGSLTTPTCD EKVVWTVFQK PIQLHRDQIL
260 270 280 290 300
AFSQKLFYDD QQKVNMTDNV RPVQSLGQRQ VFRSGAPGLL LAQPLPTLLA
310
PVLACLTVGF LR
Length:312
Mass (Da):35,151
Last modified:February 1, 1997 - v1
Checksum:iBAEA320C09426351
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58870 mRNA Translation: AAB09466.1
BC142534 mRNA Translation: AAI42535.1
RefSeqiNP_776322.1, NM_173897.1
UniGeneiBt.555

Genome annotation databases

EnsembliENSBTAT00000023909; ENSBTAP00000023909; ENSBTAG00000017969
GeneIDi280741
KEGGibta:280741

Similar proteinsi

Entry informationi

Entry nameiCAH4_BOVIN
AccessioniPrimary (citable) accession number: Q95323
Secondary accession number(s): A5PKL8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 1, 1997
Last modified: May 23, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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